EKS-OTG-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	316.1	1.7E-94	161	396	236

Status

Unreviewed

Ensembl Protein

ENSOGAP00000001550

UniProt Accession

H0WJ90;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12

Gene Synonyms/Alias

MAP3K12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000001739	ENSOGAP00000001550	ENSOGAT00000001742

Organism

Otolemur garnettii

Functional Description

Protein Length

890

Protein Sequence
(FASTA)

MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG 60

GGPSPSPGGE PPPEPFANSV LQLHEQDTGG PGGAPGSPES RASRVRADEV RLQCQSGSGF 120

LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180

EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240

VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300

MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360

HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420

EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480

LQLELKEREL LRREQALERR CPGLLKSHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540

ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAAVP 600

PHEPGGPGSS GGIGPSGWEA CPPTLCGLHH DLLLRKMSSS SPDLLSAALG SRGRGATGAG 660

DPGSPPAARG DTPPSEGSAP GSTSPDSPGG AKGEPPPPVG PGEGAGLLGT GREGTSGRGG 720

SRAGSQHLTP AALLYRAAVT RSQKRGISSE EEEGEVDSEV ELTSSQRWPQ SLNMRQSLST 780

FSSENPSDGE EGTASEPSPS GTPEVGSTNT DERPDERSDD MCSQGSEIPL DPPPLEVVPG 840

PEPSTMPMSQ QELLRGEQGP PNSEDSDCDS TELDHSNSVD ALRPPASLPP 890

Nucleotide Sequence
(FASTA)

ATGGCCTGCC TCCATGAGAC CCGAACACCC TCCCCCTCCT TTGGGGGCTT CGTGTCTACC 60

CTAAGCGAGG CATCCATGCG CAAGCTGGAC CCAGACACTT CTGATTGCAC TCCTGAAAAG 120

GACCTGACAC CTACCCAGTG TGTACTTCGA GATGTAGTAC CCCTTGGTGG GCAGGGTGGG 180

GGCGGGCCCA GCCCCTCCCC AGGTGGAGAG CCACCCCCTG AGCCTTTTGC CAATAGTGTC 240

CTACAGCTGC ATGAACAGGA CACAGGGGGC CCAGGGGGAG CCCCTGGGTC ACCTGAAAGT 300

CGGGCATCCA GAGTTCGAGC AGATGAGGTG CGGCTACAGT GCCAGAGTGG CAGTGGCTTC 360

CTTGAAGGCC TCTTTGGCTG CCTGCGCCCT GTCTGGACCA TGATTGGCAA AGCCTACTCC 420

ACGGAGCACA AGCAGCAGCA GGAAGACCTT TGGGAGGTCC CCTTTGAGGA AATCCTGGAC 480

CTGCAGTGGG TGGGCTCAGG GGCCCAGGGT GCTGTTTTCC TGGGGCGCTT CCATGGGGAG 540

GAGGTAGCTG TGAAGAAGGT ACGAGACCTC AAAGAAACTG ACATCAAGCA CCTGCGCAAG 600

CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTATGCA CCCAGGCTCC CTGCTACTGC 660

ATCCTCATGG AGTTCTGCGC CCAGGGCCAG CTGTATGAGG TACTGCGGGC TGGCCGCCCT 720

GTCACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGTGGCAT GAATTACCTG 780

CACCTACACA AGATTATCCA CAGAGACCTC AAGTCCCCCA ACATGCTAAT CACATACGAC 840

GATGTGGTGA AGATCTCAGA TTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900

ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCCCCTGAGG TGATCCGCAA TGAGCCTGTG 960

TCCGAGAAAG TCGATATCTG GTCCTTTGGT GTGGTGCTGT GGGAACTGCT GACTGGTGAG 1020

ATCCCCTACA AAGACGTAGA TTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTC 1080

