EKS-OTG-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.2	1.1E-128	82	334	253

Status

Unreviewed

Ensembl Protein

ENSOGAP00000002899

UniProt Accession

H0WMD9;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000003248	ENSOGAP00000002899	ENSOGAT00000003250

Organism

Otolemur garnettii

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

MELLRTITYQ PAAGTKMCEQ ALGKACGGDS KKKRPQQPPE EPQAPQPQTQ VQPAAQHHHH 60

HHSHSGPEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 120

PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 180

EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 240

CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 300

SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HDFFLQGFTP DRLSSSCCHT VPDFHLSSPA 360

KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEEIYKLRH DLKKTSITQQ PSKHRTDEEL 420

QPPATTVARS GTPAVENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR 480

GCLENMPEAD SIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD 540

KKTVHYYAEL GQCSVFPATD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDTRRPRL 600

YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL 660

LMSGCSLELK NRMEYALNML LQRCN 685

Nucleotide Sequence
(FASTA)

ATGGAACTCT TGCGGACTAT CACCTACCAG CCAGCTGCCG GCACCAAGAT GTGTGAGCAG 60

GCTCTGGGCA AAGCTTGCGG CGGGGATTCT AAGAAGAAGC GACCGCAGCA GCCCCCCGAA 120

GAGCCGCAAG CGCCGCAGCC CCAGACGCAG GTGCAGCCGG CGGCCCAGCA TCACCATCAC 180

CACCACTCGC ACTCGGGGCC CGAGATCTCG CGGATTATCG TCGACCCCAC GACGGGGAAG 240

CGCTACTGCC GGGGCAAAGT GCTGGGAAAG GGTGGCTTTG CGAAATGTTA CGAGATGACG 300

GATTTGACAA ATAACAAAGT CTACGCTGCA AAAATTATTC CTCACAGCAG AGTAGCTAAG 360

CCTCATCAGA GGGAAAAGAT TGACAAAGAA ATAGAGCTTC ACAGAATTCT TCACCACAAG 420

CATGTAGTGC AGTTCTACCA CTACTTTGAG GACAAAGAGA ACATTTACAT TCTCTTGGAA 480

TACTGCAGTA GGAGGTCCAT GGCTCATATT TTGAAAGCAA GAAAGGTGTT AACAGAGCCG 540

GAAGTCCGAT ACTATCTCAG GCAGATTGTG TCTGGGCTAA AGTACCTTCA TGAACAAGAA 600

ATCTTGCACA GAGATCTCAA ACTAGGGAAT TTTTTTATTA ATGAAGCCAT GGAACTGAAA 660

GTTGGGGACT TCGGTTTGGC AGCCAGGCTG GAACCCTTGG AACACAGAAG GAGAACAATA 720

TGTGGTACCC CAAATTATCT CTCTCCTGAG GTCCTCAATA AACAAGGACA CGGCTGTGAA 780

TCAGACATCT GGGCTTTAGG CTGCGTAATG TATACAATGT TACTAGGAAG GCCTCCATTT 840

GAAACTACGA ATCTGAAAGA AACTTACAGG TGCATAAGAG AAGCAAGGTA TACAATGCCA 900

TCTTCGCTGC TGGCTCCTGC CAAGCACTTA ATAGCTAGCA TGTTGTCCAA AAACCCAGAG 960

GATCGTCCCA GTTTGGATGA CATCATTCGA CATGACTTTT TCCTGCAGGG CTTCACTCCG 1020

GACAGACTTT CTTCTAGCTG TTGTCATACA GTTCCAGATT TCCACTTGTC AAGCCCAGCT 1080

AAGAATTTCT TTAAGAAAGC AGCTGCTGCT CTCTTTGGTG GCAAAAAAGA CAAAGCAAGA 1140

TACATTGACA CACATAATAG AGTGTCTAAA GAAGATGAAG AAATATACAA GCTTAGGCAT 1200

GATTTGAAAA AGACTTCAAT AACTCAACAA CCCAGCAAAC ACAGGACAGA TGAGGAGCTC 1260

CAGCCACCTG CCACTACAGT TGCCAGATCT GGAACACCTG CAGTAGAAAA CAAACAGCAG 1320

ATTGGGGATG CTATTCGAAT GATAGTCAGA GGGACTCTCG GCAGTTGTAG CAGTAGCAGT 1380

GAATGCCTTG AAGACAGTAC TATGGGAAGC GTTGCAGACA CAGTGGCCAG GGTTCTTCGG 1440

GGATGTCTAG AGAACATGCC AGAAGCTGAC TCCATTCCCA AAGAGCAGCT GAGTACATCG 1500

TTTCAGTGGG TGACCAAATG GGTCGATTAC TCTAACAAGT ACGGCTTTGG GTACCAGCTC 1560

TCAGACCACA CTGTCGGGGT CCTTTTCAAC AATGGTGCTC ACATGAGCCT CCTTCCAGAC 1620

AAAAAAACAG TTCACTATTA TGCAGAGCTT GGCCAATGCT CTGTCTTCCC AGCAACTGAT 1680

GCCCCGGAGC AATTTATTAG TCAAGTGACG GTGCTGAAAT ACTTTTCCCA TTACATGGAG 1740

GAGAACCTCA TGGATGGAGG AGATCTACCT AGTGTTACTG ATACTCGAAG ACCTCGGCTC 1800

TACCTCCTTC AGTGGCTGAA ATCTGATAAG GCCCTAATGA TGCTCTTCAA TGATGGCACG 1860

TTTCAGGTGA ATTTCTACCA TGATCATACG AAAATAATCA TCTGTAGCCA AAATGAAGAA 1920

TACCTTCTCA CTTACATCAA CGAGGACAGG ATATCTACAA CATTCAGACT GACAACTCTG 1980

CTGATGTCTG GCTGTTCATT GGAATTAAAA AATCGAATGG AATATGCCCT GAACATGCTC 2040

CTACAGAGAT GTAACTAA 2058

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 82    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  141

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 142   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  201

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 202   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  261

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 262   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  321

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl+++++++f+

Q: 322   RPSLDDIIRHDFF  334

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPSLDDIIRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013