EKS-ORC-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	250.4	1.9E-74	991	1243	253

Status

Unreviewed

Ensembl Protein

ENSOCUP00000020017

UniProt Accession

G1TSK1;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000024545	ENSOCUP00000020017	ENSOCUT00000024201

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1295

Protein Sequence
(FASTA)

PPSPMEAFEE DRRCLSGSLP VPAPAESPAT PSPVDCRAPA MAHRHLSRKN GLSKLCQSRT 60

ALSEDRWSSY CLSSLAAQNI CTSRLYCPPT PEHADRLGSC SSASCCSLLR GFSAGWPTPL 120

LPTPVSNPNK AVFTVDAKTT EILVANDKAC SLLGYSSHDL IGQKLTQFFL KSDSHVVEAL 180

SEEHVEADGR VAVVFGTVVD IVSRGGEKIA VSVWMKKVRQ EHSLCCVVVL EPVERVSAWV 240

SFQSDGTITA CDRLFAHLHG FVSAEEVVGQ RITDLIPSVQ LPPPGQQVPK NLKIQRSVGR 300

ARDGTTFPLS LKLKSEAPSE AVDEGTAAPA RGFLASVWVF CTISGLITLQ PDGSIYGINH 360

SFALMLFGYG KAELLGKNIT FLIPGFYQYM DLADDSSVQL PDLAKCLDMS SDRGPGEAPL 420

DPWPAWDPAN GAQDPRVYVA TAGSHVLPPD ETLSLGDSQD GSPETQAPLD VGGKLLPSLP 480

PQPPPGEDSM PTDRLPAPAA RSLSTDEQST QAVGREEPAA PESPAEALLP ESSSEPADAK 540

PAAACEDSET ALAAQRWSSD VMCGPPREVP RDPGGLGGPG SPGSPNSLVD VTRPEPRAVG 600

QPAEGALPAH QPRFMSEWAL HKPSQDSAPR PPGMTSVSLG TPTQDEPWQG VKDDREELQA 660

CLIKEQLCPP SFAGAPDVSY IELMPRERLA VPLPVSRCSL RGRDMHGRAD SSSARYALAT 720

DLPGVLEPVE APEPGVHSYS WNLKEAFFSD QMDRTSSHCS CAVSEPTETP CPSAGGSDSD 780

VGGLSRQGSD VDARELLLLA GTCFRLGEGR RFQESRRTEP SEVSLVSSEH FEVSDSEGPS 840

CLLPTSDASS EEAQPAAEES RPSAQVTSTP VTPGAASLGR QIQEGTYSGS CYHRDGLRLS 900

IQFEVKRVEL QGSATLFCCW LVKNLLHSHQ DSATRTRLLL ASLPSSTHSM PELPGPSRGE 960

VLRAKPWFED PPKPMELEGL AACEGAYAHK YSTLSPLGSG AFGFVWTAVD REQNKEVVVK 1020

FIKKEKVLED CWIEDPKLGR VTLEIAILSQ VEHANIIKVL DVFENQGFFQ LVMEKHGSGL 1080

DLFAFIDHHP SLDEPLASYI FRQLVSAVGY LRSRGILHRD IKDENIVIAE DFSIKLIDFG 1140

SAAYLERGKL FHTFCGTIEY CAPEVLMGNP YRGPELEMWS LGVTLYTLIF EENPFCELEE 1200

TMEAAIHPPY LVSQELMNLV SGLLQPAPQQ RTTLEKLVTD PWVTQPVNLA DYTWEEVCRI 1260

NKPENGVLLP ASLGEQSLGE AGPGTPAPGE ASSGQ 1295

Nucleotide Sequence
(FASTA)

