EKS-ORC-00381
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00381
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK392.99.5E-11845351307
StatusUnreviewed
Ensembl ProteinENSOCUP00000025283
UniProt AccessionG1U782;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK1
Gene Synonyms/Alias IRAK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000025860ENSOCUP00000025283ENSOCUT00000024951
OrganismOryctolagus cuniculus
Functional Description
Protein Length527
Protein Sequence
(FASTA)
WPGPYLIQGL FPQPRPESPV SLLHGTHPPP FCWPLCEISQ GTQNFSKELK IGEGGFGCVY 60
RAVMRKTVYA VKRLKEDADL EWSAVRQSFL TEVEQLSRFR HPNIVDFAGY CAESGFYCLV 120
YGFLPNGSLE DCLHFQTQDR SPLSWPQRLD VLLGTARAVQ FLHRHSPSLI HGDIKSSNVL 180
LDERLTPKLG DFGLARFSRF AGASPGQSST VARTRTVRGT LAYLPEEYIK TGRLAVDTDT 240
FSFGVVVLET MAGQRAMRTY GARTKYLKDL VEEEAEELGV ALKSAQSTVQ VGVAADAWAA 300
PIATRIYQKH LDPRPGPCRP ELGLALGRLA CCCLHRRAKK RPPMTQVYEM LEKLQTAEAS 360
AEPEAAGRSP PSPQENSYVS TGSAQSRGSP WQPPTQNAER PQRGANQPVE SDESVCGLSA 420
ALHSWRLAPS SCTQGGAAGQ SSWGSSPSLQ PTAVEGSPLG SSTSSSSSSE PPQIIINPAR 480
QKMVHKLALY EDGVLDSLQL LSSSSVPGLG LEREDRRGPE ESDEFQS 527
Nucleotide Sequence
(FASTA)
TGGCCTGGGC CTTACCTCAT CCAGGGTCTC TTCCCTCAGC CACGCCCAGA GAGCCCAGTG 60
TCCCTCCTCC ACGGGACCCA CCCCCCTCCG TTCTGCTGGC CCCTCTGTGA GATCTCCCAG 120
GGCACCCAGA ATTTTTCCAA GGAGCTCAAG ATCGGGGAGG GCGGCTTTGG GTGCGTGTAC 180
CGGGCGGTGA TGAGGAAGAC TGTCTACGCG GTGAAGAGGC TGAAAGAGGA CGCCGACCTC 240
GAGTGGAGCG CAGTGAGACA GAGCTTCCTG ACCGAGGTGG AACAGCTGTC CAGGTTCCGG 300
CACCCGAACA TCGTGGACTT TGCTGGCTAC TGTGCTGAGA GCGGCTTCTA CTGCCTCGTC 360
TATGGCTTCC TGCCCAACGG CTCCCTGGAA GACTGTCTCC ACTTCCAGAC CCAGGACCGC 420
AGCCCTCTCT CCTGGCCTCA GCGACTGGAT GTCCTCCTGG GTACGGCCCG GGCCGTTCAG 480
TTTCTGCATC GGCACAGCCC CAGCCTCATC CACGGAGACA TCAAGAGTTC CAACGTCCTC 540
CTGGATGAGA GACTGACGCC GAAACTCGGA GACTTCGGCC TGGCCCGTTT CAGCCGCTTC 600
GCGGGGGCCA GCCCTGGCCA GAGCAGCACC GTGGCCCGGA CACGGACTGT GCGGGGCACC 660
CTGGCCTACC TGCCCGAGGA GTACATCAAG ACGGGGAGGC TGGCGGTGGA CACTGATACC 720
TTCAGCTTTG GGGTGGTAGT GCTGGAGACC ATGGCTGGCC AGAGGGCTAT GAGGACATAT 780
GGTGCCAGGA CCAAGTATTT GAAGGACCTG GTGGAGGAGG AAGCCGAGGA GCTCGGGGTG 840
GCCCTGAAAA GCGCCCAGAG CACTGTCCAA GTGGGCGTGG CTGCTGACGC CTGGGCTGCC 900
CCGATCGCCA CCCGGATCTA CCAGAAACAC CTGGATCCCA GGCCTGGGCC GTGCCGGCCG 960
GAGCTGGGCC TAGCCCTGGG CCGACTGGCT TGCTGCTGCC TGCACCGCCG TGCTAAGAAG 1020
AGACCCCCCA TGACCCAGGT GTACGAGATG CTGGAGAAGC TGCAGACGGC AGAGGCGTCG 1080
GCAGAGCCAG AGGCCGCTGG CCGCAGCCCT CCTTCCCCGC AGGAGAACTC CTACGTGTCC 1140
ACTGGAAGTG CCCAGAGCCG GGGCAGCCCA TGGCAGCCCC CCACGCAGAA CGCAGAGCGG 1200
CCCCAGAGAG GCGCCAACCA GCCCGTGGAG AGTGACGAGA GCGTCTGTGG CCTCTCTGCT 1260
GCCCTGCACT CCTGGCGCTT GGCCCCAAGC AGCTGTACGC AGGGGGGCGC CGCTGGCCAG 1320
TCCAGCTGGG GGAGTAGCCC CAGCCTCCAG CCCACAGCAG TGGAAGGATC GCCCCTGGGC 1380
AGCTCCACGT CGTCGTCGTC GTCGTCAGAA CCCCCGCAGA TTATCATCAA CCCCGCCCGC 1440
CAGAAGATGG TGCACAAGCT GGCGCTGTAC GAGGACGGGG TGCTGGACAG CCTGCAGCTC 1500
