EKS-OTG-00337
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00337
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20294.56.8E-881210210
StatusUnreviewed
Ensembl ProteinENSOGAP00000000909
UniProt AccessionH0WHP6;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K3
Gene Synonyms/Alias MAP4K3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000001016ENSOGAP00000000909ENSOGAT00000001018
OrganismOtolemur garnettii
Functional Description
Protein Length815
Protein Sequence
(FASTA)
MMKDCKHPNI VAYFGSYLRR DKLWICMEFC GGGSLQDIYH VTGPLSELQI AYVSRETLQG 60
LYYLHSKGKM HRDIKGANIL LTDNGHVKLA DFGVSAQITA TIAKRKSFIG TPYWMAPEVA 120
AVERKGGYNQ LCDLWAVGIT AIELAELQPP MFDLHPMRAL FLMTKSNFQP PKLKDKMKWS 180
NSFHHFVKMA LTKNPKKRPT AEKLLQHPFV TQPLTRSLAI ELLDKVNNPD HSTYHDFDDD 240
DPEPLVAVPH RIHSTSRNVR EEKTRSEINF GQVKFDPPLR KETEPHHELD LQLEYGQGHQ 300
SSYFLGANKS LLKSVEEELH QRGHVAHLED DEEDDDDSKQ STMKAKVPPP LPPKVDKFIF 360
PFEFLHSNTS KKGIGFMKLC PTKQCLVAFN SLNFSHPANR INGTLPTVIK TLSSGMQFDG 420
EKLLTMKCQV GSRVQLSYSF RVLKSLKKPL QSASPYTCKV QMGACFSKVF NGCPLKIHCA 480
TSWINPDTRD QYLIFGAEEG IYTLNLNELH ETSMEQLFPR RCTWLYVMNN CLLSISGKAS 540
QLYSHNLPGL FDYARQMQKL PVAIPAHKLP DRILPRKFSV SAKIPETKWC QKCCVALTVR 600
NPYTGHKYLC GALQTSIVLL EWVEPMQKFM LIKHIDFPIP CPLRLFEMLV VPEQEYPLVC 660
VGVSRGRDFN QVVRFETVNP NSTSSWFTES DTPQTSVTHV TQLERDTILV CLDCCIKIVN 720
LQGRLKSSRK LSSELTFDFQ IESIVCLQDS VLAFWKHGMQ GRSFRSNEVT QEISDSTRIF 780
RLLGSDRVVV LESRPTDNPT ANSNLYILAG HENSY 815
Nucleotide Sequence
(FASTA)
ATGATGAAAG ACTGTAAACA CCCAAATATC GTTGCTTATT TTGGAAGCTA TCTCAGGCGG 60
GATAAACTTT GGATTTGCAT GGAGTTTTGT GGAGGTGGTT CTTTACAGGA TATTTATCAC 120
GTGACTGGAC CTCTGTCAGA ACTACAAATT GCATATGTTA GCAGAGAAAC ACTACAGGGA 180
TTATATTATC TTCACAGTAA AGGAAAAATG CACAGAGATA TAAAGGGTGC TAACATTCTA 240
TTAACGGATA ATGGTCATGT GAAATTAGCT GACTTTGGAG TATCCGCCCA GATAACAGCG 300
ACAATTGCCA AACGGAAGTC TTTCATTGGC ACACCATATT GGATGGCCCC AGAGGTCGCA 360
GCAGTTGAGA GGAAGGGCGG TTACAACCAG CTGTGTGATC TCTGGGCTGT GGGGATCACC 420
GCCATAGAGC TCGCTGAGCT GCAGCCTCCC ATGTTTGACT TGCACCCAAT GAGAGCATTA 480
TTTCTAATGA CAAAAAGCAA TTTTCAACCT CCTAAACTAA AGGATAAAAT GAAATGGTCA 540
AATAGTTTTC ATCATTTTGT GAAAATGGCA CTTACCAAAA ATCCAAAAAA AAGACCTACT 600
GCTGAAAAAT TATTACAGCA CCCTTTTGTC ACACAGCCTT TGACACGGTC TTTGGCAATT 660
GAGCTGTTGG ATAAAGTGAA TAATCCAGAT CATTCCACTT ATCATGATTT CGATGATGAT 720
GATCCTGAGC CACTTGTTGC CGTACCACAT AGAATTCACT CAACAAGCAG AAATGTGAGA 780
GAAGAAAAAA CACGCTCAGA GATAAACTTT GGCCAAGTAA AATTTGATCC TCCCTTAAGG 840
AAGGAGACAG AACCACATCA TGAACTTGAT CTACAACTAG AATATGGACA AGGACACCAA 900
AGTAGTTACT TCTTAGGTGC AAACAAGAGT CTTCTCAAGT CTGTTGAAGA AGAATTACAT 960
CAGCGAGGAC ATGTGGCACA TTTAGAAGAT GATGAAGAGG ATGATGATGA CTCTAAACAG 1020
TCAACCATGA AAGCAAAAGT TCCACCTCCT TTGCCACCAA AGGTAGATAA ATTCATTTTT 1080
CCATTTGAAT TTCTTCATTC TAATACTTCA AAAAAAGGAA TAGGTTTTAT GAAACTCTGT 1140
CCAACCAAGC AGTGCCTTGT TGCTTTCAAC AGTTTAAATT TTAGCCATCC TGCTAATAGG 1200
ATTAATGGCA CTCTACCAAC GGTGATAAAA ACTCTTAGCT CAGGAATGCA ATTTGATGGG 1260
GAAAAGCTGC TGACCATGAA ATGCCAGGTA GGATCCCGTG TGCAGCTAAG TTATTCTTTT 1320
CGGGTACTGA AGTCTTTAAA AAAACCATTA CAGTCAGCTA GTCCATATAC ATGTAAAGTT 1380
CAAATGGGTG CATGTTTTTC AAAGGTTTTT AATGGGTGTC CTTTGAAAAT ACACTGTGCA 1440
