EPS-ORC-00124

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00124

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	618.9	1.6E-186	121	432	312

Status

Reviewed

Ensembl Protein

ENSOCUP00000018147

UniProt Accession

P55739;

Protein Name

Serine/threonine-protein phosphatase 5

Protein Synonyms/Alias

PP5; Protein phosphatase T; PPT;

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C; PPP5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000021025	ENSOCUP00000018147	ENSOCUT00000023487

Organism

Oryctolagus cuniculus

Functional Description

May play a role in the regulation of RNA biogenesisand/or mitosis.

Protein Length

435

Protein Sequence
(FASTA)

YYGQRALAYL RTECYGYALG DTRAIEIDKK YIKGYYRRAA SNMALGKFRA ALRDYETVVK 60

VKPHDKDAKL KYQECNKIVK QKAFERAIAG DEHKRSVVDS LDIESMTIED EYSGPKLEDG 120

RVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLRET EKITVCGDTH 180

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 240

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 300

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENHLDYII 360

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL RGSDLRPQFH QFTAVPHPNV 420

KPMAYANALL QLGVM 435

Nucleotide Sequence
(FASTA)

TACTACGGGC AACGGGCCTT GGCCTACCTG CGCACCGAGT GCTATGGCTA TGCGCTGGGC 60

GACACGCGGG CCATCGAGAT TGACAAGAAG TACATCAAGG GCTACTACCG CCGGGCCGCC 120

AGCAACATGG CACTGGGCAA GTTCCGGGCC GCGCTGCGGG ACTACGAGAC GGTGGTGAAG 180

GTGAAGCCCC ATGACAAGGA CGCCAAGTTG AAGTACCAGG AGTGCAACAA GATCGTGAAG 240

CAGAAGGCCT TCGAGCGGGC CATCGCGGGC GACGAGCACA AGCGCTCCGT CGTGGACTCG 300

CTGGACATCG AGAGCATGAC CATCGAGGAC GAGTACAGCG GACCCAAGCT GGAGGACGGC 360

AGAGTGACAA TCACCTTCAT GAAGGAGCTC ATGCAGTGGT ACAAGGACCA GAAGAAACTG 420

CACCGGAAGT GCGCCTACCA GATTCTGGTG CAGGTCAAGG AAGTCCTCTC CAAGCTGAGC 480

ACGCTCGTGG AGACCACGCT GAGAGAGACA GAGAAGATTA CGGTATGTGG GGACACCCAT 540

GGCCAGTTCT ACGACCTCCT CAACATATTT GAGCTCAACG GTTTACCCTC AGAGACCAAC 600

CCCTACATAT TCAATGGCGA CTTCGTGGAC CGCGGCTCCT TCTCCGTAGA AGTGATCCTC 660

ACCCTTTTCG GCTTCAAGCT CCTGTACCCA GACCACTTTC ACCTACTTCG AGGCAACCAC 720

GAGACGGACA ACATGAACCA GATCTATGGC TTCGAGGGCG AGGTGAAGGC CAAGTACACG 780

GCCCAGATGT ACGAGCTCTT CAGCGAGGTG TTTGAGTGGC TGCCGCTGGC CCAGTGCATC 840

AACGGCAAAG TGCTGATCAT GCACGGGGGC CTGTTCAGTG AGGACGGCGT CACTCTGGAC 900

GACATCCGGA AGATCGAGCG GAATCGGCAG CCCCCAGACT CAGGTCCCAT GTGCGACCTG 960

CTCTGGTCGG ACCCACAGCC ACAGAACGGG CGCTCGGTCA GCAAGCGAGG CGTGAGCTGC 1020

CAGTTCGGGC CTGACGTTAC CAAGGCCTTC CTGGAGGAGA ACCACCTGGA CTACATCATC 1080

CGCAGCCACG AGGTCAAGGC CGAGGGCTAC GAGGTGGCAC ACGGCGGCCG CTGTGTCACC 1140

GTCTTCTCCG CCCCCAACTA CTGCGACCAG ATGGGGAACA AAGCCTCCTA CATCCACCTG 1200

CGGGGCTCCG ACCTGCGGCC CCAGTTCCAC CAGTTCACAG CAGTGCCTCA CCCCAACGTC 1260

AAGCCCATGG CCTACGCCAA CGCGCTGCTG CAGTTAGGGG TGATG 1305

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         +v+i f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e++++e++kitvcGdth

Q: 121   RVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLRETEKITVCGDTH  180

         6899********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 181   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  240

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 241   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  300

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 301   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENHLDYII  360

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih+r++dlr+++++f+av+hp+v

Q: 361   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLRGSDLRPQFHQFTAVPHPNV  420

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 421   KPMAYANALLQL  432

         *********987

Domain Sequence
(FASTA)

RVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLRET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENHLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL RGSDLRPQFH QFTAVPHPNV 300

KPMAYANALL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

InterPros

IPR011236

; Ser/Thr_PPase_5.

Pfam

SMARTs

Prosites

PS00125

; SER_THR_PHOSPHATASE; PARTIAL.

Prints

Created Date

20-Feb-2013