EKS-OTG-00126

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00126

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	481.4	6.5E-145	1079	1339	261

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003527

UniProt Accession

H0WNV1;

Protein Name

Protein Synonyms/Alias

Hepatocyte growth factor receptor;

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000003961	ENSOGAP00000003527	ENSOGAT00000003964

Organism

Otolemur garnettii

Functional Description

Protein Length

1382

Protein Sequence
(FASTA)

MKASTVLAPG ILALLFTLVQ RSNGECKEAL AMSKMNVDMK YQLPNFTAET PIQNIVLHEH 60

HIYLGAINYI YVLDDKDLQK VAEYKTGPVL EHPDCFPCQD CSDKANLSGG IWKDNVNMAL 120

LVDTYYDDQL ISCGSVNRGA CQRHVLPRNN AADIQSKVHC MFSPQADEEP GQCPDCVVSA 180

LGAKVLLSEK DRFINFFVGN TINSSYFPNH PLHSISVRRL KETQDGFKFL TDQSYIDVLP 240

EFRDSYPIKY VHAFESNHFI YFLTVQRETL DSQTFHTRII RFCSVDSGLH SYMEMPLECI 300

LTEKRRKRST RKEVFNILQA AYVSKPGAHL AKQIGVSVND DILFGVFAQS KPDSAEPMNR 360

SAVCAFPIKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE 420

FTTALQRVDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQIVVSR SGSSTPHVNF 480

HLDSHPVSPE VIVEHTVNQN GYTLVVTGKK ISKIPLNGLG CEHFQSCSQC LSAPPFVQCG 540

WCHDKCVRSE ECPSGSWTQE TCRPAVHKVF PTSAPLEGGT RLTICGWDFG FRRNNKFDLK 600

KTRVLLGNES CTLTLSESTT NTLKCTVGPA MNEHFNMSIV ISNGRETTQY STFSYVDPVI 660

TSISPSYGPK AGGTLLTLIG KYLNSGNSRH ISIGGKTCTL KSVSNSILEC YTPAQIISTE 720

FPVKLKIDLA IREASSFSYQ EDPIVYEIHP MKSFVSGGST ITGVGKNLNS VSVPRMVIHV 780

REAGRNFTVA CQHRSNAEIL CCTTPSLQQL NLQLPLKTKA FFMLDGVLSK YFDLIYVHNP 840

VFKPFEKPVM ISMGNENILE IKGNDIDPEA VKGEVLKVGN KSCENIHSRS EAVLCTVPND 900

LLKLNSELNI EWKQAVSSTV LGKVIVQPDQ NFTGLIVGVV SISIILLLLL GLFLWLKKRK 960

QNKDPGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG 1020

SCRQVQYPLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH 1080

FNEVIGRGHF GCVYHGTLLD NDGKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV 1140

LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200

FVHRDLAARN CMLDENFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260

FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC 1320

WHPKAEMRPS FSELVSRISA IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNIDGEV 1380

DT 1382

Nucleotide Sequence
(FASTA)

