EKS-OTG-00286

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00286

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	432.8	5.7E-130	205	492	288

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003648

UniProt Accession

H0WP57;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVRL1

Gene Synonyms/Alias

ACVRL1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000004094	ENSOGAP00000003648	ENSOGAT00000004095

Organism

Otolemur garnettii

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

MILGCPRKGF LMLLMALGLT CGDPMKPSQG PLVTCTCDNP YCRGPTCQGA WCTVVLVREA 60

GKQLHEERGC GSLNHEPCKG HPTEFVHHHC CYSHLCNHNV SLQLKATQTP SEQPREDDQL 120

PLLLILSPML ALLALVALGA LGLWHVRRKQ EKQQGLHSKL GESSLILKSS EKGDSMFEDI 180

LDSDCTTGSG SGLPFLVQRT VARQVTLVEC VGKGRYGEVW RGLWHGESVA IKIFSSRDEQ 240

SWFRETEIYN TVLLRHDNIL GFIASDMTSR NSSTQLWLIT HYHEHGSLYD FLQRQTLEPQ 300

LALRLAVSAA CGLAHLHVEI FGTQGKPAIA HRDLKSRNVL VKSNLQCCIA DLGLAVMHSQ 360

GSDYLDIGNN PRVGTKRYMA PEVLDEQIRT DCFESYKWTD IWAFGLVLWE IARRTIVNGI 420

VEDYRPPFYD VVPNDPSFED MRKVVCVDQQ TPTIPNRLAA DPVLSGLAQM MRECWYPNPS 480

ARLTALRIKK TLQKISNSPE KPKVIH 506

Nucleotide Sequence
(FASTA)

ATGATATTGG GCTGCCCCAG GAAGGGTTTT CTGATGCTAC TGATGGCCTT GGGCCTGACC 60

TGTGGTGACC CCATGAAGCC CTCTCAGGGC CCGCTGGTGA CCTGCACGTG TGATAACCCG 120

TATTGCAGGG GGCCTACCTG CCAGGGGGCT TGGTGCACAG TAGTGCTGGT ACGGGAGGCA 180

GGCAAACAGC TCCATGAAGA GCGGGGCTGT GGGAGCCTGA ACCATGAGCC CTGCAAGGGA 240

CACCCCACTG AGTTCGTCCA CCACCACTGC TGCTACAGCC ACCTCTGCAA CCACAACGTA 300

TCCCTGCAAC TGAAGGCCAC CCAAACTCCT TCGGAGCAGC CAAGAGAAGA TGACCAGCTG 360

CCTCTGCTTC TGATCCTGAG CCCCATGCTG GCCTTGCTGG CCCTGGTGGC CCTGGGTGCC 420

CTGGGCCTGT GGCATGTCCG GCGAAAGCAG GAGAAGCAGC AGGGCCTGCA CAGCAAGCTG 480

GGAGAGTCCA GCCTCATCCT CAAGTCATCT GAGAAGGGGG ACAGCATGTT TGAGGACATC 540

CTGGACAGTG ACTGCACCAC AGGCAGTGGC TCAGGGCTCC CCTTCCTGGT GCAGAGGACA 600

GTGGCACGGC AGGTCACCCT GGTGGAATGT GTGGGAAAGG GCCGCTATGG TGAGGTGTGG 660

CGTGGCTTGT GGCATGGTGA GAGTGTGGCC ATCAAGATCT TCTCCTCGAG GGATGAACAG 720

TCCTGGTTCC GGGAGACTGA GATCTATAAC ACCGTGCTGC TCAGACATGA CAACATTCTA 780

GGCTTCATCG CATCAGATAT GACCTCCCGC AACTCTAGCA CGCAGCTGTG GCTCATCACG 840

CACTACCACG AACACGGCTC GCTCTACGAC TTTCTGCAGA GGCAGACGCT AGAGCCCCAG 900

CTGGCCTTGA GGCTTGCTGT GTCGGCGGCC TGTGGCCTGG CACACCTGCA CGTGGAGATC 960

TTTGGCACAC AGGGCAAACC AGCCATCGCT CACCGCGACC TCAAGAGCCG CAATGTGCTG 1020

GTCAAGAGCA ACCTGCAGTG CTGCATCGCA GACCTGGGTC TGGCTGTGAT GCACTCCCAG 1080

GGTAGTGATT ACCTGGACAT TGGCAACAAC CCAAGAGTGG GCACCAAGCG GTACATGGCA 1140

CCTGAGGTGT TAGACGAACA GATTCGCACT GACTGCTTTG AGTCCTACAA GTGGACCGAC 1200

ATCTGGGCCT TTGGCCTGGT GCTGTGGGAG ATCGCCCGCC GGACCATTGT CAATGGCATT 1260

GTGGAGGACT ACAGACCACC CTTCTATGAC GTGGTGCCCA ATGACCCGAG CTTTGAGGAC 1320

ATGCGGAAGG TGGTGTGTGT TGATCAGCAG ACCCCCACCA TTCCTAACCG GCTGGCTGCA 1380

GACCCGGTCC TCTCAGGCCT GGCTCAGATG ATGCGGGAGT GCTGGTACCC CAACCCCTCT 1440

GCCCGACTCA CTGCGCTGAG GATCAAGAAG ACACTACAGA AAATCAGCAA CAGTCCAGAG 1500

AAGCCCAAAG TGATCCACTA A 1521

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+e++gkGrygeVw++ ++ge+vA+Kifs++de+sw+rE+eiy+tvllrh+nil+fia

Q: 205   VTLVECVGKGRYGEVWRGLWHGESVAIKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA  264

         5899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+

Q: 265   SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlks+N+lvk++l+cciaDlGLa+++++ ++ ld+ +n +vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf++vv++dPs+e+m

Q: 383   VLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIV-NGIVEDYRPPFYDVVPNDPSFEDM  441

         *********************************99.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l

Q: 442   RKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

VTLVECVGKG RYGEVWRGLW HGESVAIKIF SSRDEQSWFR ETEIYNTVLL RHDNILGFIA 60

SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALR LAVSAACGLA HLHVEIFGTQ 120

GKPAIAHRDL KSRNVLVKSN LQCCIADLGL AVMHSQGSDY LDIGNNPRVG TKRYMAPEVL 180

DEQIRTDCFE SYKWTDIWAF GLVLWEIARR TIVNGIVEDY RPPFYDVVPN DPSFEDMRKV 240

VCVDQQTPTI PNRLAADPVL SGLAQMMREC WYPNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004675	; F:transmembrane receptor protein serine/threonine kinase activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013