EKS-OTG-00436

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00436

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	391.4	2.0E-117	16	278	263

Status

Unreviewed

Ensembl Protein

ENSOGAP00000004521

UniProt Accession

H0WR84;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK1

Gene Synonyms/Alias

ULK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000005056	ENSOGAP00000004521	ENSOGAT00000005060

Organism

Otolemur garnettii

Functional Description

Protein Length

1045

Protein Sequence
(FASTA)

MEPGRGGTET VGKFEFSRKD LIGHGAFAVV FKGRHREKHD LEVAVKCINK KNLAKSQTLL 60

GKEIKILKEL KHENIVALYD FQEMANSVYL VMEYCNGGDL ADYLHTMRTL SEDTIRLFLQ 120

QIAGAMRLLH SKGIIHRDLK PQNILLSNPG GRRANPNNIR VKIADFGFAR YLQSNMMAAT 180

LCGSPMYMAP EVIMSQHYDG KADLWSIGTI VYQCLTGKAP FQASSPQDLR LFYEKNKTLI 240

PTIPRETSAP LRQLLLALLQ RNHKDRMDFD EFFHHPFLEA SPSVKKSPPV PVPSYPSSGS 300

GSSSSSSSTS HLASPPSLGE MQQLQKTLTS PADATGFLHG SRDSGGSKDS SCDTDDFVIV 360

PAHFPADLVA EVAGAKPPPD SLMCSGSSLV ASAGLESHGR TPSPSPPCSS SPSPSGRAGP 420

FSSSRYGASV PIPVPTQVQN YQRIEQNLQS PTQYQTPRSS AIRRSGSTSP LGFMRASPSP 480

PAPTEHGAVL ARKLSLGGGR PYTPSPQVGT IPERPGWNRA PSPQGAEMRP GRSPRPGSSV 540

PEHSPRSSGL GSRLHSAPNL SDLHVVRPKL PKPPTDPLGA MLSTPQASPP QPPHGLPSCR 600

TLRGSPKLPD FLQRNPLPPI LGSPTKAVPA VDFPKTPSSQ NLLTLLARQG VVVTPPRNRT 660

LPDLSEMGPF QGQQLGPGLR PSEDTKGPFG RSFSTSRLTD LLLKAAFGTQ APDSGSTDSL 720

QEKPMEIAPS AGFGGSLHPG ARAGGASSPS PVVFTVGSPP SGTTPPQGPR TRMFSVGSSS 780

SSSARHLVPG ACSEATPELP SHCCTFADPI AANLEGAVTF EAPDLPEETL MEQEHTETLH 840

SLRCTLLFAQ HVLEIAALKG SAGEAAGDPD YQLQESVVAD QISLLSREWG FAEQLVLYLK 900

VAELLSSGLQ TAIDQIRAGK LCLSSTVKQV VRRLNELYKA SVVSCQGLSL RLQRFFLDKQ 960

RLLDRVHSIT AEKLIFSHAV QMVQSAALDE MFQHREGCVP RYHKALLLLE GLQHMLSDQA 1020

DIENVAKCKL CIERRLSALL TGICA 1045

Nucleotide Sequence
(FASTA)

