EKS-ORC-00303

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00303

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	323.9	8.7E-97	410	658	249

Status

Unreviewed

Ensembl Protein

ENSOCUP00000023590

UniProt Accession

G1TNZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK6

Gene Synonyms/Alias

PAK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000026281	ENSOCUP00000023590	ENSOCUT00000022568
ENSOCUG00000026281	ENSOCUP00000018724	ENSOCUT00000032132

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

681

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT 60

RVQLQPMKTV VRGSSVPSDG YISGLLNDIQ KLSVTSSNTL RGRSPTSRRR AQSLGLLGDE 120

HWAADPDMYL QSPQSERTEP HGLYLSCNGG TPAGPRQGPG PEPQSPRVLP NGLAAKAQSL 180

GPAEFHGASQ RCLQLGACLQ SSPPGTSSPA AAGRRGTKAA KHGSEEARPQ SCLVGSAAGR 240

PGGEGSPSPK AQESSLKRRL FRSMFLSTPA SAAPGSSKPG PLPQSKPSSS FRQPQKDSLP 300

SLVVKAQSLP SDQPVGTFSP LPPSDTSSPL KSLRTNPATG PLPSRSSPAG SPRTRHAQIS 360

TSNLYLPQDP AAAKGALAGE DTGVVTHEQF KAALRMVVDQ GDPRLLLDSY VKIGEGSTGI 420

VCLAREKHSG RQVAVKMMDL RKQQRRELLF NEVVIMRDYQ HLNVVEMYKS YLVGEELWVL 480

MEFLQGGALT DIISQVRLNE EQIATVCEAV LQALAYLHAQ GVIHRDIKSD SILLTLDGRV 540

KLSDFGFCAQ ISKDVPKRKS LVGTPYWMAP EVISRSLYAT EVDVWSLGIM VIEMVDGEPP 600

YFSDSPVQAM KRLRDSPPPR LRNSHKVSPV LRDFLERMLV RDPQERATAQ ELLDHPFLLQ 660

TGLPECLVPL IQLYRKQTSA C 681

Nucleotide Sequence
(FASTA)

