EKS-OTG-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	302.8	2.3E-90	268	537	270

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002290

UniProt Accession

H0WL03;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK2

Gene Synonyms/Alias

EIF2AK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000002562	ENSOGAP00000002290	ENSOGAT00000002565

Organism

Otolemur garnettii

Functional Description

Protein Length

552

Protein Sequence
(FASTA)

MASDTPSNSI PGYFMEELNK YRQRENVVLE YREVTKSGPA HNLRFTFQVI IDEREFPEAE 60

GKTKKEAKNA AAKLAVEILN KENKGVSPLS LTTTDTSEGS IGNYIGLVNR LAQKKKLTVN 120

YEQCESGDPT RFHYKCKIGQ KEYGIGKSST KQEAKQLAAK LAYLQINPEG SSKKFDSALS 180

DSFTSPSNFG SMSSNNSMCA SESSSESDFS ANAPISHNDD NVKNSSCSLN GLINNQKKVR 240

RKLAPRFDPP EMNGSKYTVN DRFAKDYKEI EPIGKGGYGQ VFKAKHRIDK KTYVIKRVKY 300

NSEKVEREVK ALAGLDEHEN IVRYHGCWDG EDYDPETSGY DTETSDYDSK KNANHLGRTT 360

RCLFIQMEFC DKGTLEQWID NRRGKKPDKA LALEFFEQIT KGVDFIHSKQ LIHRDLKPSN 420

IFLVDKKKIK IGDFGLVTSL ENDEKRTSNR GTRRYMSPEQ ISSQEYGKEV DIYALGLILA 480

ELLYICDTST ETAKIFIDLR NGLVPNVFDN KEKILLQKLL SKDPKERPNT SEILNTLSLW 540

KDVAEKKKRN TC 552

Nucleotide Sequence
(FASTA)

