EKS-OTG-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	531.4	3.4E-160	1007	1274	268

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002659

UniProt Accession

H0WLU7;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSR

Gene Synonyms/Alias

INSR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000002968	ENSOGAP00000002659	ENSOGAT00000002972

Organism

Otolemur garnettii

Functional Description

Protein Length

1366

Protein Sequence
(FASTA)

MAALLVGAAG HLYPGEVCPG MDIRNNLTRL RELENCSVIE GHLQILLMFK TSPEDFRDLS 60

FPKLIMITDY LLLFRVYGLE SLKDLFPNLT VIRGSRLFFN YALVIFEMVH LKELGLYNLM 120

NITRGSVRIE KNNELCYLAT IDWSRILDSV EDNYIVLNKD DNEECGDVCP GTAKGKTNCP 180

ATVINGQFVE RCWTHSHCQK VCPTVCKSHG CTAEGLCCHS ECLGNCSEPD DPTKCMACRN 240

FYLDGRCVEA CPPPYYHFQD WRCVNFSFCY DLHNKCKNSR RPGCHQYVIH NRRCIPECPS 300

GYTMNSSNLM CTPCLGPCPK VCHILESEKT IDSVTSAQEL RGCTVINGSL IINIRGGNNL 360

AAELEANLGL IEEISGYLKI RRSYALVSLS FFRKLRLIRG ETLEMGSYSF YALDNQNLRQ 420

LWDWSKHNLT ITQGKLFFHY NPKLCLSEIH KMEEVSGTKG RQERNDIALK TNGDQASCEN 480

ELLKFSYIRT SFDKILLKWE PYWPPDFRDL LGFMLFYKEA PYKNVTEFDG QDACGSNSWT 540

VVDVDPPLRS NDPKSQNHPG WLMRGLKPWT QYAIFVKTLV TFSDERRTYG AKSDIIYVQT 600

DATNPSVPLD PISVSNSSSQ ILLKWKPPSD PNGNITHYLV FWERQAEDSE LYELDYCLKG 660

LKLPSRTWSP PFESEDSQKH NQSEYEDSAG ECCSCPKTDS QILKELEESS FRKTFEDYLH 720

NVVFVPRKTS SGTGAEDPRP SRKRRSLGEV GNVTMVAVPT VPGFPNISST IMPTSPEEHR 780

PFEKVVNKES LVISGLRHFT GYRIELQACN QDAPDERCSV AAYVSARTMP EAKADDIVGP 840

VTHEIFENNI VHLMWQEPKE PNGLIVLYEV SYRRYGDEEL HLCVSRKHYA LERGCRLRGL 900

SPGNYSVRVR ATSLAGNGSW TEATHFYMTD YLDVPSNIAK IIIGPLIFVF LFSIVIGSIY 960

IFLRKRQPDG PLGPLYASSN PEYLSASDVF PCSVYVPDEW EVPREKITLL RELGQGSFGM 1020

VYEGNARDIV KGEAETRVAV KTVNESASLR ERIEFLNEAS VMKGFTCHHV VRLLGVVSKG 1080

QPTLVVMELM AHGDLKSYLR SLRPEAENNP GRPPPTLQEM IQMAAEIADG MAYLNAKKFV 1140

HRDLAARNCM VAHDFTVKIG DFGMTRDIYE TDYYRKGGKG LLPVRWMAPE SLKDGVFTTS 1200

SDMWSFGVVL WEITSLAEQP YQGLSNEQVL KFVMDGGYLD QPDNCPERVT DLMRMCFQFN 1260

PKMRPTFLEI VNLLKDDLHP SFPDVSFFHS EENKAPESEE LEMEFEDMES VPLDRSSHCQ 1320

REEAGGREGG SSLGLKRNYE EHIPYTHMNG GKRNGRILAL PRSNPS 1366

Nucleotide Sequence
(FASTA)

