EKS-ORC-00409

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00409

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	319.7	1.9E-95	6	242	237

Status

Unreviewed

Ensembl Protein

ENSOCUP00000022416

UniProt Accession

G1TZ94;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK3

Gene Synonyms/Alias

ULK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000022077	ENSOCUP00000022416	ENSOCUT00000024464
ENSOCUG00000022077	ENSOCUP00000020206	ENSOCUT00000028413

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

439

Protein Sequence
(FASTA)

ARCWCAKDTR EVVAIKCVAK KSLNKASVEN LLTEIEILKG IRHPHIEQLR DFQWDSEHIY 60

LIMEFCAGGD LSRFIHTRRI LPEKVARVFM QQLASALQFL HERNISHLDL KPQNILLSSL 120

ERPHLKLADF GFAQHMSPWD EKHVLRGSPL YMAPEMVCRR QYDARVDLWS VGVILYEALF 180

REPPFASRSF SELEEKIRSS RVIELPLRPP LSRDCRDLLQ RLLERDPSRR ISFQDFFAHP 240

WVDLEHMPSG ESLARATALV VQAVAKDQEG DAAAALSLYC KALDFFVPAL HCESWAVPRG 300

WLPLQVSQYV SRAEELKAIV SSSNQALLRQ GPSARDLLRE MARDKPRLLA ALEVSAAAMA 360

KEEEAGGEQD ALDLYERSLG ELLLLLAAEP PGRRRELLHT EVQTLMARAE YLKEQVKMRE 420

SHWEAETLDK EGLSESVRS 439

Nucleotide Sequence
(FASTA)

GCCAGGTGCT GGTGCGCAAA GGACACTCGC GAGGTGGTGG CTATAAAATG TGTGGCCAAG 60

AAGAGCCTGA ACAAGGCGTC CGTGGAGAAC CTGCTGACGG AGATCGAGAT CCTCAAGGGC 120

ATTCGGCACC CTCACATCGA GCAGCTCAGG GACTTCCAGT GGGACAGCGA GCACATCTAC 180

CTCATCATGG AGTTCTGCGC GGGCGGCGAC CTGTCCCGCT TCATCCACAC CCGCAGGATT 240

CTGCCTGAGA AAGTGGCCCG GGTCTTCATG CAACAGCTGG CCAGTGCCCT GCAGTTCCTG 300

CACGAACGGA ACATCTCCCA CCTGGACCTG AAGCCACAGA ACATTCTGCT GAGCTCCCTG 360

GAGCGGCCGC ACCTGAAGCT GGCAGACTTC GGCTTCGCCC AGCACATGTC CCCGTGGGAC 420

GAGAAGCACG TGCTGCGCGG CTCGCCCCTC TACATGGCGC CCGAGATGGT GTGTCGGCGG 480

CAGTACGACG CCCGCGTGGA CCTCTGGTCC GTGGGGGTCA TCCTGTACGA GGCACTCTTC 540

CGAGAACCCC CGTTCGCGTC CAGGTCCTTC TCGGAGCTGG AGGAAAAGAT CCGAAGCAGC 600

CGGGTCATCG AGCTCCCCCT GCGGCCGCCG CTCTCCCGAG ACTGCCGGGA CCTGCTGCAG 660

CGGCTCCTGG AGCGGGACCC CAGCCGCCGC ATCTCCTTCC AGGACTTCTT CGCCCACCCC 720

TGGGTGGACC TGGAACACAT GCCCAGCGGG GAGAGCCTGG CCCGAGCCAC CGCCCTGGTG 780

GTGCAGGCCG TGGCGAAGGA CCAGGAGGGG GACGCGGCCG CAGCCTTGTC GCTCTACTGC 840

AAGGCCCTGG ACTTCTTTGT GCCCGCCCTC CACTGTGAGT CCTGGGCGGT GCCCCGTGGG 900

TGGCTCCCCC TGCAGGTGAG CCAGTACGTG TCCCGGGCGG AGGAGCTCAA GGCCATCGTG 960

TCCTCCTCCA ATCAGGCCCT GCTGCGCCAG GGGCCCTCTG CCCGCGACCT GCTCAGAGAG 1020

ATGGCCCGGG ACAAGCCACG CCTCCTGGCT GCCCTGGAAG TGTCTGCTGC TGCCATGGCC 1080

AAGGAGGAGG AAGCTGGCGG GGAGCAGGAC GCCCTGGACC TGTACGAGCG CAGCCTAGGG 1140

GAGCTGCTGC TGCTGCTGGC AGCAGAGCCC CCCGGCCGGA GGCGGGAGCT GCTTCACACC 1200

GAGGTCCAGA CCCTCATGGC TCGAGCTGAG TACCTGAAGG AGCAGGTCAA GATGAGGGAG 1260

TCTCACTGGG AAGCAGAGAC CCTGGACAAA GAGGGGCTGT CGGAGTCGGT CCGCAGC 1317

Domain Profile

S: 21    rkktsqvvAikvvekkkl.kkslenlekeikilkelkhenivalldveetskevylvmey  79

          k+t++vvAik+v+kk+l k+s+enl +ei+ilk ++h++i +l d++++s+++yl+me+

Q: 6     AKDTREVVAIKCVAKKSLnKASVENLLTEIEILKGIRHPHIEQLRDFQWDSEHIYLIMEF  65

         5899**************999***************************************

S: 80    caggdLakllkqkkeLsedtvreflqqlasalkaLhskkivhrDlkPqniLlsyadakke  139

         caggdL++++++++ L+e+++r+f+qqlasal++Lh+++i+h DlkPqniLls      +

Q: 66    CAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLS------S  119

         *****************************************************......8

S: 140   lkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvkeqqydakaDlWSiGtilyell  199

         l+  +lkladFg+a++++ +++++ l+GsplYmaPE+v+++qyda++DlWS+G+ilye+l

Q: 120   LERPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYEAL  179

         99**********************************************************

S: 200   vGkpPfaaesiseLvekiekndvleppipkeisselkdllqsLLqrdpkkRisfeelfah  259

         + +pPfa++s+seL+eki++ +v+e+p++  +s++++dllq+LL+rdp++Risf+++fah

Q: 180   FREPPFASRSFSELEEKIRSSRVIELPLRPPLSRDCRDLLQRLLERDPSRRISFQDFFAH  239

         ************************************************************

S: 260   pfl  262

p++

Q: 240   PWV  242

*96

Domain Sequence
(FASTA)

AKDTREVVAI KCVAKKSLNK ASVENLLTEI EILKGIRHPH IEQLRDFQWD SEHIYLIMEF 60

CAGGDLSRFI HTRRILPEKV ARVFMQQLAS ALQFLHERNI SHLDLKPQNI LLSSLERPHL 120

KLADFGFAQH MSPWDEKHVL RGSPLYMAPE MVCRRQYDAR VDLWSVGVIL YEALFREPPF 180

ASRSFSELEE KIRSSRVIEL PLRPPLSRDC RDLLQRLLER DPSRRISFQD FFAHPWV 237

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0045880	; P:positive regulation of smoothened signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR007330	; MIT.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF04212	; MIT; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013