EKS-ORC-00039

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00039

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	435.1	9.2E-131	37	303	267

Status

Unreviewed

Ensembl Protein

ENSOCUP00000015720

UniProt Accession

G1TFM7;

Protein Name

Protein Synonyms/Alias

Gene Name

VRK1

Gene Synonyms/Alias

VRK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000021326	ENSOCUP00000015720	ENSOCUT00000027107

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

415

Protein Sequence
(FASTA)

MPRVKAAQAG RQGPAKRRLA EQFAAGEIVT DLSKKEWKLG LPIGQGGFGC IYLADTNSSK 60

SVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD 120

KNGKSYRFMI MDRFGSDLQK IYEANARRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA 180

SNLLLSYKNP DQVYLVDYGL AYRYCPEGVH KEYKEDPKRC HDGTLEFTSI DAHNGVAPSR 240

RGDLEILGYC MVQWLSGHLP WEDNLKDPNY VRDSKIRYRE DIAGLMDKCF PEKNKPGEIA 300

KYLETVKLLG YTEKPLYQNL RDILLQGLKA IGSKDDGKLD LSVVENGDLK AKTVTKKRKK 360

EKEESTASSV EDMECSSAQT EETIQTRSEE PPGAAYGSMS QPEAGSSSHD SEWEQ 415

Nucleotide Sequence
(FASTA)

ATGCCTCGTG TAAAAGCAGC TCAAGCTGGG AGACAGGGCC CAGCAAAACG GCGTCTCGCG 60

GAGCAGTTTG CCGCTGGGGA GATAGTGACT GACTTGTCAA AGAAGGAATG GAAGCTGGGG 120

TTGCCCATTG GCCAAGGCGG CTTTGGTTGT ATCTATCTCG CTGATACAAA TTCTTCAAAG 180

TCCGTTGGCA GTGATGCACC TTGCGTTGTG AAAGTGGAAC CGAGTGACAA TGGACCTCTT 240

TTTACTGAAT TAAAGTTCTA CCAACGAGCT GCTAAACCAG AGCAAATTCA GAAATGGATT 300

CGTACCCATA AACTGAAGTA CCTGGGTGTT CCTAAGTATT GGGGGTCTGG TCTGCATGAT 360

AAAAATGGAA AAAGTTACAG GTTTATGATA ATGGATCGCT TTGGGAGTGA CCTTCAGAAA 420

ATATACGAAG CAAATGCCAG AAGGTTTTCT CGGAAAACTG TCTTGCAGCT AAGCTTAAGA 480

ATTCTGGATA TTCTGGAATA TATTCACGAG CATGAGTATG TACATGGAGA TATCAAGGCC 540

TCGAATCTCC TCCTGAGCTA CAAGAATCCT GACCAGGTGT ACTTGGTGGA CTATGGCCTT 600

GCTTATCGAT ACTGCCCAGA AGGAGTTCAT AAAGAATACA AAGAAGACCC CAAGAGGTGT 660

CACGACGGCA CCCTTGAATT CACCAGTATC GATGCACACA ATGGCGTGGC CCCATCGAGA 720

CGTGGTGATT TGGAAATCCT TGGTTACTGC ATGGTCCAGT GGCTCAGTGG CCATCTTCCT 780

TGGGAGGATA ATTTGAAAGA CCCTAACTAT GTTAGAGATT CCAAAATTAG GTACAGAGAA 840

GATATTGCAG GTTTGATGGA TAAATGTTTT CCTGAGAAAA ACAAGCCAGG TGAAATTGCT 900

AAATACTTGG AAACAGTGAA ATTACTGGGC TATACTGAAA AACCTCTTTA TCAAAATTTA 960

CGAGATATTC TTCTGCAAGG ACTAAAAGCT ATAGGAAGTA AGGATGATGG CAAACTGGAC 1020

CTCAGTGTTG TGGAGAACGG AGATTTGAAA GCGAAGACAG TGACGAAGAA GAGAAAGAAA 1080

GAAAAGGAAG AAAGCACAGC CTCTAGTGTT GAAGATATGG AATGCTCAAG CGCGCAGACG 1140

GAGGAGACCA TACAAACCCG AAGTGAGGAG CCCCCAGGAG CAGCGTATGG AAGCATGTCT 1200

CAGCCAGAGG CTGGCAGCAG CAGCCATGAC AGTGAGTGGG AACAA 1245

Domain Profile

S: 1     wklgkkigkggfGeiyla..ltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqi  58

         wklg +ig+ggfG+iyla  +++k++++da +vvkvep++nGpLf+elkfyqraak+eqi

Q: 37    WKLGLPIGQGGFGCIYLAdtNSSKSVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI  96

         9*****************999999************************************

S: 59    kkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlq  118

         +kw++++klk+lg+P++++sGlh+++g++yRf++++r+g+dLqk++e+n++r+s+ktvlq

Q: 97    QKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANARRFSRKTVLQ  156

         ************************************************************

S: 119   lavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeyked  178

         l++r+ld+ley+He+eYvHgdikA+nlll++++++qvyLvdyGlayrycpeg+hkeyked

Q: 157   LSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPEGVHKEYKED  216

         ************************************************************

S: 179   krraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkake  238

         ++r+HdGtlefts+DaH+GvapsrR+DleiLgYc+++Wl+g+LPWe++lkdp++v+++k

Q: 217   PKRCHDGTLEFTSIDAHNGVAPSRRGDLEILGYCMVQWLSGHLPWEDNLKDPNYVRDSKI  276

         ************************************************************

S: 239   kfldelpellkkllkkkssseelakyl  265

         ++ ++++ l++k++++k++++e+akyl

Q: 277   RYREDIAGLMDKCFPEKNKPGEIAKYL  303

         **************************8

Domain Sequence
(FASTA)

WKLGLPIGQG GFGCIYLADT NSSKSVGSDA PCVVKVEPSD NGPLFTELKF YQRAAKPEQI 60

QKWIRTHKLK YLGVPKYWGS GLHDKNGKSY RFMIMDRFGS DLQKIYEANA RRFSRKTVLQ 120

LSLRILDILE YIHEHEYVHG DIKASNLLLS YKNPDQVYLV DYGLAYRYCP EGVHKEYKED 180

PKRCHDGTLE FTSIDAHNGV APSRRGDLEI LGYCMVQWLS GHLPWEDNLK DPNYVRDSKI 240

RYREDIAGLM DKCFPEKNKP GEIAKYL 267

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005795	; C:Golgi stack
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0090166	; P:Golgi disassembly
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013