ATGGCCGCTC TGCTGGTGGG CGCCGCAGGC CACCTGTACC CGGGAGAGGT GTGTCCCGGC 60

ATGGATATCC GGAACAACCT CACCAGGCTG CGGGAGCTGG AGAACTGCTC CGTCATCGAA 120

GGCCATTTGC AGATACTCTT GATGTTCAAA ACAAGCCCTG AAGACTTCCG AGACCTCAGT 180

TTCCCCAAAC TCATAATGAT CACTGATTAC TTGCTGCTCT TCCGGGTCTA CGGGTTGGAG 240

AGCCTGAAGG ACCTGTTCCC CAACCTCACT GTTATCCGAG GCTCACGCCT CTTCTTCAAC 300

TATGCCCTAG TCATCTTTGA GATGGTTCAC CTGAAGGAGC TCGGTCTCTA CAATCTGATG 360

AACATAACCC GGGGCTCCGT CCGCATCGAG AAAAACAATG AGCTCTGCTA CTTGGCCACA 420

ATCGACTGGT CCCGCATCCT GGATTCTGTG GAGGACAATT ACATTGTGTT GAACAAGGAC 480

GACAACGAGG AGTGTGGGGA CGTCTGTCCA GGGACTGCCA AGGGCAAGAC CAACTGCCCT 540

GCCACCGTCA TCAACGGCCA GTTTGTGGAA CGGTGCTGGA CTCACAGTCA TTGCCAGAAA 600

GTCTGCCCCA CTGTCTGCAA GTCGCACGGC TGTACTGCCG AAGGCCTCTG CTGCCATAGC 660

GAGTGTCTGG GCAACTGTTC TGAGCCTGAT GACCCCACCA AGTGCATGGC CTGCCGCAAC 720

TTCTACCTGG ACGGCAGGTG TGTGGAGGCC TGCCCACCCC CGTACTACCA CTTCCAGGAC 780

TGGCGCTGCG TGAACTTTAG CTTCTGCTAT GACCTGCACA ACAAATGCAA GAACTCACGG 840

AGGCCGGGCT GCCACCAGTA CGTCATTCAC AACCGCAGGT GCATTCCTGA ATGTCCCTCT 900

GGATACACAA TGAACTCCAG CAACCTGATG TGCACACCGT GCCTGGGCCC CTGTCCCAAG 960

GTCTGCCACA TCCTAGAAAG TGAGAAGACC ATCGACTCGG TGACATCTGC CCAGGAGCTC 1020

CGAGGATGTA CTGTTATCAA CGGGAGTCTG ATCATCAACA TCCGAGGGGG CAATAACCTG 1080

GCAGCAGAGC TAGAAGCCAA TCTTGGCCTC ATTGAAGAAA TTTCAGGGTA TCTGAAAATC 1140

CGTCGATCTT ACGCTCTGGT GTCACTTTCC TTCTTCCGGA AGTTACGTCT GATTCGAGGA 1200

GAGACCTTGG AAATGGGGAG CTATTCTTTC TATGCCTTGG ACAACCAGAA CCTAAGGCAG 1260

CTCTGGGACT GGAGCAAACA CAACCTCACC ATCACTCAGG GGAAACTCTT CTTCCACTAC 1320

AATCCCAAAC TCTGCTTGTC AGAAATCCAC AAGATGGAAG AAGTTTCAGG AACCAAGGGC 1380

CGCCAGGAGA GGAACGACAT TGCCCTGAAG ACCAATGGGG ACCAGGCATC CTGTGAAAAT 1440

GAATTACTTA AATTTTCTTA CATTCGGACA TCTTTTGACA AGATCTTGCT GAAATGGGAG 1500

CCTTACTGGC CCCCCGACTT CCGAGACCTC TTGGGCTTTA TGCTGTTCTA CAAAGAGGCC 1560

CCTTATAAGA ATGTGACAGA GTTCGACGGG CAGGACGCTT GTGGTTCCAA CAGCTGGACA 1620

GTGGTGGACG TGGACCCCCC TTTGAGGTCC AATGACCCCA AGTCTCAGAA CCACCCTGGG 1680

TGGCTAATGC GTGGTCTCAA GCCCTGGACC CAGTATGCCA TCTTTGTCAA GACCCTGGTC 1740

ACCTTTTCAG ATGAACGCCG GACCTATGGG GCCAAGAGTG ACATCATTTA TGTCCAGACA 1800

GATGCCACCA ATCCTTCCGT CCCCCTGGAC CCCATCTCGG TTTCTAATTC CTCATCCCAG 1860

ATTCTTCTGA AGTGGAAGCC CCCCTCTGAC CCCAATGGCA ACATCACTCA CTACCTGGTT 1920

TTCTGGGAGA GGCAGGCGGA AGACAGCGAG CTATATGAGC TGGACTATTG CCTCAAAGGG 1980

TTGAAGCTGC CCTCCCGGAC GTGGTCTCCA CCGTTTGAGT CTGAGGACTC TCAGAAGCAC 2040

AACCAGAGTG AGTACGAGGA CTCGGCTGGC GAGTGCTGCT CCTGCCCCAA AACAGACTCT 2100

CAGATCCTGA AGGAGCTGGA GGAGTCCTCG TTTAGGAAGA CGTTTGAGGA CTACCTGCAC 2160

AACGTGGTCT TCGTGCCCAG AAAAACCTCT TCTGGAACTG GTGCTGAGGA TCCTAGGCCA 2220

TCTCGGAAGC GCAGGTCTCT CGGCGAAGTT GGAAATGTGA CGATGGTGGC TGTGCCCACT 2280

GTCCCAGGTT TCCCCAATAT CTCCTCAACC ATCATGCCCA CAAGCCCAGA GGAGCACAGG 2340

CCCTTTGAGA AAGTGGTGAA TAAAGAGTCA CTGGTCATCT CTGGCCTGCG ACACTTCACG 2400

GGCTATCGCA TTGAGCTGCA AGCTTGCAAC CAAGATGCCC CGGACGAGCG GTGCAGTGTG 2460

GCGGCCTATG TCAGTGCCAG GACCATGCCT GAAGCCAAGG CTGATGACAT CGTAGGCCCC 2520

