EKS-ORC-00181

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00181

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	516.4	2.1E-155	4	284	281

Status

Unreviewed

Ensembl Protein

ENSOCUP00000016559

UniProt Accession

G1THZ7;

Protein Name

Protein Synonyms/Alias

Gene Name

ICK

Gene Synonyms/Alias

ICK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000027465	ENSOCUP00000016559	ENSOCUT00000023609

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

632

Protein Sequence
(FASTA)

MNRYTMIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 60

NVVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMFQIL QGLAFIHKHG 120

FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP 180

IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFRWPQ 240

CVPNNLKTLI PNASSEAIQL LRDMLQWDPK KRPTASQALR YPYFLIGHPR GGTLQSVQDP 300

GKPQKDLLEK AGPAPHIKPV PPAQPPTKPH PRISSRPHPS SQAPQHLTYP YKAEASRTDH 360

PSHLQEDKPS PLLLPSLHNK NPQSKLPAGL EHKNGEMKPK SRRRWGLISR STKDSDDWAD 420

LDDLDFSPSL TRIDVKNKKR QSDDTLCRFE SVLDLKPSEP MGTGNSAPTQ TSYQRRDTPT 480

LRSAAKQHYL KHSRYLPGIN IRNGILPNPG KDFVPSNPWS SSGLSGKSSG TVSVISKINS 540

VGSSSTSSSG LTGNYIPSFL KKEIGSAMQR VHLAPIPDPA PGYSSLKAVR PHPGRPFFHT 600

QPRSTPGLIP RPPAAQPVHG RTDWASKYAS RR 632

Nucleotide Sequence
(FASTA)