ATGGCCAGTG ATACTCCATC AAACAGTATA CCAGGTTACT TCATGGAAGA ACTTAATAAA 60

TACCGTCAGA GAGAGAATGT GGTACTTGAG TATCGTGAAG TGACTAAGTC AGGACCTGCC 120

CATAACCTAA GGTTTACATT TCAAGTTATA ATAGATGAGA GAGAATTTCC AGAAGCTGAA 180

GGTAAAACAA AGAAGGAAGC GAAAAACGCT GCTGCCAAAT TAGCTGTCGA GATACTTAAT 240

AAAGAAAACA AGGGTGTTAG TCCTTTATCA TTGACAACTA CAGATACTTC AGAAGGCAGT 300

ATTGGGAATT ACATAGGCCT TGTTAATAGG TTGGCCCAGA AGAAAAAATT AACTGTAAAT 360

TATGAACAGT GTGAATCAGG GGACCCTACA AGATTTCATT ATAAATGCAA AATTGGGCAG 420

AAAGAATACG GTATTGGTAA AAGTTCTACT AAACAGGAGG CAAAACAGTT GGCTGCTAAA 480

CTTGCTTATC TTCAGATAAA CCCAGAAGGA AGCTCTAAGA AATTTGACTC AGCATTATCC 540

GATTCTTTTA CTTCTCCGAG TAACTTTGGA AGCATGTCTT CTAACAATAG CATGTGTGCT 600

TCTGAATCAT CATCTGAAAG TGACTTTTCA GCAAATGCAC CAATAAGTCA TAACGATGAC 660

AATGTCAAAA ATTCTTCTTG TTCGCTGAAC GGTCTCATAA ATAATCAAAA GAAGGTAAGA 720

AGAAAGTTGG CACCTAGATT TGATCCACCT GAGATGAATG GAAGCAAGTA TACGGTGAAC 780

GACAGGTTTG CCAAGGATTA TAAGGAAATA GAACCAATTG GCAAAGGTGG ATATGGCCAA 840

GTTTTCAAAG CAAAACACAG AATTGATAAA AAGACTTACG TTATCAAGCG TGTTAAATAC 900

AATAGCGAGA AGGTGGAGCG GGAAGTGAAA GCACTGGCAG GCCTCGACGA GCACGAGAAT 960

ATTGTTCGCT ACCATGGTTG TTGGGATGGA GAGGATTATG ATCCTGAGAC CAGTGGTTAC 1020

GATACTGAGA CCAGTGACTA TGATTCCAAG AAGAACGCAA ATCATTTAGG ACGAACGACT 1080

AGGTGTCTTT TCATCCAAAT GGAATTCTGT GATAAAGGGA CATTGGAACA ATGGATTGAT 1140

AACAGAAGAG GCAAGAAACC GGATAAAGCA TTGGCTTTGG AATTCTTCGA ACAAATAACA 1200

AAAGGAGTGG ATTTTATACA TTCAAAACAG TTAATTCATA GAGATCTTAA GCCAAGTAAC 1260

ATATTTTTAG TAGATAAGAA AAAAATAAAG ATCGGAGACT TTGGACTTGT GACATCCCTA 1320

GAAAATGATG AAAAACGAAC GAGTAACAGG GGAACTAGGC GATACATGAG CCCAGAACAG 1380

ATTTCTTCAC AAGAATATGG AAAAGAAGTG GACATCTATG CTTTGGGGTT AATTCTTGCT 1440

GAACTTCTTT ACATATGTGA CACTTCTACA GAAACAGCTA AGATTTTCAT CGATCTAAGG 1500

AATGGCTTGG TTCCAAATGT ATTTGATAAC AAAGAAAAAA TTCTTTTACA GAAATTACTC 1560

TCAAAGGATC CCAAGGAGCG ACCTAATACA TCTGAAATCC TGAACACCTT GTCTTTGTGG 1620

AAGGATGTCG CAGAGAAAAA GAAACGAAAC ACGTGTTAG 1659

Domain Profile

S: 2     eeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLakl.ehpniv  60

         +ei+ +GkGg+g+V+kak+++dkk+y ikr+k+n+     ekverevkaLa l eh+niv

Q: 268   KEIEPIGKGGYGQVFKAKHRIDKKTYVIKRVKYNS-----EKVEREVKALAGLdEHENIV  322

         68999*****************************9.....78***********55*****

S: 61    rYfaawleekeesltd.sseveaeaeleesesseesdtkllyiqmelceketLkdwider  119

         rY+ +w  e++++ t+  +++++++++++  ++    t++l+iqme+c+k tL++wid+r

Q: 323   RYHGCWDGEDYDPETSgYDTETSDYDSKKNANHLGRTTRCLFIQMEFCDKGTLEQWIDNR  382

         ****************999*****************************************

S: 120   kllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalae  179

         + ++  + l +++f+q+ +g++++Hsk liHrdLkpsniFl +++++KigDFgL+t+l++

Q: 383   RGKKPDKALALEFFEQITKGVDFIHSKQLIHRDLKPSNIFLVDKKKIKIGDFGLVTSLEN  442

         87777777777**********************************************999

S: 180   alkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfste  239

         ++k+             t++ gt++ymsPeq+++++Y+k+vDi++LGlil+eLly ++t+

Q: 443   DEKR-------------TSNRGTRRYMSPEQISSQEYGKEVDIYALGLILAELLYICDTS  489

         9885.............99*****************************************

S: 240   mervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellkse  290

          e+++++ +lr+g +p+ fd+   kek llqklls+dpkeRp++se+l++

Q: 490   TETAKIFIDLRNGLVPNVFDN---KEKILLQKLLSKDPKERPNTSEILNTL  537

         *********************...99**********************975

Domain Sequence
(FASTA)

KEIEPIGKGG YGQVFKAKHR IDKKTYVIKR VKYNSEKVER EVKALAGLDE HENIVRYHGC 60

WDGEDYDPET SGYDTETSDY DSKKNANHLG RTTRCLFIQM EFCDKGTLEQ WIDNRRGKKP 120

DKALALEFFE QITKGVDFIH SKQLIHRDLK PSNIFLVDKK KIKIGDFGLV TSLENDEKRT 180

SNRGTRRYMS PEQISSQEYG KEVDIYALGL ILAELLYICD TSTETAKIFI DLRNGLVPNV 240

FDNKEKILLQ KLLSKDPKER PNTSEILNTL 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0003725	; F:double-stranded RNA binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001159	; Ds-RNA-bd.
IPR014720	; dsRNA-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00035	; dsrm; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00358

; DSRM; 2.

Prosites

PS50137	; DS_RBD; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013