EKS-OTG-00163

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00163

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.7	3.3E-188	408	687	280

Status

Unreviewed

Ensembl Protein

ENSOGAP00000000281

UniProt Accession

H0WG62;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000000314	ENSOGAP00000000281	ENSOGAT00000000315

Organism

Otolemur garnettii

Functional Description

Protein Length

718

Protein Sequence
(FASTA)

LSNEFYHMNS RRENLHMVSS EFIRETKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60

RNRKRKAEPY ETSQGKGTPR GHKISDYFER RVEQPLYGLD GSAAKEASEE QSALPTLMSV 120

MLAKPRLDTE QLAQRGAGLC FTFVSAQQNS PSSTGSGNTE HSCSSQKQIS IQHRQTQSDL 180

TIEKISALEN SKNSDLEKKE GRIDDLLRAN CDLRRQIDEQ QKMLEKYKER LNRCVTMSKK 240

LLIEKSKQEK MACRDKSMQD RLRLGHFTTV RHGASFTEQW TDGYAFQNLI KQQERINSQR 300

EEIERQRKML AKRKPPAMGQ APPATNEQKQ RKSKTNGAEN ETLTLAEYHE QEEIFKLRLG 360

HLKKEEAEIQ AELERLERVR NLHIRELKRI HNEDNSQFKD HPTLNDRYLL LHLLGRGGFS 420

EVYKAFDLTE QRYVAVKIHQ LNKNWRDEKK ENYHKHACRE YRIHKELDHP RIVKLYDYFS 480

LDTDSFCTVL EYCEGNDLDF YLKQHKLMSE KEARSIIMQI VNALKYLNEI KPPIIHYDLK 540

PGNILLVNGT ACGEIKITDF GLSKIMDDDS YNSVDGMELT SQGAGTYWYL PPECFVVGKE 600

PPKISNKVDV WSVGVIFYQC LYGRKPFGHN QSQQDILQEN TILKATEVQF PPKPVVTPEA 660

KAFIRRCLAY RKEDRIDVQQ LACDPYLLPH IRKSVSTSSP AGAAIASTSG ASNNSSSN 718

Nucleotide Sequence
(FASTA)

TTAAGTAATG AATTTTACCA CATGAATTCT AGAAGGGAAA ATCTGCATAT GGTAAGTTCA 60

GAGTTTATAA GGGAAACGAA AGGGCCACTC AATAGTGAGT CTTCCAATCA GAGCTTGTGC 120

AGTGTGGGGT CCTTGAGTGA TAAAGAAGTA GAGACTCCTG AAAAAAAGCA GAATGACCAG 180

CGAAATCGGA AAAGAAAAGC TGAACCATAT GAAACTAGCC AAGGGAAAGG TACTCCTAGG 240

GGACATAAAA TTAGTGATTA CTTTGAGCGG CGAGTAGAGC AGCCCCTTTA TGGCTTAGAT 300

GGCAGTGCTG CAAAGGAGGC ATCAGAGGAG CAGTCTGCCC TCCCAACCCT CATGTCGGTG 360

ATGCTAGCAA AGCCTCGGCT TGACACGGAG CAGTTGGCAC AGAGGGGAGC TGGGCTCTGC 420

TTCACTTTTG TTTCAGCTCA ACAAAACAGT CCTTCTTCTA CGGGATCTGG CAACACAGAG 480

CATTCCTGTA GCTCCCAAAA ACAGATCTCC ATCCAGCACA GACAGACCCA GTCTGACCTC 540

ACAATAGAAA AAATATCTGC ACTAGAAAAC AGTAAGAATT CTGACTTAGA GAAGAAGGAG 600

GGAAGAATAG ATGATTTATT AAGAGCCAAC TGTGATTTGA GACGGCAGAT TGATGAACAG 660

CAAAAGATGC TAGAGAAATA CAAGGAACGA TTAAATAGAT GTGTGACAAT GAGCAAGAAA 720

CTCCTTATAG AAAAGTCAAA ACAAGAGAAG ATGGCATGTA GAGATAAGAG TATGCAAGAT 780

CGCTTGAGAT TGGGCCACTT TACTACTGTC CGACACGGAG CCTCTTTTAC CGAACAATGG 840

ACAGATGGTT ATGCTTTCCA GAACCTTATC AAGCAACAGG AAAGGATAAA TTCACAGAGG 900

GAGGAGATAG AAAGACAACG GAAAATGTTA GCAAAGCGGA AACCTCCTGC CATGGGCCAG 960

GCCCCTCCAG CAACCAATGA GCAAAAACAG CGGAAAAGCA AGACCAATGG AGCTGAAAAT 1020

GAAACGTTAA CATTAGCAGA ATACCATGAA CAAGAAGAAA TTTTCAAACT CAGATTAGGT 1080

CATCTTAAAA AGGAGGAAGC AGAGATCCAG GCAGAGCTGG AAAGACTAGA AAGGGTTAGA 1140

AATCTACATA TCAGGGAATT AAAAAGGATA CATAATGAAG ATAATTCACA ATTTAAAGAT 1200

CATCCCACGC TAAATGACAG ATATTTGTTG TTACATCTTT TGGGTAGAGG AGGTTTCAGT 1260

GAAGTTTATA AGGCATTTGA TCTAACAGAG CAAAGATATG TAGCTGTGAA AATTCACCAG 1320

TTAAATAAAA ACTGGAGAGA TGAGAAAAAG GAGAATTACC ACAAGCATGC ATGTAGGGAA 1380

TACCGGATTC ACAAAGAACT GGATCATCCC AGAATAGTAA AGCTGTATGA TTACTTTTCA 1440

CTGGACACTG ACTCGTTTTG TACAGTATTA GAATACTGTG AGGGAAATGA TCTGGACTTC 1500

TACTTGAAAC AGCACAAATT AATGTCGGAG AAAGAGGCCC GATCCATTAT CATGCAGATT 1560

GTGAATGCTT TAAAGTACTT AAATGAAATA AAACCTCCCA TCATACACTA TGACCTCAAA 1620

CCAGGTAATA TTCTTTTAGT AAATGGTACA GCGTGTGGAG AGATAAAAAT TACAGATTTT 1680

GGTCTTTCCA AGATCATGGA TGATGATAGC TACAATTCAG TGGATGGCAT GGAGCTAACA 1740

TCACAAGGTG CTGGTACTTA CTGGTATTTA CCACCAGAGT GTTTTGTGGT TGGGAAAGAA 1800

CCACCAAAGA TCTCAAATAA AGTTGACGTC TGGTCAGTGG GTGTGATCTT CTACCAGTGT 1860

CTTTATGGAA GGAAGCCTTT TGGCCATAAC CAGTCCCAGC AAGACATTCT GCAAGAGAAT 1920

ACTATTCTTA AAGCTACTGA AGTGCAGTTC CCGCCAAAGC CAGTAGTAAC ACCTGAAGCA 1980

AAGGCATTTA TTCGACGATG CTTGGCCTAC CGAAAGGAAG ACCGCATCGA TGTCCAGCAA 2040

CTGGCCTGTG ACCCCTACTT GCTGCCTCAC ATCCGAAAGT CGGTCTCCAC GAGTAGCCCT 2100

GCTGGAGCTG CTATTGCATC AACCTCTGGG GCATCCAATA ACAGTTCTTC GAATTGA 2157

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 408   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  467

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 468   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  527

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 528   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  587

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 588   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  647

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 648   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  687

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013