EKS-OTG-00413
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00413
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk555.81.4E-167538809272
StatusUnreviewed
Ensembl ProteinENSOGAP00000004233
UniProt AccessionH0Y0E3;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK3
Gene Synonyms/Alias NTRK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000004733ENSOGAP00000004233ENSOGAT00000004737
ENSOGAG00000004733ENSOGAP00000021836ENSOGAT00000024794
OrganismOtolemur garnettii
Functional Description
Protein Length825
Protein Sequence
(FASTA)
MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEISCRRPDD GSLFPLLEGQ 60
DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 120
RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELRLEQN FFNCSCDIRW MQLWQEQGEA 180
RLNAQNLYCI SADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVVT CNGSGSPLPD 240
VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 300
VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEVSE 360
GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILV DEVSPTPPIT 420
VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 480
LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 540
KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 600
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 660
SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI 720
RWMPPESIMY RKFTTESDVW SFGVILWEIF TYGKQPWFQL SNTEVIECIT QGRVLERPRV 780
CPKEVYDVML GCWQREPQQR LNIKEIYKIL HALGKATPIY LDVLG 825
Nucleotide Sequence
(FASTA)
ATGGATGTGT CTCTTTGCCC AGCCAAGTGT AGTTTCTGGC GGATTTTCTT GCTGGGAAGC 60
GTCTGGCTGG ACTATGTGGG CTCCGTGCTG GCTTGCCCTG CAAATTGTGT CTGCAGCAAG 120
ACTGAGATCA GTTGCCGGCG GCCGGACGAT GGGAGCCTCT TTCCCCTCCT GGAAGGGCAG 180
GATTCAGGGA ACAGCAATGG GAACGCCAGC ATTAACATCA CGGACATCTC AAGGAATATC 240
ACTTCCATAC ACATAGAGAA TTGGCGTAGC CTGCACACGC TCAACGCCGT GGACATGGAG 300
CTGTATACGG GACTTCAAAA ACTGACCATC AAGAACTCAG GACTTCGGAG CATCCAGCCC 360
AGAGCCTTTG CCAAGAACCC CCACTTGCGC TATATAAACC TGTCGAGTAA CCGGCTCACC 420
ACACTCTCGT GGCAGCTCTT CCAGACGCTG AGTCTTCGGG AATTGAGATT GGAACAGAAC 480
TTCTTCAACT GCAGCTGTGA CATCCGCTGG ATGCAGCTGT GGCAGGAGCA GGGGGAGGCC 540
AGGCTGAACG CCCAGAACCT GTACTGCATC AGCGCCGACG GCTCGCAGCT CCCTCTCTTC 600
CGCATGAACA TCAGTCAGTG TGACCTTCCT GAGATCAGCG TGAGCCATGT CAACCTGACT 660
GTACGAGAGG GTGACAATGC TGTCGTCACT TGCAATGGTT CTGGGTCGCC CCTGCCTGAT 720
GTGGACTGGA TAGTCACTGG GCTACAGTCC ATCAACACCC ACCAGACAAA TCTGAACTGG 780
ACCAATGTCC ATGCTATCAA CTTGACGCTG GTGAATGTGA CGAGTGAGGA CAATGGCTTC 840
ACCCTGACAT GCATTGCAGA GAATGTGGTG GGCATGAGCA ATGCCAGCGT CGCCCTCACT 900
GTCTACTACC CCCCACGTGT GGTGAGCCTG GAGGAGCCGG AGCTGCGCCT GGAGCACTGC 960
ATCGAGTTCG TGGTGCGTGG CAACCCCCCG CCTACGCTGC ACTGGCTGCA CAACGGGCAG 1020
CCGCTGCGGG AGTCCAAGAT AATCCATGTG GAGTACTACC AGGAGGGTGA GGTCTCCGAG 1080
GGCTGCCTGC TCTTCAACAA GCCCACGCAC TACAACAATG GCAACTACAC CCTCATTGCC 1140
AAAAACCCGC TGGGCACAGC CAACCAGACC ATCAACGGCC ACTTTCTCAA GGAGCCCTTT 1200
CCAGAGAGCA CAGATAACTT TATCTTGGTG GATGAAGTGA GCCCCACACC GCCTATTACT 1260
GTGACCCACA AGCCAGAGGA AGACACTTTC GGGGTGTCCA TAGCAGTTGG GCTTGCTGCT 1320
TTTGCCTGTG TCCTGCTGGT GGTTCTCTTT ATCATGATCA ACAAGTATGG TCGGCGGTCC 1380
AAATTTGGAA TGAAGGGTCC TGTGGCTGTC ATTAGTGGTG AGGAGGACTC AGCCAGCCCA 1440
CTGCACCACA TCAACCATGG CATCACCACA CCCTCGTCGC TGGACGCTGG GCCCGACACT 1500
GTGGTCATTG GCATGACACG CATCCCTGTC ATTGAGAACC CCCAGTACTT CCGTCAAGGA 1560
CACAACTGCC ACAAGCCAGA CACATATGTG CAGCACATCA AGAGGAGAGA CATCGTGTTG 1620
AAGCGAGAAC TGGGCGAGGG AGCCTTTGGG AAGGTCTTCC TGGCCGAGTG CTACAACCTC 1680
AGTCCAACCA AGGACAAGAT GCTGGTGGCA GTGAAGGCCC TGAAGGACCC TACCCTGGCT 1740
