EKS-OTG-00395

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00395

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	3.5E-97	1080	1344	265

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002413

UniProt Accession

B4USZ3;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 1 (Predicted);

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000002694	ENSOGAP00000002413	ENSOGAT00000002700

Organism

Otolemur garnettii

Functional Description

Protein Length

1349

Protein Sequence
(FASTA)

MENKETLKGL HKMDDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV KPIPVKGDGS 60

EMNNLAAESP GEGQASTTSS APKGRRSPSP GSSPSGRTVK SESPGVRRKR VSPVPSGRIT 120

PPRRAPSPDG FSPYSPEETN RRVNKVMRAR LYLLQQIGPN SFLIGGDSPD NKYRVFIGPQ 180

NCSCGRGTFC IHLLFVMLRV FQLEPSDPML WRKTLKNFEV ESLFQKYHSR RSSRIKAPSR 240

NTIQKFVSRM SNSHTLSSSS TSTSSSENSI KDEEEQMCPI CLLGMLDEES LTVCEDGCRN 300

KLHHHCMSIW AEECRRNREP LICPLCRSKW RSHDFYSHEL SSPVDSPSPL RAAQQQTIPQ 360

QPLAGAQRRN QESNFNLTHY GTQQIPPAYK DLAEPWIQVF GMELVGCLFS RNWNVREMAL 420

RRLSHDVSGA LLLANGESTG NSGGSGGSSP ATGAASGSSQ PSVSGDVVEA CCSVLSMVCA 480

DPVYKVYVAA LKTLRAMLVY TPCHSLAERI KLQRLLRPVV DTILVKCADA NSRTSQLSIS 540

TLLELCKGQA GELAVGREIL KAGSIGIGGV DYVLNCILGN QTESNNWQEL LGRLCLIDRL 600

LLEFPAEFYP HIVSTEVSQA EPVEIRYKKL LSLLTFALQS IDNSHSMVGK LSRRIYLSSA 660

RMVTTVPHVF SKLLEMLSVS SSTHFSRMRR RLMAIADEVE IAEAIQLGIE ETLGGQQDDF 720

LQASVPNSCP ETTENGSLEC TVHLEKTGKL LRATNLSASS EDISDRLASI SVGLPSSAAT 780

TEQPKPMVQT KGRPHSQCLN SSPLSHHSQL TFPAKSASCA GASPSVPAPS VPASTVTDAS 840

KHRPQGFIPC KIPSASPQMQ RKFSLQFQRN CSENKDSGKV SPIFTQSRPL LSSNIHRPKP 900

SRPTPGNASK QGDVSKNSMT LDLNSTKCDD SFGSSNSSSN AVIPSDETVF TPVEEKSRLD 960

VNTELNSSIE DLLEASMPSS DTTVTFKSEV AVLSPEKAEN DDTYKDDVNH NRKCKEKMEA 1020

EEEEALAIAM AMSASQDALP VVPQLQVENG EDIIIIQQDT PETLPGHTKA KQPYREDTEW 1080

LKGQQIGLGA FSSCYQAQDV GTGTLMAVKQ VTYVRNTSSE QEEVVEALRE EIRMMSHLNH 1140

PNIIRMLGAT CEKSNYNLFI EWMAGGSVAH LLSKYGAFKE SVVINYTEQL LRGLSYLHEN 1200

QIIHRDVKGA NLLIDSTGQR LRIADFGAAA RLASKGTGAG EFQGQLLGTI AFMAPEVLRG 1260

QQYGRSCDVW SVGCAIIEMA CAKPPWNAEK HSNHLALIFK IASATTAPSI PSHLSPGLRD 1320

VALRCLELQP QDRPPSRELL KHPVFRTTW 1349

Nucleotide Sequence
(FASTA)

