EPS-OTG-00020

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-OTG-00020

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	293.2	2.0E-87	23	293	271

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002338

UniProt Accession

H0WL41;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000002613	ENSOGAP00000002338	ENSOGAT00000002615

Organism

Otolemur garnettii

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSSHLLEHIT TNEDFRGPTK SGSALELSVE NVKNGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLCRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 300

VSEEAVKKDL ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

NVIEAVYSRL NPHRESDGAS DEAKESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL 420

AKVEGEESPA EPAATATSAN SDAGNPVTMQ ESHTESESGL AELDSSKEDA GTKMSGEKI 479

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACG GAAAAACATA ATGCTCATGG TGCTGGGAAT 60

GGTTTACGTT ATGGCCTGAG CAGCATGCAA GGATGGAGAG TGGAAATGGA AGATGCACAC 120

ACAGCTGTTG TAGGTATTCC TCATGGCTTG GAAGACTGGT CATTTTTTGC AGTTTATGAT 180

GGTCATGCTG GATCCCGAGT GGCAAATTAC TGTTCGTCAC ATTTATTAGA ACACATCACT 240

ACTAATGAAG ACTTTAGAGG ACCTACAAAA TCAGGATCTG CTCTTGAGCT TTCAGTGGAG 300

AATGTCAAGA ATGGTATCAG AACTGGCTTT TTGAAAATTG ACGAATACAT GCGTAACTTT 360

TCAGACCTTA GAAATGGGAT GGACAGGAGC GGGTCAACTG CAGTGGGAGT TATGATTTCA 420

CCTAAGCACA TCTACTTCAT CAACTGTGGT GATTCACGTG CTGTTCTATG TAGGAATGGA 480

CAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGCAACC CAAGGGAAAA AGAGCGAATC 540

CAAAATGCAG GAGGCAGCGT AATGATACAA CGTGTTAATG GTTCATTAGC AGTGTCTCGT 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GCCCAACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGT AATGAGGAGC TGTGTGAATT TGTTAAATCT 780

AGACTTGAGG TATCTGATGA CCTGGAAAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTAGAGATAA CATGAGTATT GTACTAGTTT GCTTTTCAAA TGCCCCCAAG 900

GTCTCAGAAG AAGCAGTGAA AAAAGATTTA GAGTTGGATA AGCACTTGGA ATCACGGGTT 960

GAAGAGATTA TGGAGAAGTC TGGTGAGGAA GGAATGCCTG ATCTTGCCCA TGTCATGCGC 1020

ATCTTGTCTG CAGAAAATAT CCCTAATTTG CCTCCCGGGG GAGGTCTTGC TGGCAAGCGC 1080

AATGTTATTG AAGCTGTTTA TAGTAGACTG AATCCACATA GAGAAAGCGA TGGGGCCTCC 1140

GATGAAGCAA AGGAAAGTGG ATCACAGGGA AAATTGGTGG AAGCACTCAG GCAAATGAGA 1200

ATTAATCATA GGGGAAACTA CCGACAACTT CTGGAGGAGA TGCTGACTAG TTACAGGCTA 1260

GCTAAAGTAG AGGGAGAAGA AAGCCCTGCT GAACCAGCTG CTACAGCTAC TTCTGCGAAC 1320

AGTGATGCTG GAAACCCAGT GACAATGCAG GAAAGCCATA CTGAATCAGA AAGTGGTCTT 1380

GCTGAATTAG ACAGCTCTAA AGAAGATGCA GGGACAAAGA TGAGTGGTGA AAAAATATGA 1440

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSSHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e + ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TTNEDfrgptksgsALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99******99999999*****************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravLcrng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPKHIYFINCGDSRAVLCRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS SHLLEHITTN 60

EDFRGPTKSG SALELSVENV KNGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPK 120

HIYFINCGDS RAVLCRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013