EKS-ORC-00283
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00283
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk518.73.5E-156499768270
StatusUnreviewed
Ensembl ProteinENSOCUP00000019469
UniProt AccessionG1TR20;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameLTK
Gene Synonyms/Alias LTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000026867ENSOCUP00000024671ENSOCUT00000030996
ENSOCUG00000026867ENSOCUP00000019469ENSOCUT00000026881
OrganismOryctolagus cuniculus
Functional Description
Protein Length853
Protein Sequence
(FASTA)
MGRSGRLLLW LGAAGAILCS SSGSQAPSLP SSPRPLSIPS AQDPKVTTRP GSLEPPFPLN 60
PLGTEGPWLF STCGASGRRG PTQTQCDGAY AGSSVAVTVG AAGPLRGVQL WQPPGPGQYL 120
ISAYGAAGGK GAKNHLSRAH GVFVSAVFSL GRGDPLYILV GQQGEDACPG GSPESRRVCL 180
GESWAAEEHE ATDGPETVPG SRRTFVFQMR EGELEPLLVA AGGGGRAYLR RRDGGRTQAA 240
PEKLENRSAA PGSGGRGGAA GGGGGWTSRA PSPQAGHSLR EGAEGGQGCA EAWAALGSSR 300
AGRQTGRNGM CSETLHHSQP AGGDASETDT LWADGEDGVS FIHPSSELYL QPLAVMESHG 360
EVEIRRHLNC SHCPLKDCQW QAALQSPQCL CPEGMELSVD NITCMDLPAP PGPLVLMVAV 420
MATLTLSLLM VCGILILVNQ KKWQGLWGTR LPGPELELSK LRTSAIRTAP NPYYCQVGQG 480
PAQSWPLPPG LTEISPANVT LLRALGHGAF GEVYEGLVIG LPGDSSPLQV AIKTLPELCS 540
RQDELDFLME ALIISKFSHR NIVRCVGLSL RAAPRLILLE LMSGGDMKSF LRHSRPHLGQ 600
PSPLVMQDLL QLAQDIAQGC HYLEENHFIH RDIAARNCLL SCTGPSRVAK IGDFGMARDI 660
YRASYYRKGG RALLPVKWMP PEAFLEGIFT PKTDSWSFGV LLWEIFSLGY MPYPGRTNQE 720
VLDFVVAGGR MDPPRGCPGP VYRIMTQCWQ HQPELRPCFA SILERLQYCT QDPDVLNAAL 780
PVELGPPLEE EGASGLGNRA LEGLRALQPQ ELSPENMKSW GGNALGPWLS SGLKPLKSRG 840
LQPQNLWNPT YGS 853
Nucleotide Sequence
(FASTA)
ATGGGCCGGT CGGGCCGGCT GCTGCTGTGG CTCGGCGCCG CGGGCGCCAT TCTCTGCTCC 60
AGCTCGGGGT CCCAAGCGCC TTCTCTGCCA TCCTCACCAC GGCCGCTGTC CATTCCCAGC 120
GCCCAGGACC CAAAAGTCAC CACCCGACCT GGCAGCTTGG AGCCACCCTT TCCCCTAAAT 180
CCCCTAGGCA CCGAGGGGCC TTGGCTGTTC TCCACCTGCG GGGCCAGCGG CCGACGCGGC 240
CCCACACAAA CGCAGTGTGA CGGGGCGTAC GCGGGCAGCA GCGTGGCGGT GACGGTGGGC 300
GCCGCGGGGC CGCTGCGAGG TGTGCAGCTG TGGCAACCGC CCGGCCCTGG GCAATACCTG 360
ATCTCGGCTT ACGGAGCCGC GGGCGGCAAA GGCGCCAAGA ACCACCTGTC GCGGGCACAC 420
GGCGTCTTCG TCTCCGCCGT CTTCTCGCTG GGTCGCGGGG ACCCACTTTA CATCCTCGTG 480
GGGCAGCAGG GAGAGGACGC CTGCCCCGGC GGGAGCCCGG AGAGCCGGCG CGTCTGCCTC 540