GCCCGGAAGG ACTTTCAGAG GGAGGCTGAG CTGCTCACCA ACCTACAGCA TGAGCACATT 1800
GTCAAGTTCT ACGGAGTGTG CGGTGATGGG GACCCCCTCA TCATGGTCTT TGAGTACATG 1860
AAGCATGGGG ACCTCAACAA GTTCCTGAGG GCCCATGGGC CAGATGCGAT GATCCTTGTG 1920
GATGGGCAGC CACGCCAAGC CAAGGGTGAG CTAGGGCTCT CCCAAATGCT ACACATTGCC 1980
AGTCAGATTG CCTCAGGCAT GGTCTATCTG GCCTCCCAGC ACTTTGTGCA CCGGGACCTA 2040
GCCACCAGGA ACTGCCTGGT TGGAGCCAAC TTGCTGGTGA AGATTGGAGA CTTCGGCATG 2100
TCCAGAGATG TCTACAGCAC TGACTACTAC AGGGTGGGAG GACATACCAT GCTCCCCATC 2160
CGGTGGATGC CCCCTGAAAG CATCATGTAC CGGAAGTTCA CCACAGAGAG CGATGTGTGG 2220
AGCTTCGGGG TGATCCTTTG GGAGATCTTC ACCTATGGGA AGCAGCCGTG GTTCCAGCTG 2280
TCAAACACAG AGGTCATTGA GTGCATTACC CAAGGTCGTG TTTTGGAGCG ACCCCGAGTC 2340
TGCCCCAAAG AGGTGTACGA CGTCATGCTG GGGTGCTGGC AGAGGGAACC GCAGCAGCGG 2400
CTGAACATCA AGGAGATCTA CAAAATCCTC CACGCTTTGG GGAAGGCCAC CCCAATCTAC 2460
CTGGACGTTC TCGGCTAG 2478
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlkrelgegafgkvflaecynl+p+kdk+lvavkalkd++ aarkdf+reaelltnlqh
Q: 538   IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQH  597
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep...kgelglsqll  117
         ehivk+yGvc +gdpl++vfeymkhGdlnkflrahgpda++lv+g+p   kgelglsq+l
Q: 598   EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPrqaKGELGLSQML  657
         ***********************************************9999*********
S: 118   aiakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtm  177
         +ia+qia+G+vylasqhfvhrdlatrnclvg++llvkigdfgmsrdvystdyyrvgg+tm
Q: 658   HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTM  717
         ************************************************************
S: 178   lpirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvler  237
         lpirw+ppesi+yrkfttesdvws+Gv+lwei+tyGkqp++qlsnteviecitqGrvler
Q: 718   LPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLER  777
         ************************************************************
S: 238   pracpkevydlmlgcwqrepqkrlnikeiyal  269
         pr+cpkevyd+mlgcwqrepq+rlnikeiy++
Q: 778   PRVCPKEVYDVMLGCWQREPQQRLNIKEIYKI  809
         *****************************985
Domain Sequence
(FASTA)
IVLKRELGEG AFGKVFLAEC YNLSPTKDKM LVAVKALKDP TLAARKDFQR EAELLTNLQH 60
EHIVKFYGVC GDGDPLIMVF EYMKHGDLNK FLRAHGPDAM ILVDGQPRQA KGELGLSQML 120
HIASQIASGM VYLASQHFVH RDLATRNCLV GANLLVKIGD FGMSRDVYST DYYRVGGHTM 180
LPIRWMPPES IMYRKFTTES DVWSFGVILW EIFTYGKQPW FQLSNTEVIE CITQGRVLER 240
PRVCPKEVYD VMLGCWQREP QQRLNIKEIY KI 272
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-CAJ-00415
EKS-CAF-00412
EKS-CAP-00438
EKS-DAR-00796
EKS-EQC-00403
EKS-GAG-00347
EKS-GAA-00497
EKS-GOG-00402
EKS-HOS-00417
EKS-ICT-00390
EKS-LOA-00419
EKS-MAM-00409
EKS-MEG-00340
EKS-MIM-00063
EKS-MOD-00388
EKS-MUM-00443
EKS-MUP-00405
EKS-MYL-00406
EKS-NOL-00374
EKS-ORN-00522
EKS-ORA-00358
EKS-PEM-00224
EKS-POA-00403
EKS-RAN-00425
EKS-SAH-00380
EKS-SUS-00363
EKS-TAG-00481
EKS-TUT-00124
EKS-XIM-00513
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005030; F:neurotrophin receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR001611; Leu-rich_rpt.
IPR000372; LRR-contain_N.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020446; Tyr_kin_neurotrophic_rcpt_3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07679; I-set; 2.
PF01462; LRRNT; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00013; LRRNT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS51450; LRR; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01942; NTKRECEPTOR3.
PR00109; TYRKINASE.
Created Date20-Feb-2013