EKS-OTG-00404

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00404

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	601.4	5.7E-181	600	958	359

Status

Unreviewed

Ensembl Protein

ENSOGAP00000004108

UniProt Accession

H0WQ92;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000004602	ENSOGAP00000004108	ENSOGAT00000004605

Organism

Otolemur garnettii

Functional Description

Protein Length

1106

Protein Sequence
(FASTA)

MWFPGVMLAL VLKGQLLVLP LLLLLEPQIS QGLVITPPGP ELVLNISSTF VLTCSGSAPV 60

VWERMSQEPL QEMTMTQDGT FSSMLTLTNV TGLDTGEYFC TYNDSHGLES GERKRLYIFV 120

PDPTMGFLPN DPEELFIFLT EITEITIPCR VTDPQLVVTL HEKKVDVPLP VPYDHQRGFS 180

GTFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITVMCIVIGN 240

EVVNFEWTYP RKESGRLVEP VTDFLMDMPY HILSILHIPN AELGDSGTYI CNVSESVNDH 300

QDEKAINVTV VESGFVRLLE DVGPLQFAEL HRSRTLHVVF EAYPPPTVLW FKDNYTLGVS 360

SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGHYTMRAFN EDAEAQLSFQ LQINVPVRVV 420

ELSESHPASG EQTIRCRGRG MPQPNITWSA CRDFKRCPRE LPPTPLGNSS EEESQLETNV 480

TYWEEEQEFE VVSMLRLQHV DRPMSVRCTL RNAASHDMKE VIVVPHSLPF KVVVISAILA 540

LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWEVPRDQL 600

VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 660

HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHRSDKRRP PSAELYSNAL 720

PVGLPLSSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP 780

SAPERTYRAT LINESPLLSY TDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 840

KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 900

GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER 960

LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RFPGFHGLRS PLDTSSVLYT AVQPNEGDND 1020

YIIPLPDPKP EAAEDGPLEG SPSLASSTLN EANTSSTISC DSPLDPQEEP EPEPQLESQV 1080

EPKLEVEQLP ESGCPGPRAE AEDSFL 1106

Nucleotide Sequence
(FASTA)

