EKS-ORC-00325
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00325
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ack392.96.8E-118116377262
StatusUnreviewed
Ensembl ProteinENSOCUP00000023801
UniProt AccessionG1U343;
Protein Name
Protein Synonyms/Alias
Gene NameTNK1
Gene Synonyms/Alias TNK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000025052ENSOCUP00000023801ENSOCUT00000025850
OrganismOryctolagus cuniculus
Functional Description
Protein Length667
Protein Sequence
(FASTA)
MLPDAGSPWL LRLLRDIQLA QFYRPILEEL NVTRPEHFDF VRPEDLDGIG MGRPAQRRLA 60
EALKRHRSGL KSKNWVYKIL GGFNPEHKET TPAADSPVRL PEAEAGLKCL IPEGAVCRGE 120
LLGSGCFGVV HRGVWTLPSG QSVSVAIKSL RVGPEGPVGT ELGDFLREVS VMMNLEHPHV 180
LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPLLPVA LLCLFLRQLA AAMTYLGACG 240
LVHRDLATRN LLLASPRTIK VADFGLVRPL RGPRGRYVMG GPRPIPYAWC APESLRQGAF 300
SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEKER ARLPRPPLCS RALYALALRC 360
WAPHPADRPS FSHLEGLLQE AWPSEGHCIR DVTEPGALRM EPGDPITIIE GRSSSHSPDS 420
ATWKGQNGRT FKVGSFPASA VALADVGGQP APYPVHRGPP ARGERRRGVT DGDREKAKLR 480
DVPPARGQRK NVPLQRMKGI SKSLESVLSL GPCPTGGGSS PPELRHARAV PQGLPVLPPR 540
PLIPSGSSQP SQPPRERPPW PKRDPPHNHR TGGPGAGKAA VPPGGLLPDQ EFQRKISEVE 600
LGVHGVTYQE CQAALRATGG DVASAIQNLK VDQLFHMSSR SRADCRRILE HYQWDLSAAS 660
RYVLARS 667
Nucleotide Sequence
(FASTA)
ATGCTGCCCG ATGCCGGCTC CCCCTGGCTG CTGCGGCTGC TCCGGGACAT CCAACTGGCC 60
CAGTTCTACA GGCCCATCCT GGAGGAACTT AATGTCACTC GCCCAGAGCA CTTCGACTTC 120
GTAAGGCCCG AGGATCTGGA TGGCATTGGC ATGGGCCGGC CTGCCCAGCG CAGATTGGCT 180
GAAGCTCTCA AGAGGCACCG CTCAGGGCTG AAGTCCAAGA ACTGGGTCTA CAAGATCCTT 240
GGGGGCTTTA ACCCTGAGCA CAAGGAGACC ACCCCAGCGG CTGACAGCCC AGTCCGCCTC 300
CCCGAGGCCG AAGCAGGACT CAAGTGTCTG ATCCCAGAGG GGGCTGTGTG CAGAGGGGAG 360
CTGCTGGGCT CCGGCTGCTT CGGCGTGGTG CACCGGGGGG TGTGGACGCT GCCCAGCGGC 420
CAGAGTGTCT CAGTGGCTAT CAAGTCCCTC CGGGTGGGTC CTGAAGGTCC CGTGGGCACC 480
GAGCTGGGGG ACTTCCTGCG AGAGGTGTCC GTCATGATGA ACCTGGAGCA CCCACACGTG 540
CTGCGACTGC ACGGCCTGGT CCTGGGCCAG CCCCTGCAGA TGGTGATGGA GCTGGCGCCC 600
CTGGGCTCCC TGCACGCGCG CCTGACGGCC CCGGCCCCGA CCCCCTTGCT GCCCGTGGCC 660
CTGCTCTGCC TCTTCCTGCG GCAGCTGGCA GCGGCCATGA CGTACTTGGG GGCCTGCGGG 720
CTGGTGCACC GGGACCTCGC CACGCGCAAC CTGCTTCTGG CTTCGCCGCG TACCATCAAG 780
GTGGCCGACT TCGGGCTGGT GCGGCCGCTG CGCGGTCCCC GGGGCCGCTA CGTCATGGGC 840
GGGCCCCGCC CCATCCCCTA TGCCTGGTGT GCCCCAGAGA GCCTGCGCCA GGGAGCCTTC 900
TCGTCCGCCT CGGACGTGTG GATGTTTGGG GTGACGCTGT GGGAGATGTT CTCCGGCGGC 960
GAGGAGCCCT GGGCGGGGGT GCCGCCATAT CTCATCCTGC AGCGGCTGGA GAAGGAACGC 1020
GCCCGGCTGC CCAGGCCTCC GCTCTGCTCC AGGGCGCTCT ATGCCCTGGC CTTGCGCTGC 1080
TGGGCCCCCC ACCCAGCTGA CCGGCCCAGC TTTTCCCATC TGGAGGGGCT GCTCCAAGAG 1140
GCCTGGCCTT CTGAGGGACA CTGTATAAGG GATGTCACAG AGCCAGGTGC CCTGCGGATG 1200
GAGCCGGGTG ACCCCATCAC GATCATCGAG GGCAGGTCCT CTTCCCACAG CCCGGACTCT 1260
GCCACCTGGA AGGGCCAGAA CGGCCGCACC TTCAAAGTGG GCAGCTTCCC AGCCTCGGCA 1320
GTGGCGCTGG CAGATGTGGG GGGCCAGCCA GCCCCCTACC CAGTCCACAG AGGCCCCCCT 1380
GCCCGGGGAG AGCGCCGCCG GGGAGTCACA GACGGGGACA GAGAGAAAGC AAAGCTCCGG 1440
