EKS-OTG-00181
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00181
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC434.91.1E-130350604255
StatusUnreviewed
Ensembl ProteinENSOGAP00000003592
UniProt AccessionH0WP04;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCD
Gene Synonyms/Alias PRKCD;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000004030ENSOGAP00000003592ENSOGAT00000004034
OrganismOtolemur garnettii
Functional Description
Protein Length677
Protein Sequence
(FASTA)
MAPFLRIAFN SYELGTLQAE DEASQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD 60
AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120
FLEDGDCKQS MRSEDEAKFP TMNRRGAIKQ AKIHCIKNHE FIATFFGQPT FCSVCKEFVW 180
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFKIDMP HRFKVHNYMS 240
PTFCDHCGSL LWGLVKQGQK CEDCGMNVHH KCQEKVANLC GINQKLLAEA LNQVTQRASR 300
KAEPASSEPV GIYQGFEKKP GISGDDSLDN NGTYGKIWEG RPEKCKINNF TFHKVLGKGS 360
FGKVLLAELK SNGQYFAIKT LKKDVVLIDD DVECTMVEKR VLALAGENPF LTHLICTFQT 420
KDHLFFVMEF LNGGDLMFHI QDKGRFELYR ATFYAAEIIC GLQFLHSKGI IYRDLKLDNV 480
MLDLDGHIKI ADFGMCKENI FGENLASTFC GTPDYIAPEI LQGLKYSFSV DWWSFGVLLY 540
EMLIGQSPFH GDDEDELFES IRVDTPHYPR WITKESKDIL EKLFERDPNK RLGVTGNIRL 600
HPFFKTINWS LLEKRKIEPP FKPKVKSPKD YSNFDQEFLN EKPRLSFSDK TLIDSMDQSA 660
FEGFSFVNPK FERLLER 677
Nucleotide Sequence
(FASTA)
ATGGCACCAT TCTTACGCAT CGCCTTCAAT TCCTATGAAC TGGGTACCCT GCAGGCCGAG 60
GACGAGGCGA GCCAGCCCTT CTGTGCTGTA AAGATGAAGG AAGCACTCAG CACAGAACGC 120
GGCAAGACAC TGGTACAGAA GAAGCCTACC ATGTATCCTG AGTGGAAGTC GACATTTGAT 180
GCCCATATCT ATGAAGGCCG AGTCATTCAG ATTGTCCTGA TGAGGGCAGC TGAGGAGCCA 240
GTGTCTGAGG TGACTGTGGG CGTGTCTGTG CTGGCCGAGC GCTGCAAGAA GAACAATGGC 300
AAGGCCGAGT TCTGGCTGGA CCTGCAGCCT CAGGCCAAGG TGTTGATGTC TGTGCAGTAC 360
TTCCTGGAGG ACGGGGATTG CAAGCAGTCT ATGCGCAGTG AAGACGAGGC CAAGTTCCCA 420
ACAATGAACC GCCGTGGAGC CATCAAACAG GCCAAAATCC ACTGTATCAA GAACCATGAG 480
TTTATCGCCA CCTTCTTTGG GCAGCCCACC TTCTGTTCTG TGTGCAAAGA ATTTGTCTGG 540
GGTCTCAACA AGCAAGGCTA CAAATGCAGG CAATGCAATG CTGCCATCCA CAAGAAATGC 600
ATCGACAAGA TCATCGGCCG GTGCACGGGC ACTGCAGCCA ACAGCCGGGA CACCATATTC 660
CAGAAAGAAC GCTTCAAAAT CGACATGCCG CACCGGTTCA AGGTTCACAA CTACATGAGC 720
CCAACCTTCT GTGACCACTG TGGCAGCCTG CTCTGGGGAC TGGTGAAGCA GGGACAAAAG 780
TGTGAAGACT GTGGCATGAA CGTGCACCAT AAATGCCAGG AGAAGGTGGC CAACCTCTGT 840
GGCATCAACC AGAAGCTCTT GGCGGAGGCC TTAAACCAAG TCACCCAGAG AGCTTCACGG 900
AAAGCAGAAC CAGCATCTTC CGAGCCTGTT GGCATATACC AGGGTTTTGA GAAGAAGCCA 960
GGAATCTCTG GTGATGATTC CCTAGACAAC AATGGGACCT ACGGCAAGAT CTGGGAAGGC 1020
AGACCTGAGA AGTGCAAGAT CAATAACTTC ACCTTCCACA AGGTCCTGGG CAAAGGCAGC 1080
TTTGGGAAGG TGCTGCTTGC AGAGCTGAAG AGCAACGGAC AGTACTTTGC TATCAAGACC 1140
CTAAAGAAAG ATGTGGTTCT AATTGATGAC GATGTGGAGT GTACCATGGT AGAGAAGCGA 1200
GTGCTGGCGC TTGCAGGGGA GAATCCCTTT CTCACTCACC TCATCTGCAC CTTCCAGACC 1260
