EKS-OTG-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	448.6	5.3E-135	268	517	250

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003013

UniProt Accession

H0WMN4;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000003375	ENSOGAP00000003013	ENSOGAT00000003380

Organism

Otolemur garnettii

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

MGCIKSKENK TPAIKYRTEN TPEPVSTSVS QYGAEPSAKG TSVNFSSLSI TPFGGSSGVT 60

PFGGASSSFS VVPSSYPAVL TGGVTIFVAL YDYEARTTED LSFKKGERFQ IINNTEGDWW 120

EARSIATGKN GYIPSNYVAP ADSIQAEEWY FGKMGRKDAE RLLLNPGNQR GIFLVRESET 180

TKGAYSLSIR DWDELRGDNV KHYKIRKLDN GGYYITTRAQ FETLQKLVKH YTEHADGLCH 240

KLTTVCPTVK PQTQGLAKDA WEIPRESLRL EVKLGQGCFG EVWMGTWNGT TKVAIKTLKP 300

GTMMPEAFLQ EAQIMKKLRH DKLVPLYAVV SEEPIYIVTE FMSKGSLLDF LKEGDGKYLK 360

LPQLVDMAAQ IADGMAYIER MNYIHRDLRA ANILVGENLV CKIADFGLAR LIEDNEYTAR 420

QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILQTELVTKG RVPYPGMVNR EVLEQVERGY 480

RMPCPQGCPE SLHDLMNQCW KKDPDERPTF EYIQSFLEDY FTATEPQYQP GENL 534

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TTAAAAGTAA AGAAAACAAA ACTCCAGCCA TTAAATATAG AACAGAAAAC 60

ACTCCAGAGC CTGTCAGTAC AAGTGTCAGC CAATATGGAG CAGAGCCTTC AGCAAAGGGA 120

ACGTCGGTGA ATTTTAGCAG TCTTTCCATC ACACCATTTG GAGGATCCTC AGGGGTGACG 180

CCTTTTGGAG GGGCATCTTC CTCTTTTTCA GTGGTGCCAA GTTCATATCC TGCTGTTTTA 240

ACAGGTGGTG TTACTATATT TGTGGCCTTA TATGATTACG AAGCTAGAAC TACAGAAGAC 300

CTTTCATTTA AGAAGGGTGA AAGATTTCAA ATTATTAACA ACACGGAAGG AGACTGGTGG 360

GAAGCTAGAT CAATTGCTAC AGGAAAGAAT GGTTACATCC CTAGCAATTA TGTCGCGCCT 420

GCAGATTCCA TTCAGGCAGA AGAATGGTAT TTTGGCAAAA TGGGAAGAAA AGATGCTGAA 480

AGATTACTTC TGAATCCTGG GAATCAACGA GGTATTTTCT TAGTAAGAGA GAGTGAAACT 540

ACTAAAGGTG CTTATTCCCT TTCCATTCGT GATTGGGATG AGCTAAGAGG CGACAATGTA 600

AAACACTACA AAATTAGGAA ACTTGACAAT GGCGGATACT ATATCACAAC CAGAGCACAG 660

TTTGAAACTC TGCAGAAATT AGTGAAACAC TATACAGAAC ATGCTGATGG ATTATGTCAC 720

AAGCTAACAA CTGTGTGTCC AACTGTGAAA CCTCAGACTC AAGGTCTAGC AAAGGATGCT 780

TGGGAAATTC CTCGAGAATC TTTACGGCTA GAGGTTAAAC TAGGACAAGG ATGTTTTGGT 840

GAAGTATGGA TGGGAACATG GAATGGAACA ACAAAAGTAG CAATCAAAAC ACTAAAGCCA 900

GGTACAATGA TGCCAGAAGC TTTTCTTCAA GAAGCTCAAA TCATGAAAAA ATTAAGACAT 960

GATAAACTTG TTCCACTATA TGCTGTTGTT TCTGAAGAGC CAATATACAT TGTCACTGAA 1020

TTTATGTCAA AAGGGAGCTT ATTAGATTTC CTTAAGGAAG GAGATGGAAA GTATTTGAAG 1080

CTTCCACAAC TGGTCGATAT GGCTGCTCAG ATTGCTGATG GTATGGCATA TATTGAAAGA 1140

ATGAACTATA TTCACCGAGA TCTTCGGGCT GCTAATATTC TTGTAGGAGA AAATCTTGTA 1200

TGCAAAATAG CAGATTTTGG GTTAGCAAGA TTAATCGAAG ACAATGAATA CACAGCAAGA 1260

CAAGGTGCAA AATTTCCAAT CAAATGGACA GCTCCTGAGG CTGCCCTGTA TGGTCGATTT 1320

ACAATAAAGT CTGATGTATG GTCATTTGGA ATTCTACAAA CAGAACTGGT AACAAAGGGC 1380

AGAGTGCCAT ATCCAGGTAT GGTAAACCGG GAAGTGCTGG AGCAGGTGGA ACGAGGATAC 1440

AGGATGCCCT GCCCTCAGGG CTGTCCAGAA TCCCTCCATG ATTTGATGAA TCAGTGCTGG 1500

AAGAAGGACC CTGATGAAAG ACCAACGTTT GAATATATAC AGTCCTTCTT GGAAGACTAC 1560

TTCACTGCTA CAGAGCCACA GTACCAGCCA GGAGAAAATT TATAA 1605

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 268   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  327

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 328   AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  386

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 387   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  446

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l++l+++cwkkdp+e

Q: 447   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHDLMNQCWKKDPDE  506

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 507   RPTFEYIQSFL  517

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHDLMN QCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013