GATGTGCCCC CAGCCCGGGG CCAGAGAAAG AACGTGCCCC TGCAGAGGAT GAAAGGCATC 1500
TCCAAGAGTC TGGAGTCGGT TCTGTCCCTG GGTCCTTGCC CTACAGGGGG TGGTTCAAGC 1560
CCCCCTGAAC TTCGACATGC CAGAGCTGTG CCCCAGGGAC TCCCAGTCCT GCCTCCACGC 1620
CCACTCATCC CCTCCGGCTC TTCTCAGCCT AGCCAACCCC CCAGGGAACG GCCTCCCTGG 1680
CCCAAAAGAG ACCCTCCTCA CAATCATCGC ACAGGGGGGC CTGGAGCCGG CAAAGCTGCT 1740
GTCCCCCCTG GAGGCCTCTT GCCCGACCAG GAGTTTCAGA GGAAGATTTC AGAGGTGGAG 1800
CTGGGCGTTC ATGGGGTCAC CTACCAGGAG TGCCAGGCGG CTCTAAGAGC CACCGGCGGA 1860
GATGTGGCTT CTGCCATCCA GAACCTCAAG GTGGACCAGC TGTTCCACAT GAGCAGCCGG 1920
TCGAGAGCTG ACTGCCGGCG CATCCTGGAG CACTACCAGT GGGACCTGTC AGCTGCCAGC 1980
CGCTACGTCC TGGCCCGGTC CTGA 2004
Domain Profile
S: 1     iklleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkl  58
         ++++e+lG+G+fgvv+rg+W+ psg+sv+va+k+l+  ++  ++tel+dflrevsv+++l
Q: 116   VCRGELLGSGCFGVVHRGVWTLPSGQSVSVAIKSLRvgPEGPVGTELGDFLREVSVMMNL  175
         56889******************************9999*********************
S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118
         eh++++rl+G+vl+qpl++v+ela+lgsl++rl+++a ++ l+vall+ +++q+a +++y
Q: 176   EHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPLLPVALLCLFLRQLAAAMTY  235
         ************************************************************
S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPesl  178
         l+++ lvhrdla+rnlllas++++k++dfGlvr+l   +++yv+  ++++P+aWcaPesl
Q: 236   LGACGLVHRDLATRNLLLASPRTIKVADFGLVRPLRGPRGRYVMGGPRPIPYAWCAPESL  295
         ************************************************************
S: 179   rtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediys  238
         r+ +fssasdvW+fGvtlWemfs GeePW+g++++ il++++ke++rl++P++c++++y+
Q: 296   RQGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKERARLPRPPLCSRALYA  355
         ************************************************************
S: 239   lllkcWakkpadrpkfsalkek  260
         l+l+cWa +padrp+fs+l++ 
Q: 356   LALRCWAPHPADRPSFSHLEGL  377
         *******************976
Domain Sequence
(FASTA)
VCRGELLGSG CFGVVHRGVW TLPSGQSVSV AIKSLRVGPE GPVGTELGDF LREVSVMMNL 60
EHPHVLRLHG LVLGQPLQMV MELAPLGSLH ARLTAPAPTP LLPVALLCLF LRQLAAAMTY 120
LGACGLVHRD LATRNLLLAS PRTIKVADFG LVRPLRGPRG RYVMGGPRPI PYAWCAPESL 180
RQGAFSSASD VWMFGVTLWE MFSGGEEPWA GVPPYLILQR LEKERARLPR PPLCSRALYA 240
LALRCWAPHP ADRPSFSHLE GL 262
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>
EKS-AIM-00324
EKS-BOT-00346
EKS-CAJ-00352
EKS-CAF-00351
EKS-CAP-00380
EKS-ECT-00058
EKS-EQC-00338
EKS-ERE-00047
EKS-FEC-00334
EKS-GOG-00343
EKS-HOS-00353
EKS-ICT-00327
EKS-LOA-00355
EKS-MAM-00347
EKS-MUM-00378
EKS-MUP-00341
EKS-MYL-00347
EKS-NOL-00316
EKS-OCP-00065
EKS-OTG-00351
EKS-PAT-00328
EKS-POA-00336
EKS-PRC-00058
EKS-PTV-00087
EKS-RAN-00361
EKS-SUS-00306
Gene Ontology
GO:0005829; C:cytosol
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030308; P:negative regulation of cell growth
GO:0046580; P:negative regulation of Ras protein signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013