CCACCCTCCC CCATGGAAGC CTTTGAAGAG GACCGGAGAT GCCTGTCTGG GAGCCTCCCC 60

GTGCCAGCCC CTGCGGAGAG CCCCGCCACA CCGAGCCCCG TGGATTGCCG GGCCCCGGCC 120

ATGGCCCACA GGCACCTGAG CAGGAAGAAC GGGCTTTCCA AGCTCTGCCA GAGCAGAACG 180

GCGCTCTCTG AGGACAGGTG GAGCTCCTAC TGCCTGTCGT CACTGGCTGC TCAGAACATC 240

TGCACCAGCC GACTGTACTG CCCGCCGACG CCCGAGCATG CCGACCGGCT GGGCTCCTGC 300

AGCAGCGCGT CCTGCTGCTC CCTGCTGCGC GGCTTCTCTG CCGGTTGGCC CACGCCCCTG 360

CTGCCCACCC CCGTGAGCAA CCCCAACAAG GCCGTCTTCA CCGTGGACGC CAAGACCACA 420

GAGATCCTGG TGGCCAACGA TAAAGCTTGC AGCCTCCTGG GGTACAGCAG CCATGACCTG 480

ATTGGCCAGA AGCTCACACA GTTCTTCCTG AAGTCGGATT CCCACGTGGT CGAGGCTCTC 540

AGTGAGGAAC ACGTGGAGGC AGATGGCCGT GTTGCAGTGG TATTTGGCAC CGTGGTGGAC 600

ATCGTCAGCC GTGGCGGCGA GAAGATCGCC GTCTCCGTGT GGATGAAGAA GGTGCGGCAG 660

GAGCACAGCC TGTGCTGCGT GGTGGTCCTG GAGCCCGTGG AGAGGGTCTC AGCCTGGGTC 720

TCCTTCCAGA GCGATGGAAC CATCACAGCC TGTGACCGCC TCTTTGCCCA CCTCCACGGG 780

TTTGTGTCTG CAGAGGAAGT GGTCGGGCAG CGCATCACAG ACCTGATTCC GTCCGTGCAG 840

CTCCCTCCAC CCGGCCAGCA AGTCCCAAAG AATCTCAAGA TTCAGAGATC TGTTGGCAGA 900

GCCAGAGACG GCACCACCTT CCCTCTGAGT CTGAAGCTGA AGTCGGAAGC CCCCAGCGAG 960

GCAGTAGACG AGGGCACCGC GGCCCCCGCG CGAGGTTTCT TGGCTTCTGT CTGGGTCTTC 1020

TGCACCATCA GCGGCCTCAT CACCCTGCAG CCGGATGGCA GCATCTACGG CATCAACCAC 1080

AGCTTCGCCC TCATGCTGTT CGGTTATGGG AAGGCTGAGC TCCTGGGCAA GAACATCACT 1140

TTCCTGATCC CTGGCTTCTA CCAGTACATG GACCTTGCCG ATGACAGCTC TGTGCAGCTG 1200

CCAGACCTGG CCAAGTGCCT GGACATGAGC AGCGACCGTG GACCTGGGGA GGCGCCCTTG 1260

GACCCCTGGC CAGCCTGGGA CCCAGCCAAT GGAGCTCAGG ATCCGAGAGT TTATGTCGCA 1320

ACAGCTGGCA GCCACGTTCT GCCCCCAGAT GAGACCCTGA GTCTGGGAGA CAGCCAGGAT 1380

GGCTCTCCTG AGACTCAGGC CCCGCTGGAC GTTGGAGGCA AGCTCCTGCC CTCGCTGCCA 1440

CCTCAGCCAC CTCCTGGAGA GGACAGCATG CCAACAGATA GGCTGCCGGC CCCTGCCGCG 1500

CGGTCATTGT CCACAGACGA GCAAAGCACC CAAGCCGTGG GGAGGGAGGA GCCTGCAGCA 1560

CCAGAGAGCC CCGCAGAGGC CCTTCTGCCA GAGAGCAGCT CAGAGCCAGC AGACGCAAAG 1620

CCGGCCGCAG CCTGTGAAGA CTCTGAAACT GCGCTTGCAG CCCAGCGGTG GAGCAGCGAC 1680

GTCATGTGTG GCCCGCCTCG GGAAGTCCCA CGGGACCCCG GGGGTCTCGG GGGTCCTGGT 1740

AGTCCTGGCA GTCCTAACTC CTTGGTGGAT GTCACCAGGC CTGAGCCCCG TGCTGTGGGG 1800