GGAGAGTCCT GGGCGGCTGA AGAGCACGAG GCGACGGATG GGCCCGAAAC GGTGCCTGGG 600
TCGAGGCGCA CTTTCGTCTT CCAGATGCGC GAGGGCGAGC TGGAGCCGCT GCTAGTGGCT 660
GCCGGAGGCG GTGGTCGGGC CTACCTGAGG CGGCGGGACG GAGGCCGGAC TCAGGCCGCC 720
CCCGAGAAAC TGGAGAACCG CTCAGCAGCG CCCGGGAGCG GCGGGAGAGG CGGGGCGGCA 780
GGTGGAGGCG GCGGCTGGAC TTCGCGGGCC CCCTCGCCGC AGGCGGGCCA CTCGCTGCGG 840
GAGGGGGCCG AGGGCGGCCA GGGCTGCGCC GAAGCCTGGG CTGCCCTTGG CTCGAGCCGA 900
GCAGGGAGGC AGACAGGCAG AAATGGCATG TGTAGTGAAA CCCTCCATCA CTCTCAACCC 960
GCAGGGGGTG ATGCTTCTGA GACTGACACA CTCTGGGCTG ATGGGGAAGA TGGGGTGTCC 1020
TTCATACACC CCAGCAGTGA GCTCTACCTG CAGCCTCTGG CAGTCATGGA GAGTCACGGC 1080
GAAGTGGAGA TCCGAAGGCA CCTCAACTGC AGCCATTGCC CTCTGAAAGA CTGCCAGTGG 1140
CAGGCAGCGC TCCAGTCGCC CCAGTGCTTA TGCCCAGAGG GCATGGAGCT CTCTGTGGAC 1200
AACATCACCT GCATGGACCT GCCAGCGCCC CCCGGCCCTC TGGTTCTGAT GGTGGCTGTG 1260
ATGGCGACCT TGACACTGAG CCTCCTTATG GTGTGTGGGA TCCTCATTCT GGTGAACCAG 1320
AAGAAGTGGC AGGGCCTTTG GGGGACGAGG CTGCCAGGCC CTGAGCTCGA GCTGAGCAAG 1380
CTCCGAACGT CTGCCATCAG GACAGCCCCC AATCCCTATT ATTGTCAAGT GGGGCAGGGC 1440
CCGGCACAGT CCTGGCCTCT GCCCCCAGGG CTCACTGAGA TTTCCCCAGC CAACGTCACC 1500
CTGCTCAGGG CTCTGGGCCA TGGCGCCTTT GGGGAGGTAT ATGAGGGACT GGTCATTGGT 1560
CTTCCTGGGG ACTCCAGCCC CCTGCAGGTG GCTATCAAGA CGCTGCCCGA GCTGTGCTCG 1620
CGCCAGGATG AGCTGGATTT CCTCATGGAG GCGCTCATCA TCAGCAAGTT CAGCCATCGG 1680
AACATCGTGC GGTGTGTGGG GCTCAGCCTG CGGGCTGCCC CTCGCCTCAT TCTGCTGGAG 1740
CTGATGTCTG GCGGGGACAT GAAGAGTTTT CTGAGGCACA GCCGGCCACA CCTGGGTCAG 1800
CCGTCACCTC TGGTCATGCA AGACCTGCTG CAGCTGGCTC AGGACATAGC CCAGGGCTGC 1860
CACTACTTGG AGGAAAATCA TTTCATCCAC AGGGACATTG CTGCCCGTAA CTGCCTGCTG 1920
AGCTGCACTG GGCCCAGCCG AGTGGCCAAG ATTGGGGACT TCGGGATGGC AAGAGACATC 1980
TACCGGGCCA GCTATTACCG CAAGGGGGGC CGGGCCTTGC TGCCCGTCAA GTGGATGCCC 2040
CCAGAGGCCT TCTTGGAGGG CATCTTCACA CCCAAGACAG ACTCCTGGTC TTTTGGGGTG 2100
CTGCTCTGGG AGATCTTCTC CCTGGGGTAC ATGCCCTACC CTGGGCGCAC CAACCAGGAG 2160
GTGCTAGACT TCGTTGTGGC GGGGGGCCGG ATGGACCCTC CCAGGGGCTG TCCGGGGCCT 2220
GTGTACCGCA TCATGACCCA GTGTTGGCAG CACCAGCCTG AGCTGCGCCC CTGCTTCGCC 2280
AGCATCCTGG AGCGGCTCCA GTACTGCACT CAGGACCCTG ATGTGCTGAA TGCAGCCCTG 2340
CCGGTGGAGC TGGGGCCCCC CCTGGAGGAG GAAGGGGCGT CCGGGCTGGG AAACCGGGCT 2400