ATGGAGCCCG GCCGCGGTGG CACAGAGACC GTGGGCAAGT TCGAGTTCTC GCGCAAGGAC 60

CTGATCGGAC ACGGCGCCTT CGCTGTGGTC TTCAAGGGCC GCCACCGCGA GAAGCATGAT 120

CTGGAGGTCG CGGTCAAGTG CATTAATAAG AAGAACCTCG CCAAGTCCCA GACGCTGCTG 180

GGGAAGGAAA TTAAGATCCT CAAGGAACTG AAACATGAAA ACATTGTTGC GTTGTATGAC 240

TTCCAGGAAA TGGCCAATTC TGTTTACCTG GTTATGGAGT ATTGCAACGG TGGGGACTTG 300

GCTGATTACC TGCACACCAT GCGGACGCTG AGTGAGGACA CCATCAGGCT CTTCCTGCAG 360

CAGATTGCTG GTGCCATGCG GCTTCTACAC AGCAAGGGCA TCATCCACCG TGACCTGAAG 420

CCCCAGAACA TCCTGCTGTC CAACCCTGGT GGGCGCCGGG CCAACCCCAA TAACATCCGT 480

GTCAAGATCG CTGACTTTGG GTTTGCCCGG TATCTCCAGA GCAACATGAT GGCAGCCACG 540

CTCTGCGGCT CCCCCATGTA CATGGCTCCT GAGGTCATCA TGTCCCAACA CTATGATGGG 600

AAGGCAGACC TGTGGAGCAT CGGTACTATT GTCTACCAGT GCCTGACAGG GAAGGCACCC 660

TTCCAGGCCA GCAGCCCTCA GGACCTCCGC CTGTTCTATG AGAAGAACAA GACACTGATC 720

CCCACTATCC CACGGGAGAC ATCGGCCCCC CTAAGGCAGC TGCTGCTGGC TCTGCTCCAG 780

CGCAACCACA AAGACCGCAT GGACTTCGAT GAGTTTTTCC ATCACCCTTT CCTCGAGGCC 840

AGCCCATCAG TCAAGAAGTC CCCACCTGTA CCTGTGCCCT CCTACCCGAG CTCGGGGTCT 900

GGCAGCAGTT CCAGCAGCAG CTCCACCTCC CACCTGGCCT CCCCACCGTC CTTGGGGGAG 960

ATGCAGCAGC TGCAGAAGAC CCTGACCTCC CCCGCTGATG CCACTGGCTT CCTGCATGGC 1020

TCCCGGGACT CAGGTGGCAG CAAGGACTCC TCCTGCGACA CGGATGACTT TGTCATTGTC 1080

CCAGCCCACT TTCCAGCTGA CTTGGTGGCC GAGGTGGCTG GTGCCAAGCC CCCGCCGGAC 1140

AGTCTGATGT GCAGCGGGAG CTCACTGGTG GCCTCTGCTG GCCTGGAGAG CCACGGCCGG 1200

ACCCCATCTC CATCCCCACC CTGCAGCAGC TCTCCCAGCC CTTCAGGCCG GGCTGGTCCA 1260

TTCTCCAGCA GCAGGTATGG TGCCTCTGTG CCCATTCCAG TGCCTACTCA GGTGCAGAAC 1320

TACCAGCGCA TTGAACAGAA CCTGCAGTCA CCCACCCAGT ACCAGACACC CCGGTCCTCT 1380

GCCATCCGTA GGTCCGGCAG CACCAGCCCC CTGGGCTTTA TGCGAGCCAG CCCGTCGCCT 1440

CCAGCCCCCA CAGAGCATGG AGCTGTCCTG GCAAGGAAAT TGTCCTTGGG CGGGGGCCGG 1500

CCCTACACAC CATCTCCACA AGTTGGGACC ATCCCTGAGC GGCCAGGTTG GAACAGGGCG 1560

CCCTCCCCAC AAGGAGCCGA GATGCGGCCT GGCAGGTCCC CTCGTCCAGG CTCCTCTGTG 1620

CCTGAGCACT CTCCCCGCTC CTCTGGACTC GGCAGCCGCC TGCATAGCGC CCCCAACCTG 1680

TCCGACCTGC ACGTTGTCCG CCCCAAGCTG CCCAAGCCCC CCACAGACCC TCTGGGCGCT 1740

ATGCTCAGCA CCCCACAGGC CAGCCCTCCC CAGCCACCCC ATGGGCTGCC ATCCTGCCGG 1800

ACCCTGCGCG GCTCTCCCAA GCTGCCAGAC TTCCTGCAGA GGAACCCCCT GCCCCCCATC 1860

CTGGGCTCCC CGACCAAGGC TGTGCCCGCG GTTGACTTCC CCAAGACACC TAGCTCCCAG 1920

AATCTGCTGA CCCTCCTGGC TCGGCAGGGT GTGGTGGTGA CACCCCCAAG GAACCGGACT 1980

CTGCCTGACC TCTCAGAGAT GGGGCCTTTC CAGGGACAGC AGCTGGGCCC GGGCCTGCGG 2040

CCTAGTGAGG ATACCAAAGG CCCATTTGGC CGGTCCTTTA GCACCAGCCG CCTCACCGAC 2100

TTACTCCTGA AGGCTGCATT TGGGACACAG GCCCCAGACT CCGGCAGCAC TGACAGCCTT 2160