ATGGAGAATA AAGAAACTCT CAAAGGGTTG CACAAAATGG ACGATCGCCC AGAGGAGCGA 60

ATGATCAGGG AGAAGCTGAA GGCAACCTGT ATGCCAGCCT GGAAGCATGA GTGGTTGGAA 120

AGGAGGAATA GGCGCGGCCC CGTGGTGGTA AAACCAATCC CTGTTAAAGG AGATGGATCC 180

GAAATGAATA ACTTGGCCGC TGAGTCTCCA GGGGAGGGCC AGGCAAGCAC CACTTCATCA 240

GCCCCCAAAG GCCGCCGCAG TCCTTCTCCT GGAAGCTCCC CATCAGGTCG CACAGTGAAA 300

TCAGAATCTC CGGGAGTAAG GAGAAAAAGA GTTTCCCCAG TGCCTAGTGG CAGAATCACA 360

CCACCTCGAA GAGCCCCTTC ACCAGATGGC TTCTCACCAT ACAGCCCCGA GGAGACAAAC 420

CGCCGTGTGA ACAAAGTGAT GCGGGCCAGG CTGTATTTAC TACAGCAAAT AGGACCCAAC 480

TCTTTCCTGA TTGGAGGAGA CAGCCCAGAC AATAAATACC GGGTGTTTAT TGGGCCTCAG 540

AACTGTAGCT GTGGGCGTGG AACATTTTGT ATTCATCTGC TATTCGTTAT GCTCCGGGTA 600

TTTCAACTAG AACCTTCAGA CCCAATGTTG TGGCGGAAAA CTTTAAAGAA TTTCGAGGTT 660

GAGAGTTTGT TCCAGAAATA TCACAGTAGG CGTAGCTCAA GGATCAAAGC TCCATCTCGT 720

AACACCATCC AGAAGTTTGT TTCACGCATG TCAAATTCTC ATACATTGTC ATCATCTAGT 780

ACTTCTACAT CTAGTTCAGA AAACAGCATA AAAGATGAAG AGGAGCAGAT GTGTCCTATT 840

TGCTTGCTGG GCATGCTTGA TGAAGAGAGT CTCACAGTGT GTGAGGACGG CTGCAGGAAC 900

AAGCTGCACC ACCACTGCAT GTCCATCTGG GCAGAGGAAT GTAGAAGAAA TAGAGAACCT 960

TTAATATGTC CCCTTTGTAG GTCTAAGTGG AGATCCCACG ATTTCTATAG CCATGAGTTG 1020

TCAAGCCCGG TGGATTCCCC TTCTCCCCTG AGAGCTGCAC AGCAGCAGAC CATCCCACAG 1080

CAGCCTTTGG CTGGAGCACA AAGAAGGAAT CAAGAGAGCA ACTTCAACCT TACCCATTAT 1140

GGAACTCAGC AGATCCCTCC TGCTTACAAA GATTTAGCTG AGCCATGGAT TCAGGTGTTT 1200

GGAATGGAAC TCGTTGGCTG CTTATTTTCT AGAAACTGGA ATGTAAGAGA GATGGCCCTC 1260

AGGCGTCTAT CCCACGATGT TAGTGGGGCC CTGCTGTTGG CAAATGGGGA GAGCACTGGA 1320

AATTCCGGGG GCAGTGGTGG AAGCAGCCCG GCCACTGGCG CTGCCAGTGG GTCTTCCCAG 1380

CCCAGTGTCT CAGGAGACGT GGTGGAGGCG TGCTGCAGCG TTTTATCAAT GGTCTGTGCT 1440

GACCCTGTCT ACAAAGTGTA TGTTGCTGCT TTAAAAACAT TGAGAGCCAT GCTGGTATAT 1500

ACGCCATGCC ATAGTTTGGC AGAAAGAATC AAACTTCAGA GACTTCTGCG GCCAGTTGTA 1560

GACACCATCC TAGTCAAGTG TGCAGATGCC AATAGCCGCA CCAGTCAGCT GTCCATATCA 1620

ACACTGCTGG AGTTGTGCAA AGGCCAAGCA GGAGAGTTGG CAGTTGGAAG AGAAATACTA 1680

AAAGCTGGTT CCATTGGTAT TGGTGGTGTT GATTATGTCT TAAATTGTAT TCTTGGAAAC 1740

CAAACTGAAT CCAACAACTG GCAAGAACTC CTGGGCCGCC TTTGTCTTAT AGATAGACTA 1800

TTGTTGGAAT TTCCTGCTGA ATTTTATCCT CATATTGTCA GTACTGAAGT TTCACAAGCT 1860

GAGCCTGTTG AAATCAGGTA TAAGAAGCTG CTGTCCCTCT TGACCTTTGC TTTGCAGTCC 1920

ATTGATAATT CCCACTCAAT GGTTGGCAAA CTTTCCCGAA GGATCTATTT GAGTTCTGCA 1980

AGAATGGTTA CCACAGTCCC CCACGTGTTT TCAAAGCTGT TAGAAATGCT GAGTGTTTCC 2040

AGCTCCACTC ACTTCTCCAG GATGCGTCGC CGCTTGATGG CTATTGCAGA TGAGGTGGAA 2100

ATCGCCGAGG CCATCCAGCT GGGCATAGAA GAGACTTTGG GTGGGCAGCA GGACGACTTT 2160

CTGCAGGCAT CTGTCCCTAA CAGCTGTCCA GAAACCACAG AGAATGGTTC TCTTGAGTGC 2220

ACAGTCCATT TAGAGAAAAC TGGAAAATTG TTACGTGCTA CAAATTTGAG TGCCAGTTCA 2280

