EKS-OTG-00002

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00002

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	516.1	1.2E-155	633	889	257

Status

Unreviewed

Ensembl Protein

ENSOGAP00000001736

UniProt Accession

H0WJP9;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA7

Gene Synonyms/Alias

EPHA7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000001945	ENSOGAP00000001736	ENSOGAT00000001946

Organism

Otolemur garnettii

Functional Description

Protein Length

998

Protein Sequence
(FASTA)

MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG 60

LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 120

ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 180

GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 240

EAENSPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RGFYKSSSQD LQCSRCPTHS 300

FSDREGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 360

NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG 420

VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 480

YEKDQRERTY STVKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEATG 540

KMFEATAVSS EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF 600

KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG RLKLPGKRDV 660

AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV VTRGKPVMIV IEFMENGALD 720

AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA DMGYVHRDLA ARNILVNSNL VCKVSDFGLS 780

RVIEDDPEAV YTTTGGKIPV RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM 840

SNQDVIKAIE EGYRLPAPMD CPAGLHQLML DCWQKERAER PKFEQIVGIL DKMIRNPNSL 900

KTPLGTCSRP ISPLLDQNTP DFTTFCSVGE WLQAIKMERY KDNFTAAGYN SLESVARMTI 960

EDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV 998

Nucleotide Sequence
(FASTA)

