EKS-OTG-00345

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00345

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	361.7	2.6E-108	167	583	417

Status

Unreviewed

Ensembl Protein

ENSOGAP00000001008

UniProt Accession

H0WHY2;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK1

Gene Synonyms/Alias

EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000001130	ENSOGAP00000001008	ENSOGAT00000001132

Organism

Otolemur garnettii

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

MLGGSSGAGE HEAEGDGAGA VGAPPAIDFP AESSDPKYDE SDVPAELQVL KEPLQQPTFP 60

FAVANQLLLV SLLEHLSHVH EPNPLRSRQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 120

NRAITHLMRS AKERVRQDPC EDISHGENFR SKEVAFEPQT SRYLNEFEEL AILGKGGYGR 180

VYKVRNKLDG QYYAIKKILI KGATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVV 240

QPQADRVSIQ LPSLEMLSDE AEDRDEYGIK NDGSGSSSII FAELTSEKEK LFGELDTENQ 300

NNKLMNYTIN LVIKDDNELD SSFELQDNGL ADLSTRSIVK QQRLLRHNSD LEENFTSTEE 360

SSEENVSLLQ QTEAQFRLML HIQMQLCELS LWDWIVERNK RVQESVDESA CPYVMASVAT 420

KIFQELVEGV FYIHNMGIVH RDLKPRNIFL HGPDQQVKIG DFGLACTDII QKNTDWTNRN 480

GKRIPTHTSR VGTCLYASPE QLEGSEYDAK SDMYSLGVIL LELFQPFGTE MERAEVLTGL 540

RTGQIPESLS KRCPIQAKYI QHLTRRNSFQ RPSAIQLLQS ELFQNSGNVN LTLQMKIIEQ 600

EKEIEELKKQ LKLLSQDKGL KDSMKDGGVP V 631

Nucleotide Sequence
(FASTA)

