EKS-OTG-00010

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00010

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	487.5	6.2E-147	615	872	258

Status

Unreviewed

Ensembl Protein

ENSOGAP00000004544

UniProt Accession

H0WRA2;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA2

Gene Synonyms/Alias

EPHA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000005079	ENSOGAP00000004544	ENSOGAT00000005086

Organism

Otolemur garnettii

Functional Description

Protein Length

977

Protein Sequence
(FASTA)

MERWAARAWL ALLWGCALAA VAAAQGKEVV LLDFAAAKGE LGWLTQPYGS GWDLMQNIMN 60

DMPIYMYSVC NVVSGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 120

LYYAESDVDY GTNFQKRQFT KIDTIAPDEI TVNSDFEARH VKLNVEVRSV GPLTRKGFYL 180

AFQDIGACVA LLSVRVYYKK CPELLQGLAR FPETIPVSNA PSLATVAGTC VDNAVVPPGG 240

EEPRMHCAAD GEWLVPIGQC LCQAGYEKME DTCQACSPGF FKFEASESRC LECPAHTLPS 300

PEGATSCECE EGYFRAPHDP LSLPCTRPPS APHYLTAVGM GAKVELRWTP PQDSGGREDI 360

IYSVTCEHCW PESGECGPCE ASVHYSEPPH ALTHTSVTVS GLEPHMNYTF TVEARNGVSD 420

LVTSRSFRTA SVSINQTEPP KVKLEGRSTT SLSVSWSIPP LQQSRVWKYE VTYRKKGDSN 480

SYNVRRTEGF SVILDDLAPD TTYLVQVQAL TQEGQGAGSK VHEFQTLSAL EGSGNMAVIG 540

GVAVCIVLLL VLAGVGFFIH RRRKNLRARQ SSEDVYFSKS EQLKPLKTYV DPHTYEDPNQ 600

AVLKFTTEIH PSCVTRQKVI GAGEFGEVYK GTLKASSGKK EVPVAIKTLK AGYTEKQRVD 660

FLSEASIMGQ FSHHNIIRLE GVVSKYKPMM IITEYMENGA LDKFLREKDG EFNVLQLVGM 720

LRGIGAGMKY LANMNYVHRD LAARNILVNS NLVCKVSDFG LSRVLEDDPE ATYTTSGGKI 780

PIRWTAPEAI SYRKFTSASD VWSYGIVMWE VMTYGERPYW ELSNHEVMKA INEGFRLPTP 840

MDCPSAIYQL MMQCWQQERA RRPKFADIVS ILDKLIRAPD SLKTLADFDP RVSIRLPSTS 900

GSEGVPFRTV SEWLESIKMQ QYTEHFMAAG YTAIEKVVQM TNDDIKRIGV RLPGHQKRIA 960

YSLLGLKDQV NTVGIPI 977

Nucleotide Sequence
(FASTA)