ATGGTTTTTC AAACTCGGTA CCCTTCATGG ATTATTTTAT GCTACATCTG GCTGCTTCGC 60

TTTGCACACA CTGGGGAGGC GCAGGCTGCG AAGGAAGTAC TACTGCTGGA TTCTAAAGCA 120

CAACAAACAG AGTTGGAATG GATCTCCTCT CCACCCAATG GGTGGGAAGA AATTAGTGGT 180

TTGGATGAGA ACTATACCCC GATACGAACG TACCAGGTGT GCCAGGTCAT GGAGCCCAAC 240

CAAAACAACT GGCTGCGGAC TAACTGGATT TCGAAAGGCA ACGCACAAAG GATTTTTGTA 300

GAATTGAAAT TCACCCTGAG GGATTGTAAC AGTCTTCCTG GAGTACTGGG AACTTGCAAG 360

GAAACCTTTA ATTTGTACTA TTACGAAACA GACTATGACA CTGGCAGGAA TATAAGAGAA 420

AACCTTTATG TAAAAATAGA CACCATTGCT GCCGATGAAA GTTTTACCCA AGGTGACCTT 480

GGTGAAAGAA AGATGAAGCT TAACACTGAG GTGAGAGAGA TTGGACCTTT GTCCAAAAAG 540

GGATTCTATC TTGCCTTTCA GGATGTAGGG GCTTGCATAG CTTTGGTTTC TGTCAAAGTG 600

TACTACAAGA AGTGCTGGTC CATTATTGAG AACTTAGCTA TCTTTCCAGA TACAGTGACT 660

GGTTCAGAAT TTTCCTCTTT AGTCGAGGTT CGAGGGACAT GTGTCAGCAG TGCAGAGGAA 720

GAGGCGGAGA ACTCCCCCAG GATGCACTGC AGTGCAGAAG GAGAATGGTT AGTGCCCATT 780

GGAAAATGTA TCTGCAAAGC GGGCTACCAG CAAAAAGGGG ACACTTGTGA ACCCTGTGGC 840

CGGGGATTCT ACAAATCTTC CTCTCAAGAT CTTCAGTGTT CTCGTTGTCC AACTCACAGT 900

TTTTCGGACA GAGAAGGCTC CTCCAGATGT GAATGTGAAG ATGGGTATTA CAGGGCTCCA 960

TCTGACCCGC CATATGTTGC ATGTACAAGG CCTCCATCTG CACCACAGAA CCTCATTTTC 1020

AACATCAACC AAACCACAGT CAGTTTGGAA TGGAGTCCTC CTGCAGACAA TGGGGGGAGA 1080

AACGATGTGA CCTACAGAAT CTTGTGTAAG CGGTGCAGCT GGGAGCAGGG CGAGTGTGTT 1140

CCCTGTGGGA GTAACATTGG GTACATGCCC CAGCAGACGG GACTGGAGGA TAACTACGTC 1200

ACTGTCATGG ACCTGCTAGC CCACGCTAAT TACACTTTTG AAGTTGAAGC TGTAAATGGA 1260

GTTTCTGACT TAAGCCGATC CCAGAGGCTC TTTGCAGCTG TCAGCATCAC TACTGGCCAA 1320

GCAGCTCCCT CGCAAGTGAG CGGAGTAATG AAGGAGAGAG TGCTGCAGCG GAGTGTGGAG 1380

CTCTCCTGGC AGGAGCCGGA GCATCCCAAT GGAGTCATCA CAGAGTATGA GATCAAGTAC 1440

TATGAGAAGG ATCAAAGGGA ACGGACCTAC TCTACTGTAA AAACCAAATC CACGTCAGCC 1500

TCCATTAATA ATCTGAAACC AGGAACAGTG TACGTTTTCC AGATTCGAGC TTTTACTGCG 1560

GCTGGCTATG GAAATTACAG TCCGAGACTT GATGTGGCTA CACTGGAGGA AGCTACAGGT 1620

AAAATGTTTG AAGCCACAGC TGTCTCCAGT GAGCAGAATC CAGTGATCAT CATCGCCGTG 1680

GTGGCTGTGG CAGGGACCAT CATTTTGGTG TTTATGGTCT TTGGCTTCAT CATTGGAAGA 1740

AGGCACTGTG GTTATAGCAA AGCTGACCAA GAAGGAGATG AAGAACTTTA CTTTCATTTT 1800

AAATTTCCAG GCACCAAAAC CTACATTGAC CCTGAAACCT ATGAGGACCC AAATAGAGCT 1860

GTCCATCAAT TCGCCAAGGA GCTAGATGCC TCCTGTATTA AAATTGAGCG TGTGATTGGT 1920

GCAGGAGAAT TTGGAGAAGT CTGCAGTGGT CGTTTGAAAC TTCCAGGAAA ACGAGATGTT 1980

GCGGTAGCCA TAAAAACCCT GAAAGTTGGT TACACAGAGA AACAAAGGCG AGACTTTCTA 2040

TGTGAAGCAA GCATCATGGG GCAGTTTGAC CACCCAAACG TTGTCCACTT GGAAGGGGTC 2100

GTCACCAGAG GGAAACCAGT CATGATTGTA ATAGAATTCA TGGAAAATGG AGCCCTAGAT 2160

GCATTTCTTA GGAAGCATGA TGGACAATTT ACAGTCATTC AGTTGGTGGG AATGCTGAGG 2220

GGCATCGCGG CGGGGATGAG ATACTTGGCC GACATGGGAT ACGTTCACAG GGACCTCGCT 2280

GCCCGCAATA TTCTTGTCAA CAGCAATCTT GTTTGTAAAG TGTCAGATTT CGGCCTGTCC 2340

CGGGTTATAG AGGATGACCC TGAAGCTGTC TATACCACCA CTGGTGGAAA AATCCCAGTA 2400

AGATGGACAG CACCTGAAGC CATCCAATAC CGGAAATTCA CCTCGGCCAG CGATGTGTGG 2460

AGCTATGGAA TAGTCATGTG GGAAGTTATG TCTTACGGAG AAAGACCTTA CTGGGACATG 2520

TCGAACCAAG ATGTTATAAA AGCGATAGAA GAAGGTTATC GCTTACCAGC GCCCATGGAC 2580

TGCCCGGCTG GTCTTCACCA GCTAATGCTG GATTGTTGGC AAAAGGAGCG TGCTGAAAGA 2640

CCCAAGTTTG AACAGATAGT CGGGATTCTA GACAAAATGA TTCGAAACCC AAATAGTCTG 2700

AAAACACCCC TGGGAACTTG TAGTAGGCCA ATTAGCCCTC TTCTGGATCA GAACACTCCC 2760

GACTTCACAA CCTTTTGCTC TGTTGGAGAA TGGCTACAAG CTATTAAGAT GGAGAGATAT 2820

AAAGATAACT TCACAGCAGC TGGCTACAAC TCCCTGGAAT CAGTGGCCAG GATGACTATT 2880

GAGGATGTGA TGAGTTTAGG GATCACACTG GTTGGCCATC AAAAGAAAAT CATGAGCAGC 2940

ATTCAGACTA TGAGAGCACA GATGCTGCAT TTACATGGAA CAGGCATTCA AGTGTGA 2997

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kie+viGaGefGevcsGrlklpgkr++avaiktlk g+tekqrrdfl+easi+Gqfdhp

Q: 633   IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP  692

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n+++leGvvt++kpvmiv+e+mengald+flrk+dgqftviqlvgmlrGia+gm+yl+dm

Q: 693   NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM  752

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarnilvnsnlvckvsdfGlsrv+edd+ea+ytt+ggkip+rwtapeai+yrk

Q: 753   GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK  812

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlp+pmdcpa+l+qlmldc

Q: 813   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC  872

         ************************************************************

S: 241   wqkdraerpkfeqivsi  257

         wqk+raerpkfeqiv i

Q: 873   WQKERAERPKFEQIVGI  889

         **************987

Domain Sequence
(FASTA)

IKIERVIGAG EFGEVCSGRL KLPGKRDVAV AIKTLKVGYT EKQRRDFLCE ASIMGQFDHP 60

NVVHLEGVVT RGKPVMIVIE FMENGALDAF LRKHDGQFTV IQLVGMLRGI AAGMRYLADM 120

GYVHRDLAAR NILVNSNLVC KVSDFGLSRV IEDDPEAVYT TTGGKIPVRW TAPEAIQYRK 180

FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPAPMDCP AGLHQLMLDC 240

WQKERAERPK FEQIVGI 257

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013