EKS-OTG-00390

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00390

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	363.0	1.1E-108	680	936	257

Status

Unreviewed

Ensembl Protein

ENSOGAP00000000498

UniProt Accession

H0WGN9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5

Gene Synonyms/Alias

MAP3K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000000556	ENSOGAP00000000498	ENSOGAT00000000557

Organism

Otolemur garnettii

Functional Description

Protein Length

1371

Protein Sequence
(FASTA)

MSAEAGEGIT FSVPPFAPSG FCPIPEGGIC RRGGAAAEGE ESQLQPPPPG SFWDVENTAA 60

PGTGCPTATS GSSASRCRGN SGSGGSRRTT VAYVINEASQ GQLVVAESEA LQSLREACEA 120

VGATLETLHF GKLDFGETTV LDRFYNADIA VVEMSDAFRQ PSLFYHLGVR ESFSMANNII 180

LYCDTNSDSL QSLKEIICQK NTMCTGNYTF VPYMITPHNK VYCCDSSFMK GLTELMQPNF 240

ELLLGPICLP LVDRFVQLLK VAQATSSQYF RESILNDIRK ARNLYTGKEL AAELARIRQR 300

VDNIEVLTAD IVINLLLSYR DIQDYDSIVK LVEALEKLPT FDLASHHHVK FHYAFALNRR 360

NLPGDRAKAL DIMIPMVQSE GQVASDLYCL VGRIYKDMFL DSNFTDTESR DHGASWFKKA 420

FESEPTLQSG INYAVLLLAA GHQFESSFEL RKVGVKLSSL LGKKGNLEKL QSYWEVGFFL 480

GASVLANDHM RVIQASEKLF KLKTPAWYLR SIVETILIYK HFVKLPIEQP VARQELVDFW 540

MDFLVEATKT DVTVVRFPVL ILEPTKIYQP SYLSINNEVE EKTISIWHVL PDDKKGIHEW 600

NFSASAIRGV SISKFEERCC FLYVLHNSDD FQIYFCTELH CKKFFEMVNT ITEEKGRGTE 660

EGDCEGDSLE YDYEYDENGD RVVLGKGTYG IVYAGRDLSN QVRIAIKEIP ERDSRYSQPL 720

HEEIALHKHL KHKNIVQYLG SFSENGFIKI FMEQVPGGSL SALLRSKWGP LKDNEQTIGF 780

YTKQILEGLK YLHDNQIVHR DIKGDNVLIN TYSGVLKISD FGTSKRLAGI NPCTETFTGT 840

LQYMAPEIID KGPRGYGKAA DIWSLGCTII EMATGKPPFY ELGEPQAAMF KVGMFKVHPE 900

IPESMSAEAK AFILKCFEPD PDKRAGANDL LVDEFLKVSS KKKKTQPKLS ALSAGSNEYL 960

RSISLPVPVL VEDTSSSSEY GSVSPDTELK VDPFSFKTRA KSCGERDVKG IRTLFLGIPD 1020

ENFEDHSAPP SPEEKDSGFF MLRKDSERRA TLHRILTEDQ DKIVRNLMES LAQGAEEPKL 1080

KWEHITTLIA SLREFVRSTD RKIIATTLSK LKLELDFDSH GISQVQVVLF GFQDAVNKVL 1140

RNHNIKPHWM FALDSIIRKA VQTAITILVP ELRPHFSLAS ESDTADQEDL DDDHEEQPSN 1200

QTVRRPQAVI EDAVATSGVS TLSSTVSHDS QSAHRSLSVQ LGRMKIETNS RLLEELVRKE 1260

KELQALLHQA IEEKDQEIKH LKLKSQPIEI SGLPVCPLNS PGTNTEDSEL TDWLRENGAD 1320

EDTISRFLAE DYTLDDVLYC VTRDDLKCLR LRGGMLCTLW KAIVDFRDKK T 1371

Nucleotide Sequence
(FASTA)