ATGTTCCGCA AGAAGAAGAA GAAACGCCCC GAGATCTCCG CCCCGCAGAA CTTCCAGCAC 60

CGCGTCCACA CCTCCTTTGA CCCTAAGGAG GGCAAGTTTG TGGGGCTCCC CCCACAGTGG 120

CAGAACATCC TGGACACTCT GCGGCGCCCC AAGCCTGTGG TGGACCCTTC ACGCATCACA 180

CGGGTGCAGC TGCAGCCCAT GAAGACTGTG GTGCGGGGCA GTTCAGTGCC CTCCGACGGC 240

TACATCTCAG GGCTGCTCAA TGACATCCAG AAGTTGTCGG TCACCAGCTC CAACACCCTG 300

CGCGGCCGCA GCCCCACCAG CCGGCGGCGG GCCCAGTCCC TGGGGCTGCT GGGGGACGAG 360

CACTGGGCCG CTGACCCGGA CATGTACCTC CAGAGCCCAC AGTCGGAGCG CACCGAGCCC 420

CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCCCAGGCA GGGGCCGGGG 480

CCCGAGCCGC AGAGTCCGCG CGTCCTGCCT AACGGGCTGG CCGCCAAGGC GCAGTCCCTG 540

GGCCCCGCCG AGTTCCACGG TGCCTCGCAG CGCTGCCTGC AGCTCGGTGC CTGCTTGCAG 600

AGCTCCCCGC CCGGCACGTC TTCTCCCGCG GCAGCTGGCA GGCGTGGCAC AAAGGCTGCC 660

AAGCACGGCT CCGAGGAGGC CCGGCCACAG TCCTGCCTGG TAGGCTCGGC CGCAGGCAGG 720

CCCGGAGGGG AAGGCAGCCC GAGCCCCAAG GCCCAGGAGA GCAGCCTGAA GCGCAGGCTG 780

TTCCGAAGCA TGTTCCTGTC CACTCCCGCC TCAGCCGCTC CGGGCAGCAG CAAGCCAGGC 840

CCTCTACCGC AGAGCAAGCC CAGCTCCTCC TTCCGCCAGC CGCAGAAAGA CTCCCTGCCA 900

AGCCTGGTGG TCAAGGCCCA GTCCTTGCCT TCAGACCAGC CTGTGGGGAC ATTCAGTCCT 960

CTGCCCCCTT CGGACACCAG CAGCCCCCTG AAGTCCCTCC GTACCAACCC GGCCACCGGC 1020

CCACTGCCCA GCCGGTCCTC ACCGGCCGGC TCCCCCAGGA CCCGGCACGC TCAGATCAGC 1080

ACCAGCAACC TGTACCTGCC CCAGGACCCC GCAGCGGCCA AGGGCGCCCT GGCCGGCGAG 1140

GACACGGGTG TGGTGACTCA CGAGCAGTTC AAGGCCGCGC TCAGGATGGT GGTGGACCAG 1200

GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATCG GCGAGGGCTC CACTGGCATC 1260

GTCTGCCTGG CCCGTGAGAA GCACTCGGGC CGTCAGGTGG CCGTCAAGAT GATGGACCTC 1320

CGGAAGCAGC AGCGCCGGGA GCTGCTCTTT AATGAGGTGG TGATCATGCG AGACTACCAG 1380

CACCTGAACG TGGTAGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 1440

ATGGAGTTCC TGCAGGGTGG GGCCCTCACC GACATCATCT CCCAAGTCAG GCTGAACGAG 1500

GAGCAGATCG CCACCGTGTG CGAGGCCGTG CTGCAGGCAC TGGCTTACCT GCACGCCCAG 1560

GGAGTCATCC ACCGGGACAT CAAGAGCGAC TCCATCCTGC TGACCCTGGA CGGCAGGGTG 1620

AAGCTCTCCG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ATGTCCCTAA GAGGAAGTCC 1680

CTGGTGGGAA CCCCCTACTG GATGGCTCCA GAAGTGATCT CCAGGTCTCT GTATGCCACC 1740

GAGGTGGATG TCTGGTCCCT GGGCATCATG GTGATCGAGA TGGTGGATGG GGAGCCACCC 1800

TACTTCAGCG ACTCGCCGGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCGCCCAGG 1860

CTGAGGAATT CCCACAAGGT CTCCCCGGTG CTTCGAGACT TCCTGGAGCG GATGCTGGTG 1920

CGGGACCCCC AAGAGAGGGC CACAGCCCAG GAGCTCCTGG ACCACCCCTT CCTGCTGCAG 1980

ACGGGGCTGC CCGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGCAAGCA GACCTCCGCC 2040

TGC 2043

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v+larek++g++va+k+++l+kq++ e+l++e+ ++++++h n+ve+++

Q: 410   YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYK  469

         679*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ eelw++me+l+gG+l+d+++   + +l+Eeqia++++ vl+aL+ylH+++viHrd

Q: 470   SYLVGEELWVLMEFLQGGALTDIIS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHRD  526

         *************************...99******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt +g+VkLsdfg++aq++k++ krk++vgtpywmAPEvi+  ++ Y +++D+

Q: 527   IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS--RSLYATEVDV  584

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++ +p++a+ +  +++pp+l++++k+s+ +++f+e++l ++p+

Q: 585   WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPRLRNSHKVSPVLRDFLERMLVRDPQ  644

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ell+h+Fl

Q: 645   ERATAQELLDHPFL  658

         *************7

Domain Sequence
(FASTA)

YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL FNEVVIMRDY QHLNVVEMYK 60

SYLVGEELWV LMEFLQGGAL TDIISQVRLN EEQIATVCEA VLQALAYLHA QGVIHRDIKS 120

DSILLTLDGR VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDVWSLGI 180

MVIEMVDGEP PYFSDSPVQA MKRLRDSPPP RLRNSHKVSP VLRDFLERML VRDPQERATA 240

QELLDHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013