ATGTGGTTTC CAGGTGTGAT GCTGGCTCTG GTCCTCAAAG GCCAATTGCT GGTGCTGCCC 60

CTGCTGTTAC TGCTGGAACC ACAGATCTCT CAGGGCCTGG TCATCACACC TCCAGGACCA 120

GAGCTTGTCC TTAATATATC CAGCACCTTT GTTCTGACCT GCTCGGGTTC AGCTCCAGTA 180

GTGTGGGAAC GAATGTCCCA GGAGCCCTTA CAGGAAATGA CTATGACCCA GGATGGCACC 240

TTCTCCAGCA TGCTGACACT GACCAATGTC ACTGGACTAG ACACGGGAGA ATACTTTTGC 300

ACCTACAATG ACTCCCATGG TTTGGAGTCT GGTGAGCGGA AACGGCTCTA CATCTTTGTG 360

CCAGATCCCA CCATGGGCTT CCTCCCAAAT GACCCTGAGG AACTATTCAT CTTTCTTACG 420

GAAATAACTG AGATCACAAT TCCATGCCGA GTGACAGACC CACAGCTGGT GGTGACACTG 480

CATGAGAAGA AAGTGGATGT CCCGCTGCCT GTCCCTTATG ACCACCAACG TGGCTTTTCT 540

GGCACCTTTG AGGATAGGAG CTACATCTGC AAAACCACCA TTGGAGACAG GGAGGTGGAT 600

TCTGATGCCT ACTATGTCTA CAGACTCCAG GTGTCATCCA TCAATGTCTC AGTGAACGCA 660

GTGCAGACTG TGGTCCGCCA GGGTGAGAAC ATCACTGTTA TGTGCATTGT GATTGGAAAT 720

GAGGTGGTCA ACTTTGAGTG GACATATCCC CGAAAGGAGA GTGGGCGGCT GGTGGAGCCA 780

GTGACCGACT TTCTCATGGA TATGCCCTAC CACATCCTCT CCATCCTGCA TATCCCCAAT 840

GCCGAGCTAG GCGACTCAGG CACCTACATC TGCAATGTGT CAGAGAGTGT GAACGACCAT 900

CAAGATGAAA AGGCCATCAA TGTCACTGTG GTTGAGAGCG GCTTCGTGCG GTTGCTCGAA 960

GATGTGGGCC CTTTACAATT CGCTGAACTA CACCGGAGTC GGACACTGCA TGTGGTATTT 1020

GAGGCCTACC CTCCGCCTAC CGTCCTGTGG TTCAAGGACA ACTACACCCT GGGCGTTTCC 1080

AGCGCGGGTG AAATTGCCCT GTCCACGCGC AATGTGTCTG AGACCCGGTA TGTGTCAGAA 1140

CTGACACTGG TACGGGTGAA GGTGGCAGAG GCTGGCCACT ACACCATGCG GGCTTTCAAT 1200

GAGGATGCTG AGGCCCAGCT CTCCTTTCAG CTGCAGATCA ATGTCCCTGT CCGAGTGGTG 1260

GAGCTGAGTG AGAGCCACCC TGCCAGTGGG GAACAGACAA TCCGCTGTCG TGGCCGAGGC 1320

ATGCCCCAAC CCAACATCAC CTGGTCTGCT TGCAGAGATT TCAAAAGGTG TCCACGTGAG 1380

CTTCCCCCCA CACCACTGGG AAACAGCTCT GAGGAGGAGA GCCAGCTGGA GACTAATGTG 1440

ACTTACTGGG AGGAAGAGCA GGAGTTTGAG GTGGTGAGCA TGCTGCGCCT GCAACACGTG 1500

GACCGGCCGA TGTCAGTGCG CTGCACGCTG CGCAATGCTG CTAGCCATGA CATGAAGGAG 1560

GTCATCGTGG TGCCACACTC CCTGCCCTTT AAGGTGGTGG TGATCTCAGC CATCCTGGCC 1620

TTGGTGGTCC TCACCATCAT CTCCCTCATC ATTCTTATCA TGCTGTGGCA GAAGAAGCCA 1680

CGTTATGAGA TCCGGTGGAA GGTGATTGAG TCGGTGAGCT CTGATGGCCA TGAGTACATC 1740

TACGTGGACC CCATGCAGCT GCCCTATGAC TCCACATGGG AGGTGCCACG GGACCAGCTT 1800

GTGCTTGGAC GTACTCTTGG CTCTGGGGCC TTTGGGCAGG TGGTGGAGGC CACGGCTCAT 1860

GGCCTGAGCC ATTCACAGGC CACAATGAAA GTGGCTGTCA AGATGCTGAA ATCCACAGCC 1920

CGCAGCAGTG AGAAGCAAGC TCTCATGTCA GAGCTGAAGA TCATGAGTCA CCTCGGGCCT 1980

CACCTGAATG TGGTCAACCT GCTGGGGGCC TGCACCAAAG GAGGACCCAT CTACATCATC 2040

ACCGAGTACT GCCGCTATGG TGACTTGGTG GACTATCTGC ACCGGAACAA GCACACCTTC 2100

CTGCAGCACC GCTCCGACAA GCGCCGCCCA CCCAGTGCCG AGCTCTACAG CAATGCCCTG 2160

CCCGTTGGGC TGCCCCTGTC CAGCCATGTG TCCTTGACTG GGGAGAGTGA TGGCGGCTAC 2220

ATGGACATGA GCAAGGACGA GTCAGTGGAC TATGTGCCCA TGCTGGACAT GAAAGGAGAC 2280

GTCAAATATG CAGACATCGA GTCCTCCAAC TACATGGCGC CTTATGATAA CTATGTCCCC 2340

TCCGCCCCAG AGAGGACCTA TCGGGCAACT TTGATCAACG AGTCCCCACT GCTTAGCTAC 2400

ACAGACCTCG TGGGCTTCAG CTACCAGGTG GCCAATGGCA TGGAGTTCCT GGCCTCCAAG 2460

AATTGTGTCC ATCGAGACCT GGCGGCCAGG AACGTGCTTA TCTGCGAGGG CAAACTGGTC 2520

AAGATCTGTG ACTTTGGCCT GGCTCGAGAC ATCATGCGGG ACTCAAACTA CATCTCCAAA 2580

GGCAGTACCT TCCTGCCTCT GAAGTGGATG GCCCCAGAGA GCATCTTCAA TAGCCTGTAC 2640

ACCACCCTGA GTGATGTGTG GTCCTTCGGG ATCCTGCTCT GGGAAATCTT CACTCTGGGT 2700

GGCACCCCTT ACCCAGAGCT GCCTATGAAT GAGCAGTTCT ACAATGCCAT CAAGCGGGGT 2760

TACCGCATGG CCCAGCCTGC TCATGCTTCT GATGAGATCT ACGAGATCAT GCAAAAGTGC 2820

TGGGAAGAAA AGTTTGAGAT CCGGCCCCCC TTCTCCCAGC TGGTGCTGCT GCTCGAGAGA 2880

CTGCTGGGTG AGGGCTACAA AAAGAAGTAC CAGCAGGTGG ATGAGGAGTT TCTAAGGAGC 2940

GACCACCCAG CCATCCTTCG GTCCCAAGCC CGCTTTCCTG GATTCCATGG CCTCAGATCT 3000

CCCCTGGACA CCAGCTCTGT CCTCTACACT GCTGTGCAGC CCAATGAGGG TGACAATGAC 3060

TACATCATCC CCCTGCCTGA CCCCAAACCG GAGGCTGCTG AGGACGGCCC CCTGGAGGGT 3120

TCCCCCAGCC TTGCCAGCTC CACCCTGAAT GAAGCCAACA CCTCCTCGAC CATCTCCTGT 3180

GATAGCCCCC TGGACCCCCA AGAGGAACCA GAGCCAGAGC CCCAGCTGGA GTCCCAGGTA 3240

GAGCCCAAGT TGGAAGTAGA GCAGCTGCCA GAGTCAGGCT GCCCTGGGCC TCGGGCCGAA 3300

GCGGAGGACA GCTTCCTGTA G 3321

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG

Q: 600   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  659

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl++ ++k++++++el+s+a

Q: 660   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHRSDKRRPPSAELYSNA  719

         ************************************************************

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

         l+++  l s++sl+ es++ y+d++kd                ++d++ss++++++++++

Q: 720   LPVGLPLSSHVSLTGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYMAPYDNYV  779

         ************************************************************

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          sa er+++a+l++e s  l+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk

Q: 780   PSAPERTYRATLINE-SPLLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  838

         **************9.99******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+

Q: 839   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  898

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll

Q: 899   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  958

         ********************************************************9986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60

PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHRSDKRR PPSAELYSNA 120

LPVGLPLSSH VSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 180

PSAPERTYRA TLINESPLLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240

VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300

GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084	; P:vascular endothelial growth factor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 1.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013