EKS-OTG-00166

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00166

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	496.2	1.8E-149	456	713	258

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003544

UniProt Accession

H0WNW3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000003977	ENSOGAP00000003544	ENSOGAT00000003982

Organism

Otolemur garnettii

Functional Description

Protein Length

773

Protein Sequence
(FASTA)

TGGLGAAEAL GSSTWDPGTR EAAKPGSPEE HRLSGGGAMP LAQLKEPWPL MELVPLDPEN 60

GQTSGEEARL QPSKDEGILK EIAITHHVKA GSEKADPSHF ELLKVLGQGS FGKVFLVRKV 120

TRPDSGHLYA MKVLKKATLK VRDRVRTKME RDILADVNHP FVVKLHYAFQ TEGKLYLILD 180

FLRGGDLFTR LSKEVMFTEE DVKFYLAELA LGLDHLHSLG IIYRDLKPEN ILLDEEGHIK 240

LTDFGLSKEA IDHEKKAYSF CGTVEYMAPE VVNRQGHTHS ADWWSYGVLM FEMLTGSLPF 300

QGKDRKETMT LILKAKLGMP QFLSTEAQSL LRALFKRNPA NRLGSGPDGA EEIKRHVFYS 360

TIDWNKLYRR EIKPPFKPAV AQPDDTFYFD TEFTSRTPRD SPGIPPSAGA HQLFRGFSFV 420

ATGLMEDDSK PRATQAPLNS VVQQLHGKNL VFSDGYVVKE TIGVGSYSVC KRCVHKATNM 480

EYAVKVIDKS KRDPSEEIEI LLRYGQHPNI ITLKDVYDDG KHVYLVTELM RGGELLDKIL 540

RQKFFSEREA SCVLHTISKT VEYLHSQGVV HRDLKPSNIL FVDESGNPEC LRICDFGFAK 600

QLRAENGLLM TPCYTANFVA PEVLKRQGYD EGCDIWSLGI LLYTMLAGYT PFANGPSDTP 660

EEILTRIGSG KFTLSGGNWN TVSETAKDLV SKMLHVDPHQ RLTAKQVLQH PWITQKDKLP 720

QSQLSHQDLQ LVKGAMAATY SALNSSKPTP QLKPIESSIL AQRRVRKLPS TTL 773

Nucleotide Sequence
(FASTA)

