EPS-ORC-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	194.2	3.9E-57	40	293	254

Status

Unreviewed

Ensembl Protein

ENSOCUP00000023119

UniProt Accession

G1TF35;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000026526	ENSOCUP00000015524	ENSOCUT00000022866
ENSOCUG00000026526	ENSOCUP00000023119	ENSOCUT00000031486

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

338

Protein Sequence
(FASTA)

TEIETVKLAR SVFSKLHEIC CSWVKDFPLR RRPQLYYETS IHAIKNMRRK MEDKHVCIPD 60

FNMLFNLEDQ EEQAYFAVFD GHGGVDAAIY ASIHLHVNLV RQEMFPHDPA EALCRAFRVT 120

DERFVQKAAR ESLRCGTTGV VTFIRGNMLH VAWVGDSQVM LVRKGQAVEL MKPHKPDRED 180

EKQRIEALGG CVVWFGAWRV NGSLSVSRAI GDAEHKPYIC GDADSASTVL DGTEDYLILA 240

CDGFYDTVNP DEAVKVVSDH LKENNGDSSM VAHKLVASAR DAGSSDNITV IVVFLRDMNK 300

AVNGGQEDGG DDKIEASKPR SAQFLPPVEM FCPGVPKE 338

Nucleotide Sequence
(FASTA)

ACAGAGATTG AGACAGTGAA ATTGGCCCGT TCTGTCTTCA GCAAACTACA CGAGATTTGT 60

TGCAGCTGGG TGAAAGACTT CCCTCTCCGC AGGAGACCCC AGCTTTATTA TGAGACATCA 120

ATCCATGCCA TCAAAAACAT GCGCAGGAAA ATGGAGGACA AACATGTCTG CATTCCTGAC 180

TTTAATATGC TCTTCAACCT AGAGGACCAG GAAGAACAAG CTTACTTTGC AGTGTTTGAT 240

GGCCATGGGG GAGTAGATGC TGCCATTTAT GCCTCAATTC ACCTACACGT TAACTTAGTT 300

CGCCAGGAGA TGTTCCCCCA TGATCCTGCT GAGGCCCTGT GCCGGGCCTT CCGGGTCACT 360

GATGAGCGGT TTGTACAGAA AGCGGCCAGG GAGAGCTTAA GATGTGGGAC CACAGGAGTG 420

GTGACTTTTA TCAGAGGTAA CATGCTACAC GTGGCCTGGG TGGGTGACTC CCAGGTTATG 480

CTTGTGAGAA AGGGCCAAGC TGTTGAACTA ATGAAGCCGC ATAAACCAGA CAGAGAGGAT 540

GAAAAGCAGC GAATTGAGGC CCTTGGAGGT TGTGTAGTCT GGTTTGGTGC CTGGAGGGTA 600

AATGGAAGTC TGTCCGTATC CAGAGCTATT GGAGATGCTG AACATAAGCC ATATATATGT 660

GGGGATGCTG ATTCTGCCTC TACTGTTTTG GATGGGACCG AAGACTACCT CATTCTGGCC 720

TGTGATGGCT TCTATGACAC TGTGAATCCC GATGAGGCAG TGAAAGTTGT GTCTGACCAC 780

TTGAAAGAGA ATAACGGAGA CAGCAGCATG GTTGCCCACA AGTTAGTGGC ATCAGCTCGT 840

GATGCTGGGT CAAGTGATAA CATCACTGTT ATTGTGGTAT TCCTGAGGGA CATGAACAAA 900

GCGGTAAATG GAGGGCAAGA AGATGGTGGG GATGATAAGA TAGAAGCAAG CAAACCTCGC 960

AGTGCCCAGT TTTTGCCACC AGTTGAGATG TTCTGTCCTG GTGTACCAAA GGAA 1014

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 40    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  99

         567899**************99766555544459************************99

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 100   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  153

         99955....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         vGdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 154   VGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  212

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+  +++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 213   AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  272

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 273   HKLVASARDAGSSDNITVIVV  293

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWVGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGTEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013