CATCTGCCTG TGCCCTCCAG CTGCCCAGAT GGCTTCAAAA TCCTGCTTCG CCAGTGCTGG 1140

AATAGCAAAC CACGAAATCG TCCATCATTC CGACAGATCC TGTTGCATCT GGACATTGCC 1200

TCAGCTGATG TACTCTCCAC ACCCCAGGAG ACTTACTTTA AGTCCCAGGC AGAATGGCGG 1260

GAAGAAGTAA AACTGCACTT TGAAAAAATT AAGTCAGAAG GGACCTGTTT GCACCGCCTA 1320

GAAGAGGAGC TGGTGATGCG GAGGAGGGAA GAGCTCAGAC ATGCCTTGGA CATCAGGGAG 1380

CACTATGAAC GGAAGCTGGA GAGAGCCAAC AACCTATACA TGGAACTCAA CGCCCTCATG 1440

TTGCAGCTGG AACTCAAGGA GCGAGAGTTG CTCAGGCGGG AGCAGGCTTT AGAAAGAAGG 1500

TGCCCAGGAT TGCTGAAATC ACACCCCTCC CGGGGCCTTC TGCATGGGAA CACAATGGAG 1560

AAGCTCATCA AGAAGAGGAA TGTGCCACAG AAGCTCTCGC CCCATAGCAA AAGGCCAGAT 1620

ATCCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 1680

CCTGGGTGTC CTAAAGGCCC CCCCTCACCA GGAAGGAGTC GTCGTGGCAA GACCCGCCAC 1740

CGCAAGGCCA GCGCCAAAGG CAGCTGTGGG GACCTGCCTG GGCTTCGTGC AGCCGTACCA 1800

CCCCATGAAC CTGGGGGACC AGGAAGCTCA GGGGGAATAG GACCCTCAGG CTGGGAGGCC 1860

TGTCCCCCGA CCCTCTGTGG GCTCCATCAT GACCTCCTGC TCCGCAAGAT GTCTTCATCA 1920

TCCCCAGACC TGCTGTCAGC AGCACTGGGG TCCCGGGGCC GGGGAGCCAC AGGAGCTGGG 1980

GATCCTGGCT CACCACCTGC AGCCCGGGGT GACACCCCCC CAAGTGAGGG CTCAGCCCCT 2040

GGCTCCACCA GCCCTGATTC ACCTGGGGGA GCCAAAGGGG AGCCACCCCC ACCAGTAGGA 2100

CCTGGTGAAG GTGCGGGGCT GCTGGGAACT GGAAGGGAAG GGACTTCGGG CCGGGGAGGA 2160

AGCCGGGCTG GGTCCCAGCA CTTGACCCCA GCTGCACTCC TGTACAGGGC TGCTGTCACT 2220

CGCAGTCAGA AACGAGGCAT CTCCTCAGAG GAAGAGGAAG GAGAGGTGGA CAGCGAAGTA 2280

GAACTGACTT CAAGCCAGAG GTGGCCTCAG AGCCTGAACA TGCGCCAGTC ACTATCTACC 2340

TTCAGCTCAG AGAATCCATC AGATGGGGAG GAAGGTACAG CTAGTGAGCC TTCCCCCAGT 2400

GGCACTCCTG AAGTTGGCAG TACCAACACA GATGAACGGC CAGATGAACG GTCTGATGAT 2460

ATGTGCTCCC AGGGCTCAGA AATCCCACTA GATCCACCTC CTTTGGAGGT GGTCCCTGGC 2520

CCTGAACCCA GCACCATGCC CATGTCACAA CAGGAGCTAC TCAGAGGGGA GCAGGGCCCT 2580

CCCAATTCTG AGGACTCAGA CTGTGACAGC ACTGAATTGG ACCACTCCAA CAGCGTTGAT 2640

GCCTTGCGGC CCCCAGCCTC CCTCCCTCCA TGA 2673

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii

Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325

         ***********.99****************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+

Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 386   NRPSFRQILLH  396

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180

IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013