ATGCTGGGGG GCAGCTCCGG GGCCGGTGAG CATGAAGCAG AAGGAGACGG GGCGGGGGCT 60

GTGGGTGCAC CACCGGCCAT CGACTTCCCT GCTGAGAGCT CGGACCCCAA ATATGATGAA 120

TCTGATGTTC CAGCAGAACT CCAGGTATTA AAAGAACCCC TACAACAGCC AACTTTCCCT 180

TTTGCAGTTG CAAACCAACT ATTGCTTGTT TCTTTGCTGG AGCACTTGAG CCATGTGCAT 240

GAACCAAACC CACTTCGTTC AAGACAGGTG TTTAAATTAC TTTGTCAGAC TTTTATCAAA 300

ATGGGGCTTC TGTCTTCCTT CACTTGTAGT GATGAGTTTA GCTCATTGAG ACTACATCAC 360

AACAGAGCTA TTACTCATTT AATGAGATCT GCTAAGGAGA GAGTTCGTCA GGATCCTTGT 420

GAAGATATTT CCCATGGCGA GAATTTCAGA TCAAAGGAAG TTGCCTTTGA ACCACAAACT 480

TCACGTTACT TAAATGAATT TGAAGAGCTT GCCATCTTAG GAAAAGGTGG ATATGGAAGA 540

GTATACAAGG TCAGGAATAA ATTAGATGGT CAGTATTATG CAATTAAAAA AATCCTGATT 600

AAGGGTGCAA CTAAAACAGA TTGCATGAAG GTGTTAAGGG AAGTGAAGGT GCTGGCAGGT 660

CTTCAGCACC CTAATATTGT AGGCTATCAC ACTGCGTGGA TAGAACATGT TCATGTGGTC 720

CAGCCACAAG CAGACAGAGT TTCCATTCAG TTGCCATCTT TGGAAATGCT CTCTGACGAG 780

GCAGAGGACA GAGATGAATA TGGTATTAAA AATGATGGAA GTGGTAGCTC TTCTATTATC 840

TTTGCTGAGC TTACCTCAGA AAAAGAAAAA CTCTTTGGAG AATTGGACAC TGAAAATCAG 900

AATAACAAAT TGATGAACTA TACCATTAAT TTAGTCATAA AAGACGACAA TGAATTAGAC 960

TCGTCCTTTG AGCTCCAAGA TAATGGTTTG GCTGATTTGT CTACCAGATC AATTGTTAAG 1020

CAGCAGCGGC TACTTAGGCA TAACTCAGAC CTAGAAGAGA ATTTTACATC CACTGAAGAA 1080

TCTTCCGAAG AAAATGTCAG CTTGTTGCAG CAGACAGAGG CACAGTTTCG CCTGATGCTA 1140

CATATCCAGA TGCAGCTGTG TGAGCTCTCC CTGTGGGATT GGATAGTGGA AAGAAACAAG 1200

CGGGTCCAAG AGAGTGTGGA TGAATCTGCC TGTCCTTACG TTATGGCCAG TGTTGCAACA 1260

AAAATTTTTC AAGAATTGGT AGAAGGTGTG TTCTACATAC ATAATATGGG AATTGTGCAC 1320

AGAGATCTGA AGCCTAGAAA TATTTTCCTT CATGGCCCTG ATCAGCAAGT AAAAATAGGA 1380

GACTTTGGTT TGGCCTGCAC AGACATTATA CAAAAGAACA CAGATTGGAC CAACAGAAAT 1440

GGGAAGAGAA TACCAACACA TACTTCCAGA GTGGGTACTT GTCTATATGC TTCACCTGAA 1500

CAGTTGGAAG GATCTGAGTA TGATGCCAAG TCAGATATGT ATAGCCTGGG TGTGATCCTG 1560

CTGGAGCTCT TTCAGCCATT TGGAACAGAA ATGGAGCGAG CAGAAGTTTT AACAGGCTTA 1620

AGAACTGGTC AGATACCTGA ATCCCTCAGT AAAAGGTGTC CAATACAAGC CAAGTATATC 1680

CAGCACTTAA CTAGAAGGAA CTCATTCCAG AGACCATCTG CTATTCAGCT ACTGCAAAGT 1740

GAACTTTTTC AAAATTCTGG AAATGTTAAT CTCACCCTAC AGATGAAGAT AATAGAACAA 1800

GAAAAAGAAA TTGAAGAACT AAAAAAGCAG TTAAAACTCC TTTCTCAGGA CAAAGGGCTG 1860

AAGGATAGCA TGAAAGATGG AGGTGTACCA GTCTAG 1896

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         fee+++lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni

Q: 167   FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  226

         899*********************************************************

S: 60    vrYfaawleekeesl.................................tdsseveaeael  86

         v Y++aw+e+ +  +                                  +ss ++ae ++

Q: 227   VGYHTAWIEHVHVVQpqadrvsiqlpslemlsdeaedrdeygikndgsGSSSIIFAELTS  286

         ************999999999999999999999999999999999986448888888888

S: 87    eesesseesdtk................................................  98

         e+++ + e dt+

Q: 287   EKEKLFGELDTEnqnnklmnytinlvikddneldssfelqdngladlstrsivkqqrllr  346

         888888888888999999999999999999999999999999999999999999999999

S: 99    ................................llyiqmelceketLkdwiderk......  120

                                         +l+iqm+lce  +L+dwi er+

Q: 347   hnsdleenftsteesseenvsllqqteaqfrlMLHIQMQLCE-LSLWDWIVERNkrvqes  405

         99999999999999999999999999999999**********.*******9999897777

S: 121   llesrselvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLa  174

         ++es++ +vm     ++f++l+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa

Q: 406   VDESACPYVMasvatKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQVKIGDFGLA  465

         7778888888************************************99************

S: 175   talaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLly  234

         ++++ ++++d+++++ ++ ++ht++vgt+ly+sPeqle+s+Y++k+D++sLG+il+eL++

Q: 466   CTDIIQKNTDWTNRNGKRIPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQ  525

         ************************************************************

S: 235   pfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292

         pf temer+e+lt lr+g+ipe++++++p ++k++q+l++r++ +Rpsa +ll+sel+

Q: 526   PFGTEMERAEVLTGLRTGQIPESLSKRCPIQAKYIQHLTRRNSFQRPSAIQLLQSELF  583

         *******************************************************986

Domain Sequence
(FASTA)

FEELAILGKG GYGRVYKVRN KLDGQYYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60

VGYHTAWIEH VHVVQPQADR VSIQLPSLEM LSDEAEDRDE YGIKNDGSGS SSIIFAELTS 120

EKEKLFGELD TENQNNKLMN YTINLVIKDD NELDSSFELQ DNGLADLSTR SIVKQQRLLR 180

HNSDLEENFT STEESSEENV SLLQQTEAQF RLMLHIQMQL CELSLWDWIV ERNKRVQESV 240

DESACPYVMA SVATKIFQEL VEGVFYIHNM GIVHRDLKPR NIFLHGPDQQ VKIGDFGLAC 300

TDIIQKNTDW TNRNGKRIPT HTSRVGTCLY ASPEQLEGSE YDAKSDMYSL GVILLELFQP 360

FGTEMERAEV LTGLRTGQIP ESLSKRCPIQ AKYIQHLTRR NSFQRPSAIQ LLQSELF 417

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013