EKS-OTG-00400

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00400

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	552.2	1.8E-166	494	758	265

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002278

UniProt Accession

H0WKZ3;

Protein Name

Protein Synonyms/Alias

Gene Name

MERTK

Gene Synonyms/Alias

MERTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000002544	ENSOGAP00000002278	ENSOGAT00000002549

Organism

Otolemur garnettii

Functional Description

Protein Length

887

Protein Sequence
(FASTA)

LAFNHTVGHI ILSEHKDVKF NCSINVPNIY QDTTISWWKD GKELLGAHHA VTQFYPDDEV 60

TAIIASFSIT SVQRSDNGSY ICKMKINNEE IVSDPIYIEV QGLPYFTKQP ESMNVTRNTA 120

FNLTCQAVGP PEPVNIFWVQ NSSRINEQPE KSPSVLIVPG LTEMAVFSCE AHNDKGLTVS 180

KGVQINIKAI PFPPTEVYVH NSTAHSILIS WVPGFDGYSP LRNCNIQVKE ADPLSNGSVM 240

IFHASASPHL YQIEQLQALA NYSVAVSCMN EIGWSEVSPW ILASTTEGAP SVAPLNITVF 300

LNESSNHVDV RWTRPPMKRQ DGELVGYRIS HIWQSMGTTK ELSEEVGYSG SYAQISIPVR 360

NASCTVRMAA ITKGGVGPFS DPVQIFIPQH GSVDYAPSST PAPGNTDPVL IILGCFCGFV 420

LIGLIFYISL AIKKRVQETK FGNAFTEEDS ELVVNYIAKK SFCRRAIELT LQSLGVSEDL 480

QNKLEDVVID RNLLILGKIL GEGEFGSVME GNLKQQDGTS QKVAVKTMKL DNFSQREIEE 540

FLSEAACMKD FSHPNVIRLL GVCIEMSSQG VPKPMVILPF MKYGDLHTYL LYSRLETGPK 600

HIPLQTLLKF MVDIALGMEY LSNRNFLHRD LAARNCMLRD DMTVCVADFG LSKKIYSGDY 660

YRQGRIAKMP VKWIAIESLA DRVYTSKSDV WAFGVTMWEI ATRGMTPYPG VQNHEMYDYL 720

LHGHRLKQPE DCLDDLYEIM YSCWRADPLD RPTFSVLRLQ LEKLLESLPD VQDKADIIYV 780

NTQLPENYEA LAEGSVLGPL DMNIDPDSII ASCTPSATIS VVTAEVHENR PHEERYILGE 840

KNGVLPEDRL ARNGVSWSLS STLPLQSPSA DELLFADDSS EGSEVLM 887

Nucleotide Sequence
(FASTA)

