EKS-OTG-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.5	1.5E-140	171	458	288

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003716

UniProt Accession

H0WPB6;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000004163	ENSOGAP00000003716	ENSOGAT00000004167

Organism

Otolemur garnettii

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

ALQCFCHLCT KDNFTCVTDG LCFVSVTETT DKVIHNSMCI AEIDLIPRDR PFVCAPSSKT 60

GSTTYCCNQD HCNKIELPTT VKPSPGLGPV ELAAVIAGPV CFVCISLMLM VYICHNRTVI 120

HHRVPNEEDP SLDRPFISEG TTLKDLIYDM TTSGSGSGLP LLVQRTIART IVLQESIGKG 180

RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA ADNKDNGTWT 240

QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ GKPAIAHRDL 300

KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL DDSINMKHFE 360

SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV VCEQKLRPNI 420

PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTLSQ LSQQEGIKM 469

Nucleotide Sequence
(FASTA)

GCATTACAGT GTTTTTGCCA CCTCTGTACA AAGGACAATT TTACTTGTGT GACAGATGGG 60

CTCTGCTTTG TCTCTGTCAC AGAGACCACG GACAAAGTGA TACACAATAG CATGTGTATA 120

GCTGAAATTG ACTTAATTCC TCGAGATAGG CCATTTGTAT GTGCACCCTC TTCAAAAACT 180

GGGTCTACAA CATATTGCTG CAATCAAGAC CATTGCAATA AAATAGAACT CCCAACTACT 240

GTAAAGCCGT CACCTGGCCT TGGTCCTGTG GAACTGGCAG CGGTCATTGC TGGACCGGTC 300

TGCTTCGTCT GCATCTCTCT CATGTTGATG GTCTATATCT GCCATAACCG CACTGTGATC 360

CACCATCGAG TGCCAAATGA GGAGGACCCT TCATTAGATC GCCCTTTTAT CTCAGAGGGG 420

ACTACATTAA AAGATTTAAT TTATGATATG ACAACATCAG GTTCTGGATC AGGTTTACCC 480

TTGCTTGTTC AGAGAACGAT TGCAAGAACT ATTGTGTTAC AAGAAAGCAT TGGCAAGGGT 540

CGGTTTGGAG AAGTTTGGCG AGGGAAGTGG AGGGGAGAAG AAGTTGCCGT TAAGATATTT 600

TCCTCCAGAG AAGAGCGATC CTGGTTCCGG GAGGCAGAGA TTTATCAAAC TGTAATGTTA 660

CGTCATGAAA ACATCCTGGG ATTTATAGCA GCGGACAATA AAGACAACGG TACTTGGACT 720

CAGCTCTGGT TGGTATCTGA TTATCATGAG CATGGATCCC TTTTTGATTA CTTGAACAGA 780

TACACAGTTA CTGTGGAAGG AATGATTAAA CTCGCTCTGT CCACTGCAAG TGGTCTTGCC 840

CATCTTCACA TGGAGATTGT TGGTACCCAA GGAAAACCAG CCATTGCTCA CAGAGATTTG 900

AAATCAAAGA ATATCTTGGT GAAGAAGAAT GGGACCTGCT GTATTGCAGA CTTAGGACTG 960

GCAGTGAGAC ATGATTCAGC CACAGATACA ATTGATATTG CTCCAAACCA CAGAGTGGGA 1020

ACAAAAAGGT ACATGGCCCC TGAAGTTCTA GATGATTCCA TAAATATGAA ACACTTTGAA 1080

TCCTTCAAAC GTGCTGACAT CTATGCAATG GGCTTAGTAT TCTGGGAAAT CGCTCGACGA 1140

TGTTCCATTG GAGGAATTCA TGAAGACTAC CAGCTGCCTT ATTATGATCT TGTACCTTCT 1200

GATCCATCAG TTGAAGAAAT GAGAAAAGTT GTTTGTGAAC AGAAGTTAAG GCCAAATATT 1260

CCAAACAGAT GGCAGAGTTG TGAAGCCTTG AGAGTAATGG CTAAAATTAT GAGAGAATGT 1320

TGGTATGCCA ATGGAGCAGC TAGGCTCACA GCTTTGCGGA TTAAGAAAAC ATTGTCACAA 1380

CTCAGTCAAC AGGAAGGCAT CAAAATGTAG 1410

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 171   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  230

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 231   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  290

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 291   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  348

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 349   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  407

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 408   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  458

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013