CAGCCAGCAG AGGGCGCTCT CCCCGCACAC CAGCCTCGGT TCATGAGCGA GTGGGCCCTG 1860

CATAAGCCCA GCCAGGACTC GGCCCCCAGG CCCCCAGGAA TGACGAGTGT GTCTCTTGGG 1920

ACGCCCACAC AGGATGAGCC GTGGCAGGGG GTGAAAGACG ACCGGGAGGA GCTGCAGGCC 1980

TGCCTAATTA AGGAGCAGCT GTGCCCACCC AGCTTTGCAG GAGCCCCAGA CGTCTCCTAC 2040

ATCGAGCTCA TGCCCAGGGA GCGCCTGGCC GTCCCCCTGC CCGTGTCCCG CTGCAGTCTG 2100

AGAGGCAGGG ACATGCACGG CCGTGCGGAC AGCTCCTCGG CCCGCTACGC CCTAGCCACG 2160

GACCTGCCGG GTGTCCTGGA GCCTGTGGAG GCCCCGGAGC CCGGCGTGCA TTCCTACTCC 2220

TGGAACCTCA AGGAAGCCTT CTTCAGTGAC CAGATGGACC GAACTTCATC ACATTGTTCC 2280

TGTGCTGTGT CCGAGCCCAC GGAGACCCCC TGCCCCTCTG CAGGGGGCTC CGACTCGGAC 2340

GTGGGCGGCC TCTCCAGGCA GGGGTCCGAT GTGGACGCCA GGGAGCTGTT GCTGCTGGCT 2400

GGCACGTGCT TTAGGCTTGG CGAGGGCCGG CGGTTCCAGG AGAGCCGCCG GACAGAGCCC 2460

TCGGAGGTCT CTCTGGTGTC CTCTGAGCAC TTCGAAGTGA GCGACAGCGA AGGCCCCAGC 2520

TGCCTCCTTC CCACGTCAGA TGCCAGCTCT GAGGAGGCGC AGCCAGCAGC AGAGGAGTCG 2580

AGGCCAAGTG CCCAGGTCAC CTCCACACCT GTGACGCCGG GCGCCGCCAG CCTGGGGCGG 2640

CAGATCCAGG AGGGCACCTA TTCAGGGAGC TGCTACCACC GGGACGGTTT GCGGCTGAGC 2700

ATCCAGTTTG AAGTGAAGCG GGTGGAGCTC CAAGGCTCTG CCACCCTGTT CTGCTGCTGG 2760

CTGGTGAAGA ACCTCTTGCA CAGCCACCAG GACTCTGCCA CCAGGACACG CCTGCTGCTG 2820

GCCAGCTTGC CCAGCTCCAC GCACTCCATG CCGGAGCTCC CCGGGCCCAG CCGGGGGGAG 2880

GTGCTCCGGG CCAAGCCGTG GTTTGAGGAC CCCCCCAAGC CCATGGAGCT GGAGGGGCTG 2940

GCGGCCTGCG AGGGAGCGTA TGCCCACAAG TACAGCACCC TGAGCCCACT GGGCAGTGGC 3000

GCCTTCGGCT TCGTGTGGAC CGCAGTGGAC AGGGAGCAGA ACAAGGAGGT GGTGGTGAAG 3060

TTCATTAAGA AGGAGAAGGT CTTGGAGGAT TGTTGGATCG AGGACCCCAA ACTCGGAAGA 3120

GTGACTCTGG AGATTGCCAT CCTGTCCCAG GTGGAGCACG CCAACATCAT CAAGGTGCTG 3180

GATGTGTTTG AAAACCAGGG GTTTTTCCAG CTCGTGATGG AGAAGCATGG CTCCGGCCTG 3240

GACCTCTTCG CGTTCATCGA CCACCACCCC AGCCTGGACG AGCCCCTGGC AAGCTACATC 3300

TTCCGACAGC TGGTGTCCGC GGTGGGTTAC CTGCGCTCCA GGGGCATCCT GCACCGTGAC 3360

ATCAAGGACG AGAACATCGT GATCGCCGAG GACTTCAGCA TCAAGCTCAT CGACTTTGGC 3420

TCGGCTGCCT ACCTGGAGAG GGGCAAGCTG TTTCACACGT TCTGCGGAAC GATCGAGTAC 3480

TGCGCGCCCG AAGTGCTCAT GGGGAATCCC TACCGAGGGC CCGAGCTGGA GATGTGGTCT 3540

CTGGGGGTGA CGCTGTACAC GCTGATCTTC GAGGAGAACC CCTTCTGTGA GCTGGAGGAG 3600