ATGAATAGAT ACACAATGAT CAAGCAGCTT GGGGATGGGA CCTATGGTTC CGTCCTATTG 60

GGAAGAAGCA TTGAGTCTGG GGAACTTATT GCTATCAAAA AAATGAAAAG AAAGTTTTAT 120

TCCTGGGAGG AATGTATGAA CCTTCGGGAG GTCAAGTCAT TAAAGAAGCT CAACCATGCC 180

AATGTAGTAA AATTAAAAGA AGTTATCAGG GAAAATGATC ATCTTTATTT TATCTTCGAG 240

TACATGAAGG AAAATCTTTA CCAGCTTATT AAAGAAAGGA ATAAATTATT TCCTGAGTCG 300

GCTATCAGGA ATATCATGTT TCAGATCCTG CAAGGACTTG CCTTTATTCA CAAACATGGC 360

TTCTTCCATC GGGACTTAAA GCCGGAAAAC CTACTCTGCA TGGGACCAGA ACTTGTGAAA 420

ATTGCAGACT TTGGGCTGGC CCGAGAAATC CGATCCAGAC CTCCATACAC GGACTACGTA 480

TCTACCAGAT GGTACAGGGC CCCAGAAGTA CTCCTGAGAT CCACCAACTA CAGCTCCCCT 540

ATTGATGTCT GGGCCGTGGG CTGCATCATG GCAGAGGTGT ACACCCTCAG GCCGCTCTTC 600

CCTGGTGCCA GTGAGATTGA CACGATATTC AAAATTTGCC AAGTCCTGGG GACACCGAAA 660

AAGACTGACT GGCCTGAAGG CTACCAACTT TCAAGTGCTA TGAACTTCCG CTGGCCCCAG 720

TGTGTCCCCA ATAACTTAAA GACCCTGATC CCAAATGCCA GCAGCGAAGC GATTCAGCTC 780

CTGAGAGACA TGCTCCAATG GGATCCCAAG AAACGACCAA CAGCTAGTCA GGCCCTTCGA 840

TACCCTTACT TCCTTATTGG GCACCCACGG GGCGGCACCC TACAGAGTGT TCAGGATCCA 900

GGAAAACCAC AGAAAGACCT CTTGGAAAAA GCAGGCCCTG CTCCTCATAT AAAGCCTGTC 960

CCTCCTGCCC AGCCCCCCAC CAAGCCTCAC CCACGGATTT CTTCACGACC ACATCCCTCC 1020

AGCCAGGCCC CCCAGCATCT CACCTACCCC TACAAAGCAG AGGCCTCCAG GACGGATCAC 1080

CCGAGCCATC TTCAGGAGGA CAAGCCCAGC CCCTTGCTCT TGCCATCCCT GCACAACAAG 1140

AATCCTCAGT CGAAACTTCC AGCTGGCCTA GAGCACAAAA ATGGAGAGAT GAAGCCAAAG 1200

AGTAGGAGGA GATGGGGTCT CATTTCTAGA TCAACGAAAG ATTCTGATGA CTGGGCTGAC 1260

TTGGACGACT TGGACTTCAG TCCATCCCTC ACCAGGATTG ATGTGAAAAA CAAGAAGAGA 1320

CAGAGCGATG ACACTCTCTG CAGATTCGAA AGTGTTTTGG ACCTGAAGCC ATCTGAGCCC 1380

ATGGGTACAG GAAACAGTGC CCCTACCCAG ACTTCGTATC AGAGGCGAGA CACCCCCACC 1440

CTGAGATCAG CCGCCAAGCA GCACTACTTG AAGCACTCTC GATACTTGCC TGGAATCAAT 1500

ATAAGAAATG GCATCCTGCC AAACCCAGGC AAGGACTTCG TTCCATCAAA TCCATGGTCT 1560

AGTTCTGGTT TGTCCGGAAA GTCTTCAGGG ACAGTATCGG TCATCAGCAA AATAAATTCA 1620

GTTGGTTCCA GCTCTACAAG TTCTAGTGGA CTGACTGGAA ACTACATCCC TTCCTTTCTG 1680

AAAAAAGAAA TTGGTTCTGC TATGCAGAGG GTACACCTGG CACCTATCCC AGACCCTGCC 1740

CCTGGTTATT CTTCCCTGAA GGCTGTACGA CCTCATCCTG GACGACCTTT CTTCCACACC 1800

CAGCCTAGAA GCACCCCTGG GTTGATACCA CGGCCTCCAG CCGCCCAGCC AGTGCATGGC 1860

CGGACAGACT GGGCTTCCAA GTACGCATCT CGGCGATGA 1899

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         y++ik+lGdGt+g+vll++s+++gel+aikkmkrkf+s+ee++nlrevkslkkln h+n+

Q: 4     YTMIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANV  62

         99*****************************************************.****

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         +klkevi  rend+ly+++e+m+enlyqlik+r+kl++es++++i++qil+glafihkhg

Q: 63    VKLKEVI--RENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMFQILQGLAFIHKHG  120

         *******..***************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         ffhrdlkPen+l++g+elvk+adfGlare+rs++PytdyvstrwyraPevllrs++yssp

Q: 121   FFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSP  180

         ************************************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +d+wavGc++aev++lrplfPGaseid+ifki++vlGtPkk++w+e+y+l+sa+n+++pq

Q: 181   IDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQ  240

         ************************************************************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         +++++lktl++nas+ea++ll+d+l++dP++r+ta+qal+ypyf

Q: 241   CVPNNLKTLIPNASSEAIQLLRDMLQWDPKKRPTASQALRYPYF  284

         *******************************************9

Domain Sequence
(FASTA)

YTMIKQLGDG TYGSVLLGRS IESGELIAIK KMKRKFYSWE ECMNLREVKS LKKLNHANVV 60

KLKEVIREND HLYFIFEYMK ENLYQLIKER NKLFPESAIR NIMFQILQGL AFIHKHGFFH 120

RDLKPENLLC MGPELVKIAD FGLAREIRSR PPYTDYVSTR WYRAPEVLLR STNYSSPIDV 180

WAVGCIMAEV YTLRPLFPGA SEIDTIFKIC QVLGTPKKTD WPEGYQLSSA MNFRWPQCVP 240

NNLKTLIPNA SSEAIQLLRD MLQWDPKKRP TASQALRYPY F 281

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0043231	; C:intracellular membrane-bounded organelle
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013