TTGGAGGGCC TCAGAGCCCT CCAACCCCAG GAACTGAGTC CAGAGAACAT GAAGAGCTGG 2460
GGAGGGAACG CTCTTGGCCC CTGGTTGTCT TCTGGCCTCA AGCCCCTCAA ATCCAGGGGC 2520
CTCCAACCGC AGAACCTCTG GAACCCTACC TACGGCTCC 2559
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         ++l+ralG+GafGevyeglv+glpgd+s+l+va+ktlpe +s+qdeldfl+ealiiskf+
Q: 499   VTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSRQDELDFLMEALIISKFS  558
         689*********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr++G+sl+++prlillel++GGd+ksflr+srp+  q+s+l+m+dll++a+d+a+
Q: 559   HRNIVRCVGLSLRAAPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMQDLLQLAQDIAQ  618
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gc+yleen+fihrdiaarn+lls++Gpsrvaki+dfGmardiyra+yyrkggrallpvkw
Q: 619   GCHYLEENHFIHRDIAARNCLLSCTGPSRVAKIGDFGMARDIYRASYYRKGGRALLPVKW  678
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeafleGift ktd+wsfGvllwe+fslG++pypg++nqevl++vv Ggr+d+p+++p
Q: 679   MPPEAFLEGIFTPKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVAGGRMDPPRGCP  738
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+h+pe rp f+silerlq+
Q: 739   GPVYRIMTQCWQHQPELRPCFASILERLQY  768
         ****************************97
Domain Sequence
(FASTA)
VTLLRALGHG AFGEVYEGLV IGLPGDSSPL QVAIKTLPEL CSRQDELDFL MEALIISKFS 60
HRNIVRCVGL SLRAAPRLIL LELMSGGDMK SFLRHSRPHL GQPSPLVMQD LLQLAQDIAQ 120
GCHYLEENHF IHRDIAARNC LLSCTGPSRV AKIGDFGMAR DIYRASYYRK GGRALLPVKW 180
MPPEAFLEGI FTPKTDSWSF GVLLWEIFSL GYMPYPGRTN QEVLDFVVAG GRMDPPRGCP 240
GPVYRIMTQC WQHQPELRPC FASILERLQY 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-CAE-00256
EKS-CAJ-00313
EKS-CAP-00342
EKS-DRM-00153
EKS-EQC-00293
EKS-FEC-00288
EKS-GOG-00303
EKS-HOS-00308
EKS-ICT-00291
EKS-LOA-00318
EKS-MAE-00034
EKS-MOD-00296
EKS-MUM-00339
EKS-NOL-00277
EKS-OTG-00309
EKS-PAT-00291
EKS-POA-00293
EKS-PTV-00067
EKS-RAN-00318
EKS-SAH-00288
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0008283; P:cell proliferation
GO:0071300; P:cellular response to retinoic acid
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0010976; P:positive regulation of neuron projection development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR026984; LTK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013