AAGGACCACC TGTTCTTCGT GATGGAGTTC CTCAATGGAG GGGATCTGAT GTTCCACATC 1320
CAGGACAAAG GCCGCTTTGA GCTCTACCGT GCCACGTTTT ATGCAGCTGA GATAATCTGT 1380
GGACTTCAGT TTCTGCACAG CAAGGGGATC ATTTACAGGG ACCTCAAATT GGACAACGTG 1440
ATGCTGGACC TGGATGGTCA CATCAAGATT GCTGACTTTG GGATGTGCAA AGAGAACATA 1500
TTTGGGGAGA ACCTGGCCAG CACCTTCTGT GGCACCCCTG ACTATATTGC CCCTGAGATC 1560
CTACAGGGCC TGAAGTACTC ATTCTCTGTG GACTGGTGGT CCTTTGGGGT CCTCCTCTAT 1620
GAAATGCTCA TTGGTCAGTC CCCATTCCAT GGTGATGATG AGGATGAACT CTTCGAGTCC 1680
ATACGTGTGG ACACGCCACA CTATCCCCGC TGGATCACCA AGGAGTCCAA AGACATCCTG 1740
GAGAAGCTAT TTGAAAGGGA CCCAAACAAG AGGCTGGGAG TGACAGGAAA CATCAGACTC 1800
CACCCCTTCT TCAAGACCAT CAATTGGAGT TTGCTGGAAA AGCGGAAGAT AGAGCCACCC 1860
TTCAAGCCCA AAGTGAAGTC CCCCAAAGAC TACAGCAACT TTGACCAGGA GTTCCTGAAT 1920
GAGAAGCCAC GCCTCTCCTT CAGTGACAAG ACCCTCATCG ACTCCATGGA CCAGTCTGCA 1980
TTTGAAGGCT TCTCCTTTGT AAACCCCAAA TTCGAGCGTC TCCTAGAACG TTGA 2034
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kvlGkGsfgkvllaelk++ +++aik lkkdvvl dddve+t+vekrvlala ++p
Q: 350   FTFHKVLGKGSFGKVLLAELKSNGQYFAIKTLKKDVVLIDDDVECTMVEKRVLALAGENP  409
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl++l+++fqt+d+lffv+e++nGGdlmfhiq++++++  ra+fyaaeii++l+flh+kg
Q: 410   FLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKG  469
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld +Ghik+adfG+cke+i+ ++ +stfcGtPdyiaPeil++ +y++s
Q: 470   IIYRDLKLDNVMLDLDGHIKIADFGMCKENIFGENLASTFCGTPDYIAPEILQGLKYSFS  529
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++l+++dp+
Q: 530   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFERDPN  589
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  +i+ h+ff
Q: 590   KRLGV--TG--NIRLHPFF  604
         *****..56..79999998
Domain Sequence
(FASTA)
FTFHKVLGKG SFGKVLLAEL KSNGQYFAIK TLKKDVVLID DDVECTMVEK RVLALAGENP 60
FLTHLICTFQ TKDHLFFVME FLNGGDLMFH IQDKGRFELY RATFYAAEII CGLQFLHSKG 120
IIYRDLKLDN VMLDLDGHIK IADFGMCKEN IFGENLASTF CGTPDYIAPE ILQGLKYSFS 180
VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDTPHYP RWITKESKDI LEKLFERDPN 240
KRLGVTGNIR LHPFF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00166
EKS-ANC-00168
EKS-BOT-00176
EKS-CAE-00133
EKS-CAJ-00179
EKS-CAF-00183
EKS-CAP-00173
EKS-CIS-00207
EKS-DAR-00469
EKS-DRM-00086
EKS-EQC-00174
EKS-FEC-00164
EKS-GAM-00094
EKS-GAG-00150
EKS-GAA-00213
EKS-GOG-00175
EKS-HOS-00182
EKS-ICT-00169
EKS-LAC-00183
EKS-LOA-00173
EKS-MAM-00172
EKS-MEG-00108
EKS-MOD-00172
EKS-MUM-00180
EKS-MYL-00181
EKS-NOL-00169
EKS-OCP-00109
EKS-ORN-00221
EKS-ORC-00160
EKS-ORL-00208
EKS-PAT-00166
EKS-PES-00154
EKS-PEM-00089
EKS-POA-00169
EKS-RAN-00172
EKS-SAH-00166
EKS-SUS-00150
EKS-TAG-00204
EKS-TAR-00227
EKS-TEN-00221
EKS-XET-00163
EKS-XIM-00214
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013