CAGGAGAAGC CCATGGAGAT AGCGCCCTCT GCTGGCTTTG GAGGGAGCCT GCACCCGGGA 2220

GCCCGTGCAG GGGGCGCCAG CAGCCCCTCT CCCGTGGTCT TCACGGTGGG CTCCCCCCCA 2280

AGTGGGACCA CACCGCCCCA GGGCCCCCGC ACCAGAATGT TCTCAGTGGG CTCTTCGAGT 2340

TCCTCCTCTG CTCGCCACCT GGTGCCTGGG GCCTGCAGCG AGGCCACTCC TGAGCTCCCT 2400

AGCCACTGCT GCACTTTTGC TGACCCCATC GCCGCCAACC TGGAAGGGGC TGTAACCTTT 2460

GAGGCCCCTG ACCTCCCTGA AGAGACCCTC ATGGAGCAAG AGCACACGGA GACCCTGCAC 2520

AGCCTGCGCT GCACGCTCCT GTTCGCACAG CATGTCCTGG AGATCGCAGC CCTGAAGGGC 2580

AGTGCTGGCG AGGCAGCTGG AGACCCTGAC TACCAGCTTC AGGAGAGCGT GGTGGCCGAC 2640

CAGATCAGCC TACTGAGCCG CGAATGGGGC TTTGCAGAGC AGCTTGTGCT GTATCTGAAG 2700

GTGGCCGAGT TGCTGTCCTC AGGCCTACAG ACTGCCATTG ACCAGATTCG AGCTGGCAAG 2760

CTCTGCCTGT CATCCACTGT GAAGCAGGTG GTGCGCAGGC TGAACGAGTT GTACAAGGCC 2820

AGCGTGGTGT CCTGCCAGGG CCTGAGCCTG CGGCTACAAC GCTTTTTCCT GGACAAGCAA 2880

CGGCTCCTGG ACCGCGTCCA CAGCATCACT GCTGAGAAGC TCATCTTTAG CCATGCTGTG 2940

CAGATGGTGC AGTCAGCTGC CCTGGATGAG ATGTTCCAGC ACCGTGAGGG CTGTGTGCCA 3000

CGCTACCACA AGGCCCTGCT GCTTCTGGAG GGGCTGCAGC ACATGCTCTC AGATCAGGCG 3060

GACATTGAGA ATGTGGCCAA GTGCAAACTT TGCATTGAGC GGAGACTCTC GGCCCTGCTG 3120

ACCGGCATCT GTGCCTGA 3138

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         +s ++ iG+G+favv+kgr+r+k++ +vA+k+++kk+l+ks++ l keikilkelkheni

Q: 16    FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI  75

         7889********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+d++e++++vylvmeyc+ggdLa++l+++++Lsedt+r flqq+a a+++Lhsk+i+

Q: 76    VALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQQIAGAMRLLHSKGII  135

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLls+  +++ + +++++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 136   HRDLKPQNILLSNPGGRRaNPNNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMS  195

         *************999999*****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+yd kaDlWSiGti+y++l+Gk+Pf+a+s+++L+ ++ekn++l p+ip+e+s+ l++ll

Q: 196   QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLIPTIPRETSAPLRQLL  255

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++f+e+f+hpfl

Q: 256   LALLQRNHKDRMDFDEFFHHPFL  278

         *********************96

Domain Sequence
(FASTA)

FSRKDLIGHG AFAVVFKGRH REKHDLEVAV KCINKKNLAK SQTLLGKEIK ILKELKHENI 60

VALYDFQEMA NSVYLVMEYC NGGDLADYLH TMRTLSEDTI RLFLQQIAGA MRLLHSKGII 120

HRDLKPQNIL LSNPGGRRAN PNNIRVKIAD FGFARYLQSN MMAATLCGSP MYMAPEVIMS 180

QHYDGKADLW SIGTIVYQCL TGKAPFQASS PQDLRLFYEK NKTLIPTIPR ETSAPLRQLL 240

LALLQRNHKD RMDFDEFFHH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013