EKS-OTG-00289

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00289

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	395.2	1.6E-118	269	562	294

Status

Unreviewed

Ensembl Protein

ENSOGAP00000000109

UniProt Accession

H0WFS7;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000000125	ENSOGAP00000000109	ENSOGAT00000000125

Organism

Otolemur garnettii

Functional Description

Protein Length

592

Protein Sequence
(FASTA)

MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SGKELEEFKD ASVYLCCNRT VHPLRHVNND 60

MMVTDNNGAV KLPQLCKFCD VRFSTCDNQK SCLSNCSITS ICEKPQEVCV AVWRKNDENI 120

TLETVCHDPK LPYHEFILED AASTKCIMKE KKKSGETFFM CSCSADECND NIIFSEDYNN 180

SNPDLLQVIF QVTGVSLLPP LAIAVAVIII FYCYRVNRQQ KLSPSWESTK PQKLMDFSDN 240

CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300

VKIFPYEEYA SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 360

YLMRHVVSWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 420

CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 480

EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDNVLRDR GRPEIPSFWL NHQGIQMVCE 540

TLTECWDHDP EARLTAQCVA ERFSELEHLD RLSGRSCSEE KIPEDGSLNT TK 592

Nucleotide Sequence
(FASTA)

ATGGGTCGGG GGCTGCTCAG GGGCCTGTGG CCGCTGCACA TCGTCCTGTG GACACGCATA 60

GCCAGCACTA TCCCACCGCA CGTTCAGAAG TCGGGAAAAG AGCTAGAAGA GTTCAAGGAT 120

GCATCAGTTT ATTTATGCTG TAATAGGACT GTTCATCCAC TGAGACATGT TAATAATGAC 180

ATGATGGTCA CTGACAACAA TGGCGCAGTG AAGCTTCCAC AACTGTGTAA ATTCTGTGAT 240

GTGCGATTTT CCACCTGTGA CAACCAGAAG TCCTGCCTGA GCAACTGCAG CATCACATCC 300

ATCTGTGAGA AGCCACAGGA AGTCTGCGTG GCAGTATGGA GAAAGAATGA TGAGAACATA 360

ACGCTAGAGA CAGTTTGCCA TGACCCCAAA CTCCCCTACC ATGAATTCAT CCTGGAAGAT 420

GCTGCTTCTA CAAAGTGCAT TATGAAGGAA AAAAAGAAGT CTGGCGAGAC TTTCTTCATG 480

TGCTCCTGCA GTGCTGATGA GTGCAATGAC AACATCATCT TCTCAGAAGA CTACAACAAC 540

AGCAATCCTG ACTTGTTACA AGTCATATTC CAAGTGACAG GTGTGAGCCT TCTGCCACCG 600

CTGGCAATCG CCGTAGCTGT CATCATCATC TTCTACTGCT ACCGCGTTAA CCGGCAGCAG 660

AAGCTGAGTC CTTCCTGGGA AAGCACCAAG CCACAGAAAC TCATGGACTT CAGCGACAAC 720

TGTGCCATCA TTCTGGAAGA TGACCGCTCT GACATCAGCT CCACGTGCGC CAACAACATC 780

AACCACAACA CGGAGCTGCT GCCCATCGAG CTGGACACCC TGGTGGGGAA AGGTCGCTTC 840

GCCGAGGTCT ACAAAGCCAA GCTGAAGCAG AACACTTCCG AGCAGTTCGA GACGGTGGCA 900

GTCAAGATCT TCCCCTATGA GGAGTACGCC TCCTGGAAGA CGGAGAAGGA CATCTTCTCA 960

GACATCAACC TGAAGCATGA GAACATCCTC CAGTTCCTGA CGGCTGAGGA GAGGAAGACA 1020

GAGCTGGGGA AACAGTACTG GCTGATCACC GCCTTCCATG CCAAGGGCAA CCTACAGGAG 1080

TACCTCATGC GGCACGTGGT CAGCTGGGAG GACCTGCGAA AGCTCGGCAG CTCCCTGGCC 1140

CGGGGCATCG CTCACCTCCA CAGTGACCAC ACCCCGTGCG GGCGGCCCAA GATGCCCATC 1200

GTGCACAGGG ACCTCAAGAG CTCCAACATC CTTGTGAAAA ATGACCTGAC CTGCTGTCTC 1260

TGTGACTTTG GCCTTTCCCT GCGTCTGGAC CCTACTCTGT CCGTGGATGA CCTGGCTAAC 1320

AGTGGGCAGG TGGGAACTGC AAGATACATG GCTCCAGAAG TCCTAGAGTC CAGAATGAAT 1380

TTGGAGAATG TTGAGTCCTT CAAGCAGACC GATGTGTACT CCATGGCTCT GGTGCTCTGG 1440

GAAATGACAT CTCGCTGTAA CGCAGTGGGA GAAGTGAAAG ATTATGAGCC TCCCTTCGGT 1500

TCCAAGGTGA GGGAGCATCC CTGTGTGGAG AGCATGAAGG ACAATGTGTT GAGAGACCGA 1560

GGACGACCAG AAATTCCCAG CTTCTGGCTC AACCACCAGG GCATCCAGAT GGTGTGCGAG 1620

ACATTGACCG AGTGCTGGGA CCACGACCCC GAGGCCCGTC TCACAGCCCA GTGTGTGGCA 1680

GAACGCTTCA GCGAGCTGGA GCACCTGGAC AGGCTCTCTG GGAGGAGCTG CTCGGAGGAG 1740

AAGATTCCCG AAGACGGCTC CCTGAACACT ACCAAATAG 1779

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 269   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  328

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL r+++++e+l +l +sla+G+ahLH+

Q: 329   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLMRHVVSWEDLRKLGSSLARGIAHLHS  388

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 389   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  447

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 448   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  506

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 507   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  562

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLMRHVVS WEDLRKLGSS LARGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013