EKS-OTG-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	433.3	2.6E-130	247	499	253

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002761

UniProt Accession

H0WM37;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000003078	ENSOGAP00000002761	ENSOGAT00000003084

Organism

Otolemur garnettii

Functional Description

Protein Length

514

Protein Sequence
(FASTA)

MGCIESKRKD NLNDDGVDLK TQPVRNTDRT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 60

PEEHGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLSTKRE GFIPSNYVAK 120

VNTLETEEWF FKDITRKDAE RQLLAPGNSA GSFLIRESET LKGSFSLSVR DYDPVHGDVI 180

KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW 240

EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300

KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360

KNYIHRDLRA ANVLVSEALM CKIADFGLAR IIEDNEYTAR EGAKFPIKWT APEAINFGCF 420

TIKSDVWSFG ILLYEIVTYG KIPYPALGRT NADVMAALAQ GYRMPRVENC PDELYDIMKM 480

CWKEKAEERP TFDYLQSVLD DFYTATEGQY QQQP 514

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAGAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATTTGAAG 60

ACTCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120

CAGCAAAGGC CAGTTCCAGA ATCTCAGCTC TTACCAGGAC AGAGGTTTCA AACTAAAGAT 180

CCAGAGGAGC ACGGAGACAT TGTGGTGGCC TTGTACCCCT ACGATGGCAT CCATCCAGAC 240

GACTTGTCAT TCAAGAAAGG AGAAAAGATG AAAGTCCTGG AGGAGCATGG AGAATGGTGG 300

AAAGCTAAGT CCCTTTCAAC CAAGAGAGAA GGCTTCATCC CCAGCAACTA CGTGGCCAAA 360

GTCAACACCT TGGAGACGGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA GGATGCAGAA 420

AGGCAGCTCC TGGCTCCAGG AAACAGTGCT GGGTCCTTTC TTATCAGAGA AAGTGAAACG 480

TTAAAAGGAA GCTTCTCTCT GTCTGTCAGA GACTATGACC CGGTGCACGG TGATGTCATT 540

AAGCACTACA AAATCAGAAG TCTGGACAAT GGGGGTTATT ACATCTCTCC ACGGATCACT 600

TTTCCCTGTA TCAGCGACAT GATTAAGCAT TACCAAAAGC AGTCAGATGG CTTGTGCAGA 660

AGGTTGGAGA AAGCATGTAT TAGCCCCAAG CCACAGAAGC CATGGGATAA AGATGCCTGG 720

GAGATCCCAC GAGAGTCCAT CAAGTTGGTG AAAAGGCTCG GCGCTGGACA GTTTGGGGAA 780

GTCTGGATGG GTTACTATAA CAATAGTACC AAGGTGGCTG TAAAAACCCT GAAACCAGGC 840

ACCATGTCTG TGCAAGCCTT CCTTGAAGAA GCCAACCTCA TGAAGACCCT CCAGCACGAC 900

AAGCTTGTGA GACTCTATGC TGTGGTCACC AGGGAGGAGC CCATTTACAT CATCACCGAG 960

TATATGGCCA AAGGCAGTTT GCTGGATTTC CTGAAGAGTG ATGAGGGTGG CAAAGTGCTG 1020

CTTCCAAAGC TCATTGACTT TTCTGCTCAG ATTGCAGAAG GGATGGCTTA CATTGAGCGG 1080

AAGAACTACA TCCACAGAGA CCTGCGAGCA GCCAACGTCC TGGTCTCCGA GGCGCTCATG 1140

TGCAAGATTG CGGATTTTGG CCTTGCTAGA ATAATTGAGG ATAACGAGTA CACAGCGAGG 1200

GAAGGTGCCA AGTTCCCTAT TAAGTGGACA GCTCCAGAAG CAATCAACTT CGGATGTTTT 1260

ACTATTAAGT CTGATGTGTG GTCCTTTGGA ATTCTCCTGT ATGAAATCGT CACCTATGGG 1320

AAAATTCCCT ACCCAGCCCT AGGGAGGACT AATGCTGACG TGATGGCCGC CCTGGCCCAG 1380

GGCTACAGGA TGCCTCGCGT GGAGAACTGC CCAGATGAGC TCTATGATAT TATGAAAATG 1440

TGCTGGAAAG AAAAGGCCGA AGAGAGACCC ACATTCGATT ACTTACAGAG TGTCCTGGAT 1500

GACTTCTACA CTGCCACCGA AGGACAGTAC CAGCAGCAGC CTTAG 1545

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 307   AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+e l++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANVLVSEALMCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPyp..Gmtneevleqvergyrlprpeecpeelyelllecwkkdp  238

         WsfGill+eivt+Gk+Pyp  G tn++v+ ++ +gyr+pr e+cp+ely+++++cwk+++

Q: 427   WSFGILLYEIVTYGKIPYPalGRTNADVMAALAQGYRMPRVENCPDELYDIMKMCWKEKA  486

         ******************97789*************************************

S: 239   eerPtfetlqevl  251

         eerPtf++lq+vl

Q: 487   EERPTFDYLQSVL  499

         **********986

Domain Sequence
(FASTA)

IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTREEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS EALMCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180

WSFGILLYEI VTYGKIPYPA LGRTNADVMA ALAQGYRMPR VENCPDELYD IMKMCWKEKA 240

EERPTFDYLQ SVL 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013