ACTGGGGGCT TGGGGGCCGC GGAGGCTCTG GGGAGCAGCA CCTGGGACCC CGGCACCCGG 60

GAGGCGGCGA AGCCGGGGTC TCCGGAGGAA CACCGGCTGT CCGGCGGCGG CGCGATGCCG 120

CTCGCCCAGC TCAAGGAGCC CTGGCCGCTC ATGGAGCTAG TGCCGCTGGA CCCGGAGAAT 180

GGACAGACCT CAGGGGAAGA AGCTAGACTT CAGCCATCAA AGGATGAGGG CATCCTCAAG 240

GAGATCGCCA TCACACATCA TGTCAAGGCT GGCTCTGAGA AGGCCGATCC ATCCCACTTT 300

GAGCTCCTCA AAGTTCTGGG CCAGGGATCC TTTGGCAAAG TCTTCCTGGT GCGGAAGGTC 360

ACCCGGCCTG ACAGTGGGCA CCTGTATGCC ATGAAGGTGC TGAAGAAGGC GACCCTGAAA 420

GTGCGTGACC GTGTTCGGAC CAAGATGGAG AGAGACATCC TGGCTGATGT AAACCACCCG 480

TTTGTGGTGA AGTTGCACTA TGCCTTCCAG ACCGAGGGCA AGCTCTATCT CATTCTGGAC 540

TTCCTGCGTG GGGGAGACCT CTTCACACGG CTCTCAAAAG AGGTTATGTT CACGGAGGAG 600

GACGTGAAGT TTTACCTGGC CGAGCTGGCT TTGGGCCTGG ACCACCTGCA CAGCCTGGGA 660

ATCATTTATA GAGACCTTAA GCCTGAGAAC ATCCTTCTGG ATGAAGAGGG CCACATCAAG 720

CTCACAGACT TTGGCCTGAG CAAGGAGGCC ATTGACCACG AGAAGAAGGC CTACTCCTTC 780

TGTGGGACAG TGGAGTACAT GGCCCCTGAG GTCGTCAACC GCCAGGGCCA CACCCACAGT 840

GCAGACTGGT GGTCCTATGG GGTGTTGATG TTTGAGATGC TGACAGGCTC CCTGCCCTTC 900

CAGGGGAAGG ACCGGAAAGA GACCATGACG CTAATTCTGA AGGCAAAGCT GGGCATGCCC 960

CAGTTTCTGA GCACGGAAGC CCAGAGCCTT CTGCGGGCCC TGTTCAAGCG GAATCCTGCC 1020

AACCGGCTCG GCTCCGGCCC TGATGGGGCA GAGGAAATCA AACGGCATGT CTTCTACTCC 1080

ACCATTGACT GGAATAAGCT TTACCGTCGT GAGATCAAGC CTCCTTTTAA GCCAGCTGTG 1140

GCTCAGCCTG ATGACACCTT CTACTTTGAC ACTGAGTTCA CGTCCCGCAC ACCCAGGGAT 1200

TCTCCCGGCA TCCCCCCCAG TGCTGGTGCC CATCAACTCT TTCGTGGCTT CAGCTTTGTG 1260

GCCACTGGCC TGATGGAGGA TGACAGCAAG CCTCGAGCCA CCCAGGCGCC ACTGAACTCA 1320

GTGGTGCAGC AACTCCATGG GAAGAACCTG GTTTTTAGCG ACGGCTACGT GGTAAAAGAA 1380

ACAATCGGTG TGGGCTCCTA CTCTGTGTGC AAGCGCTGTG TCCACAAGGC CACCAACATG 1440

GAGTATGCTG TCAAGGTCAT CGACAAGAGC AAGCGGGATC CCTCAGAAGA GATAGAAATT 1500

CTTCTGCGGT ACGGGCAGCA CCCCAACATC ATCACTTTGA AAGATGTGTA CGATGATGGC 1560

AAGCACGTGT ACCTGGTGAC GGAGCTGATG CGGGGTGGGG AGCTGCTGGA CAAGATCTTA 1620

CGGCAGAAGT TCTTCTCTGA GCGGGAGGCC AGCTGTGTCT TGCACACCAT CAGCAAGACC 1680

GTGGAGTATC TACACTCACA GGGGGTTGTG CACAGGGACC TCAAGCCCAG CAACATCCTG 1740

TTCGTGGACG AGTCCGGGAA TCCCGAGTGC CTACGCATCT GTGACTTCGG CTTTGCCAAA 1800

CAGCTGCGGG CTGAGAATGG GCTCCTCATG ACACCTTGCT ACACAGCCAA CTTCGTGGCA 1860

CCCGAGGTGC TGAAGCGCCA GGGCTATGAT GAAGGGTGTG ACATCTGGAG CCTCGGTATT 1920

CTGCTCTACA CCATGCTGGC GGGATACACT CCGTTTGCCA ATGGGCCCAG TGACACACCA 1980

GAGGAAATCC TGACCCGGAT CGGCAGTGGG AAGTTTACGC TCAGTGGAGG AAACTGGAAC 2040

ACAGTTTCAG AGACAGCCAA GGACCTGGTA TCTAAGATGT TGCACGTGGA TCCCCACCAG 2100

CGCCTCACAG CCAAGCAGGT CCTGCAGCAC CCATGGATCA CCCAGAAAGA CAAGCTTCCC 2160

CAGAGCCAGC TGTCCCACCA GGACCTGCAG CTTGTGAAGG GAGCCATGGC AGCCACATAC 2220

TCTGCACTCA ACAGCTCCAA GCCTACCCCC CAGCTGAAGC CCATTGAGTC ATCTATCCTG 2280

GCCCAGCGGC GAGTGAGGAA GCTGCCATCC ACCACCCTGT GA 2322

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke++GvGsysvckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 456   YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  515

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgk+vylv+el++GGelld+i+++kffsereas +l+t++k+veylh+qGvvhrdlk

Q: 516   VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASCVLHTISKTVEYLHSQGVVHRDLK  575

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nil+vdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+

Q: 576   PSNILFVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  635

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vse+akdlvsk+l+

Q: 636   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH  695

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 696   VDPHQRLTAKQVLQHPWI  713

         *****************8

Domain Sequence
(FASTA)

YVVKETIGVG SYSVCKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKHVYL VTELMRGGEL LDKILRQKFF SEREASCVLH TISKTVEYLH SQGVVHRDLK 120

PSNILFVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGSGKFTLS GGNWNTVSET AKDLVSKMLH 240

VDPHQRLTAK QVLQHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013