ATGAAGGCCT CCACTGTGCT TGCACCTGGC ATCCTTGCAC TTCTGTTTAC CTTGGTACAG 60

CGGAGCAACG GGGAGTGTAA AGAGGCATTA GCAATGTCCA AGATGAACGT GGATATGAAG 120

TATCAGCTTC CCAACTTCAC CGCGGAAACA CCCATTCAGA ATATCGTTCT CCATGAGCAT 180

CACATTTACC TCGGTGCCAT TAACTACATT TACGTGTTAG ATGACAAAGA CCTGCAGAAG 240

GTTGCAGAAT ACAAGACTGG GCCTGTGCTG GAACACCCAG ATTGTTTCCC GTGTCAGGAC 300

TGCAGCGACA AGGCCAATTT ATCAGGTGGC ATTTGGAAAG ATAATGTCAA CATGGCTCTG 360

CTTGTCGACA CCTACTACGA TGACCAACTC ATCAGCTGTG GCAGCGTCAA CAGAGGGGCC 420

TGCCAGCGCC ATGTCCTTCC ACGCAATAAC GCAGCTGACA TACAGTCGAA GGTTCATTGC 480

ATGTTCTCCC CGCAGGCAGA TGAGGAGCCA GGCCAGTGTC CTGACTGTGT GGTGAGTGCC 540

CTGGGAGCCA AAGTCCTCCT GTCTGAAAAG GACCGCTTCA TCAACTTCTT TGTAGGCAAT 600

ACCATAAATT CTTCTTATTT TCCAAATCAT CCATTGCATT CAATATCAGT TAGAAGGCTA 660

AAGGAAACAC AGGATGGTTT TAAGTTTTTG ACGGACCAGT CCTATATTGA TGTTTTACCT 720

GAGTTCCGAG ACTCTTACCC CATTAAGTAT GTCCATGCCT TTGAAAGCAA CCATTTTATT 780

TACTTTCTGA CCGTCCAAAG GGAAACTCTG GACTCTCAGA CTTTTCATAC TCGAATAATC 840

AGGTTCTGTT CCGTAGACTC TGGGCTGCAT TCGTACATGG AAATGCCCCT GGAGTGTATT 900

CTCACCGAAA AGAGAAGAAA GAGATCCACA AGGAAGGAAG TATTCAACAT CCTCCAAGCT 960

GCATACGTCA GTAAGCCTGG GGCCCACCTT GCCAAGCAGA TAGGAGTCAG TGTGAATGAT 1020

GACATTCTTT TTGGGGTGTT CGCACAAAGC AAGCCAGATT CTGCTGAACC GATGAATCGA 1080

TCAGCCGTCT GTGCATTCCC TATCAAATAC GTCAATGAAT TCTTCAACAA GATTGTCAAC 1140

AAAAACAATG TGAGATGCCT CCAACATTTT TATGGACCAA ATCATGAGCA CTGCTTTAAC 1200

AGGACACTTC TAAGAAATTC ATCAGGCTGT GAAGTACGCA GTGATGAATA TCGGACAGAG 1260

TTTACCACAG CTCTGCAACG TGTCGACTTA TTCATGGGCC AATTCAACCA AGTCCTCTTA 1320

ACATCTATAT CTACTTTCAT TAAAGGCGAC CTCACCATTG CTAATCTTGG GACATCAGAG 1380

GGTCGCTTCA TGCAGATTGT GGTTTCTCGA TCCGGATCCT CAACCCCTCA TGTGAACTTT 1440

CACCTGGATT CCCACCCTGT GTCTCCAGAA GTGATCGTGG AGCACACAGT GAACCAGAAT 1500

GGCTACACGC TGGTTGTCAC CGGGAAGAAG ATCTCCAAGA TCCCACTGAA TGGCTTGGGC 1560

TGCGAACATT TCCAGTCCTG CAGTCAGTGT CTGTCCGCTC CTCCCTTTGT CCAGTGTGGC 1620

TGGTGCCACG ATAAATGTGT GCGATCAGAG GAATGCCCCA GCGGGTCGTG GACGCAAGAG 1680

ACCTGCCGGC CTGCGGTCCA CAAGGTTTTC CCAACTAGCG CACCCCTGGA AGGGGGAACG 1740

AGGCTGACTA TATGTGGCTG GGACTTTGGA TTCCGGAGGA ATAATAAATT TGACTTAAAG 1800

AAAACCAGAG TTCTCCTTGG AAATGAGAGC TGTACCTTGA CCTTGAGTGA GAGCACCACA 1860

AACACATTGA AATGCACAGT TGGTCCTGCA ATGAATGAGC ACTTCAATAT GTCCATAGTT 1920

ATTTCAAATG GTCGGGAGAC CACACAATAT AGTACATTTT CCTATGTGGA TCCCGTAATC 1980

ACAAGTATTT CTCCGAGTTA TGGTCCTAAG GCCGGTGGTA CTTTACTTAC GTTAATTGGA 2040

AAGTACCTAA ACAGTGGGAA TTCGAGACAC ATTTCAATTG GTGGAAAAAC ATGTACTTTA 2100

AAAAGTGTGT CAAATAGTAT TCTTGAATGT TATACCCCTG CCCAAATCAT TTCAACTGAG 2160

TTTCCTGTTA AATTGAAAAT TGACTTAGCC ATCCGAGAGG CGAGCAGCTT CAGTTACCAG 2220

GAAGATCCCA TCGTCTATGA AATTCATCCA ATGAAATCTT TTGTTAGTGG TGGGAGCACA 2280

ATAACAGGTG TTGGAAAAAA CCTGAATTCT GTTAGTGTGC CCAGGATGGT GATACATGTG 2340