GTGACCCATG AAATCTTCGA GAACAACATT GTTCACTTAA TGTGGCAGGA GCCAAAGGAA 2580

CCCAATGGTC TGATTGTGCT GTATGAAGTG AGTTATCGGC GATATGGTGA TGAGGAGCTG 2640

CACCTCTGCG TCTCCCGCAA GCATTATGCT CTGGAGCGAG GCTGCAGGCT GCGCGGGCTG 2700

TCGCCAGGGA ACTACAGCGT GCGAGTCAGG GCCACCTCCC TGGCGGGCAA TGGTTCCTGG 2760

ACAGAAGCCA CCCATTTCTA CATGACAGAC TATCTAGATG TCCCATCAAA TATTGCAAAA 2820

ATTATCATTG GCCCCCTTAT CTTTGTCTTT CTCTTCAGTA TTGTGATTGG AAGTATTTAT 2880

ATATTCCTGA GAAAAAGGCA GCCAGATGGG CCACTGGGAC CACTGTACGC ATCCTCAAAC 2940

CCAGAGTACC TCAGTGCCAG TGATGTGTTT CCTTGTTCTG TGTATGTGCC GGACGAGTGG 3000

GAGGTGCCTC GAGAGAAGAT CACCCTCCTT CGAGAGCTGG GACAGGGTTC CTTTGGCATG 3060

GTGTACGAGG GCAATGCCAG GGACATCGTC AAGGGTGAGG CGGAGACCCG AGTGGCAGTG 3120

AAGACTGTCA ATGAGTCGGC CAGTCTCCGG GAGCGGATCG AGTTCCTCAA TGAGGCTTCA 3180

GTTATGAAGG GTTTCACCTG TCATCATGTG GTCCGCCTCC TGGGGGTGGT GTCTAAGGGG 3240

CAGCCAACGT TGGTGGTGAT GGAGTTGATG GCTCACGGAG ACCTGAAGAG CTACCTCCGT 3300

TCTCTGCGGC CCGAGGCTGA GAATAACCCA GGTCGCCCTC CCCCAACCTT GCAAGAGATG 3360

ATTCAGATGG CAGCGGAGAT TGCCGATGGG ATGGCATACC TGAATGCCAA GAAGTTTGTG 3420

CACCGGGACC TCGCTGCTAG AAACTGCATG GTTGCTCACG ATTTCACTGT CAAAATTGGA 3480

GACTTTGGAA TGACCAGAGA CATCTACGAG ACCGATTACT ACAGGAAAGG GGGCAAGGGC 3540

CTGTTGCCCG TGCGGTGGAT GGCACCAGAG TCTCTGAAGG ATGGGGTCTT TACCACTTCT 3600

TCTGACATGT GGTCCTTCGG CGTGGTCCTT TGGGAAATCA CCAGCTTGGC AGAGCAGCCT 3660

TACCAAGGCC TATCTAATGA ACAGGTGTTA AAATTTGTCA TGGATGGGGG CTACCTGGAT 3720

CAACCTGACA ACTGTCCAGA GAGAGTCACG GACCTGATGC GCATGTGCTT CCAGTTCAAC 3780

CCCAAGATGC GGCCAACCTT TCTGGAGATC GTCAACCTGC TCAAGGACGA CCTGCACCCT 3840

AGCTTCCCAG ACGTTTCCTT CTTCCACAGC GAGGAGAACA AGGCTCCTGA GAGTGAGGAG 3900

CTGGAGATGG AGTTTGAGGA CATGGAGAGC GTCCCCCTGG ACCGGTCCTC ACACTGCCAG 3960

AGGGAGGAGG CTGGGGGCCG AGAAGGAGGG TCCTCGCTGG GCCTCAAGCG GAACTATGAG 4020

GAGCACATCC CCTACACCCA CATGAACGGG GGCAAGAGAA ACGGGCGGAT TCTGGCCTTG 4080

CCTCGCTCCA ACCCCTCCTA A 4101

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+llrelGqGsfGmvyeG+a+d+vkge+etrva+ktvne+as reriefl+easvmk f+

Q: 1007  ITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFT  1066

         789*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrpe+en+++++pp+l+++iqmaae

Q: 1067  CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAE  1126

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1127  IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1186

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+l++p+ncp

Q: 1187  MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  1246

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         e++t+lmr+c+q+npk+rp+fleiv+ll

Q: 1247  ERVTDLMRMCFQFNPKMRPTFLEIVNLL  1274

         *************************976

Domain Sequence
(FASTA)

ITLLRELGQG SFGMVYEGNA RDIVKGEAET RVAVKTVNES ASLRERIEFL NEASVMKGFT 60

CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEMIQMAAE 120

IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MAPESLKDGV FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240

ERVTDLMRMC FQFNPKMRPT FLEIVNLL 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013