EPS-OTG-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-OTG-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	207.3	3.3E-61	905	1150	246

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002081

UniProt Accession

H0WKH9;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000002330	ENSOGAP00000002081	ENSOGAT00000002332

Organism

Otolemur garnettii

Functional Description

Protein Length

1442

Protein Sequence
(FASTA)

PSEPQDLEPQ PARSALAAVG GPPRAPPADL PLPGDDRGGW ARCASRVSPA PSDSSPGEPF 60

ARGPTSPPGT PRPLDGAAAG PASDTESFSL SPSAESVSDR LDPYSSGGGG GSSSSDELEA 120

DPAPAGAPSQ LRRLGRPSPG SPPGPQQKAP RGVDGPGGVA RDGPWGEKAA VTAALGGPMS 180

IPGRSGVAAE KAPPPPPPPT LYVQLHGETT RRLEADEKPL QIQNDYLFQL GFGELWRVQE 240

EGMDSEIGCL IRFYAGKPHS IGSSERIQLS GMYNVRKGKM QLPVNRWTRR QVILCGTCLI 300

VSSVKDSLTG KMHVLPLIGG KVEEVKKHQH CLAFSSSGPQ SQTYYICFDT FTEYLRWLRQ 360

VSKVASQRIS SVDLSCCSLE HLPANLFYSQ DLTHLNLKQN FLRQNPSLPA ARGLNELQRF 420

TKLKSLNLSN NHLGDFPLAV CSIPTLAELN VSCNALRAVP AAVGAMHNLQ TFLLDGNFLQ 480

SLPAELENMH QLSYLGLSFN EFTDIPEVLE KLTAVDKLCM SGNCMETLRL QALRKMPHIK 540

HVDLRLNTIR KLIADEVDFL QHVTQLDLRD NKLGDLDAMI FNNIEVLHCE RNQLVTLNIC 600

GYFLKALYAS SNELVQLDVY PVPNYLSYMD VSRNRLENVP EWVCESRKLE VLDISHNEIC 660

ELPARLFCNS SLRKLLAGHN QLARLPERLE RTSVEVLDVQ HNQILELPPN LLMKADSLRF 720

LNASANKLET LPPATLCEET NSILQELYLT NNSLTDKCVP LLTGHPHLKI LHMAYNRLQS 780

FPASKMAKLE ELEEIDISGN KLKAIPTTIM NCRRMHTVIA HSNCIEVFPE VMQLPEIKCV 840

DLSCNELSEV TLPENLPPKL QELDLTGNPR LVLDHKTLEL LNNIRCFKID QPSAGDTSGA 900

PAVWSHGYTE ASGVKNKLCV AALSVNNFCD NREALYGVFD GDRNVEVPYL LQCTMSDILA 960

EELQKTKNEE EYMVNTFIVM QRKLGTAGQK LGGAAVLCHI KHDPVDPGGS FTLTSANVGK 1020

CQSVLCRNGK PLPLSRSYVM SCEEELKRIK QHKAIITEDG KVNGVTESTR ILGYTFLHPS 1080

VVPRPHVQSV LLTPRDEFFI LGSKGLWDSL SIEEAVEAVR NVPDALAAAK KLCTLAQSYG 1140

CHDSISAVVV QLSVTEDSFC CCELSASGTV PPPSPGIFPP SVNMVIKDRP SDGLGVPSSS 1200

SGMASEISSE LSTSEMSSEV GSTASDEPPP GALNESSPAC PSEQRCMLHP LCLSNSFQRQ 1260

LSSATFSSAF SDNGLDSDDE EPIEGVFTNG SRVEVEVDIH CSRAKEREKQ QHLLQVPAEA 1320

SDEGIVISAN EDEPGLPRKA DFSAVGTIGR RRPNGSVAPQ ERSHNVIEVA ADAPLRKPGG 1380

YFAAPAQPDP DDQFIIPPEL EEEVKEIMKH HQEQQQPQPQ LQPPPQRHYQ VDQLPDCYDT 1440

PL 1442

Nucleotide Sequence
(FASTA)

