EKS-OTG-00407
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00407
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR569.62.6E-171580909330
StatusUnreviewed
Ensembl ProteinENSOGAP00000004104
UniProt AccessionH0WQ88;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000004598ENSOGAP00000004104ENSOGAT00000004601
OrganismOtolemur garnettii
Functional Description
Protein Length962
Protein Sequence
(FASTA)
MDLGVLLLLL VATAWHGQGV PVIEPSGPEL VVKPGTTVTL RCMGNGSVEW DGPLSPHWTL 60
DPDAPSSVLT TNNATFKNTG TYHCREPGDP LGGSATIHLY VKDPQRPWNL LAEEVTVFED 120
QDALLPCLIT DPALGKNVSL VRTRGRNPRR QTNYSFSLWN GFTIHKAKYI ENDHYQCSAL 180
VDGRKVTSLG IQLNVLKVIP GPPSLTLEPA ELVRIQGEAA QIVCSASNVD VDFDVFLQHN 240
GTKLAIPQQS DFQDNHYQKV LTLNLDQVNF QHAGNYSCKA TNAQGTRSAA MVFRVVEHAY 300
LNLISEQSLL QEVAVGEELS LEVKVEAYPG LQGFNWTYQG PFSEHQPKLD FATTKDTYRY 360
TSTLSLPRLK PSEAGYYSFL ARNVGGWSAL TFELTLLYPP EVKVTWTLTN GSRALLCEAS 420
GYPQPNVTWL QCRSHTDRCD EAQDLRVWED SHPQVLSQEP FHKVTVQSLL SIGTLEHNRT 480
YECRAHNSMG NSSQTFRPIA AGTRTHPPDE FLFTPVVVAC ISIMALLLLL LLLLLYKYKQ 540
TPRQRAEWQA RESYEGNSYT FIDPTQLPYN EKWEFPRNNL QFGKTLGAGA FGKVVEATAF 600
GLGKEDAVLK VAVKMLKSTA HTDEKEALMS ELKIMSHLGQ HENIVNLLGA CTHGGPVLVI 660
TEYCCYGDLL NFLRKKAEAM LGPSLSSGQD PEGGTGYKNI HLEKKYVRRD SGFSSQGVDT 720
YVEMRPVSTS SSNNSFSEQD VDKEDGRPLG LQDLLRFSSQ VAQGMAFLAS KNCIHRDVAA 780
RNVLLTNGHV AKIGDFGLAR DIMNDSNYIV KGNARLPVKW MAPESIFDCV YTVQSDVWSY 840
GILLWEIFSL GLNPYPGILV NSKFYKLVKD GYQMAQPAFA PKNIYSIMQA CWALEPTQRP 900
TFQQICSLLQ EQAQADRRER DYANLPSSSS EPEEESSSEH LACCEQGDIA QPLLQPNNYQ 960
FC 962
Nucleotide Sequence
(FASTA)
ATGGATCTAG GAGTCCTGCT GCTTCTTCTG GTGGCCACAG CTTGGCATGG TCAAGGGGTC 60
CCAGTGATAG AGCCCAGCGG TCCTGAGCTA GTGGTGAAGC CAGGTACAAC GGTGACACTG 120
CGATGTATGG GCAATGGCAG CGTGGAATGG GATGGCCCCC TCTCACCCCA CTGGACCCTG 180
GACCCTGATG CCCCCAGCAG TGTCCTGACC ACAAACAATG CCACCTTCAA AAACACGGGC 240
ACCTATCACT GCAGGGAGCC TGGAGACCCC TTGGGAGGCA GTGCCACCAT CCACCTCTAC 300
GTCAAAGACC CTCAACGGCC CTGGAACTTG TTAGCGGAGG AGGTGACGGT GTTTGAGGAC 360
CAGGATGCAC TGCTACCCTG CCTGATCACT GACCCGGCAC TGGGGAAGAA CGTCTCGCTG 420
GTGCGTACGC GGGGCCGGAA CCCCAGGCGC CAAACCAACT ACTCCTTCTC ACTCTGGAAT 480
GGCTTCACCA TCCACAAGGC CAAGTACATT GAGAACGACC ACTACCAATG CAGTGCCCTG 540
GTGGACGGCA GGAAGGTGAC ATCCCTGGGC ATCCAGCTCA ATGTGTTGAA AGTCATCCCA 600
GGGCCACCAT CCTTGACACT GGAGCCTGCA GAGCTGGTGC GGATCCAAGG GGAGGCTGCC 660
CAGATTGTGT GCTCAGCCAG CAATGTTGAC GTTGACTTTG ATGTCTTCCT CCAACACAAT 720
GGCACCAAGC TTGCCATCCC TCAACAATCG GACTTTCAGG ATAACCATTA CCAAAAGGTC 780
CTCACCCTCA ACCTTGATCA AGTAAACTTC CAACATGCCG GCAACTACTC CTGCAAAGCC 840
ACGAATGCGC AGGGCACCCG CTCTGCTGCC ATGGTCTTCC GGGTGGTAGA GCATGCCTAT 900
TTGAACTTGA TCTCTGAGCA GAGCCTCCTC CAGGAGGTGG CTGTGGGTGA GGAGCTCAGT 960
CTCGAAGTCA AGGTGGAGGC CTACCCAGGA CTGCAGGGTT TTAACTGGAC CTATCAGGGA 1020
CCCTTCTCTG AACACCAGCC CAAGCTTGAT TTTGCCACCA CCAAGGACAC ATACAGGTAT 1080
ACCTCTACCC TCTCCCTGCC CCGCCTGAAG CCCTCCGAGG CTGGCTACTA CTCCTTCCTG 1140
GCCAGAAACG TGGGAGGCTG GAGTGCTCTG ACTTTTGAGC TCACCCTTCT ATACCCCCCA 1200
GAGGTAAAAG TCACATGGAC CTTGACCAAT GGCTCTCGAG CACTGCTCTG TGAAGCCTCT 1260
GGGTACCCCC AGCCCAACGT GACGTGGCTG CAGTGCAGGA GCCACACGGA TAGGTGTGAT 1320
GAGGCCCAAG ACCTGCGGGT CTGGGAGGAC TCACACCCCC AGGTCCTGAG CCAGGAGCCC 1380
TTCCACAAGG TGACCGTGCA GAGCCTGCTG AGCATCGGGA CTTTAGAGCA CAACAGGACA 1440
