EKS-ORC-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR560.22.3E-168572897326
StatusUnreviewed
Ensembl ProteinENSOCUP00000020310
UniProt AccessionG1TTE0;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000021056ENSOCUP00000020310ENSOCUT00000021641
OrganismOryctolagus cuniculus
Functional Description
Protein Length938
Protein Sequence
(FASTA)
MGPGALLVLL ATTVWQGGGV PVIEPSGPEL VVEPGAVVTL RCLGNGTVKW DGPISSYWTL 60
DPDAPSSVLI TNNATFKNTG TYHCTELGDP LGESATIHVY VKASELPWHR VTSIKRSASE 120
PPCPHLSLSV QTHLPGSTSS RSTTNYTFSP WHGFTIHKAK LESRDYYCCA LVDGKIMKSI 180
GIELRVQQGE WWRKPPPAGQ APSAIVEMGE SEPGPRLSTG LEMGVSPCNE LWETKLALSE 240
DSDFHDGSYH KVLTLSLSDV SFQDAGNYTC VATNPQGTRS SSMVFRVVGS AYVNLTSKQN 300
LFQEVSVGET LNLQVQVEAY PDLQSFNWTY LGPFSDYEPK LEFITNKDMY RYTSSLSLRR 360
LKPTEAGRYC FLARNVGGSS ALTFELALQY PPAVTLTRTL VNGSDALFCD VSGYPQPNVT 420
WLQCRGHADR CDEAHVLWIW EDPSPKVLSQ EPFHKVTVQS LLSTGSLEHN VTYECRALNT 480
VGNDSETFRP VSIGAYVQLP EGSLFTPVVV ACLSVMALLL LLLLLLLYKY KQKPKYQVRW 540
KIIESSEGNS YTFVDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT AFGLGKEDAV 600
LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTHGGPVL VITEYCCYGD 660
LLNFLRRKAE AMLGPSQEEP EGENGYKNVH LEKKYICRDS GFSSQGMDTY VEMRPISTSS 720
SNDPSEQGLD KEDGRLLELR DLLHFSSQVA QGMAFLASKN CIHRDVAARN VLLTSGHVAK 780
IGDFGLARDI MNDSNYIVKG NARLPVKWMA PESIFDCVYT VQSDVWSYGI LLWEIFSLGL 840
NPYPGILVNS KFYKLVKDGY QMAQPAFAPK NIYSIMQACW ALEPTHRPTF QQICVLLQEQ 900
VQAATREQDY TNLPEHLACC EPGETAQPSL QPNNYQFC 938
Nucleotide Sequence
(FASTA)
ATGGGCCCAG GGGCTCTGCT TGTCCTGCTG GCAACCACAG TGTGGCAAGG TGGAGGAGTG 60
CCCGTGATAG AACCCAGCGG CCCTGAGCTG GTGGTGGAGC CGGGTGCGGT GGTGACCCTG 120
CGATGCCTGG GCAATGGCAC CGTCAAGTGG GATGGCCCCA TCTCCTCATA CTGGACCCTG 180
GACCCGGACG CCCCCAGCAG CGTCCTGATC ACAAACAATG CCACCTTCAA AAACACGGGG 240
ACCTATCACT GCACAGAGCT TGGAGACCCT CTTGGGGAGA GCGCCACCAT CCATGTCTAC 300
GTCAAAGCAT CTGAACTACC TTGGCACAGA GTGACCTCGA TCAAACGATC TGCCTCTGAG 360
CCTCCCTGTC CCCACCTGTC TCTCTCGGTC CAGACCCATC TGCCTGGATC TACTAGTTCC 420
CGCTCCACCA CCAATTATAC CTTCTCGCCC TGGCATGGCT TCACCATCCA CAAGGCCAAA 480
CTTGAGAGCC GGGATTACTA TTGTTGTGCT CTGGTGGACG GCAAGATAAT GAAGTCCATC 540
GGTATTGAGC TCAGAGTGCA GCAAGGTGAG TGGTGGAGGA AGCCTCCCCC TGCTGGGCAG 600
GCACCCAGTG CAATCGTGGA GATGGGTGAG AGTGAGCCGG GTCCCAGGCT CAGCACTGGG 660
CTTGAGATGG GAGTCAGTCC CTGTAATGAG CTGTGGGAAA CAAAACTCGC GCTCTCTGAA 720
GACTCCGACT TCCATGATGG TAGCTACCAT AAAGTCCTGA CCCTCAGCCT CAGTGACGTA 780
AGCTTCCAAG ATGCGGGCAA CTACACCTGC GTGGCCACCA ACCCCCAGGG CACCCGCTCC 840
TCCTCCATGG TCTTCCGGGT GGTAGGGAGT GCCTATGTGA ACCTGACCTC GAAGCAGAAC 900
CTATTCCAGG AGGTCTCAGT GGGCGAGACC CTGAACCTCC AAGTGCAGGT GGAGGCCTAC 960
CCAGACCTGC AGAGTTTTAA CTGGACTTAC CTGGGGCCTT TCTCCGACTA TGAGCCCAAG 1020
CTTGAGTTTA TCACCAACAA GGACATGTAC AGGTACACGT CCAGCCTCTC CCTGCGCCGT 1080
CTGAAGCCCA CCGAGGCCGG CCGCTACTGC TTCCTGGCCA GGAACGTGGG TGGCTCCAGT 1140
GCTCTGACCT TCGAGCTCGC CCTGCAATAC CCCCCAGCAG TGACCCTCAC CAGGACCCTA 1200
GTCAATGGCT CAGACGCCCT CTTCTGTGAT GTGTCCGGGT ACCCCCAGCC CAACGTGACT 1260
TGGCTGCAGT GCAGGGGCCA TGCTGACAGA TGTGATGAGG CCCACGTGCT GTGGATCTGG 1320
GAGGACCCGT CGCCCAAGGT GCTGAGCCAG GAGCCCTTCC ACAAAGTGAC CGTCCAGAGC 1380
