EKS-OTG-00305

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00305

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	455.7	4.1E-137	709	965	257

Status

Unreviewed

Ensembl Protein

ENSOGAP00000001341

UniProt Accession

H0WIR3;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3

Gene Synonyms/Alias

ERBB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000001507	ENSOGAP00000001341	ENSOGAT00000001509

Organism

Otolemur garnettii

Functional Description

Protein Length

1341

Protein Sequence
(FASTA)

MRANGALQVL GLLLSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYARCEVVM 60

GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120

LNYNTNSSHA LRQLRFTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR CAEIVVKDNG 180

RSCPPCHEVC KGRCWGPGPE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 240

TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVANC PHNFVVDQTS 300

CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGAGSRF QTVDSSNIDG FVNCTKILGN 360

LDFLITGLNG DPWHKIPALD PEKLNVFQTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420

RSLYNRGFSL LIMKNLNVTS LGLRSLKEIS AGRIYISANR QLCYHHSLNW TKLLRGPSEE 480

RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPSQCLSC RNYSRGGVCV THCNFLNGEP 540

REFAHDAKCF SCHPECQPME GTATCNGSGS DACTQCAHFR DGPHCVSSCP NGVLGAKGPI 600

YKYPDVQNEC QPCHENCTQG CKGPELQDCL DQSLELISKT HLTMALMVIV GLVAIFLILG 660

GTFLYWRGRQ IQNKRAMRRY LERGESIEPL DPSEKANKVL ARIFKETELR KLKVLGSGVF 720

GTVHKGVWIP EGESIKIPVC IKVIEDKSGR QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG 780

SSLQLVTQYL PLGSLLDHVR QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV 840

LLKSPSQVQV ADFGVADLLP PDDKQLLHSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT 900

VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI DENIRPTFKE 960

LANEFTRMAR DPPRYLVIKR ESGPGIAPGA EPPALTDKEL EEVELEPELD LDLDLEAEED 1020

NLATTLGSAL SLPIGTLNRP RGSQSLLNPS SGYMPMNQGN LGEASQDSAV CGGSERCPRP 1080

VSLYPIPRTR LASESSEGHV TGSEAELQEK VSMCRSRSRS RSRSPRPRGD SAYHSQRHSL 1140

LTPVTPLSPP GLEEEDVNGY VMPDTHLKGT PSSREGTLSS VGLSSVLGTE EDEDEEYEYM 1200

NRRRHGPLHP PRPSSLEELG YEYMDVGSDL SASLGSTQSC PLHPVPIMPT AGTTPDEDYE 1260

YMNRRRGGGG PGGEYAAMGA CPATEQGYEE MRAFQGPSHH APHVHYARLK TLRSLEATDS 1320

AFDNPDYWHS RLFSKANAQR T 1341

Nucleotide Sequence
(FASTA)