TATGAGTGCA GGGCCCACAA CAGCATGGGG AACAGCTCCC AGACTTTCAG GCCCATTGCT 1500
GCAGGAACCC GCACACACCC GCCTGATGAG TTCCTCTTCA CCCCCGTGGT GGTCGCCTGT 1560
ATATCCATCA TGGCCCTGCT GCTGCTGCTG CTCCTGCTGC TGCTGTACAA GTACAAGCAG 1620
ACACCTAGGC AAAGAGCAGA GTGGCAGGCA AGGGAAAGCT ATGAGGGCAA CAGCTACACC 1680
TTCATTGACC CCACCCAGCT GCCCTATAAC GAGAAGTGGG AGTTCCCCAG AAACAACCTG 1740
CAGTTTGGTA AGACCCTTGG AGCTGGTGCC TTCGGGAAGG TGGTAGAGGC CACAGCCTTT 1800
GGTCTGGGCA AGGAAGATGC TGTCCTGAAG GTGGCTGTGA AGATGCTGAA GTCCACGGCT 1860
CACACTGATG AGAAGGAGGC CCTCATGTCA GAGCTGAAGA TCATGAGTCA CCTGGGCCAG 1920
CATGAGAATA TAGTCAACCT CCTGGGAGCC TGCACCCATG GAGGTCCCGT CCTAGTCATC 1980
ACCGAGTACT GCTGCTACGG GGACCTGCTC AACTTTCTGC GAAAGAAGGC CGAGGCCATG 2040
CTGGGACCCA GCCTGAGCTC AGGCCAGGAC CCTGAAGGGG GCACTGGCTA CAAGAACATC 2100
CACCTAGAGA AGAAATATGT GCGCAGGGAC AGTGGCTTCT CCAGCCAGGG TGTGGACACC 2160
TATGTGGAGA TGAGGCCTGT CTCCACTTCC TCTTCAAACA ATTCCTTCTC TGAGCAAGAC 2220
GTGGACAAGG AGGACGGCCG GCCACTGGGG CTCCAAGACC TGCTCCGCTT CTCCAGCCAA 2280
GTTGCCCAGG GCATGGCCTT CCTTGCTTCT AAGAACTGCA TCCACCGGGA TGTGGCTGCC 2340
CGCAATGTGC TGTTGACCAA TGGACATGTG GCCAAAATTG GGGACTTTGG GCTGGCTAGG 2400
GACATCATGA ATGACTCCAA CTACATTGTC AAGGGCAATG CCCGCCTGCC TGTGAAGTGG 2460
ATGGCCCCAG AGAGCATCTT TGACTGTGTC TACACAGTGC AGAGCGACGT CTGGTCCTAC 2520
GGCATCCTCC TCTGGGAGAT CTTCTCACTT GGGCTGAACC CCTACCCTGG CATCTTGGTG 2580
AATAGCAAGT TCTATAAACT GGTAAAGGAT GGATACCAAA TGGCCCAGCC TGCGTTTGCC 2640
CCAAAGAACA TATACAGCAT CATGCAAGCC TGCTGGGCCC TGGAGCCCAC CCAGAGACCC 2700
ACCTTCCAGC AGATCTGCTC CCTCCTTCAA GAGCAGGCCC AAGCAGACAG GAGAGAACGG 2760
GACTATGCTA ATCTGCCGAG CAGCAGCAGC GAGCCGGAAG AAGAGAGCTC AAGTGAGCAT 2820
CTGGCCTGCT GTGAGCAAGG GGACATTGCC CAGCCCTTGC TGCAGCCCAA CAACTACCAG 2880
TTCTGCTAA 2889
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 580   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHTDEKEALMSELKIMSHLG  639
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lr+k+e++l  sl+  +++e  + +k+
Q: 640   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRKKAEAMLGPSLSSGQDPEGGTGYKN  699
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s++++  se+            +++e
Q: 700   IhLEKKYVRRDSGFSSQGVDTYVEMRP----VSTSSSNNSFSEQ-----------DVDKE  744
         *999***********************....7766666555544...........35789
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++l l+dll fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 745   DGRPLGLQDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN  804
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 805   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  864
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q+++ll
Q: 865   YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTQRPTFQQICSLL  909
         ******************************************996
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHTDEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRKKAEA MLGPSLSSGQ DPEGGTGYKN 120
IHLEKKYVRR DSGFSSQGVD TYVEMRPVST SSSNNSFSEQ DVDKEDGRPL GLQDLLRFSS 180
QVAQGMAFLA SKNCIHRDVA ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK 240
WMAPESIFDC VYTVQSDVWS YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF 300
APKNIYSIMQ ACWALEPTQR PTFQQICSLL 330
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013