EKS-OTG-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	381.2	2.5E-114	73	369	297

Status

Unreviewed

Ensembl Protein

ENSOGAP00000001479

UniProt Accession

H0WJ32;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000001658	ENSOGAP00000001479	ENSOGAT00000001659

Organism

Otolemur garnettii

Functional Description

Protein Length

400

Protein Sequence
(FASTA)

MLARRKPVLP ALTINPAIAE GPSPTSEGAS ETNLVDLQKK LEELELDEQQ KKRLEAFLTQ 60

KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ 120

VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG 180

LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ 240

GTHYSVQSDI WSMGLSLVEL SIGRYPIPPP DAKELEALFG RAVADGLEGE AHSISPRPRP 300

PGRPISGPGL DSRPAMAIFE LLDYIVNEPP PKLPNSVFTP DFQEFVNKCL IKNPAERADL 360

KILMNHAFIK RSEVEEVDFA GWLCKTLRLN QPSTPTRTAV 400

Nucleotide Sequence
(FASTA)

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTTACCA TCAACCCCGC CATAGCCGAG 60

GGCCCGTCTC CCACCAGCGA GGGCGCCTCC GAAACAAATC TAGTGGACCT CCAAAAGAAG 120

CTCGAGGAGC TAGAACTCGA CGAGCAACAA AAGAAGCGAC TAGAAGCCTT CCTCACCCAG 180

AAGGCCAAGG TTGGCGAGCT CAAGGATGAT GACTTTGAAA GGATCTCAGA GCTGGGTGCG 240

GGCAATGGTG GGGTGGTCAC CAAAGTCCAG CACAGACCTT CAGGCCTCAT CATGGCCAGA 300

AAGCTGATCC ACCTGGAGAT CAAGCCAGCC ATCCGGAACC AAATCATTCG AGAGCTGCAG 360

GTTCTGCACG AGTGCAATTC ACCATACATC GTCGGCTTCT ACGGGGCCTT CTACAGTGAT 420

GGGGAGATCA GCATCTGCAT GGAGCACATG GATGGTGGCT CCCTGGACCA GGTGCTGAAA 480

GAAGCCAAGA GGATTCCTGA GGAGATCCTG GGGAAAGTCA GCATTGCAGT CCTCCGGGGC 540

TTGGCGTACC TACGAGAAAA GCACCAGATC ATGCACAGAG ATGTGAAACC CTCCAACATC 600

CTCGTCAACT CCAGAGGGGA GATAAAGCTG TGTGATTTCG GGGTGAGCGG GCAGCTCATC 660

GACTCCATGG CCAACTCCTT TGTAGGAACT CGATCCTACA TGTCTCCAGA GCGGTTGCAA 720

GGCACACACT ACTCGGTGCA GTCTGACATC TGGAGCATGG GCCTGTCGCT GGTGGAGCTG 780

TCCATTGGAA GGTACCCCAT CCCCCCACCC GACGCCAAGG AGCTGGAGGC CCTATTTGGC 840

CGGGCCGTGG CCGATGGGCT GGAAGGAGAG GCCCACAGCA TCTCGCCTCG GCCGAGACCA 900

CCTGGGCGCC CTATCAGTGG TCCTGGGCTG GACAGTCGGC CAGCTATGGC CATCTTCGAG 960

CTACTGGATT ACATTGTGAA TGAGCCTCCT CCCAAGCTGC CCAACAGCGT GTTCACCCCA 1020

GACTTCCAGG AGTTTGTAAA TAAATGCCTC ATCAAGAACC CTGCAGAGCG CGCAGACCTG 1080

AAGATACTCA TGAACCACGC CTTCATCAAA CGGTCCGAGG TGGAAGAGGT GGATTTTGCT 1140

GGCTGGTTGT GTAAAACGCT GCGGTTGAAC CAGCCCAGTA CACCCACACG CACAGCTGTG 1200

TGA 1203

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+++elGaGnggvV+kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 73    ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  131

         789**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl+ek

Q: 132   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREK  187

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 188   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  246

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lvel +gryp++++++

Q: 247   QSDIWSMGLSLVELSIGRYPIPPPDAkelealfgravadglegeahsisprprppgrpis  306

         ************************999*********************************

S: 208   ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh  256

                    i+ell++ivne+ppklp++ f+++fqefv+kCl+k+++eR++lk l++h

Q: 307   gpgldsrpamaIFELLDYIVNEPPPKLPNSVFTPDFQEFVNKCLIKNPAERADLKILMNH  366

         ************************************************************

S: 257   afi  259

afi

Q: 367   AFI  369

*97

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVELSI GRYPIPPPDA KELEALFGRA VADGLEGEAH SISPRPRPPG RPISGPGLDS 240

RPAMAIFELL DYIVNEPPPK LPNSVFTPDF QEFVNKCLIK NPAERADLKI LMNHAFI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013