CTGCTGTCCA CTGGGTCCCT GGAACACAAC GTGACCTATG AGTGCAGGGC CCTCAACACC 1440
GTGGGCAACG ACTCCGAGAC CTTCAGGCCC GTCTCTATAG GAGCCTACGT GCAGCTCCCC 1500
GAGGGGTCCC TCTTCACGCC AGTGGTGGTC GCTTGCCTGT CCGTCATGGC CTTGCTGCTG 1560
CTGCTCCTCT TGCTGCTCTT GTACAAGTAC AAACAGAAGC CCAAGTACCA GGTGCGCTGG 1620
AAGATCATCG AGAGCTCCGA GGGCAACAGT TACACCTTCG TCGACCCCAC GCAGCTGCCC 1680
TACAATGAGA AGTGGGAGTT CCCCCGGAAC AACCTGCAGT TTGGTAAGAC CCTGGGAGCC 1740
GGCGCCTTCG GGAAGGTGGT GGAGGCCACG GCCTTTGGTC TGGGCAAGGA AGACGCTGTG 1800
CTGAAGGTGG CTGTGAAGAT GCTGAAGTCC ACTGCCCACG CGGACGAGAA GGAGGCCCTC 1860
ATGTCGGAAC TAAAGATCAT GAGTCACCTG GGTCAGCACG AGAACATTGT CAACCTGCTG 1920
GGAGCCTGCA CCCACGGAGG CCCGGTGCTG GTCATCACGG AGTACTGTTG CTATGGCGAC 1980
CTGCTCAACT TCCTGCGGAG GAAAGCGGAG GCCATGCTGG GACCTAGCCA GGAGGAACCC 2040
GAGGGGGAGA ACGGCTACAA GAATGTCCAC CTGGAGAAGA AATACATCTG CAGGGACAGT 2100
GGCTTTTCCA GCCAGGGCAT GGACACCTAC GTGGAAATGA GGCCCATCTC CACGTCTTCT 2160
TCAAATGACC CCTCCGAGCA AGGCCTTGAC AAGGAAGATG GCCGGCTGCT GGAGCTCCGC 2220
GACCTGCTCC ACTTCTCCAG CCAAGTGGCC CAGGGCATGG CCTTCCTGGC TTCCAAGAAC 2280
TGCATCCACC GGGACGTAGC AGCCCGCAAC GTGCTGCTGA CCAGCGGCCA TGTGGCCAAG 2340
ATTGGGGACT TTGGGCTGGC TAGGGACATC ATGAACGACT CCAACTACAT CGTCAAGGGC 2400
AATGCCCGCC TGCCTGTCAA GTGGATGGCC CCGGAGAGCA TCTTTGACTG TGTCTACACC 2460
GTCCAGAGCG ATGTGTGGTC CTACGGCATC CTGCTCTGGG AGATCTTCTC ACTCGGGCTG 2520
AACCCTTACC CTGGCATCCT GGTGAACAGC AAGTTCTATA AACTGGTGAA AGACGGATAC 2580
CAAATGGCCC AGCCTGCATT TGCACCAAAG AACATATACA GCATCATGCA GGCCTGCTGG 2640
GCCCTGGAGC CCACACACAG ACCCACCTTC CAGCAGATCT GCGTCCTGCT TCAGGAGCAA 2700
GTCCAAGCGG CCACGAGAGA GCAGGACTAC ACCAATCTGC CTGAGCACCT GGCCTGCTGT 2760
GAGCCCGGGG AGACGGCCCA GCCCTCGCTG CAGCCCAATA ACTACCAGTT CTGCTGA 2817
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 572   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  631
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  s+e   e+e e  +k+
Q: 632   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSQE---EPEGENGYKN  688
         ******************************************77655...5778888888
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++ ++s +ss++ ++yv++++    +s+s+++ ++++             l++e
Q: 689   VhLEKKYICRDSGFSSQGMDTYVEMRP----ISTSSSNDPSEQG------------LDKE  732
         8799***********************....9999888887776............8899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d + lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 733   DGRLLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMN  792
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 793   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  852
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q++ ll
Q: 853   YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICVLL  897
         ******************************************986
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSQEEPE GENGYKNVHL 120
EKKYICRDSG FSSQGMDTYV EMRPISTSSS NDPSEQGLDK EDGRLLELRD LLHFSSQVAQ 180
GMAFLASKNC IHRDVAARNV LLTSGHVAKI GDFGLARDIM NDSNYIVKGN ARLPVKWMAP 240
ESIFDCVYTV QSDVWSYGIL LWEIFSLGLN PYPGILVNSK FYKLVKDGYQ MAQPAFAPKN 300
IYSIMQACWA LEPTHRPTFQ QICVLL 326
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013