ACATCGTGGA TAAACCCAGA TACAAGAGAT CAGTACTTGA TATTTGGTGC CGAAGAAGGG 1500
ATTTATACTC TGAATCTTAA TGAACTTCAT GAAACATCAA TGGAACAACT ATTCCCTCGA 1560
CGGTGTACAT GGTTATACGT AATGAACAAT TGTTTGCTAT CAATATCTGG TAAAGCTTCT 1620
CAGCTTTATT CCCATAACTT ACCAGGGCTT TTTGATTATG CAAGACAAAT GCAGAAGTTA 1680
CCTGTTGCAA TTCCAGCACA CAAACTTCCT GACAGAATAC TGCCAAGGAA ATTTTCCGTA 1740
TCAGCAAAAA TTCCTGAAAC CAAGTGGTGT CAGAAATGCT GTGTTGCCTT GACAGTGAGA 1800
AATCCTTACA CAGGCCATAA ATACCTATGC GGGGCACTGC AGACTAGCAT CGTTCTATTA 1860
GAATGGGTTG AACCAATGCA GAAATTTATG TTAATTAAGC ACATAGACTT TCCTATACCT 1920
TGTCCACTTA GATTGTTTGA AATGCTGGTA GTTCCTGAAC AGGAGTACCC TTTAGTTTGT 1980
GTTGGTGTCA GCAGAGGGAG AGACTTCAAC CAGGTGGTTC GATTTGAGAC TGTCAATCCA 2040
AACTCTACCT CTTCATGGTT TACAGAATCA GATACCCCGC AGACAAGTGT TACTCATGTA 2100
ACCCAACTGG AGAGAGATAC CATTCTTGTA TGCTTGGATT GTTGTATAAA AATTGTAAAT 2160
CTCCAAGGAA GATTAAAATC TAGCAGAAAA TTATCATCAG AGCTCACCTT TGATTTCCAG 2220
ATTGAATCAA TAGTTTGCCT ACAAGACAGT GTGCTAGCTT TCTGGAAACA CGGAATGCAA 2280
GGTAGAAGTT TTAGATCTAA TGAGGTAACA CAAGAAATTT CAGATAGCAC AAGAATTTTC 2340
AGGCTACTTG GATCTGACAG GGTCGTGGTT TTGGAAAGTA GGCCAACCGA TAACCCTACA 2400
GCAAATAGCA ATTTATACAT CCTGGCGGGT CATGAAAACA GTTACTGA 2448
Domain Profile
S: 49    vlkklkhpniveylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevl  108
         ++k++khpniv+y++s+l++++lw++me++ gGsl+d+++  ++ +l+E qiay+ re+l
Q: 1     MMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSELQIAYVSRETL  58
         69**************************************..******************
S: 109   kaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPE  168
         ++L ylHsk+++Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPE
Q: 59    QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE  118
         ************************************************************
S: 169   viaqe.ekgYdekaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkk  225
         v a+e + gY++ +D+w++GItaielae +pP++dl+p++al++++k++  ppklk+k k
Q: 119   VAAVErKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKMK  178
         ****98889*********************************999999888*********
S: 226   fskefkefvekclqknpekRpsasellkhkFl  257
         +s++f++fv+ +l+knp+kRp+a++ll+h+F+
Q: 179   WSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV  210
         *******************************7
Domain Sequence
(FASTA)
MMKDCKHPNI VAYFGSYLRR DKLWICMEFC GGGSLQDIYH VTGPLSELQI AYVSRETLQG 60
LYYLHSKGKM HRDIKGANIL LTDNGHVKLA DFGVSAQITA TIAKRKSFIG TPYWMAPEVA 120
AVERKGGYNQ LCDLWAVGIT AIELAELQPP MFDLHPMRAL FLMTKSNFQP PKLKDKMKWS 180
NSFHHFVKMA LTKNPKKRPT AEKLLQHPFV 210
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00314
EKS-ANC-00316
EKS-BOT-00314
EKS-CAJ-00322
EKS-CAF-00317
EKS-CAP-00370
EKS-DAR-00677
EKS-EQC-00314
EKS-FEC-00310
EKS-GAG-00265
EKS-GAA-00395
EKS-GOG-00311
EKS-HOS-00323
EKS-LAC-00337
EKS-LOA-00323
EKS-MAM-00317
EKS-MOD-00308
EKS-MUM-00349
EKS-MUP-00330
EKS-MYL-00322
EKS-NOL-00289
EKS-ORN-00417
EKS-ORA-00283
EKS-ORC-00316
EKS-PAT-00299
EKS-PES-00285
EKS-POA-00305
EKS-RAN-00333
EKS-SAH-00307
EKS-TAG-00329
EKS-TEN-00413
EKS-VIP-00037
EKS-XET-00383
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013