EKS-OTG-00293

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00293

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	482.0	4.5E-145	497	758	262

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003436

UniProt Accession

H0WNM6;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000003863	ENSOGAP00000003436	ENSOGAT00000003867

Organism

Otolemur garnettii

Functional Description

Protein Length

903

Protein Sequence
(FASTA)

PAFLPDPNDG SLYTLGGKNN EGLTKLPFTI PELVQASPCR SSDGILYMGK KQDIWYVIDL 60

LTGEKQQTLS SAFADSLCPS TSLLYLGRTE YTITMYDTKT RELRWNATYF DYAASLPDDD 120

MDYKMSHFVS NGDGLVVTVD SESGDVLWIQ NYASPVVAFY VWQREGLRKV MHINVAVETL 180

RYLTFMSGEV GRITKWKYPF PKETEAKSKL TPTLYVGKYS TSLYASPSMV HEGVAVVPRG 240

STLPLLDGPQ TDGVTIGDKG ECVITPSTDL KFDPGLKGKS KLNYLRNYWL LIGHHETPLS 300

ASTKMLERFP NNLPKHRENV IPADSEKKSF EEVISLVDQT TENAPTTVSS GVEEKSARAP 360

AKPEAPVDSM LKDMATIILS TFLLIGWVAF IITYPMSMHQ QQQLQHQQFQ KELEKIQLLQ 420

QQQLPFHGSG DAAQDSELLD ISGPYSESSG TSSPSTSPRA SNHSLCSGSS ASKTSPYLEQ 480

DDEDEETSMV MVGKISFCPK DVLGHGAEGT IVYRGMFDNR DVAVKRILPE CFSFADREVQ 540

LLRESDEHPN VIRYFCTEKD RQFQYIAIEL CAATLQEYVE QKDFAHLGLE PITLLQQTTS 600

GLAHLHSLNI VHRDLKPHNI LLSMPNAHGR IKAMISDFGL CKKLAVGRHS FSRRSGVPGT 660

EGWIAPEMLS EDCKENPTYT VDIFSAGCVF YYVISEGSHP FGKSLQRQAN ILLGAYSLDC 720

FHPEKHEDVI AHELIEKMIA MDPQKRPSAK HVLKHPFFWS LEKQLQFFQD VSDRIEKEPL 780

DGPVVKQLER GGRAVVKMDW RENITVPLQT DLRKFRTYKG GSVRDLLRAM RNKKHHYREL 840

PTEVQETLGS LPDDFVRYFT SRFPHLLLHT YRAMELCGHE RLLQPYYSHE PPEPQPPVTP 900

DTH 903

Nucleotide Sequence
(FASTA)

