EKS-OTG-00287

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00287

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	6.1E-126	195	481	287

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003581

UniProt Accession

H0WNZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000004021	ENSOGAP00000003581	ENSOGAT00000004023

Organism

Otolemur garnettii

Functional Description

Protein Length

516

Protein Sequence
(FASTA)

ATGAALVFFL FILNCYFYNF TGAILGRSET QECLFFNANW EKDKSNQTGV EPCYGDKDKR 60

RHCFATWKNI SGSIEIVKQG CWLDDINCYD RTDCVEKKDS PEVYFCCCEG NMCNEKFFYF 120

PEMEVTQPTS NPVTPKPPYY NILLYSLVPL MLIAGIVICA FWVYRHHKMA YPPVLVPTQD 180

PGPPPPSPLL GLKPLQLLEV KARGRFGCVW KAQLLNEYVA VKIFPIQDKQ SWQNEYEVYS 240

LPGMKHENIL QFIGAEKRGT SVDVDLWLIT AFHEKGSLSD FLKANVVSWN ELCHIAETMA 300

RGLAYLHEDI PGLKDGHKPA ISHRDIKSKN VLLKNNLTAC IADFGLALKF EAGKSAGDTH 360

GQVGTRRYMA PEVLEGAINF QRDAFLRIDM YAMGLVLWEL ASRCTAADGP VDEYMLPFEE 420

EIGQHPSLED MQEVVVHKKK RPVLRDYWQK HAGMAMLCET IEECWDHDAE ARLSAGCVGE 480

RITQMQRLTN IITTEDIVTV VTMVTNVDFP PKESSL 516

Nucleotide Sequence
(FASTA)

GCCACAGGTG CTGCCCTGGT TTTCTTTCTT TTTATATTAA ATTGTTATTT TTATAATTTT 60

ACAGGTGCTA TACTTGGTAG ATCCGAAACT CAGGAGTGTC TTTTCTTTAA TGCTAATTGG 120

GAAAAAGACA AAAGCAATCA GACTGGTGTT GAACCCTGTT ACGGTGACAA AGATAAACGG 180

CGACATTGTT TTGCTACCTG GAAGAATATT TCTGGTTCCA TTGAAATAGT GAAACAAGGT 240

TGCTGGTTAG ATGATATCAA CTGCTATGAC AGGACTGATT GTGTAGAAAA AAAAGACAGC 300

CCTGAAGTAT ATTTTTGTTG CTGTGAGGGC AATATGTGTA ATGAAAAATT TTTTTATTTC 360

CCTGAGATGG AAGTCACACA GCCCACTTCA AATCCAGTTA CACCTAAGCC ACCCTATTAT 420

AACATCCTAC TTTATTCCTT GGTGCCACTT ATGTTAATTG CGGGGATTGT CATTTGTGCA 480

TTTTGGGTGT ACAGGCATCA CAAGATGGCC TACCCTCCTG TACTTGTTCC AACTCAAGAC 540

CCAGGACCAC CTCCACCTTC TCCATTACTA GGTTTGAAGC CCCTGCAGTT ATTAGAAGTT 600

AAAGCAAGGG GACGATTTGG TTGTGTCTGG AAAGCCCAAT TACTCAATGA ATATGTGGCT 660

GTCAAAATAT TTCCAATACA GGACAAACAG TCATGGCAAA ATGAATATGA AGTCTATAGT 720

TTGCCTGGAA TGAAGCACGA GAACATATTA CAGTTCATTG GTGCAGAAAA ACGAGGCACC 780

AGTGTTGATG TGGATCTTTG GCTGATAACA GCATTTCATG AAAAGGGTTC TCTGTCAGAC 840

TTTCTTAAGG CTAATGTGGT CTCTTGGAAC GAACTGTGTC ATATTGCAGA AACCATGGCT 900

AGAGGACTGG CGTATTTACA TGAGGATATA CCTGGCCTGA AAGATGGGCA CAAACCTGCC 960

ATATCTCACA GGGACATCAA AAGTAAAAAT GTACTATTGA AAAACAATCT GACAGCTTGT 1020

ATTGCTGACT TTGGGTTGGC GTTAAAATTT GAGGCGGGCA AGTCTGCAGG TGATACTCAT 1080

GGACAGGTTG GTACCCGGAG GTATATGGCT CCAGAGGTAT TAGAGGGTGC TATAAACTTC 1140

CAAAGAGATG CATTTTTGAG GATAGATATG TACGCCATGG GATTAGTCCT GTGGGAACTG 1200

GCTTCTCGCT GTACTGCTGC AGATGGACCT GTAGATGAGT ACATGTTGCC ATTTGAGGAA 1260

GAAATTGGCC AGCATCCATC TCTTGAAGAC ATGCAGGAAG TTGTTGTGCA TAAAAAAAAG 1320

AGGCCCGTTT TAAGAGATTA TTGGCAGAAA CATGCTGGAA TGGCAATGCT CTGTGAAACG 1380

ATAGAAGAAT GTTGGGATCA CGATGCAGAA GCCAGATTAT CAGCTGGATG TGTAGGTGAA 1440

AGAATTACCC AGATGCAAAG ACTAACAAAT ATTATTACCA CAGAGGACAT TGTAACAGTG 1500

GTCACAATGG TGACAAATGT TGACTTTCCT CCCAAAGAAT CTAGTCTATG A 1551

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 195   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  254

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 255   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  314

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 315   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  372

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 373   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  431

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 432   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  481

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013