EKS-ORC-00450

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00450

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	523.3	1.3E-157	1	254	254

Status

Unreviewed

Ensembl Protein

ENSOCUP00000023319

UniProt Accession

G1TEL6;

Protein Name

Protein Synonyms/Alias

Gene Name

CAMK2A

Gene Synonyms/Alias

CAMK2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000017865	ENSOCUP00000023319	ENSOCUT00000029558
ENSOCUG00000017865	ENSOCUP00000021668	ENSOCUT00000022769
ENSOCUG00000017865	ENSOCUP00000015346	ENSOCUT00000017865

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

461

Protein Sequence
(FASTA)

RGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARVSNRTERE GYILRALGHP AIFRLHDSIS 60

EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL EAVLHCHQMG VVHRDLKPEN 120

LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGGAGFAGTP GYLSPEVLRK DPYGKPVDLW 180

ACGVILYILL VGYPPFWDED QHRLYQQIKA GAYDFPSPEW DTVTPEAKDL INKMLTINPS 240

KRITAAEALK HPWISHRSTV ASCMHRQETV DCLKKFNARR KLKGAILTTM LATRNFSGGK 300

SAGNKKSDGV KESSESTNTT IEDEDTKVRK QEIIKVTEQL IEAISNGDFE SYTKMCDPGM 360

TAFEPEALGN LVEGLDFHRF YFENLWSRNS KPVHTTILNP HIHLMGDESA CIAYIRITQY 420

LDAGGIPRTA QSEETRVWHR RDGKWQIVHF HRSGAPSALP Q 461

Nucleotide Sequence
(FASTA)

AGGGGAGCCT TCTCCGTCGT GCGCCGCTGT GTGAAGGTGC TGGCCGGCCA GGAGTATGCC 60

GCCAAGATCA TCAACACCAA GAAACTCTCA GCCAGAGTTA GTAACAGAAC CGAGAGGGAG 120

GGATATATTT TGAGGGCTCT TGGCCATCCC GCCATCTTCC GCCTGCACGA CAGCATCTCT 180

GAGGAGGGAC ACCACTACCT GATCTTCGAC CTGGTCACTG GCGGGGAGCT GTTTGAAGAC 240

ATCGTGGCCC GGGAGTATTA CAGTGAGGCA GATGCCAGTC ACTGTATCCA GCAGATCCTG 300

GAGGCCGTGC TGCACTGCCA CCAGATGGGG GTGGTGCACC GGGACCTGAA GCCGGAGAAT 360

CTGCTGCTGG CCTCCAAGCT CAAGGGTGCT GCTGTGAAGC TGGCGGACTT TGGCCTGGCC 420

ATAGAGGTGG AGGGGGAGCA GCAGGCGTGG TTTGGGGGAG CAGGGTTTGC AGGGACCCCC 480

GGATACCTGT CCCCAGAAGT GCTGCGCAAG GACCCGTATG GGAAGCCTGT GGACCTGTGG 540

GCCTGTGGGG TCATCCTATA CATCCTGCTG GTTGGGTACC CCCCATTCTG GGATGAAGAC 600

CAGCACCGCC TGTACCAGCA GATCAAGGCC GGCGCCTATG ATTTCCCCTC ACCAGAATGG 660

GACACTGTCA CCCCAGAAGC CAAGGACCTC ATCAACAAGA TGCTGACCAT CAACCCGTCC 720

AAACGCATCA CGGCCGCCGA GGCCCTCAAG CACCCCTGGA TCTCGCACCG GTCCACTGTG 780

GCCTCCTGCA TGCACAGACA GGAGACCGTG GACTGCCTGA AGAAGTTCAA CGCCAGGAGG 840

AAACTGAAGG GCGCCATTCT CACCACCATG CTGGCTACCA GGAACTTCTC TGGAGGGAAG 900

AGCGCGGGGA ACAAGAAGAG CGATGGCGTG AAGGAATCTT CGGAGAGCAC CAACACCACC 960

ATTGAGGATG AAGACACCAA AGTGCGGAAA CAGGAAATTA TAAAAGTGAC AGAGCAGCTG 1020

ATTGAAGCCA TAAGCAATGG AGATTTTGAG TCCTACACGA AGATGTGCGA CCCCGGGATG 1080

ACGGCCTTCG AACCCGAGGC CCTGGGGAAC CTGGTCGAGG GCCTGGACTT CCATCGATTC 1140

TATTTTGAAA ACTTGTGGTC TCGAAACAGC AAGCCCGTGC ACACCACCAT CCTGAACCCC 1200

CACATCCACC TGATGGGCGA CGAGTCGGCC TGCATTGCCT ACATCCGCAT CACGCAATAC 1260

CTGGACGCGG GCGGCATCCC CCGCACCGCG CAGTCGGAGG AGACCCGCGT GTGGCACCGC 1320

CGGGACGGCA AGTGGCAGAT CGTCCACTTC CACAGATCGG GGGCGCCCTC GGCCCTGCCG 1380

CAGTAA 1386

Domain Profile

S: 9     kgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpnivrlhdsis  68

         +gafsvvrrcvkv +gqeyaakiintkklsar  ++ ere  i r l hp i rlhdsis

Q: 1     RGAFSVVRRCVKVLAGQEYAAKIINTKKLSARVSNRTEREGYILRALGHPAIFRLHDSIS  60

         69**********************************************************

S: 69    eegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvvhrdlkpen  128

         eeg+hyl+fdlvtggelfedivareyyseadashciqqile+vlh+hq+gvvhrdlkpen

Q: 61    EEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPEN  120

         ************************************************************

S: 129   lllaskakgaavkladfglaievqgdqqawfg...fagtpgylspevlrkdpygkpvdlw  185

         lllask+kgaavkladfglaiev+g+qqawfg   fagtpgylspevlrkdpygkpvdlw

Q: 121   LLLASKLKGAAVKLADFGLAIEVEGEQQAWFGgagFAGTPGYLSPEVLRKDPYGKPVDLW  180

         *******************************54559************************

S: 186   acgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkmltinpa  245

         acgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkmltinp+

Q: 181   ACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPS  240

         ************************************************************

S: 246   kritadealkhpwi  259

         krita+ealkhpwi

Q: 241   KRITAAEALKHPWI  254

         *************8

Domain Sequence
(FASTA)

RGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARVSNRTERE GYILRALGHP AIFRLHDSIS 60

EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL EAVLHCHQMG VVHRDLKPEN 120

LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGGAGFAGTP GYLSPEVLRK DPYGKPVDLW 180

ACGVILYILL VGYPPFWDED QHRLYQQIKA GAYDFPSPEW DTVTPEAKDL INKMLTINPS 240

KRITAAEALK HPWI 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity
GO:0006816	; P:calcium ion transport
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation
GO:0048168	; P:regulation of neuronal synaptic plasticity
GO:0046928	; P:regulation of neurotransmitter secretion

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013