EKS-OTG-00285

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00285

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.4	6.2E-136	204	491	288

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002744

UniProt Accession

H0WM21;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000003063	ENSOGAP00000002744	ENSOGAT00000003066

Organism

Otolemur garnettii

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MLLRSSGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPIVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120

GPIHHKALLI SVTVCSLLLV LIIVFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTTTTGC GAAGTTCAGG AAAATTAAAC GTGGGAACCA AGAAAGAGGA TGGAGAGAGT 60

ACAGCCCCCA CTCCCCGTCC CAAGATCTTA CGTTGTAAAT GCCACCACCA TTGTCCAGAG 120

GACTCAGTCA ACAACATTTG CAGCACTGAC GGATACTGTT TCACAATGAT AGAAGAAGAT 180

GACTCTGGGA TGCCTATAGT CACTTCTGGA TGCCTAGGAC TAGAAGGCTC AGATTTTCAG 240

TGTCGGGACA CTCCCATTCC ACATCAGAGA AGATCGATTG AGTGCTGCAC GGAAAGGAAC 300

GAGTGTAATA AAGACCTGCA CCCCACGCTG CCTCCACTGA AAAACAGAGA TTTCGTTGAT 360

GGACCTATAC ACCACAAGGC TTTACTTATA TCTGTGACTG TCTGTAGTTT GCTCTTGGTC 420

CTCATCATTG TATTCTGTTA CTTCAGGTAT AAAAGACAAG AAACCAGACC TCGGTACAGC 480

ATTGGGTTAG AACAGGATGA AACGTACATT CCTCCGGGAG AATCCCTGAG AGACTTAATT 540

GAGCAGTCTC AAAGCTCTGG AAGTGGATCA GGCCTCCCTC TGCTGGTCCA AAGGACTATA 600

GCTAAGCAGA TTCAGATGGT GAAACAGATT GGAAAAGGTC GCTATGGGGA AGTTTGGATG 660

GGAAAGTGGC GTGGCGAAAA GGTAGCTGTG AAAGTCTTCT TCACCACAGA GGAAGCCAGC 720

TGGTTCAGAG AGACAGAAAT ATACCAGACA GTGCTGATGA GGCATGAAAA CATTTTGGGG 780

TTCATTGCTG CAGATATCAA AGGGACAGGG TCCTGGACCC AGTTGTACCT AATCACAGAC 840

TATCATGAAA ATGGTTCCCT TTATGATTAT CTGAAATCCA CCACCCTGGA CACTAAATCA 900

ATGCTGAAGT TAGCCTACTC TTCGGTCAGT GGCTTGTGTC ACTTACATAC CGAAATCTTT 960

AGTACTCAAG GCAAACCAGC AATTGCCCAC CGAGACCTGA AAAGTAAAAA TATCCTCGTG 1020

AAGAAAAATG GAACTTGCTG TATAGCTGAC CTGGGTCTGG CTGTTAAATT TATTAGTGAT 1080

ACAAACGAAG TTGACATCCC ACCCAACACT CGGGTTGGCA CCAAACGCTA TATGCCCCCA 1140

GAAGTGTTGG ATGAGAGCTT GAATAGAAAT CACTTCCAGT CTTACATCAT GGCCGACATG 1200

TATAGCTTCG GACTCATCCT CTGGGAGGTT GCTAGGAGAT GTGTATCAGG AGGTATTGTG 1260

GAAGAATATC AGCTTCCCTA TCATGACCTC GTGCCCAGTG ACCCCTCTTA TGAGGACATG 1320

AGAGAGATTG TGTGCATCAA GAAGTTACGT CCCTCATTCC CCAACCGGTG GAGCAGCGAC 1380

GAGTGTCTGA GGCAGATGGG GAAACTCATG ACAGAATGCT GGGCTCACAA CCCTGCTTCG 1440

AGGCTGACAG CCCTGCGTGT TAAGAAAACA CTTGCCAAAA TGTCAGAGTC CCAGGACATT 1500

AAACTGTGA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 441   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013