CCGTCGGAGC CGCAGGACTT GGAGCCGCAG CCCGCGAGGA GTGCGCTGGC TGCCGTCGGG 60

GGCCCTCCGC GCGCGCCTCC AGCCGACCTG CCTCTGCCCG GCGACGACCG GGGCGGGTGG 120

GCGCGCTGCG CCTCCCGCGT CAGCCCCGCG CCTTCAGACT CCAGCCCCGG AGAGCCGTTC 180

GCCCGGGGCC CTACTTCCCC TCCCGGCACC CCGCGGCCTC TGGATGGCGC GGCCGCCGGC 240

CCGGCCTCCG ACACCGAGAG CTTCAGCCTG AGCCCCAGCG CCGAAAGCGT GTCCGACCGG 300

TTAGACCCCT ACAGCAGCGG CGGCGGCGGC GGCTCCTCGT CGTCGGATGA GTTGGAGGCC 360

GACCCGGCCC CGGCGGGGGC CCCGAGCCAG CTCCGTCGCC TAGGCCGCCC CTCCCCGGGC 420

TCCCCACCTG GGCCACAGCA GAAAGCCCCG AGAGGTGTCG ACGGCCCGGG TGGGGTCGCT 480

CGGGATGGGC CTTGGGGAGA GAAGGCTGCG GTAACCGCGG CCCTGGGTGG CCCCATGTCC 540

ATCCCCGGGA GGAGCGGGGT GGCTGCGGAG AAAGCGCCTC CACCGCCCCC GCCGCCCACC 600

CTGTACGTGC AGCTCCACGG AGAGACCACC CGGCGCCTGG AGGCGGATGA GAAGCCGTTG 660

CAGATCCAAA ATGACTACCT CTTCCAACTG GGATTTGGGG AGCTGTGGAG GGTGCAGGAG 720

GAAGGCATGG ACTCGGAGAT TGGCTGCCTC ATACGCTTTT ATGCAGGGAA ACCTCACAGC 780

ATTGGTAGCT CTGAACGGAT TCAGCTCTCA GGAATGTATA ATGTCCGTAA AGGCAAAATG 840

CAGTTGCCAG TGAACCGATG GACAAGACGT CAGGTCATTC TGTGTGGAAC CTGCCTAATA 900

GTGTCATCAG TAAAAGACAG CTTGACCGGA AAGATGCATG TTCTTCCACT AATTGGTGGA 960

AAGGTAGAAG AAGTGAAAAA GCACCAGCAT TGTTTAGCAT TTAGCTCCTC TGGACCCCAA 1020

AGCCAGACTT ACTACATTTG CTTCGATACC TTCACAGAAT ACTTAAGGTG GCTGCGACAA 1080

GTCTCCAAGG TTGCATCACA GCGCATTAGC TCAGTGGACC TCTCATGTTG TAGCCTGGAA 1140

CATCTGCCTG CCAACCTCTT CTACAGCCAA GACCTCACTC ATCTCAATTT AAAACAAAAC 1200

TTCCTAAGGC AAAACCCTAG CCTGCCTGCT GCCAGGGGGC TCAATGAATT GCAAAGGTTC 1260

ACCAAGTTGA AGAGTCTTAA CCTTTCCAAT AATCATTTAG GGGACTTCCC ATTGGCAGTC 1320

TGCAGTATTC CAACCCTGGC AGAGTTGAAT GTGTCCTGCA ATGCCCTCCG AGCAGTCCCA 1380

GCAGCTGTTG GAGCTATGCA CAACTTACAG ACATTTCTGT TGGATGGAAA CTTTCTTCAG 1440

TCCCTTCCTG CTGAGTTGGA GAACATGCAT CAGCTTAGTT ATCTTGGTCT TTCTTTTAAT 1500

GAATTTACTG ACATTCCAGA GGTGTTGGAG AAATTGACGG CTGTGGATAA ACTTTGTATG 1560

TCTGGGAACT GCATGGAGAC CCTTAGGTTA CAGGCTTTAA GAAAAATGCC TCACATCAAA 1620

CATGTAGATC TAAGATTAAA CACAATTAGG AAGCTAATAG CAGATGAAGT GGACTTCCTG 1680

CAGCATGTCA CTCAGCTTGA CCTAAGAGAC AATAAACTTG GTGATCTAGA TGCTATGATT 1740

TTCAACAATA TTGAAGTTTT ACACTGTGAA AGGAATCAAC TGGTTACATT GAACATCTGT 1800

