EKS-OTG-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	430.2	4.9E-129	157	453	297

Status

Unreviewed

Ensembl Protein

ENSOGAP00000004668

UniProt Accession

H0WRK9;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000005221	ENSOGAP00000004668	ENSOGAT00000005224

Organism

Otolemur garnettii

Functional Description

Protein Length

483

Protein Sequence
(FASTA)

SQFLLLQNTN TGIISLPFVD TKETKNMVNF PSISNKILLK PPASYRESQT HNQMPSSELK 60

VSEMPLHSTI KIQDTKSEEK SPRKHKPALT AAEALKSFKH QLSPYEQSEI LGYTEIWFLG 120

LEAQKLNVAP EKFSKTSFDD DHGSYMKVLH DHIAYRYEVL EMIGKGSFGQ VAKCLDHKKN 180

EFVALKIIRN KKRFHHQALV ELKILEALRR KDKDNNHNVV HMKDFFYFRN HLCITFELLG 240

INLYELMKNN SFQGFSLSIV RRFTLSVLKC LQLLYVEKII HCDLKPENIV LYQKGQVSVK 300

VIDFGSSCYE HQKVYTYIQS RFYRSPEVIL GHPYNMAIDM WSLGCIMAEL YTGCPLFPGE 360

NEVEQLACFM EVLGLPPADF IQTASRRQTF FDSKGFPKNI TNNRGKKRYP DSKDLTMVLK 420

TYDTSFLDFV RKCLIWEPSL RMTPDQALKH AWIHEPRNLK PQLRTKTARK NTLCFPSEPR 480

KDK 483

Nucleotide Sequence
(FASTA)

AGCCAATTTC TCCTCCTGCA GAATACAAAC ACCGGCATTA TTTCACTCCC TTTTGTGGAC 60

ACCAAGGAGA CGAAAAACAT GGTAAACTTC CCAAGCATTA GCAACAAAAT CCTACTGAAG 120

CCACCTGCAT CGTATAGGGA GAGTCAAACT CATAATCAGA TGCCATCCTC TGAGCTCAAA 180

GTTTCAGAAA TGCCTCTCCA CTCTACCATT AAAATCCAGG ACACCAAGTC GGAGGAGAAA 240

TCACCAAGGA AGCACAAGCC GGCTCTGACA GCGGCAGAGG CCCTAAAGTC TTTTAAGCAC 300

CAGCTGTCTC CTTATGAGCA AAGTGAAATC CTGGGCTACA CAGAGATATG GTTCCTGGGG 360

CTGGAAGCCC AGAAACTGAA CGTGGCTCCT GAGAAGTTCA GCAAGACAAG TTTTGATGAT 420

GACCATGGCT CCTATATGAA GGTCCTGCAT GACCACATTG CCTACCGCTA CGAGGTCCTG 480

GAGATGATCG GAAAAGGGTC CTTTGGACAG GTGGCCAAGT GCTTGGATCA CAAAAAAAAT 540

GAGTTCGTGG CCCTGAAAAT CATCAGGAAC AAGAAGAGGT TTCACCACCA GGCCCTGGTG 600

GAGCTGAAGA TCCTGGAGGC TCTCAGAAGG AAGGACAAAG ACAACAACCA CAACGTGGTG 660

CACATGAAGG ATTTTTTCTA CTTCCGCAAC CACCTCTGCA TCACCTTCGA ACTCCTGGGA 720

ATCAACTTGT ATGAGCTGAT GAAGAATAAC AGCTTTCAAG GCTTCAGTCT TTCCATAGTT 780

CGGCGCTTCA CGCTTTCTGT TCTCAAGTGC TTGCAATTGC TTTATGTAGA GAAAATCATT 840

CACTGTGATC TCAAGCCTGA AAACATAGTG CTATACCAAA AGGGCCAAGT CTCTGTTAAA 900

GTCATTGACT TTGGATCAAG CTGTTATGAA CACCAGAAAG TGTATACCTA CATCCAAAGT 960

CGGTTCTACC GATCCCCGGA GGTGATCCTG GGCCACCCCT ACAACATGGC CATTGACATG 1020

TGGAGCCTTG GCTGCATCAT GGCGGAGTTG TACACAGGCT GCCCTCTGTT CCCAGGGGAG 1080

AATGAAGTGG AGCAGCTGGC CTGCTTCATG GAGGTCCTGG GCCTGCCACC AGCCGACTTC 1140

ATCCAGACGG CCTCCAGAAG ACAGACATTC TTTGATTCCA AAGGTTTTCC TAAAAATATA 1200

ACCAACAACA GGGGGAAAAA AAGATACCCG GATTCCAAGG ATCTCACGAT GGTGCTGAAA 1260

ACCTATGATA CCAGCTTCCT GGACTTTGTT AGAAAGTGTT TGATATGGGA ACCTTCTCTT 1320

CGAATGACCC CTGACCAGGC CCTCAAGCAT GCTTGGATTC ACGAGCCACG GAACCTTAAA 1380

CCACAACTCA GGACCAAGAC TGCAAGAAAG AATACCTTAT GTTTCCCCTC TGAGCCAAGG 1440

AAGGACAAG 1449

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle+igkGsfgqV+k+ld+k++e va+kii+nkkrf++qa  E++iLe+l++kdk+++

Q: 157   YEVLEMIGKGSFGQVAKCLDHKKNEFVALKIIRNKKRFHHQALVELKILEALRRKDKDNN  216

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nvv+++++f+frnhlc++fell +nLyel+k+n+f+g+sl++vr+++ ++lk+L+lL+

Q: 217   HNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFQGFSLSIVRRFTLSVLKCLQLLYV  276

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNi+l++k++ +vkviDFGss++++qk +ytyiqsrfYr+PE+ilg++y+

Q: 277   EKIIHCDLKPENIVLYQKGQVSVKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHPYN  335

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         +aiDmWSlGc++aEl+tG pLfpGenev+qla+++evlglpp+ ++++a+++++ff++k+

Q: 336   MAIDMWSLGCIMAELYTGCPLFPGENEVEQLACFMEVLGLPPADFIQTASRRQTFFDSKG  395

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +pk i+                ++  k+++p sk+l+++lk+++++ f d+++++l ++p

Q: 396   FPKNIT----------------NNRGKKRYPDSKDLTMVLKTYDTS-FLDFVRKCLIWEP  438

         *99766................34456789999***9999998877.*************

S: 301   akRitpkealkhpfv  315

         + R+tp++alkh ++

Q: 439   SLRMTPDQALKHAWI  453

         *************97

Domain Sequence
(FASTA)

YEVLEMIGKG SFGQVAKCLD HKKNEFVALK IIRNKKRFHH QALVELKILE ALRRKDKDNN 60

HNVVHMKDFF YFRNHLCITF ELLGINLYEL MKNNSFQGFS LSIVRRFTLS VLKCLQLLYV 120

EKIIHCDLKP ENIVLYQKGQ VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYNM 180

AIDMWSLGCI MAELYTGCPL FPGENEVEQL ACFMEVLGLP PADFIQTASR RQTFFDSKGF 240

PKNITNNRGK KRYPDSKDLT MVLKTYDTSF LDFVRKCLIW EPSLRMTPDQ ALKHAWI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013