ATGAGGGCGA ATGGGGCTCT GCAGGTGCTG GGCTTGCTTC TCAGCCTGGC CCGGGGCTCC 60

GAGGTGGGCA ACTCACAGGC AGTGTGTCCT GGGACTCTGA ATGGGCTGAG TGTGACTGGC 120

GATGCTGAGA ACCAGTACCA GACACTGTAC AAGCTCTACG CGAGGTGTGA GGTGGTGATG 180

GGGAACCTGG AGATTGTGCT CACAGGACAC AATGCTGACC TCTCCTTCCT GCAGTGGATC 240

CGAGAAGTGA CAGGCTATGT CCTCGTGGCC ATGAATGAAT TCTCTACACT ACCACTACCC 300

AACCTCCGAG TCGTGCGGGG CACCCAAGTC TATGATGGGA AGTTTGCCAT CTTTGTCATG 360

TTGAACTATA ACACCAATTC CAGCCATGCT CTTCGCCAGC TCCGCTTTAC TCAGCTCACT 420

GAGATTCTGT CAGGGGGTGT CTATATTGAG AAGAATGATA AACTTTGTCA CATGGACACG 480

ATTGACTGGA GAGACATCGT GAGGGACCGA TGTGCTGAGA TAGTGGTGAA GGACAATGGC 540

AGAAGCTGTC CCCCCTGTCA TGAGGTCTGC AAGGGGAGAT GCTGGGGTCC CGGACCAGAA 600

GACTGCCAGA CATTGACCAA GACCATCTGT GCCCCTCAGT GTAATGGTCA CTGCTTTGGG 660

CCCAACCCCA ACCAGTGCTG CCATGATGAG TGTGCAGGGG GGTGCTCAGG CCCTCAGGAC 720

ACAGACTGCT TTGCCTGTCG ACACTTCAAT GATAGTGGAG CCTGTGTACC CCGGTGTCCA 780

CAGCCTCTTG TCTATAATAA GCTAACTTTC CAGCTGGAAC CCAATCCACA CACCAAGTAC 840

CAATATGGAG GAGTTTGTGT AGCCAACTGT CCCCACAACT TTGTGGTGGA TCAGACGTCC 900

TGTGTCAGAG CCTGTCCTCC TGACAAGATG GAAGTAGATA AAAATGGGCT AAAGATGTGT 960

GAACCTTGTG GGGGGCTATG CCCTAAAGCC TGTGAGGGGA CAGGTGCTGG AAGCCGCTTC 1020

CAGACTGTGG ACTCAAGCAA CATCGATGGA TTTGTGAACT GCACCAAGAT CCTGGGCAAC 1080

CTGGACTTTC TTATCACTGG CCTTAATGGA GATCCCTGGC ACAAGATCCC TGCCCTGGAT 1140

CCTGAGAAGC TCAATGTTTT CCAGACAGTC CGGGAGATCA CAGGTTACCT GAACATCCAG 1200

TCCTGGCCTC CTCACATGCA CAACTTCAGT GTTTTTTCCA ACCTGACCAC CATTGGAGGC 1260

AGAAGCCTCT ACAACCGAGG CTTCTCGTTG CTGATCATGA AGAACTTGAA TGTAACATCT 1320

CTGGGCCTCC GGTCCCTGAA GGAAATTAGT GCTGGGCGTA TCTACATAAG TGCCAATCGG 1380

CAGCTGTGCT ACCACCATTC CTTGAACTGG ACCAAGCTGC TTCGGGGGCC TTCAGAAGAG 1440

AGACTAGACA TCAAGCACAA TCGGCCCCGC AGAGACTGTG TGGCAGAAGG CAAAGTGTGT 1500

GACCCACTGT GCTCCTCTGG GGGATGCTGG GGCCCAGGCC CTAGTCAGTG CTTATCCTGC 1560

CGAAACTACA GCCGAGGAGG TGTCTGTGTC ACCCACTGCA ACTTTCTGAA TGGGGAGCCT 1620

CGTGAGTTTG CCCATGATGC TAAATGCTTC TCCTGTCACC CAGAATGCCA ACCCATGGAG 1680

GGCACTGCCA CATGCAATGG CTCGGGCTCT GATGCTTGTA CCCAATGTGC CCATTTTCGA 1740

GATGGGCCCC ACTGTGTGAG CAGCTGCCCA AATGGAGTCT TAGGTGCCAA GGGCCCCATC 1800

TACAAGTACC CGGATGTTCA GAATGAATGT CAGCCCTGCC ATGAGAACTG CACTCAGGGG 1860

TGTAAAGGAC CAGAGCTACA AGACTGTTTA GACCAATCAT TGGAGCTGAT CAGCAAAACC 1920

CATCTGACAA TGGCTTTGAT GGTGATAGTA GGATTGGTAG CAATTTTCCT GATCTTGGGT 1980

GGCACTTTTC TCTATTGGCG TGGGCGCCAG ATTCAGAATA AAAGGGCTAT GAGGCGCTAC 2040

TTGGAACGAG GTGAGAGCAT AGAGCCTCTG GATCCCAGTG AGAAGGCTAA CAAAGTCTTG 2100

GCCAGAATCT TCAAAGAGAC AGAGCTGAGG AAGCTTAAAG TGCTTGGCTC AGGTGTCTTT 2160

GGAACTGTGC ACAAAGGAGT GTGGATCCCT GAGGGTGAAT CTATCAAGAT TCCAGTCTGC 2220

ATTAAAGTCA TTGAGGACAA GAGTGGACGG CAAAGTTTTC AAGCTGTGAC GGATCATATG 2280

CTGGCCATTG GCAGTCTAGA CCATGCCCAC ATTGTACGGC TGCTGGGACT ATGCCCAGGA 2340

TCATCTCTGC AGCTTGTCAC TCAATACTTG CCTCTGGGTT CCCTCCTGGA TCATGTAAGA 2400

