EKS-OTG-00109

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00109

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	488.9	2.5E-147	405	655	251

Status

Unreviewed

Ensembl Protein

ENSOGAP00000020379

UniProt Accession

H0XW86;

Protein Name

Protein Synonyms/Alias

Gene Name

BTK

Gene Synonyms/Alias

BTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000004545	ENSOGAP00000020379	ENSOGAT00000034106
ENSOGAG00000004545	ENSOGAP00000004057	ENSOGAT00000004548

Organism

Otolemur garnettii

Functional Description

Protein Length

662

Protein Sequence
(FASTA)

MATVILESIF LKRSQQKKKT SPLNFKKRLF LLTMNRLSYY EYDFDRGRKG SKKGSIDVEK 60

ITCVETVIPE KNPPPERQIP PTFRRGEESS EMEQISIIER FPYPFQVVYD EGPLYVFSPT 120

EELRKRWIHQ LKNVIRYNSD LVQKYHPCFW IDGQYLCCSQ TAKNAMGCQI LENRNGSLKP 180

GSSHRKTKKP LPPTPEEDQI LKKPLPPEPA AAPMSTSELK KVVALYDYMP MNANDLQLRK 240

GDEYFILEES NLPWWRARDK NGQEGYIPSN YVTEAEDSIE MYEWYSKHMT RRQAEQLLKQ 300

EGKEGGFIVR DSSKAGKYTV SVFAKSTGDP QGVIRHYVVC STPQSQYYLA EKHLFSTIPE 360

LINYHQHNSA GLISRLKYPV SQQNKNAPST AGLGYGSWEI DPKDLTFLKE LGTGQFGVVK 420

YGKWRGQYDV AIKMIREGSM SEDEFIEEAK VMMNLSHEKL VQLYGVCTKQ RPIFIITEYM 480

ANGCLLNYLR EMRHRFQTQQ LLEMCKDVCE AMEYLESKQF LHRDLAARNC LVNDQGVVKV 540

SDFGLSRYVL DDEYTSSVGS KFPVRWSPPE VLMYSKFSSK SDIWAFGVLM WEIYSLGKMP 600

YERFTNSETA EHITKGLRLY RPHLASERVY TIMYSCWHEK ADERPTFKIL LSNILDVMDE 660

ES 662

Nucleotide Sequence
(FASTA)