GGCTATTTCT TAAAGGCACT GTATGCCTCT TCTAATGAAC TTGTTCAACT TGATGTTTAC 1860

CCAGTTCCAA ATTATCTGTC CTACATGGAT GTTTCAAGGA ACCGCTTAGA AAATGTGCCA 1920

GAGTGGGTAT GTGAAAGCCG AAAACTAGAA GTTTTGGATA TTAGCCATAA TGAAATATGC 1980

GAACTTCCTG CCCGCTTATT TTGTAATAGC AGTCTCCGGA AGCTATTGGC AGGACACAAC 2040

CAGTTGGCCA GACTACCTGA GAGGCTAGAA AGAACGTCGG TGGAAGTCTT AGACGTGCAA 2100

CACAACCAGA TCCTTGAGCT ACCGCCGAAC CTTCTGATGA AGGCTGACAG CCTGAGATTC 2160

CTGAATGCAT CTGCAAACAA ACTGGAAACC CTTCCGCCAG CTACACTCTG TGAAGAGACA 2220

AACAGTATCT TACAAGAGTT GTATTTAACA AATAACAGCC TCACGGACAA ATGTGTGCCC 2280

TTACTAACTG GACACCCCCA TCTGAAGATT CTTCACATGG CCTATAACCG ACTTCAGAGT 2340

TTTCCAGCAA GTAAAATGGC GAAACTGGAG GAACTTGAAG AAATTGACAT AAGTGGGAAT 2400

AAACTGAAAG CCATCCCAAC AACTATCATG AATTGCAGGC GCATGCACAC TGTAATTGCT 2460

CACTCCAATT GCATCGAAGT CTTTCCTGAA GTTATGCAGC TCCCAGAAAT CAAGTGTGTG 2520

GACCTGAGCT GTAATGAGCT AAGTGAAGTC ACCTTACCAG AAAACCTGCC TCCTAAACTG 2580

CAAGAACTAG ACCTGACTGG AAACCCTCGC CTTGTCCTTG ATCACAAAAC CCTGGAGCTC 2640

CTGAATAATA TCCGCTGTTT CAAGATTGAC CAGCCTTCAG CAGGAGACAC ATCTGGAGCA 2700

CCGGCTGTTT GGAGCCATGG TTACACTGAA GCTTCGGGGG TGAAAAACAA GTTGTGTGTT 2760

GCAGCCCTGT CAGTGAATAA CTTCTGTGAC AACCGGGAAG CCCTGTATGG TGTGTTCGAT 2820

GGGGACCGCA ACGTGGAGGT GCCCTACCTG CTCCAGTGCA CCATGAGTGA CATTCTGGCT 2880

GAAGAGCTGC AAAAAACAAA GAATGAAGAG GAATACATGG TCAATACGTT CATTGTGATG 2940

CAAAGGAAAC TTGGAACTGC TGGGCAGAAG CTTGGAGGAG CAGCTGTCCT TTGTCACATC 3000

AAGCACGACC CTGTGGACCC AGGAGGCTCC TTCACCTTGA CCTCCGCTAA TGTGGGCAAG 3060

TGCCAATCAG TTCTCTGTCG AAATGGAAAG CCACTGCCTC TGTCCAGATC TTATGTCATG 3120

AGCTGTGAAG AAGAACTGAA GAGAATTAAA CAGCACAAGG CCATTATCAC CGAGGATGGC 3180

AAAGTGAATG GAGTGACTGA GTCCACGCGC ATCCTGGGCT ATACTTTCCT GCACCCTAGT 3240

GTGGTGCCTC GCCCCCACGT GCAGTCCGTG CTCCTGACCC CCCGGGACGA GTTCTTCATC 3300

CTGGGAAGTA AGGGGCTGTG GGACAGCCTG TCCATTGAGG AGGCCGTGGA GGCGGTGCGT 3360

AACGTGCCTG ACGCACTGGC TGCCGCCAAG AAGCTGTGCA CGCTGGCCCA GAGCTATGGC 3420

TGCCACGACA GCATCAGCGC CGTGGTGGTG CAGCTCAGTG TCACCGAGGA CAGCTTCTGC 3480

TGCTGTGAGC TCAGCGCCAG CGGGACCGTG CCTCCACCCA GCCCTGGCAT CTTCCCTCCT 3540

