EKS-OTG-00239

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00239

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	430.7	1.8E-129	46	306	261

Status

Unreviewed

Ensembl Protein

ENSOGAP00000001724

UniProt Accession

H0WJN8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK3

Gene Synonyms/Alias

MAPKAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000001932	ENSOGAP00000001724	ENSOGAT00000001933

Organism

Otolemur garnettii

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

VDMETAEEQG GPVPPLVAHG GPGSSSAPAL GGQRDPKKYA VTDDYQLSKQ VLGLGVNGKV 60

LECFHRRTGQ KCALKILYDS PKARQEVDHH WQASGGPHIV RILDVYENMH HGRRCLLIVM 120

ECMEGGELFS RIQERGDQAF TEREAAEIMR DIGTAIQFLH SQNIAHRDVK PENLLYTSKE 180

KDAVLKLTDF GFAKETTQNA LQTPCYTPYY VAPEVLGPEK YDKSCDLWSL GVIMYILLCG 240

FPPFYSNTGQ AISPGMKRRI RLGQYGFPNP EWSEVSEDAK QLIRRLLKTD PTERLTITQF 300

MNHPWINQSM VVPQTPLHTA RVLREDRDHW DEVKEEMTSA LATMRVDYDQ VKIKDLKTSN 360

NRLLNKRRKK QAGSSSASQG CNNQ 384

Nucleotide Sequence
(FASTA)

GTGGACATGG AAACTGCAGA GGAGCAGGGG GGTCCCGTAC CCCCTTTAGT TGCACACGGC 60

GGGCCAGGCT CGAGCAGTGC TCCAGCTCTA GGGGGACAGC GGGATCCCAA GAAGTACGCG 120

GTGACAGATG ACTACCAGTT ATCCAAGCAG GTTCTGGGCC TGGGTGTGAA CGGCAAGGTG 180

CTGGAGTGCT TTCATCGGCG CACTGGGCAG AAGTGTGCCC TGAAGATCCT GTATGACAGC 240

CCCAAGGCTC GGCAGGAGGT GGACCACCAC TGGCAGGCCT CTGGCGGTCC CCACATTGTA 300

CGAATCCTGG ACGTGTATGA GAACATGCAT CATGGCAGGC GCTGTCTCCT CATCGTCATG 360

GAATGCATGG AAGGTGGTGA GTTGTTCAGC AGGATTCAGG AGCGTGGCGA CCAGGCTTTC 420

ACTGAGAGAG AGGCTGCAGA GATCATGCGG GATATCGGTA CTGCCATCCA GTTCCTGCAT 480

AGCCAGAATA TTGCCCACCG AGATGTCAAG CCTGAAAATC TGCTCTACAC ATCCAAGGAG 540

AAAGATGCGG TACTTAAGCT CACTGACTTT GGCTTTGCCA AGGAGACTAC CCAAAATGCC 600

CTGCAGACAC CCTGCTACAC TCCCTATTAT GTGGCTCCTG AGGTCCTGGG TCCAGAGAAG 660

TATGACAAGT CATGTGACTT GTGGTCCCTG GGCGTCATAA TGTACATCCT CCTGTGTGGC 720

TTCCCACCCT TCTACTCCAA CACGGGCCAG GCCATCTCTC CAGGGATGAA GAGGAGGATC 780

CGCCTGGGCC AGTATGGCTT CCCCAATCCT GAGTGGTCAG AGGTCTCTGA AGATGCTAAG 840

CAGCTGATCC GCCGCCTGCT GAAAACAGAC CCCACAGAGA GACTGACTAT CACACAGTTC 900

ATGAACCACC CTTGGATCAA CCAATCAATG GTGGTGCCAC AGACCCCACT CCACACAGCT 960

CGTGTTCTAC GGGAGGACAG AGACCACTGG GATGAAGTCA AGGAGGAGAT GACCAGTGCT 1020

TTGGCTACCA TGAGGGTGGA CTATGACCAG GTGAAGATCA AGGACCTGAA GACCTCTAAC 1080

AACCGGCTCC TCAACAAGCG GAGAAAAAAG CAGGCAGGCA GCTCCTCAGC CTCACAGGGC 1140

TGCAACAACC AGTAG 1155

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         +l+++vlG G++gkvlec++++tg+k+alkil+d++k+r+ev++h+qasg ++iv+++dv

Q: 46    QLSKQVLGLGVNGKVLECFHRRTGQKCALKILYDSPKARQEVDHHWQASGGPHIVRILDV  105

         5789********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en+++++++ll+v+e++eGGel+sriqer  +afte+ea+e+++di++a++flhs+nia

Q: 106   YENMHHGRRCLLIVMECMEGGELFSRIQERgdQAFTEREAAEIMRDIGTAIQFLHSQNIA  165

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+skek+a++kl+Dfg+ake +++++l+tpc+t++yvaPevl++ek

Q: 166   HRDVKPENLLYTSKEKDAVLKLTDFGFAKE-TTQNALQTPCYTPYYVAPEVLGPEK----  220

         *****************************7.7899*********************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCDlWslGvi+yillcG+pPfys++g+ais+++k+ri+ g+y fP++eWsevse+a

Q: 221   -YDKSCDLWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDA  279

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir+lLk+dp+erlti++++nhpw+

Q: 280   KQLIRRLLKTDPTERLTITQFMNHPWI  306

         **************************8

Domain Sequence
(FASTA)

QLSKQVLGLG VNGKVLECFH RRTGQKCALK ILYDSPKARQ EVDHHWQASG GPHIVRILDV 60

YENMHHGRRC LLIVMECMEG GELFSRIQER GDQAFTEREA AEIMRDIGTA IQFLHSQNIA 120

HRDVKPENLL YTSKEKDAVL KLTDFGFAKE TTQNALQTPC YTPYYVAPEV LGPEKYDKSC 180

DLWSLGVIMY ILLCGFPPFY SNTGQAISPG MKRRIRLGQY GFPNPEWSEV SEDAKQLIRR 240

LLKTDPTERL TITQFMNHPW I 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013