CTTGCATTTA ATCACACAGT TGGGCACATA ATACTTTCTG AACATAAGGA TGTCAAATTT 60

AATTGCTCAA TCAACGTGCC TAATATATAT CAGGACACTA CAATTTCTTG GTGGAAAGAT 120

GGGAAGGAAT TGCTTGGGGC ACATCATGCA GTTACGCAGT TTTATCCAGA TGATGAAGTT 180

ACGGCGATCA TCGCTTCCTT CAGCATAACC AGCGTGCAGC GTTCAGACAA TGGGTCGTAT 240

ATCTGTAAGA TGAAAATAAA CAATGAAGAG ATTGTGTCTG ACCCCATCTA CATTGAGGTA 300

CAAGGACTTC CTTACTTTAC TAAGCAGCCG GAGAGCATGA ATGTCACCAG AAACACAGCC 360

TTCAACCTCA CCTGTCAGGC GGTGGGCCCG CCTGAGCCAG TTAACATTTT CTGGGTTCAA 420

AACAGCAGCC GCATTAATGA ACAGCCTGAA AAATCCCCCT CTGTTCTAAT TGTTCCTGGT 480

CTGACAGAGA TGGCAGTCTT CAGCTGTGAG GCCCACAATG ACAAAGGGCT GACCGTGTCC 540

AAGGGTGTGC AGATCAACAT CAAAGCAATC CCCTTCCCAC CAACTGAAGT CTACGTGCAC 600

AACAGTACAG CCCACAGCAT TCTGATCTCC TGGGTCCCGG GTTTTGATGG ATACTCCCCA 660

CTCAGGAATT GCAACATTCA GGTCAAGGAA GCTGATCCGC TGAGTAACGG CTCCGTCATG 720

ATTTTTCACG CCTCTGCCTC ACCACATCTA TATCAAATCG AGCAGCTGCA AGCCTTGGCT 780

AATTACAGCG TTGCTGTTTC CTGCATGAAT GAAATAGGCT GGTCTGAAGT GAGCCCTTGG 840

ATTCTGGCCA GCACCACCGA AGGAGCCCCA TCCGTAGCAC CTTTAAACAT CACCGTGTTT 900

CTGAATGAAT CTAGTAATCA CGTGGACGTC CGATGGACGC GGCCTCCAAT GAAGCGGCAG 960

GATGGGGAGC TGGTGGGCTA CCGGATATCT CACATCTGGC AGAGCATGGG GACTACCAAA 1020

GAACTATCAG AGGAAGTTGG CTACAGTGGC AGCTATGCTC AAATTTCCAT TCCAGTCCGC 1080

AACGCCTCCT GCACAGTGAG GATGGCAGCC ATCACCAAAG GGGGTGTTGG GCCCTTCAGT 1140

GACCCGGTGC AGATATTCAT CCCCCAACAC GGTTCGGTAG ATTATGCCCC TTCATCAACT 1200

CCAGCGCCTG GCAACACAGA TCCTGTGCTC ATCATCCTTG GCTGCTTTTG TGGATTTGTT 1260

TTGATTGGGT TGATTTTTTA TATCTCTCTG GCCATTAAAA AAAGAGTCCA GGAGACCAAG 1320

TTTGGGAATG CATTTACAGA GGAGGATTCC GAATTAGTCG TTAACTACAT AGCGAAGAAG 1380

TCCTTCTGTC GGCGAGCCAT TGAACTTACC TTGCAGAGCT TGGGAGTCAG CGAGGATCTA 1440

CAAAATAAAC TAGAAGATGT TGTGATCGAC AGGAATCTTC TGATTCTTGG AAAAATTCTG 1500

GGGGAAGGAG AGTTTGGGTC AGTGATGGAA GGAAATCTTA AGCAGCAAGA TGGGACCTCT 1560

CAGAAAGTGG CAGTTAAGAC CATGAAATTG GACAACTTTT CACAGCGGGA GATCGAAGAG 1620

TTTCTCAGTG AGGCAGCATG CATGAAAGAC TTCAGCCACC CAAATGTCAT CCGACTTCTA 1680

GGTGTATGTA TAGAAATGAG CTCTCAAGGC GTCCCAAAGC CCATGGTGAT ATTACCCTTC 1740

ATGAAATATG GGGACCTGCA CACCTATTTA CTTTATTCCC GATTGGAGAC AGGACCAAAG 1800

CATATTCCTC TGCAGACACT ATTGAAGTTC ATGGTGGATA TTGCCCTGGG AATGGAGTAT 1860

CTGAGCAACA GGAATTTTCT TCATCGAGAT CTAGCGGCGC GAAACTGCAT GTTGCGAGAT 1920

GACATGACTG TCTGTGTTGC GGACTTTGGC CTTTCTAAGA AGATTTACAG TGGCGATTAC 1980

TACCGCCAAG GCCGCATTGC TAAGATGCCT GTGAAATGGA TTGCCATAGA GAGTCTTGCA 2040

GACCGAGTCT ACACAAGTAA AAGTGACGTG TGGGCATTTG GCGTGACCAT GTGGGAAATT 2100

GCCACGCGGG GAATGACTCC CTACCCTGGG GTCCAGAACC ATGAGATGTA TGACTATCTT 2160

CTCCATGGCC ACAGGCTGAA GCAGCCCGAG GACTGCCTGG ATGACCTGTA TGAAATCATG 2220

TACTCTTGCT GGAGAGCTGA TCCCTTGGAT CGACCTACCT TTTCAGTGTT GAGGCTGCAG 2280

CTGGAGAAGC TCTTAGAAAG TTTGCCTGAT GTTCAGGACA AAGCAGATAT CATTTACGTC 2340

AACACACAGT TGCCAGAGAA CTATGAGGCC CTGGCTGAGG GCTCTGTGCT TGGTCCCCTG 2400

GACATGAACA TTGACCCTGA CTCCATAATC GCCTCCTGCA CTCCCAGCGC TACCATCAGC 2460

GTGGTCACAG CAGAAGTTCA CGAGAACAGA CCTCACGAAG AAAGGTACAT CCTAGGCGAA 2520

AAGAATGGTG TTTTACCAGA GGACAGACTT GCAAGGAATG GGGTCTCTTG GTCCCTTTCA 2580

AGCACCCTGC CCTTGCAAAG CCCATCAGCA GATGAACTTT TGTTTGCCGA TGACTCCTCA 2640

GAAGGTTCAG AAGTCCTGAT GTGA 2664

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lgk+lgegefgsvmeg+lkq+dg+++kvavkt+kld+++++eieeflseaacmk+f+h

Q: 494   LILGKILGEGEFGSVMEGNLKQQDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFSH  553

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnvirl+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++plqtl+kfmv

Q: 554   PNVIRLLGVCIEMSSQG-VPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV  612

         ****************9.******************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk

Q: 613   DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  672

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc

Q: 673   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  732

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ld+ly++my+cw+adp drp+fsvlr

Q: 733   LDDLYEIMYSCWRADPLDRPTFSVLR  758

         *************************9

Domain Sequence
(FASTA)

LILGKILGEG EFGSVMEGNL KQQDGTSQKV AVKTMKLDNF SQREIEEFLS EAACMKDFSH 60

PNVIRLLGVC IEMSSQGVPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD 120

IALGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180

IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240

DDLYEIMYSC WRADPLDRPT FSVLR 265

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013