ATGGAGCGCT GGGCAGCCCG CGCCTGGCTT GCTCTGCTGT GGGGCTGCGC GCTGGCCGCG 60

GTCGCGGCGG CACAGGGCAA GGAAGTTGTG CTGTTGGACT TTGCTGCAGC TAAGGGGGAA 120

CTCGGCTGGC TCACACAGCC ATATGGCAGC GGGTGGGACC TGATGCAGAA CATCATGAAC 180

GACATGCCCA TCTATATGTA CTCCGTGTGC AATGTGGTGT CTGGTGACCA GGACAACTGG 240

CTCCGCACCA ACTGGGTGTA CCGTGGTGAG GCCGAGCGCA TCTTCATCGA GCTCAAGTTC 300

ACCGTGCGTG ACTGCAACAG CTTCCCTGGA GGTGCCAGCT CCTGCAAGGA GACCTTTAAC 360

CTCTACTACG CCGAGTCAGA CGTGGACTAT GGCACCAACT TCCAGAAGCG CCAATTCACT 420

AAGATCGACA CCATTGCACC CGACGAGATC ACCGTCAACA GCGACTTCGA GGCACGCCAC 480

GTGAAGCTGA ATGTGGAGGT GCGCTCCGTG GGGCCACTCA CCCGCAAGGG CTTCTACTTG 540

GCTTTCCAAG ACATTGGTGC CTGTGTGGCA CTGCTCTCTG TCCGGGTCTA CTACAAGAAG 600

TGCCCGGAGC TGCTGCAGGG CCTGGCCCGC TTCCCTGAGA CCATCCCTGT CTCCAATGCA 660

CCCTCCCTGG CCACAGTGGC TGGCACTTGT GTGGACAATG CTGTGGTGCC ACCAGGGGGT 720

GAGGAGCCCC GCATGCACTG TGCAGCAGAC GGCGAGTGGC TGGTGCCCAT CGGGCAGTGC 780

CTGTGCCAGG CAGGCTATGA GAAGATGGAG GACACCTGCC AGGCCTGCTC ACCTGGATTC 840

TTTAAGTTCG AGGCGTCTGA GAGCCGCTGC TTGGAGTGCC CTGCCCACAC ACTGCCGTCC 900

CCTGAGGGTG CCACCTCCTG CGAATGTGAA GAAGGTTACT TCCGGGCACC TCACGACCCA 960

CTGTCACTGC CCTGCACACG CCCGCCCTCT GCCCCACACT ACCTCACGGC TGTGGGCATG 1020

GGTGCCAAAG TGGAGCTACG CTGGACACCC CCCCAGGACA GCGGGGGCCG TGAAGACATC 1080

ATCTATAGTG TTACCTGTGA GCACTGCTGG CCTGAGTCCG GAGAGTGCGG GCCCTGTGAG 1140

GCCAGTGTGC ACTACTCAGA GCCGCCACAT GCACTGACCC ACACCAGCGT GACAGTCAGT 1200

GGCCTGGAGC CCCACATGAA CTACACCTTC ACCGTGGAGG CCCGCAATGG TGTCTCGGAC 1260

CTGGTGACCA GCCGCAGCTT CCGCACTGCC AGCGTCAGCA TCAACCAAAC AGAGCCCCCC 1320

AAGGTGAAAC TGGAAGGCCG CAGCACCACC TCGCTGAGCG TCTCCTGGAG CATCCCCCCG 1380

CTGCAGCAGA GCCGCGTGTG GAAGTACGAG GTCACCTACC GAAAGAAGGG GGACTCCAAC 1440

AGCTACAACG TGCGCCGCAC TGAGGGCTTC TCCGTGATCC TGGATGACCT GGCTCCGGAC 1500

ACCACTTACC TGGTCCAGGT TCAGGCACTG ACGCAGGAGG GCCAGGGAGC CGGCAGCAAG 1560

GTGCATGAGT TCCAGACACT GTCAGCCCTG GAAGGATCTG GCAACATGGC GGTGATTGGC 1620

GGGGTGGCTG TCTGCATTGT CTTGCTTCTG GTGCTGGCCG GAGTCGGCTT CTTCATCCAC 1680

CGCAGGAGGA AGAACCTAAG AGCCCGCCAG TCCTCGGAGG ACGTTTACTT CTCCAAGTCA 1740

GAACAACTAA AGCCCCTGAA GACATACGTG GACCCCCACA CATATGAGGA CCCCAACCAG 1800

GCTGTGCTCA AGTTCACCAC CGAGATCCAT CCATCCTGTG TCACTCGCCA GAAAGTGATT 1860

GGGGCAGGAG AGTTCGGGGA GGTGTACAAG GGAACACTGA AGGCGTCCTC AGGGAAGAAG 1920

GAGGTGCCCG TGGCCATCAA GACCCTGAAA GCTGGCTACA CCGAGAAGCA GCGGGTGGAC 1980

TTCCTCAGCG AGGCTAGCAT CATGGGACAG TTTAGCCACC ACAACATCAT CCGCCTGGAG 2040

GGCGTCGTCT CCAAATACAA GCCTATGATG ATCATCACTG AGTACATGGA GAACGGGGCC 2100

CTGGACAAGT TCCTTCGGGA GAAGGATGGC GAGTTCAACG TGCTGCAGCT GGTGGGCATG 2160

CTGAGGGGCA TCGGGGCCGG CATGAAGTAC CTGGCCAACA TGAACTATGT GCACCGGGAC 2220

CTGGCCGCCC GCAACATCCT GGTGAACAGC AACCTGGTCT GCAAGGTGTC TGACTTTGGC 2280

CTGTCCCGTG TACTGGAAGA TGACCCTGAA GCCACTTATA CCACCAGTGG AGGCAAGATT 2340

CCAATTCGCT GGACAGCCCC AGAGGCCATT TCTTACCGCA AGTTCACCTC AGCCAGCGAC 2400

GTGTGGAGCT ATGGCATTGT CATGTGGGAG GTGATGACCT ACGGCGAGCG GCCCTATTGG 2460

GAGCTGTCAA ACCATGAGGT GATGAAAGCC ATCAATGAAG GCTTCCGGCT CCCCACGCCC 2520

ATGGACTGCC CCTCCGCCAT CTACCAGCTC ATGATGCAGT GCTGGCAGCA GGAGCGTGCC 2580

CGCCGCCCCA AGTTCGCCGA TATCGTCAGC ATCCTAGATA AGCTCATCCG TGCTCCTGAC 2640

TCCCTCAAGA CCCTGGCGGA CTTTGACCCC CGGGTGTCCA TCCGGCTGCC CAGCACCAGC 2700

GGCTCAGAGG GCGTGCCCTT CCGCACAGTG TCCGAGTGGC TTGAGTCCAT TAAGATGCAG 2760

CAGTACACAG AGCACTTCAT GGCGGCCGGC TACACTGCCA TCGAGAAGGT GGTGCAGATG 2820

ACCAATGATG ACATCAAGAG GATCGGAGTA CGGCTGCCTG GCCACCAGAA GCGCATCGCC 2880

TACAGCCTGC TGGGACTTAA GGACCAGGTG AACACGGTGG GGATCCCCAT CTGA 2934

Domain Profile

S: 2     kiekviGaGefGevcsGrlkl.pgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         + +kviGaGefGev++G+lk+ +gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+

Q: 615   TRQKVIGAGEFGEVYKGTLKAsSGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHH  674

         6789****************9678************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvv+k kp+mi+teymengald+flr+kdg+f+v+qlvgmlrGi++gmkyl++m

Q: 675   NIIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFNVLQLVGMLRGIGAGMKYLANM  734

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         +yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrk

Q: 735   NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK  794

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev++yGerpyw++sn++v+kai+eg+rlp+pmdcp+a+yqlm++c

Q: 795   FTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINEGFRLPTPMDCPSAIYQLMMQC  854

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wq++ra+rpkf++ivsil

Q: 855   WQQERARRPKFADIVSIL  872

         ***************985

Domain Sequence
(FASTA)

TRQKVIGAGE FGEVYKGTLK ASSGKKEVPV AIKTLKAGYT EKQRVDFLSE ASIMGQFSHH 60

NIIRLEGVVS KYKPMMIITE YMENGALDKF LREKDGEFNV LQLVGMLRGI GAGMKYLANM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEATYT TSGGKIPIRW TAPEAISYRK 180

FTSASDVWSY GIVMWEVMTY GERPYWELSN HEVMKAINEG FRLPTPMDCP SAIYQLMMQC 240

WQQERARRPK FADIVSIL 258

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013