CGTGAAGCAG GAAGGAACTT TACAGTGGCG TGTCAGCATC GCTCTAATGC AGAGATCCTC 2400

TGCTGCACCA CTCCTTCACT GCAACAGCTG AATCTGCAAC TCCCCCTCAA AACCAAAGCC 2460

TTTTTCATGT TAGACGGGGT TCTTTCCAAA TACTTTGATC TCATTTATGT ACATAATCCT 2520

GTGTTTAAGC CTTTTGAAAA GCCAGTGATG ATCTCAATGG GCAATGAAAA TATCCTGGAA 2580

ATTAAGGGAA ATGATATTGA CCCCGAAGCA GTTAAAGGTG AAGTGTTAAA AGTTGGAAAT 2640

AAGAGCTGTG AGAACATACA CTCACGTTCT GAAGCTGTTT TATGTACGGT CCCCAATGAC 2700

CTGCTGAAAT TGAACAGCGA GCTAAATATA GAGTGGAAGC AAGCAGTTTC TTCAACCGTC 2760

CTTGGAAAAG TAATAGTTCA ACCAGATCAG AATTTCACAG GGTTGATTGT TGGTGTTGTC 2820

TCAATATCAA TAATACTCTT ATTACTACTG GGACTTTTCC TGTGGCTGAA AAAAAGAAAG 2880

CAAAACAAAG ATCCAGGCAG TGAATTAGTT CGCTATGATG CAAGAGTACA CACTCCTCAT 2940

CTGGATAGGC TTGTAAGTGC CCGAAGTGTA AGCCCAACTA CAGAAATGGT GTCAAATGAA 3000

TCTGTAGACT ACCGAGCTAC TTTTCCAGAA GACCAGTTTC CTAACTCATC TCAGAATGGA 3060

TCATGCAGAC AAGTGCAGTA TCCTCTCACA GACTTGTCCC CCATCCTAAC TAGCGGGGAC 3120

TCTGATATAT CCAGTCCATT ACTGCAAAAT ACTGTCCACA TTGACCTCAG TGCTCTAAAT 3180

CCAGAGCTAG TCCAGGCAGT CCAGCACGTC GTGATTGGGC CCAGTAGCCT GATTGTGCAT 3240

TTCAATGAAG TCATAGGAAG AGGCCATTTT GGTTGTGTGT ATCACGGGAC TTTGTTGGAC 3300

AATGATGGCA AGAAAATTCA CTGTGCTGTG AAATCCTTGA ATAGAATCAC TGACATAGGA 3360

GAAGTTTCCC AGTTTCTGAC TGAAGGAATC ATCATGAAAG ATTTTAGCCA TCCCAACGTC 3420

CTATCGCTCT TGGGAATCTG CCTGCGCAGT GAAGGCTCTC CCCTGGTGGT CCTGCCATAC 3480

ATGAAACACG GAGACCTTCG AAATTTCATT CGAAATGAGA CTCATAACCC AACTGTAAAA 3540

GATCTTATTG GCTTTGGTCT TCAAGTAGCC AAAGGCATGA AATATCTTGC AAGCAAAAAG 3600

TTTGTGCACA GAGACTTGGC TGCAAGAAAC TGCATGCTGG ATGAGAATTT CACTGTCAAA 3660

GTTGCTGACT TTGGCCTTGC CAGAGACATG TATGATAAAG AATACTACAG TGTACATAAC 3720

AAGACAGGTG CCAAGCTGCC CGTGAAGTGG ATGGCTCTGG AAAGTCTGCA GACGCAGAAG 3780

TTCACCACCA AGTCAGACGT GTGGTCCTTT GGTGTGCTCC TCTGGGAGCT GATGACGAGA 3840

GGAGCCCCAC CTTACCCTGA CGTCAACACC TTCGATATAA CTGTTTACTT GTTACAAGGC 3900

AGAAGGCTCT TACAACCCGA ATACTGCCCA GACCCCTTGT ATGAAGTGAT GCTAAAATGC 3960

TGGCACCCTA AAGCCGAAAT GCGCCCATCC TTTTCTGAAC TGGTCTCTAG GATATCGGCA 4020

ATCTTCTCTA CTTTCATCGG AGAACACTAC GTCCATGTGA ATGCTACTTA TGTGAATGTG 4080

AAATGTGTTG CTCCATATCC CTCTCTGCTG TCATCGCAAG ATAACATCGA TGGTGAGGTG 4140

GACACATGA 4149

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1079  VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1138

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1139  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+lde++tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1199  KKFVHRDLAARNCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1258

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm

Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1317

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1318  LKCWHPKAEMRPSFSELVSRIS  1339

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDENFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013