EKS-OTG-00171

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00171

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	510.3	8.5E-154	178	436	259

Status

Unreviewed

Ensembl Protein

ENSOGAP00000003793

UniProt Accession

H0WPI1;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000004246	ENSOGAP00000003793	ENSOGAT00000004250

Organism

Otolemur garnettii

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

LVNVKLWAID RQCFQTIMMR TGLIKHTEYM EFLKSVPTFQ SLPEEILSKL ADVLEETHYE 60

NGEYIIRQGA RGDTFFIISK GKVNVTREDS PSEDPIFLRT LGKGDWFGEK ALQGEDVRTA 120

NVIAAEAVTC LVIDRDSFKH LIGGLDDVSN KAYEDAEAKA KYEAEAAFFA NLKLSDFNII 180

DTLGVGGFGR VELVQLKSEE SKTFAMKILK KRHIVDTRQQ EHIRSEKQIM QGAHSDFIVR 240

LYRTFKDSKY LYMLMEACLG GELWTILRDR GSFEDSTTRF YTACVVEAFA YLHSKGIIYR 300

DLKPENLILD HRGYAKLVDF GFAKKIGFGK KTWTFCGTPE YVAPEIILNK GHDISADYWS 360

LGILMYELLT GSPPFSGPDP MKTYNIILRG IDMIEFPKKI AKNAANLIKK LCRDNPSERL 420

GNLKNGVKDI QKHKWFEGFN WEGLRKGTLT PPIIPSVASP TDTSNFDSFP EDNDEPPPDD 480

NSGWDIDF 488

Nucleotide Sequence
(FASTA)

CTTGTAAATG TGAAGCTCTG GGCCATCGAC CGACAATGTT TTCAGACGAT AATGATGAGG 60

ACAGGACTCA TCAAGCACAC GGAGTACATG GAATTTTTAA AAAGCGTTCC AACATTCCAG 120

AGCCTTCCTG AAGAGATCCT TAGCAAGCTT GCTGATGTCC TTGAAGAGAC CCACTATGAA 180

AATGGGGAAT ATATTATCAG GCAGGGTGCA AGAGGAGATA CCTTCTTTAT CATCAGCAAG 240

GGAAAGGTAA ATGTCACTCG TGAAGACTCA CCAAGTGAAG ACCCCATCTT TCTTAGAACT 300

TTAGGAAAAG GAGACTGGTT TGGGGAGAAA GCCTTGCAGG GGGAAGATGT GAGAACAGCA 360

AACGTAATTG CCGCCGAAGC TGTGACCTGC CTTGTGATTG ACAGAGACTC TTTCAAGCAT 420

TTGATTGGAG GGCTGGATGA CGTTTCTAAT AAAGCGTATG AGGATGCTGA AGCTAAAGCA 480

AAATATGAAG CTGAAGCTGC TTTCTTCGCC AACCTGAAGC TGTCTGATTT CAACATCATT 540

GATACCCTTG GAGTTGGAGG TTTCGGACGA GTAGAACTGG TCCAGTTGAA AAGTGAAGAA 600

TCCAAAACAT TTGCAATGAA GATCCTCAAA AAACGGCACA TTGTAGACAC AAGACAGCAG 660

GAACACATCC GCTCCGAGAA GCAGATCATG CAGGGGGCTC ATTCCGATTT CATAGTGAGA 720

CTGTACAGAA CATTTAAGGA CAGCAAATAT CTGTATATGC TGATGGAAGC TTGCCTAGGT 780

GGAGAGCTCT GGACCATTCT CAGGGATAGA GGTTCGTTTG AAGATTCTAC AACCAGATTT 840

TACACAGCAT GTGTGGTAGA AGCTTTTGCC TATCTGCATT CCAAAGGAAT TATTTACAGG 900

GACCTCAAGC CAGAAAATCT CATCCTAGAT CACCGAGGTT ACGCCAAACT GGTTGATTTT 960

GGCTTTGCAA AGAAAATAGG GTTTGGAAAG AAAACATGGA CTTTTTGTGG AACTCCAGAG 1020

TATGTCGCCC CAGAGATCAT CCTGAACAAA GGACATGACA TTTCAGCTGA CTATTGGTCC 1080

CTGGGAATCC TAATGTATGA ACTTCTGACT GGCAGCCCAC CTTTCTCAGG CCCAGATCCC 1140

ATGAAGACCT ATAACATCAT CTTGAGGGGG ATTGATATGA TAGAATTTCC AAAGAAGATT 1200

GCCAAAAATG CTGCTAACCT AATTAAAAAA CTATGCAGGG ACAACCCGTC AGAAAGATTA 1260

GGGAATTTGA AAAATGGAGT CAAAGACATT CAAAAGCACA AATGGTTTGA GGGCTTTAAT 1320

TGGGAAGGCT TAAGAAAAGG CACCTTGACG CCTCCTATAA TACCCAGTGT TGCGTCGCCC 1380

ACAGACACAA GCAATTTTGA CAGTTTCCCT GAGGACAACG ATGAACCACC GCCTGACGAC 1440

AACTCAGGAT GGGACATAGA CTTCTAA 1467

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 178   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  237

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 238   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  297

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 298   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  357

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 358   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  417

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 418   ERLGNLKNGVKDIQKHKWF  436

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013