ACCATGGAGG CGGCCATACA CCCCCCGTAC CTGGTGTCCC AGGAGCTCAT GAACCTCGTG 3660

TCGGGGCTGC TGCAGCCTGC CCCTCAGCAG CGCACCACCT TGGAGAAGCT GGTGACAGAC 3720

CCGTGGGTGA CACAGCCCGT GAACCTCGCT GACTACACCT GGGAGGAAGT GTGTCGCATA 3780

AACAAGCCAG AAAACGGAGT CCTGTTGCCT GCGAGTCTTG GGGAGCAGAG CCTGGGCGAG 3840

GCAGGACCAG GGACCCCTGC CCCAGGGGAG GCTTCCAGCG GCCAG 3885

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y++l+ lG+g+fg V +a+++e++++v+vK+ikk+k+      ++ +l +++ Ei+il++

Q: 991   YSTLSPLGSGAFGFVWTAVDREQNKEVVVKFIKKEKVledcwiEDPKLGRVTLEIAILSQ  1050

         88999*******************************99999998899*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++h niik+l+v+e++ +++lv+e + sg +Lf  i ++ +l+e  a+ +f+qlvsav Y

Q: 1051  VEHANIIKVLDVFENQGFFQLVMEkHGSGLDLFAFIDHHPSLDEPLASYIFRQLVSAVGY  1110

         ************************888899******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l+s+gi HrD+K eN+++ ++ +ik++DFG a+++++gkl++tfcG+++Y+aPe+l+g++

Q: 1111  LRSRGILHRDIKDENIVIAEDFSIKLIDFGSAAYLERGKLFHTFCGTIEYCAPEVLMGNP  1170

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Y+gp++++WslGv+Ly+l++++ Pf e       e++++  ++ p+ +s+el++L++ lL

Q: 1171  YRGPELEMWSLGVTLYTLIFEENPFCEL------EETMEAAIHPPYLVSQELMNLVSGLL  1224

         *************************998......78899999******************

S: 234   vvdpekRatieeilkhewl  252

         +  p++R+t+e++++++w+

Q: 1225  QPAPQQRTTLEKLVTDPWV  1243

         ******************7

Domain Sequence
(FASTA)

YSTLSPLGSG AFGFVWTAVD REQNKEVVVK FIKKEKVLED CWIEDPKLGR VTLEIAILSQ 60

VEHANIIKVL DVFENQGFFQ LVMEKHGSGL DLFAFIDHHP SLDEPLASYI FRQLVSAVGY 120

LRSRGILHRD IKDENIVIAE DFSIKLIDFG SAAYLERGKL FHTFCGTIEY CAPEVLMGNP 180

YRGPELEMWS LGVTLYTLIF EENPFCELEE TMEAAIHPPY LVSQELMNLV SGLLQPAPQQ 240

RTTLEKLVTD PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0045719	; P:negative regulation of glycogen biosynthetic process
GO:0046777	; P:protein autophosphorylation
GO:2000505	; P:regulation of energy homeostasis
GO:0070092	; P:regulation of glucagon secretion
GO:0043576	; P:regulation of respiratory gaseous exchange

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 3.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013