CCTGCCTTCC TCCCAGATCC CAATGACGGC AGCCTATACA CACTTGGGGG CAAGAATAAT 60

GAAGGTTTGA CAAAACTTCC ATTTACCATC CCAGAGCTGG TGCAGGCATC CCCATGCCGA 120

AGTTCAGATG GAATTCTCTA CATGGGTAAA AAGCAAGACA TCTGGTATGT TATTGACCTT 180

CTCACTGGGG AGAAGCAGCA GACTTTGTCA TCCGCCTTTG CAGACAGTCT GTGCCCATCA 240

ACCTCTCTTC TGTATCTTGG GCGAACAGAA TATACCATCA CCATGTACGA CACCAAAACC 300

CGGGAGCTCC GGTGGAACGC CACCTACTTT GACTACGCAG CCTCGCTGCC TGATGACGAC 360

ATGGACTATA AGATGTCCCA CTTTGTGTCC AATGGCGATG GGCTGGTGGT TACTGTGGAC 420

AGTGAATCCG GGGACGTCCT GTGGATCCAA AACTATGCCT CCCCTGTGGT GGCTTTCTAC 480

GTCTGGCAGC GGGAGGGTCT GCGGAAGGTG ATGCACATCA ACGTCGCCGT GGAAACCTTG 540

CGCTACCTGA CCTTCATGTC GGGGGAGGTG GGGCGCATCA CCAAGTGGAA GTACCCCTTC 600

CCCAAGGAGA CGGAGGCCAA GAGTAAGCTG ACGCCCACCC TGTACGTTGG GAAGTACTCG 660

ACCAGCCTCT ATGCCTCCCC CTCCATGGTG CACGAGGGGG TTGCTGTTGT GCCCCGAGGC 720

AGCACTCTCC CTTTGCTGGA CGGCCCCCAG ACTGATGGCG TCACCATTGG AGACAAAGGG 780

GAGTGTGTGA TCACGCCTAG CACAGACCTC AAGTTTGACC CTGGACTCAA AGGCAAGAGC 840

AAGCTCAACT ACTTGCGGAA TTACTGGCTT CTGATAGGAC ACCATGAGAC CCCGCTGTCT 900

GCATCTACCA AGATGCTGGA GAGATTTCCC AACAATCTGC CCAAGCATCG AGAAAATGTG 960

ATTCCTGCAG ATTCAGAGAA AAAGAGCTTT GAGGAAGTTA TCAGCCTGGT GGACCAGACT 1020

ACAGAAAATG CGCCGACCAC TGTGTCTTCG GGTGTGGAGG AGAAGTCTGC CCGTGCCCCT 1080

GCCAAGCCCG AGGCCCCCGT GGACTCCATG CTGAAGGACA TGGCCACCAT CATCCTGAGC 1140

ACCTTCCTGC TCATCGGCTG GGTGGCCTTC ATCATCACCT ACCCCATGAG CATGCACCAG 1200

CAGCAGCAGC TCCAGCACCA GCAGTTCCAG AAGGAGCTGG AAAAGATCCA GCTCCTGCAG 1260

CAGCAGCAGC TGCCCTTCCA CGGCTCCGGG GATGCTGCCC AGGACAGTGA GCTCCTGGAC 1320

ATATCTGGCC CGTACTCGGA GAGCTCGGGC ACCAGCAGCC CCAGCACATC CCCCAGAGCC 1380

TCCAACCACT CGCTCTGCTC CGGCAGCTCC GCCTCCAAGA CCAGCCCCTA CCTGGAGCAG 1440

GATGACGAGG ATGAGGAAAC CAGCATGGTG ATGGTTGGGA AAATTTCATT CTGTCCTAAA 1500

GACGTCTTGG GCCACGGAGC TGAGGGCACA ATTGTGTACC GGGGCATGTT TGACAACCGA 1560

GATGTGGCAG TGAAGAGGAT CCTCCCCGAG TGCTTCAGCT TCGCAGACCG CGAGGTCCAG 1620

CTGCTACGGG AATCAGACGA GCACCCGAAC GTGATCCGCT ACTTCTGCAC AGAGAAGGAC 1680

CGGCAGTTCC AGTACATTGC CATCGAGCTA TGCGCGGCCA CCCTGCAGGA GTACGTGGAG 1740

CAGAAGGACT TTGCCCACCT CGGCCTGGAG CCCATCACAC TGCTGCAGCA GACCACCTCG 1800

GGGCTGGCCC ACCTCCACTC CCTCAACATC GTTCACAGAG ACCTGAAGCC CCACAACATT 1860

CTCCTGTCCA TGCCCAACGC ACATGGCAGG ATCAAGGCCA TGATCTCCGA CTTTGGCCTC 1920

TGTAAGAAGC TAGCAGTGGG CAGGCACAGC TTCAGCCGCC GTTCTGGGGT GCCTGGCACA 1980

GAGGGCTGGA TTGCCCCAGA GATGCTGAGT GAGGACTGCA AGGAGAACCC TACCTACACG 2040

GTGGACATCT TCTCTGCAGG CTGCGTCTTT TACTATGTGA TCTCTGAGGG CAGCCACCCT 2100

TTCGGCAAGT CCCTGCAGCG GCAAGCCAAC ATCCTCCTGG GTGCCTACAG CCTCGACTGC 2160

TTCCACCCTG AGAAGCACGA AGACGTCATT GCACATGAAC TAATCGAGAA AATGATTGCG 2220

ATGGATCCCC AGAAACGCCC CTCAGCCAAG CACGTGCTCA AACACCCGTT CTTCTGGAGC 2280

CTGGAGAAGC AGCTCCAGTT CTTTCAGGAC GTTAGTGACC GGATAGAAAA GGAACCCCTG 2340

GACGGCCCGG TGGTGAAGCA GCTGGAGCGA GGCGGGAGAG CCGTGGTGAA GATGGACTGG 2400

CGGGAGAACA TCACCGTCCC CCTCCAGACA GATCTGCGTA AATTCAGAAC CTATAAGGGT 2460

GGCTCCGTAA GGGACCTCCT CCGTGCCATG AGAAATAAGA AGCACCACTA CCGGGAGCTT 2520

CCCACGGAGG TACAGGAGAC GCTGGGCTCC CTCCCGGACG ACTTCGTGCG CTACTTCACG 2580

TCACGCTTCC CCCACCTGCT CTTGCACACC TACCGGGCCA TGGAGCTGTG CGGCCACGAG 2640

AGGCTCCTCC AGCCCTACTA CTCCCACGAG CCCCCAGAGC CCCAGCCCCC CGTGACTCCA 2700

GACACCCACT GA 2712

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f+pkdvlG+GaeGt+v+rG+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc

Q: 497   FCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  556

         79**********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         tekdrqf+yia+elcaa+lq+yve+kd++ + +lepi+ll+q++sGlahlhsl+ivhrdl

Q: 557   TEKDRQFQYIAIELCAATLQEYVEQKDFA-HLGLEPITLLQQTTSGLAHLHSLNIVHRDL  615

         *****************************.******************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nil+s+p+a+g+++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++ke

Q: 616   KPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE  675

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++sld++++ek+e+via++li

Q: 676   NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDCFHPEKHEDVIAHELI  735

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         +kmi++dp+krpsak+vlkhp+f

Q: 736   EKMIAMDPQKRPSAKHVLKHPFF  758

         **********************9

Domain Sequence
(FASTA)

FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60

TEKDRQFQYI AIELCAATLQ EYVEQKDFAH LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK 120

PHNILLSMPN AHGRIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN 180

PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAY SLDCFHPEKH EDVIAHELIE 240

KMIAMDPQKR PSAKHVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 4.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013