TCCGTCAACA TGGTGATCAA GGATCGGCCT TCCGATGGGC TGGGCGTGCC GTCCTCCAGC 3600

AGCGGCATGG CTTCTGAGAT CAGCAGCGAG CTTTCCACCT CAGAGATGAG CAGTGAGGTC 3660

GGGTCCACAG CCTCTGACGA GCCCCCTCCT GGAGCCCTGA ATGAGAGCAG CCCCGCCTGC 3720

CCCAGCGAGC AGCGCTGCAT GCTGCACCCG CTCTGTCTGT CCAACTCCTT CCAGCGCCAG 3780

CTGTCCAGCG CCACCTTCTC CAGCGCCTTC TCCGACAATG GCCTTGACAG TGATGACGAG 3840

GAACCCATCG AGGGCGTCTT CACCAATGGC AGCCGGGTGG AGGTGGAAGT GGACATCCAC 3900

TGCAGCCGGG CCAAGGAGAG GGAGAAACAG CAGCACCTGC TCCAGGTGCC AGCGGAGGCC 3960

AGCGACGAGG GCATTGTCAT CAGCGCCAAT GAGGACGAGC CCGGTCTGCC CAGGAAGGCA 4020

GACTTTTCTG CTGTGGGGAC CATTGGGCGC CGGAGGCCTA ATGGCTCTGT CGCACCTCAG 4080

GAGAGGAGCC ACAATGTGAT AGAGGTGGCT GCAGATGCAC CTCTCCGAAA GCCAGGAGGC 4140

TATTTTGCTG CCCCAGCTCA GCCGGATCCT GACGATCAGT TTATCATCCC TCCAGAGCTG 4200

GAAGAGGAAG TGAAAGAAAT CATGAAACAT CACCAGGAGC AGCAGCAGCC ACAGCCCCAG 4260

TTACAGCCGC CACCACAGCG GCACTACCAG GTGGACCAGC TGCCAGACTG TTACGACACA 4320

CCACTATGA 4329

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il

Q: 905   SHGYTEASGVKNKLCVAALSVNNFCDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  959

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++ik++

Q: 960   AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGAAVLCHIKHDpvdpgg  1009

         ***99....999*****************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG+++ vLcrngk+++ls+ + +s+e+El+Ri+++++ ++++   +v+Gv++

Q: 1010  sfTLTSANVGKCQSVLCRNGKPLPLSRSYVMSCEEELKRIKQHKAIITEDG--KVNGVTE  1067

         *99*****************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s+ lt++def+iL+s+Glwd +s eeav++vr+v +

Q: 1068  STRILGYTFLHPSVVPRPHVQSVLLTPRDEFFILGSKGLWDSLSIEEAVEAVRNVPD---  1124

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++d++sa+vv

Q: 1125  -ALAAAKKLCTLAQSYGCHDSISAVVV  1150

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFCDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTKNEEEYMV NTFIVMQRKL GTAGQKLGGA AVLCHIKHDP VDPGGSFTLT SANVGKCQSV 120

LCRNGKPLPL SRSYVMSCEE ELKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVLLTP RDEFFILGSK GLWDSLSIEE AVEAVRNVPD ALAAAKKLCT LAQSYGCHDS 240

ISAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>