ATGAGTGCGG AGGCTGGCGA GGGCATCACT TTCTCCGTGC CACCCTTCGC CCCCTCGGGC 60

TTCTGCCCCA TCCCCGAGGG CGGCATCTGC AGGAGAGGCG GAGCGGCAGC CGAGGGCGAG 120

GAGAGTCAGC TACAGCCGCC ACCACCGGGC AGCTTCTGGG ATGTGGAGAA CACGGCCGCT 180

CCTGGCACCG GGTGTCCCAC TGCCACCTCC GGCAGCAGTG CTAGCCGGTG TCGGGGCAAC 240

TCTGGTAGCG GGGGCAGCCG ACGGACCACC GTGGCATATG TGATCAACGA AGCGAGCCAG 300

GGGCAGCTGG TAGTGGCCGA GAGTGAGGCC CTGCAGAGCC TGAGGGAGGC GTGCGAGGCG 360

GTGGGCGCCA CCCTGGAGAC CCTGCATTTT GGTAAACTGG ACTTTGGAGA GACCACCGTG 420

CTGGACCGTT TTTACAATGC AGATATCGCT GTGGTGGAGA TGAGCGATGC CTTCCGGCAG 480

CCGTCCTTGT TCTATCACCT TGGGGTGAGA GAAAGTTTCA GTATGGCCAA CAACATCATC 540

CTCTACTGTG ATACTAACTC AGACTCTCTG CAGTCACTGA AGGAAATCAT TTGCCAGAAG 600

AATACTATGT GCACTGGGAA CTACACCTTT GTCCCTTACA TGATCACTCC ACACAACAAG 660

GTCTACTGCT GTGACAGCAG CTTCATGAAG GGCTTGACGG AGCTCATGCA GCCCAACTTT 720

GAGCTGCTCC TGGGACCCAT CTGCTTACCT CTTGTGGATC GTTTTGTTCA ACTTCTGAAG 780

GTGGCACAAG CAACTTCCAG CCAATATTTC CGGGAATCTA TACTTAACGA TATCAGGAAA 840

GCTCGTAATT TATACACTGG TAAAGAACTG GCGGCTGAAT TGGCAAGAAT TCGGCAGCGA 900

GTAGACAATA TTGAAGTCCT GACAGCAGAT ATTGTCATAA ATCTGTTACT TTCCTACAGA 960

GACATCCAGG ACTATGATTC TATTGTGAAG CTGGTAGAGG CTTTAGAAAA ACTGCCAACC 1020

TTCGACTTGG CCTCCCACCA CCACGTCAAG TTTCATTATG CATTTGCACT GAATAGGAGA 1080

AATCTCCCTG GAGACAGAGC AAAAGCTCTT GATATTATGA TTCCCATGGT GCAGAGCGAA 1140

GGGCAGGTCG CTTCAGATCT GTATTGCCTC GTTGGTCGAA TCTACAAAGA TATGTTTTTG 1200

GATTCTAATT TCACGGACAC TGAAAGTAGA GACCATGGGG CCTCTTGGTT CAAAAAGGCA 1260

TTTGAATCTG AGCCAACACT GCAGTCAGGA ATTAATTATG CCGTCCTCCT CCTGGCAGCT 1320

GGGCACCAGT TTGAATCTTC CTTTGAGCTC CGGAAAGTTG GGGTCAAGCT AAGTAGTCTT 1380

CTTGGTAAAA AGGGAAACTT GGAAAAACTG CAGAGCTACT GGGAAGTTGG ATTTTTTCTG 1440

GGGGCCAGTG TTCTGGCCAA TGACCACATG AGAGTCATTC AAGCATCTGA AAAGCTTTTT 1500

AAACTGAAGA CGCCAGCATG GTACCTCAGA TCTATTGTAG AGACAATTTT GATATATAAG 1560

CATTTTGTGA AACTGCCCAT AGAACAGCCT GTGGCCAGGC AAGAACTTGT GGACTTCTGG 1620

ATGGATTTCC TGGTGGAGGC CACGAAGACA GACGTCACTG TGGTTCGGTT TCCAGTATTA 1680

ATATTAGAAC CAACCAAAAT CTATCAGCCT TCTTATTTGT CTATCAACAA TGAAGTCGAG 1740

GAAAAAACAA TATCTATCTG GCACGTGCTT CCTGATGACA AGAAAGGCAT ACATGAGTGG 1800

AATTTTAGCG CTTCTGCTAT CAGGGGAGTG AGTATTTCTA AATTTGAAGA ACGATGCTGT 1860

TTTCTTTACG TGCTTCACAA CTCTGATGAT TTCCAAATCT ATTTCTGTAC AGAACTTCAT 1920

TGTAAAAAGT TTTTTGAAAT GGTGAACACC ATTACCGAAG AGAAGGGGAG AGGCACAGAG 1980

GAAGGAGATT GTGAAGGTGA CTCCCTGGAG TATGACTACG AATATGATGA AAATGGTGAC 2040

AGAGTGGTTT TAGGAAAAGG TACTTACGGG ATAGTCTACG CAGGTCGAGA CTTGAGCAAC 2100

CAAGTCAGAA TTGCTATTAA GGAGATACCA GAGAGAGATA GCAGATACTC TCAGCCCCTA 2160

CATGAAGAAA TAGCATTACA TAAGCACTTG AAGCACAAAA ACATTGTCCA GTATCTAGGC 2220

TCCTTCAGTG AGAATGGTTT CATTAAAATC TTCATGGAAC AGGTCCCTGG AGGAAGTCTA 2280

TCTGCTCTCC TTCGTTCCAA ATGGGGTCCA TTAAAAGACA ATGAGCAAAC AATTGGCTTT 2340

TATACAAAGC AAATACTGGA AGGACTAAAA TACCTCCATG ACAATCAGAT TGTTCACCGG 2400