ATGGCTACGG TGATACTGGA GAGCATCTTT CTAAAACGAT CTCAGCAGAA AAAGAAAACA 60

TCACCTCTAA ACTTCAAGAA GCGCCTTTTT CTCTTGACTA TGAACAGACT TTCCTACTAT 120

GAGTATGACT TTGATCGTGG GAGAAAAGGC AGTAAGAAGG GTTCAATAGA TGTGGAGAAG 180

ATCACCTGCG TTGAAACAGT GATTCCTGAA AAAAATCCTC CCCCTGAAAG ACAAATTCCG 240

CCTACTTTTA GAAGGGGTGA AGAGTCCAGT GAAATGGAGC AGATTTCAAT CATTGAAAGG 300

TTTCCTTATC CCTTCCAGGT TGTGTATGAT GAAGGCCCCC TTTATGTCTT CTCCCCAACT 360

GAAGAACTGA GGAAACGTTG GATTCACCAG CTCAAAAACG TAATCCGCTA CAACAGTGAT 420

CTGGTACAGA AATATCATCC TTGCTTCTGG ATCGATGGGC AGTATCTCTG CTGCTCTCAG 480

ACAGCCAAAA ATGCCATGGG CTGCCAAATT TTGGAGAACA GGAATGGAAG CTTAAAACCT 540

GGGAGTTCTC ACCGGAAGAC AAAAAAGCCT CTTCCCCCAA CCCCTGAGGA GGACCAGATC 600

TTGAAAAAAC CACTGCCCCC TGAGCCAGCA GCAGCACCAA TGTCCACCAG TGAGCTGAAA 660

AAGGTTGTAG CCCTTTATGA TTACATGCCA ATGAATGCAA ATGACCTACA GCTGCGGAAG 720

GGTGATGAAT ATTTTATCCT GGAGGAAAGC AACTTACCAT GGTGGCGAGC CCGAGATAAA 780

AATGGGCAGG AAGGCTACAT CCCTAGTAAC TATGTCACTG AAGCAGAAGA CTCCATAGAA 840

ATGTATGAGT GGTATTCCAA GCACATGACT CGGAGGCAAG CTGAGCAACT GCTAAAGCAA 900

GAGGGTAAAG AAGGAGGTTT CATTGTCAGA GACTCCAGTA AAGCTGGGAA ATATACAGTG 960

TCTGTATTTG CTAAATCTAC AGGGGACCCT CAAGGGGTGA TCCGCCATTA TGTTGTGTGT 1020

TCTACACCTC AGAGCCAGTA TTACCTGGCT GAGAAGCACC TTTTCAGCAC CATCCCTGAG 1080

CTCATTAACT ACCATCAGCA CAACTCTGCA GGACTCATAT CCAGGCTCAA ATATCCAGTG 1140

TCTCAACAAA ACAAGAATGC ACCTTCCACT GCTGGCCTAG GCTATGGATC ATGGGAAATT 1200

GATCCGAAGG ACCTGACCTT CTTGAAGGAG CTGGGAACTG GACAATTCGG AGTAGTGAAG 1260

TATGGGAAAT GGAGAGGCCA GTATGACGTG GCTATCAAGA TGATTAGAGA AGGCTCCATG 1320

TCTGAAGATG AGTTCATTGA AGAAGCCAAA GTCATGATGA ATCTTTCTCA TGAGAAGCTG 1380

GTGCAGTTGT ATGGCGTCTG CACCAAACAG CGCCCCATAT TCATCATCAC TGAGTACATG 1440

GCCAATGGCT GCCTCCTGAA CTACCTGAGG GAGATGCGCC ACCGCTTCCA GACTCAGCAA 1500

CTGCTAGAGA TGTGCAAGGA TGTCTGCGAA GCCATGGAAT ACCTGGAGTC AAAGCAGTTC 1560

CTTCACCGAG ACCTGGCAGC TCGAAACTGT TTGGTAAATG ATCAAGGAGT TGTTAAAGTA 1620

TCGGACTTCG GCCTGTCCAG ATATGTCCTG GATGATGAAT ACACAAGTTC AGTAGGCTCC 1680

AAATTTCCAG TCCGGTGGTC TCCACCAGAA GTCCTTATGT ATAGCAAATT CAGCAGCAAA 1740

TCTGACATTT GGGCTTTTGG GGTTTTGATG TGGGAAATTT ACTCCCTGGG GAAGATGCCA 1800

TATGAAAGAT TTACTAACAG TGAGACTGCT GAACACATTA CAAAAGGCCT ACGACTTTAC 1860

AGGCCTCATC TGGCTTCAGA GAGGGTATAC ACCATCATGT ACAGCTGCTG GCATGAGAAA 1920

GCAGATGAAC GTCCCACTTT CAAAATTCTT CTGAGCAATA TTCTAGATGT TATGGATGAA 1980

GAATCCTGA 1989

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+lkelg+gqfgvvk+gkwr+++dvaik+i+eg+mse++fieeakvmm+lsh+klvqly

Q: 405   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLY  464

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd

Q: 465   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  524

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w

Q: 525   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  584

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er

Q: 585   AFGVLMWEIYSLGKMPYERFTNSETAEHITKGLRLYRPHLASERVYTIMYSCWHEKADER  644

         ************************************************************

S: 241   ptfkellsale  251

         ptfk lls++

Q: 645   PTFKILLSNIL  655

         ********996

Domain Sequence
(FASTA)

LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IREGSMSEDE FIEEAKVMMN LSHEKLVQLY 60

GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120

LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180

AFGVLMWEIY SLGKMPYERF TNSETAEHIT KGLRLYRPHL ASERVYTIMY SCWHEKADER 240

PTFKILLSNI L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013