GAGGACATTT CTGACAGACT GGCCAGCATT TCAGTAGGAC TTCCTAGTTC AGCAGCAACA 2340

ACAGAGCAAC CAAAGCCAAT GGTTCAAACA AAAGGCAGAC CCCACAGTCA GTGTTTGAAC 2400

TCCTCTCCCT TATCTCATCA TTCCCAGTTA ACGTTCCCAG CCAAATCAGC CTCTTGTGCT 2460

GGGGCATCCC CATCCGTGCC AGCCCCATCT GTGCCAGCCA GCACTGTAAC AGATGCGTCT 2520

AAACATAGAC CTCAAGGATT CATTCCCTGC AAAATACCTT CTGCATCTCC TCAAATGCAG 2580

CGCAAGTTTT CTCTTCAATT CCAGAGAAAC TGTTCTGAAA ACAAAGACTC GGGTAAAGTT 2640

TCCCCAATCT TTACTCAGTC AAGACCTCTG CTCTCTAGTA ATATACACAG GCCAAAGCCA 2700

TCTCGACCTA CCCCAGGCAA TGCAAGTAAA CAGGGAGATG TCTCAAAAAA CAGCATGACA 2760

CTTGATCTGA ACAGTACCAA ATGTGATGAC AGCTTTGGCA GTAGCAATAG TAGTAGTAAT 2820

GCTGTCATTC CCAGTGACGA GACAGTGTTC ACCCCAGTAG AGGAGAAAAG CAGACTCGAT 2880

GTCAATACAG AGCTCAACTC CAGTATTGAG GACCTTCTTG AAGCATCCAT GCCTTCAAGT 2940

GATACGACAG TAACTTTTAA GTCAGAAGTT GCTGTCCTCT CTCCTGAAAA GGCTGAAAAT 3000

GACGATACCT ACAAAGATGA TGTGAATCAC AATCGGAAGT GCAAAGAAAA GATGGAAGCT 3060

GAAGAGGAAG AAGCTTTAGC GATTGCCATG GCAATGTCAG CGTCTCAGGA TGCCCTCCCC 3120

GTGGTTCCTC AGCTTCAGGT TGAGAATGGG GAGGATATCA TCATCATTCA ACAGGATACA 3180

CCAGAGACTC TACCAGGACA TACCAAAGCA AAGCAACCCT ACAGAGAAGA CACTGAATGG 3240

CTGAAAGGTC AGCAGATAGG CCTTGGAGCA TTTTCTTCTT GTTATCAGGC TCAAGATGTG 3300

GGAACTGGAA CTTTAATGGC TGTTAAGCAG GTGACGTACG TCAGAAACAC ATCTTCTGAG 3360

CAGGAAGAAG TAGTGGAAGC ATTAAGAGAA GAGATAAGAA TGATGAGCCA TCTGAATCAT 3420

CCGAACATCA TTAGGATGTT GGGGGCCACA TGTGAGAAGA GCAATTACAA TCTCTTCATC 3480

GAATGGATGG CAGGAGGATC TGTGGCTCAT TTGCTGAGTA AATATGGAGC CTTCAAAGAA 3540

TCAGTAGTTA TTAACTATAC TGAACAGTTA CTTCGTGGCC TTTCATATCT CCATGAAAAC 3600

CAAATCATTC ACAGAGATGT CAAAGGTGCC AATTTGCTAA TTGACAGTAC AGGTCAGAGA 3660

CTAAGAATTG CAGATTTTGG AGCTGCAGCC AGGTTGGCGT CAAAAGGAAC TGGTGCGGGA 3720

GAGTTTCAGG GGCAGTTATT GGGGACAATT GCGTTTATGG CACCTGAGGT GCTAAGAGGT 3780

CAGCAGTACG GTAGGAGCTG TGACGTGTGG AGCGTTGGCT GTGCTATTAT AGAAATGGCT 3840

TGTGCAAAAC CACCTTGGAA TGCAGAAAAA CACTCCAATC ATCTTGCTTT GATATTTAAG 3900

ATTGCTAGTG CAACTACTGC CCCATCGATC CCTTCACACC TGTCTCCTGG TTTACGAGAC 3960

GTGGCTCTTC GTTGTTTAGA ACTTCAACCT CAGGACAGAC CTCCATCAAG AGAGCTACTG 4020

AAGCATCCAG TCTTCCGTAC TACGTGGTAG 4050

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1080  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1139

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1140  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1199

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1200  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1259

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1260  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1317

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1318  LRDVALRCLELQPQDRPPSRELLKHPV  1344

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013