CAACACCGGG GAGCACTAGG GCCACAGCTG CTGCTCAACT GGGGAGTGCA AATTGCAAAG 2460

GGGATGTACT ACCTTGAGGA GCACGGTATG GTACATAGGA ACCTGGCTGC CCGAAATGTG 2520

CTACTAAAGT CACCTAGTCA GGTTCAGGTA GCAGATTTTG GTGTGGCTGA TCTGCTGCCG 2580

CCGGATGATA AACAGCTACT ACATAGTGAG GCCAAGACTC CAATTAAGTG GATGGCCCTT 2640

GAGAGTATTC ACTTTGGGAA ATACACACAC CAGAGTGACG TCTGGAGCTA TGGTGTGACA 2700

GTTTGGGAGT TGATGACCTT CGGAGCTGAG CCCTATGCAG GGCTACGATT GGCTGAAGTG 2760

CCAGATCTGC TAGAGAAAGG GGAACGGTTG GCACAGCCCC AGATCTGCAC CATTGATGTC 2820

TACATGGTGA TGGTCAAGTG CTGGATGATT GATGAGAACA TTCGACCAAC CTTTAAAGAA 2880

TTAGCCAATG AATTCACCAG GATGGCCCGA GACCCACCCC GGTATCTGGT CATAAAGAGA 2940

GAGAGTGGGC CTGGAATAGC ACCTGGGGCA GAGCCTCCTG CTCTTACAGA CAAGGAACTA 3000

GAAGAAGTAG AGCTGGAGCC AGAACTAGAC CTAGACCTAG ACTTGGAAGC AGAGGAGGAC 3060

AATCTGGCAA CCACACTGGG CTCTGCCCTC AGCCTACCCA TTGGAACACT TAATCGACCA 3120

CGTGGGAGCC AGAGCCTTTT AAATCCATCA TCTGGATACA TGCCCATGAA CCAGGGCAAT 3180

CTTGGGGAAG CTTCCCAGGA TTCTGCAGTT TGTGGAGGTA GTGAAAGGTG TCCCCGTCCA 3240

GTCTCTCTGT ATCCAATACC ACGCACACGC CTGGCATCAG AGTCATCAGA AGGCCATGTG 3300

ACAGGCTCTG AAGCTGAGCT CCAGGAGAAG GTGTCAATGT GTAGGAGCCG GAGCCGGAGC 3360

CGGAGCCGGA GCCCACGTCC CCGCGGAGAC AGTGCCTACC ATTCTCAGCG CCATAGTCTA 3420

CTTACTCCTG TCACCCCACT CTCCCCACCA GGCTTAGAGG AAGAGGATGT CAACGGTTAT 3480

GTAATGCCAG ATACACACCT TAAAGGTACT CCCTCCTCCC GAGAAGGCAC TCTTTCTTCA 3540

GTGGGTCTCA GTTCTGTCCT GGGTACTGAA GAAGATGAAG ATGAGGAGTA TGAATACATG 3600

AACCGGAGAA GGCACGGTCC ACTTCATCCC CCCAGGCCAA GTTCCCTCGA GGAGCTGGGT 3660

TATGAGTACA TGGATGTGGG ATCAGACCTC AGTGCCTCCC TGGGTAGCAC ACAGAGTTGC 3720

CCACTCCACC CTGTGCCCAT CATGCCCACT GCTGGCACAA CTCCAGATGA AGACTATGAA 3780

TATATGAATC GGCGACGTGG TGGAGGTGGT CCTGGGGGGG AATATGCAGC CATGGGGGCC 3840

TGCCCAGCAA CTGAACAAGG GTATGAAGAA ATGAGAGCTT TCCAGGGGCC TAGCCACCAT 3900

GCCCCCCATG TTCATTATGC CCGCCTCAAA ACACTACGTA GCCTAGAAGC TACTGACTCT 3960

GCCTTTGATA ACCCTGATTA CTGGCATAGC AGACTTTTCT CCAAGGCTAA TGCCCAGAGA 4020

ACATAA 4026

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh

Q: 709   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH  768

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+

Q: 769   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  828

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky

Q: 829   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  888

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw

Q: 889   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  948

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 949   MIDENIRPTFKELANEF  965

         ****************9

Domain Sequence
(FASTA)

LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAIGSLDH 60

AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120

GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180

THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240

MIDENIRPTF KELANEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013