GACATAAAGG GTGACAATGT GTTGATTAAT ACCTACAGTG GCGTTCTCAA GATCTCTGAC 2460

TTTGGGACAT CAAAGAGGCT TGCTGGCATA AACCCATGTA CTGAAACATT TACTGGTACC 2520

CTTCAGTATA TGGCACCAGA AATAATAGAT AAAGGACCGA GAGGCTACGG GAAAGCAGCC 2580

GACATCTGGT CTTTGGGCTG TACCATCATT GAGATGGCCA CAGGAAAACC ACCATTCTAC 2640

GAACTGGGAG AACCACAAGC AGCTATGTTC AAGGTGGGAA TGTTTAAAGT ACACCCTGAG 2700

ATCCCAGAGT CCATGTCTGC AGAGGCCAAA GCTTTCATAC TGAAATGTTT TGAACCAGAC 2760

CCTGACAAGA GAGCCGGTGC TAATGACTTG CTTGTTGATG AGTTCTTGAA AGTTTCAAGC 2820

AAAAAGAAAA AGACACAACC TAAGCTTTCA GCTCTTTCAG CTGGATCAAA TGAGTATCTC 2880

AGGAGTATCT CCCTGCCGGT GCCCGTGCTG GTGGAGGACA CCAGCAGCAG CAGTGAGTAC 2940

GGCTCTGTGT CGCCCGACAC GGAGTTAAAG GTGGACCCCT TCTCTTTCAA AACAAGAGCC 3000

AAGTCCTGCG GAGAAAGAGA TGTGAAAGGA ATCCGGACGC TCTTTTTGGG CATTCCAGAT 3060

GAAAATTTTG AAGATCACAG TGCACCCCCT TCCCCTGAAG AAAAAGATTC TGGATTCTTT 3120

ATGCTGAGGA AGGACAGTGA GAGGCGGGCC ACGCTTCACA GGATCCTGAC AGAAGACCAA 3180

GACAAAATCG TGAGAAACTT AATGGAATCC TTAGCACAGG GTGCTGAAGA ACCTAAACTA 3240

AAGTGGGAAC ACATCACAAC CCTCATTGCA AGCCTCAGAG AGTTCGTGAG ATCCACGGAC 3300

CGAAAAATCA TAGCCACCAC GTTGTCAAAG CTGAAACTGG AGCTAGACTT CGACAGCCAC 3360

GGCATTAGCC AAGTGCAGGT GGTACTCTTT GGTTTTCAAG ATGCTGTTAA TAAAGTTCTT 3420

CGGAATCATA ACATCAAGCC ACACTGGATG TTTGCCCTAG ATAGTATCAT CCGAAAGGCG 3480

GTACAGACAG CTATTACCAT TCTGGTTCCA GAACTGAGGC CACATTTCAG CCTTGCATCT 3540

GAAAGTGATA CCGCCGATCA AGAAGACCTG GACGACGACC ATGAGGAACA GCCTTCTAAT 3600

CAAACTGTCC GAAGACCTCA GGCCGTCATT GAAGATGCTG TAGCTACCTC AGGGGTGAGC 3660

ACGCTCAGTT CTACTGTGTC CCACGATTCC CAGAGTGCTC ACCGATCACT GAGTGTACAG 3720

CTTGGAAGGA TGAAAATAGA AACTAACAGC AGATTGCTGG AAGAATTGGT TCGGAAAGAG 3780

AAAGAATTAC AAGCACTCCT TCATCAAGCT ATTGAAGAAA AAGACCAAGA AATTAAACAC 3840

CTGAAGCTTA AGTCCCAACC CATAGAAATC AGTGGATTGC CTGTGTGTCC CCTAAATTCT 3900

CCTGGCACAA ATACTGAAGA TTCCGAACTT ACTGACTGGC TGCGAGAAAA TGGAGCTGAT 3960

GAAGACACTA TAAGCCGGTT TCTGGCTGAG GATTACACAT TAGATGATGT TCTCTACTGT 4020

GTTACACGTG ATGATTTAAA ATGCCTGAGA CTAAGGGGAG GGATGCTGTG CACGCTGTGG 4080

AAGGCCATCG TTGACTTTCG AGACAAAAAG ACTTGA 4116

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 680   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  734

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+

Q: 735   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  794

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 795   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  851

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+

Q: 852   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  911

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ kc+e dp+kr+ a++LL +efl

Q: 912   FILKCFEPDPDKRAGANDLLVDEFL  936

         **********************996

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180

ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240

DPDKRAGAND LLVDEFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013