EKS-ORC-00260

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00260

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	455.8	6.5E-137	191	478	288

Status

Unreviewed

Ensembl Protein

ENSOCUP00000015408

UniProt Accession

G1TRG6;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000017934	ENSOCUP00000019622	ENSOCUT00000027212
ENSOCUG00000017934	ENSOCUP00000015408	ENSOCUT00000017934

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

LLGGSGGAGP PSPAALLCAC TSCLQTNDTC ETDGACMVSI FNLDGIEHHV RTCIPKVELV 60

PAGKPFYCLS SEDLRNTHCC YTDFCNKIDL RVPSGHLKEP EHPSMWGPVE LVGIIAGPVF 120

LLFLIIIIVF LVINYHQRVY HNRQRLDMED PSCEMCLSKD KTLQDLVYDL STSGSGSGLP 180

LFVQRTVART IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML 240

RHENILGFIA ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA 300

HLHMEIVGTQ GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG 360

TKRYMAPEVL DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS 420

DPSIEEMRKV VCDQKLRPNV PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTLSQ 480

LSVQEDVKI 489

Nucleotide Sequence
(FASTA)

TTATTAGGAG GGAGTGGTGG AGCCGGACCC CCGTCTCCCG CAGCCTTGCT GTGTGCGTGC 60

ACCAGCTGCC TGCAGACCAA CGACACATGT GAGACGGATG GGGCCTGCAT GGTGTCCATT 120

TTCAACCTGG ACGGGATTGA GCACCATGTG CGCACCTGCA TCCCCAAGGT GGAGCTGGTG 180

CCCGCCGGGA AGCCGTTCTA CTGCCTGAGC TCGGAGGACC TGCGCAACAC CCACTGCTGC 240

TACACGGACT TCTGCAACAA GATCGACCTG CGGGTGCCCA GTGGCCACCT CAAGGAGCCC 300

GAGCACCCGT CCATGTGGGG CCCCGTGGAG CTGGTGGGCA TCATCGCCGG CCCCGTGTTC 360

CTGCTCTTTC TCATCATCAT CATCGTCTTC CTCGTCATTA ACTACCATCA GCGTGTCTAC 420

CACAACCGCC AGAGACTGGA CATGGAGGAC CCCTCCTGCG AGATGTGCCT GTCCAAGGAC 480

AAGACGCTGC AGGACCTCGT CTACGATCTC TCCACCTCGG GCTCCGGCTC AGGGCTGCCC 540

CTATTTGTCC AGCGCACAGT GGCCCGAACC ATTGTTTTAC AGGAGATTAT CGGCAAAGGC 600

CGCTTTGGGG AGGTGTGGCG CGGCCGCTGG CGGGGCGGCG ACGTGGCTGT GAAAATCTTC 660

TCTTCCCGCG AAGAGCGCTC CTGGTTCCGG GAGGCTGAGA TCTACCAGAC GGTCATGCTG 720

CGCCACGAGA ACATCCTGGG CTTCATCGCC GCCGACAACA AAGATAACGG CACGTGGACG 780

CAGCTGTGGC TGGTTTCCGA TTACCACGAG CATGGCTCGC TGTTCGATTA CCTGAACCGG 840

TACACGGTGA CCATCGAGGG CATGATCAAG CTGGCCCTGT CGGCTGCTAG TGGGCTGGCG 900

CACCTGCACA TGGAGATCGT GGGGACCCAA GGGAAGCCGG GGATTGCTCA CCGGGACTTG 960

AAGTCCAAGA ACATCCTGGT GAAGAAGAAC GGCATGTGTG CCATCGCAGA CCTGGGCCTG 1020

GCTGTGCGCC ACGACGCCGT CACCGACACC ATCGACATTG CCCCCAACCA GAGGGTGGGC 1080

ACCAAGCGGT ACATGGCCCC GGAAGTACTG GACGAAACCA TCAACATGAA GCACTTTGAT 1140

TCGTTCAAGT GTGCCGACAT CTATGCCCTC GGGCTGGTGT ACTGGGAGAT TGCCCGACGG 1200

TGCAACTCTG GAGGAGTCCA CGAGGAGTAT CAGCTGCCGT ATTACGACTT GGTGCCGTCC 1260

GACCCCTCCA TCGAGGAGAT GCGGAAGGTT GTTTGTGACC AGAAGCTACG TCCCAATGTC 1320

CCCAACTGGT GGCAGAGCTA CGAGGCGCTG CGGGTGATGG GCAAGATGAT GCGGGAGTGT 1380

TGGTACGCCA ACGGTGCGGC GCGCCTCACC GCCCTGCGCA TCAAGAAGAC GCTGTCCCAG 1440

CTCAGCGTGC AGGAGGATGT GAAGATC 1467

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 191   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  250

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 251   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  310

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 311   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  368

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 369   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  427

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP++p+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 428   RKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  478

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNV PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001942	; P:hair follicle development
GO:0001701	; P:in utero embryonic development
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013