TTGTCGTCCA GCTCTGTCCC AGGCTTGGGC CTGGAGCGCG AGGACAGGCG GGGGCCCGAA 1560
GAGAGCGACG AATTTCAGAG CTGA 1584
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         fs++ +igeGgfg+vyr+ +++t++avk+lke adl++++++qsfltE+++l+rfrH+ni
Q: 45    FSKELKIGEGGFGCVYRAVMRKTVYAVKRLKEDADLEWSAVRQSFLTEVEQLSRFRHPNI  104
         899*********************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcq.kgsepLsWpqRlsillGtaraiefLHe  119
         ++++gy+aes+++cLvY++++nGsLed L+ q ++ +pLsWpqRl++llGtara++fLH+
Q: 105   VDFAGYCAESGFYCLVYGFLPNGSLEDCLHFQtQDRSPLSWPQRLDVLLGTARAVQFLHR  164
         *******************************9999*************************
S: 120   aspslihgdiksaNiLLDekltpKlgDfglar...fapesekqsstvlrtskvrgtlaYl  176
         +spslihgdiks+N+LLDe+ltpKlgDfglar   fa++s+ qsstv+rt +vrgtlaYl
Q: 165   HSPSLIHGDIKSSNVLLDERLTPKLGDFGLARfsrFAGASPGQSSTVARTRTVRGTLAYL  224
         ********************************98899***********************
S: 177   peefirvgqltvkvDvySfGiVllEvltGlra.vdedrktkyLkdllkeeieeekv....  231
         pee+i++g+l+v++D++SfG+V+lE+++G+ra ++ +++tkyLkdl++ee+ee +v    
Q: 225   PEEYIKTGRLAVDTDTFSFGVVVLETMAGQRAmRTYGARTKYLKDLVEEEAEELGValks  284
         ********************************66789***********************
S: 232   ....................eilekfldkkagkleeellealielalaclaekakkrPtm  271
                              i++k+ld ++g++ +el  al +la++cl+++akkrP+m
Q: 285   aqstvqvgvaadawaapiatRIYQKHLDPRPGPCRPELGLALGRLACCCLHRRAKKRPPM  344
         ************************************************************
S: 272   sqvlell  278
         +qv+e+l
Q: 345   TQVYEML  351
         ****987
Domain Sequence
(FASTA)
FSKELKIGEG GFGCVYRAVM RKTVYAVKRL KEDADLEWSA VRQSFLTEVE QLSRFRHPNI 60
VDFAGYCAES GFYCLVYGFL PNGSLEDCLH FQTQDRSPLS WPQRLDVLLG TARAVQFLHR 120
HSPSLIHGDI KSSNVLLDER LTPKLGDFGL ARFSRFAGAS PGQSSTVART RTVRGTLAYL 180
PEEYIKTGRL AVDTDTFSFG VVVLETMAGQ RAMRTYGART KYLKDLVEEE AEELGVALKS 240
AQSTVQVGVA ADAWAAPIAT RIYQKHLDPR PGPCRPELGL ALGRLACCCL HRRAKKRPPM 300
TQVYEML 307
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00394
EKS-BOT-00406
EKS-CAE-00355
EKS-CAJ-00411
EKS-CAF-00406
EKS-CIS-00165
EKS-DAR-00793
EKS-DRM-00191
EKS-EQC-00398
EKS-ERE-00006
EKS-GAA-00495
EKS-GOG-00398
EKS-HOS-00412
EKS-ICT-00385
EKS-LAC-00421
EKS-LOA-00415
EKS-MIM-00062
EKS-MOD-00395
EKS-MUM-00438
EKS-MUP-00400
EKS-MYL-00401
EKS-ORN-00520
EKS-ORA-00354
EKS-OTG-00408
EKS-PAT-00384
EKS-PEM-00221
EKS-POA-00398
EKS-RAN-00420
EKS-SAH-00376
EKS-SUS-00360
EKS-TAR-00515
EKS-TEN-00517
EKS-TUT-00120
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007250; P:activation of NF-kappaB-inducing kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0051259; P:protein oligomerization
GO:0001959; P:regulation of cytokine-mediated signaling pathway
GO:0032494; P:response to peptidoglycan
GO:0034134; P:toll-like receptor 2 signaling pathway
GO:0034142; P:toll-like receptor 4 signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013