EKS-ORC-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	497.7	7.5E-150	422	679	258

Status

Unreviewed

Ensembl Protein

ENSOCUP00000016825

UniProt Accession

G1TIQ4;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000025948	ENSOCUP00000022426	ENSOCUT00000020937
ENSOCUG00000025948	ENSOCUP00000016825	ENSOCUT00000024491

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

740

Protein Sequence
(FASTA)

MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINL QTEEGSIKEI AITHHVKEGH 60

EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD 120

ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA 180

LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV 240

NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR 300

MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE 360

FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD 420

GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK 480

DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL 540

KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD 600

IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML 660

HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP 720

VGRSTLAQRR GIKKITSTAL 740

Nucleotide Sequence
(FASTA)

ATGCCGCTGG CGCAGCTGGC AGACCCGTGG CAGAAGATGG CTGTGGAGAG CCCGTCCGAC 60

AGCGCTGAGA ATGGACAGCA AATTATGGAT GAACCTATGG GAGAGGAGGA GATTAATCTA 120

CAAACTGAAG AAGGCAGTAT CAAAGAAATT GCAATCACAC ATCATGTAAA GGAAGGTCAT 180

GAAAAGGCAG ATCCTTCCCA GTTTGAGCTT TTAAAAGTAT TAGGACAGGG ATCATTTGGA 240

AAGGTTTTCT TGGTGAAAAA AATCTCAGGC TCTGATGCTA GACAGCTTTA TGCCATGAAG 300

GTATTGAAGA AGGCCACACT GAAAGTTCGA GACCGTGTTC GGACAAAAAT GGAACGTGAT 360

ATTTTGGTAG AAGTTAATCA TCCTTTTATT GTCAAGTTAC ATTATGCTTT TCAGACTGAA 420

GGAAAGTTGT ATCTTATTTT GGATTTTCTC AGGGGAGGAG ATTTGTTTAC ACGATTATCC 480

AAAGAGGTGA TGTTCACAGA AGAAGATGTC AAATTCTACT TGGCTGAACT TGCACTTGCT 540

TTAGACCATC TACATAGCCT GGGAATAATC TATAGAGACT TAAAGCCAGA AAACATACTT 600

CTTGATGAAG AAGGTCACAT CAAGTTAACA GATTTTGGCC TAAGTAAAGA GTCTATTGAC 660

CATGAAAAGA AGGCATATTC TTTTTGTGGA ACTGTGGAAT ATATGGCTCC AGAAGTAGTT 720

AATCGTCGTG GTCATACTCA GAGTGCTGAC TGGTGGTCAT TTGGTGTGTT AATGTTTGAA 780

ATGCTCACTG GTACATTACC GTTCCAAGGA AAAGATCGAA AAGAAACAAT GACTATGATT 840

CTTAAAGCCA AACTTGGGAT GCCACAGTTT TTGAGTCCTG AAGCCCAGAG TCTTTTACGA 900

ATGCTTTTCA AACGAAATCC AGCCAACAGA TTAGGCGCAG GACCAGATGG AGTTGAAGAG 960

ATTAAGAGAC ATTCATTTTT CTCAACAATA GACTGGAATA AACTATATAG GAGAGAAATT 1020

CATCCACCTT TTAAACCTGC AACTGGTAGG CCTGAAGATA CATTCTATTT TGATCCTGAA 1080

TTTACTGCAA AAACTCCCAA AGATTCACCC GGCATTCCAC CTAGTGCTAA TGCACACCAG 1140

CTCTTTCGGG GGTTTAGTTT TGTTGCTATT ACCTCAGACG ATGAAAGCCA AGCAATGCAG 1200

ACAGTTGGTG TACATTCAAT TGTTCAGCAA TTGCACAGGA ACAGTATCCA GTTTACTGAT 1260

GGATATGAAG TAAAAGAAGA TATTGGAGTT GGATCATACT CTGTTTGCAA GAGATGTATA 1320

CATAAAGCCA CAAACATGGA GTTTGCAGTG AAGATTATTG ATAAAAGCAA GAGAGATCCA 1380

ACTGAGGAAA TTGAAATTCT TCTCCGTTAT GGACAGCACC CAAACATTAT TACCCTAAAG 1440

GACGTATATG ATGATGGAAA ATATGTGTAT GTAGTAACAG AACTTATGAA AGGAGGTGAA 1500

TTACTGGATA AAATTCTTAG ACAGAAATTT TTCTCTGAAC GAGAAGCCAG TGCTGTCCTG 1560

TTTACCATAA CCAAAACTGT CGAATATCTT CATGCACAAG GGGTGGTTCA CAGAGACTTG 1620

AAACCTAGCA ACATTCTTTA TGTGGATGAA TCTGGTAATC CAGAATCTAT TCGAATTTGT 1680

GATTTTGGCT TTGCAAAACA GCTGAGAGCA GAAAATGGTC TTCTCATGAC TCCCTGTTAT 1740

ACTGCAAATT TTGTTGCACC AGAGGTTTTA AAGCGACAAG GCTATGATGC TGCTTGTGAT 1800

ATATGGAGTC TTGGTGTCCT CCTCTATACA ATGCTTACTG GCTACACTCC ATTTGCAAAT 1860

GGTCCTGATG ACACACCAGA GGAAATATTG GCACGAATAG GTAGCGGAAA ATTCTCACTC 1920

AGTGGTGGTT ACTGGAATTC CGTTTCAGAC ACAGCAAAGG ACCTGGTGTC AAAGATGCTT 1980

CACGTAGACC CTCATCAGAG ACTGACTGCT GCTCTGGTGC TCAGACATCC TTGGATCGTC 2040

CACTGGGACC AACTGCCGCA ATACCAACTG AACAGACAGG ATGCGCCACA TCTAGTAAAG 2100

GGTGCCATGG CAGCTACGTA CTCTGCTTTA AACCGTAATC AGTCACCAGT CTTGGAACCG 2160

GTAGGCCGCT CCACTCTTGC TCAGCGGAGA GGTATTAAAA AAATCACCTC AACAGCCCTG 2220

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         yevked+GvGsysvckrc+hkatn+efavkiidkskrd++eeieillry+qhpni+tlkd

Q: 422   YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  481

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 482   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK  541

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+

Q: 542   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  601

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++akdlvsk+l+

Q: 602   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH  661

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++ +l+h+w+

Q: 662   VDPHQRLTAALVLRHPWI  679

         *****************8

Domain Sequence
(FASTA)

YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 240

VDPHQRLTAA LVLRHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032496	; P:response to lipopolysaccharide
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013