EKS-OTG-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC479.52.7E-144342600259
StatusUnreviewed
Ensembl ProteinENSOGAP00000001074
UniProt AccessionH0WI40;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000001199ENSOGAP00000015780ENSOGAT00000033490
ENSOGAG00000001199ENSOGAP00000001074ENSOGAT00000001201
OrganismOtolemur garnettii
Functional Description
Protein Length673
Protein Sequence
(FASTA)
MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS 120
LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIDR EVLIVVVRDA 180
KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL 240
SVEIWDWDLT SRNDFMGSLS FGISELQKAG VDGWFKLLSQ EEGEYFNVPV PPEGSEGNEE 300
LRQKFERAKI GQGTKVPEEK TTNTISKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE 360
RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM 420
EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI 480
KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP 540
FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF 600
RYIDWEKLER KEIQPPYKPK ACGRNAENFD RFFTRHPPVL TPPDQEVIRN IDQSEFEGFS 660
FVNSEFLKPE VKS 673
Nucleotide Sequence
(FASTA)
ATGGCTGACC CGGCTGCGGG GCCGCCGCCG AGCGAGGGCG AGGAGAGCAC TGTGCGCTTC 60
GCCCGCAAAG GCGCTCTCCG GCAGAAGAAC GTGCACGAGG TGAAGAACCA CAAATTCACC 120
GCCCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGCTTC 180
GGGAAGCAGG GATTCCAGTG TCAAGTTTGC TGCTTTGTTG TGCACAAGCG GTGCCATGAA 240
TTTGTCACAT TCTCCTGCCC TGGCGCTGAC AAGGGCCCAG CCTCTGATGA CCCCCGGAGC 300
AAACATAAGT TTAAGATCCA CACATACTCC AGCCCCACGT TTTGTGACCA CTGTGGTTCA 360
CTGCTGTATG GACTCATCCA CCAGGGGATG AAATGTGACA CCTGCATGAT GAACGTCCAC 420
AAGCGCTGTG TGATGAACGT CCCCAGCCTC TGTGGCACAG ACCACACGGA GCGCCGTGGC 480
CGCATCTACA TCCAGGCCCA CATCGACAGG GAGGTCCTCA TCGTCGTTGT AAGAGATGCT 540
AAAAACCTTG TACCCATGGA CCCCAATGGC TTGTCAGATC CCTACGTAAA ACTGAAACTG 600
ATTCCTGACC CCAAAAGTGA GAGCAAGCAG AAGACCAAAA CCATCAAGTG CTCCCTCAAC 660
CCTGAGTGGA ATGAGACATT TAGATTTCAA CTGAAAGAAT CAGATAAAGA CAGGAGACTG 720
TCCGTAGAGA TTTGGGATTG GGATCTGACC AGCAGGAATG ACTTCATGGG ATCTCTGTCA 780
TTTGGCATTT CTGAACTGCA GAAAGCCGGT GTCGATGGCT GGTTTAAGTT ACTGAGCCAG 840
GAGGAAGGTG AATACTTCAA TGTCCCCGTG CCGCCAGAAG GAAGTGAGGG GAATGAGGAA 900
CTGAGGCAGA AATTTGAGAG GGCCAAGATC GGCCAGGGAA CCAAGGTTCC AGAAGAAAAG 960
ACGACCAACA CCATATCCAA GTTTGACAAC AATGGCAACA GGGACCGGAT GAAACTGACT 1020
GATTTTAACT TCCTGATGGT GCTGGGGAAA GGCAGCTTTG GCAAGGTCAT GCTCTCGGAG 1080
CGGAAAGGCA CAGATGAACT CTACGCCGTG AAGATCCTGA AGAAGGACGT CGTGATCCAA 1140
GATGACGACG TGGAGTGCAC CATGGTGGAG AAGCGGGTGC TGGCCCTGCC TGGGAAGCCG 1200
CCCTTCCTCA CCCAGCTCCA CTCCTGCTTC CAGACCATGG ACCGCCTGTA CTTCGTGATG 1260
GAGTATGTGA ACGGAGGTGA CCTCATGTAC CACATCCAGC AAGTCGGCCG GTTTAAAGAG 1320
CCTCATGCTG TATTTTACGC TGCAGAAATT GCCATCGGTC TATTCTTCTT ACAGAGCAAG 1380
GGCATCATTT ACCGTGACCT AAAACTTGAC AATGTGATGC TGGATTCTGA GGGGCACATC 1440
AAGATCGCTG ACTTTGGCAT GTGTAAGGAA AACATCTGGG ATGGGGTGAC AACTAAGACG 1500
TTCTGTGGCA CTCCAGACTA CATCGCCCCT GAGATAATTG CTTATCAGCC CTATGGGAAG 1560
TCCGTGGATT GGTGGGCATT TGGAGTCCTG CTGTATGAAA TGTTGGCTGG ACAGGCGCCC 1620
TTCGAAGGGG AGGATGAGGA TGAACTCTTT CAGTCCATCA TGGAACACAA CGTGGCTTAT 1680
CCAAAGTCCA TGTCCAAGGA GGCTGTGGCC ATATGCAAAG GGCTGATGAC CAAACACCCA 1740
GGCAAACGTC TGGGTTGTGG CCCTGAAGGT GAACGTGACA TCAAAGAGCA TGCGTTTTTC 1800
CGGTATATTG ATTGGGAGAA ACTTGAACGC AAAGAGATTC AGCCCCCATA TAAGCCAAAA 1860
GCTTGTGGGC GAAATGCTGA AAACTTCGAC CGATTTTTCA CCCGCCATCC ACCAGTCCTA 1920
ACACCTCCTG ACCAGGAAGT CATCAGGAAT ATTGACCAAT CAGAATTCGA AGGATTTTCC 1980
TTTGTTAACT CTGAATTTTT AAAACCTGAA GTCAAGAGCT AA 2022
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 342   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  401
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg
Q: 402   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  461
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 462   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  521
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 522   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  581
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 582   KRLGCGPEGERDIKEHAFF  600
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00168
EKS-CAJ-00172
EKS-CAF-00175
EKS-CAP-00168
EKS-DAR-00459
EKS-EQC-00173
EKS-FEC-00158
EKS-GAM-00088
EKS-GAG-00144
EKS-GAA-00202
EKS-GOG-00171
EKS-HOS-00174
EKS-ICT-00163
EKS-LAC-00180
EKS-MAM-00166
EKS-MOD-00167
EKS-MUM-00173
EKS-MUP-00172
EKS-MYL-00177
EKS-NOL-00161
EKS-OCP-00107
EKS-ORN-00212
EKS-ORC-00156
EKS-PAT-00159
EKS-PES-00148
EKS-POA-00165
EKS-RAN-00164
EKS-SAH-00162
EKS-TEN-00211
EKS-XET-00157
EKS-XIM-00206
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013